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Matches 1 - 50 out of 40,136

Document Document Title
WO/2019/029521A1
The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation me...  
WO/2019/029613A1
A deuterated quinoline compound, specifically a compound represented by formula (I), a stereochemical isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof for use in the preparation of a medicament for treating...  
WO/2019/029541A1
Provided are a fibroblast growth factor receptor (FGFR) irreversible inhibitor as represented by formula I, a pharmaceutically acceptable salt, a stereoisomer thereof, and pharmaceutical preparations, pharmaceutical compositions and uses...  
WO/2019/028508A1
Disclosed herein are a series of compounds based on Formula (I). These compounds comprise perylene core which has been extended with optionally functionalised imidazoles at the 3,4;9,10 positions. The compounds of Formula (I) can be func...  
WO/2019/029629A1
Disclosed are novel pyrzaolopyrimidines of Formula (I), their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds have protein kinases inhibitory activities and are expected to be useful for the t...  
WO/2019/029554A1
The present invention relates to a sulfonamide derivative and a preparation method and medical use thereof. In particular, the present invention relates to a sulfonamide derivative shown in formula (I), a preparation method and pharmaceu...  
WO/2019/024908A1
Substituted penta- and hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a preparation method therefor, a drug combination that...  
WO/2019/027765A1
Disclosed are new small molecules having a substituted pyrimidine or substituted fused pyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising t...  
WO/2019/025521A1
The present invention relates to a novel polymorphic form of varenicline fumarate, to processes for their preparation,to pharmaceutical compositions comprising the same and to their therapeutic uses.  
WO/2019/028440A1
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...  
WO/2019/026728A1
[Problem] The purpose of the present invention is to provide an organic EL element in which, as a highly efficient and highly durable organic EL material, various materials excelling in electron injection/transport performance, hole bloc...  
WO/2019/028284A1
Provided herein are methods for treating a subject with PNH comprising administering to a subject a therapeutically effective amount of complement component C5 (C5) inhibitor, complement component C3 (C3) inhibitor, or complement factor ...  
WO/2019/028301A1
Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R5, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7...  
WO/2019/026883A1
The present invention relates to a method for producing a macrocyclic compound, the method comprising a step for reacting an aldehyde represented by formula (3) and a pyrrole ring compound represented by formula (4) to obtain a macrocycl...  
WO/2019/028171A1
A method of use for Cpd 1 as an inhibitor of dihydroorotate dehydrogenase (DHODH) function in treating or ameliorating a hematological cancer in a subject in need thereof comprising, administering an effective amount of Cpd 1 to the subj...  
WO/2019/028473A1
Disclosed are methods for performing dynamic nuclear polarization using the polarizing agents described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polar...  
WO/2019/025440A1
The present invention covers combinations of at least two components, component A and component B, comprising component A being an inhibitor of ATR kinase, particularly an inhibitor of ATR kinase selected from VX-803, VX-970, AZD-6738, a...  
WO/2019/027783A1
The present invention provides a compound of Formula (I), wherein X is H or C1-C3 alkyl optionally substituted with hydroxyl; Y is H, hydroxy, or methyl; R is ethyl, n-propyl, cyclopropyl, or Formula (II); and A is methyl, cyclopropyl or...  
WO/2019/023022A1
A copolymer comprising a repeat unit A, wherein repeat unit A comprises a 1,2,5,6-naphthalenediimide monomer and at least one repeat unit B, wherein repeat unit B comprises an aryl group. The copolymer can be regio-random or regio-regular.  
WO/2019/020792A1
The present invention relates to new compounds of general formula (I) that show dual activity towards α2δ subunit of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit, and to the noradrenaline transporter (NET). The...  
WO/2019/023021A1
A method comprising converting 2, 6-naphthalene diol to produce a 1, 2, 5, 6-naphthalenediimide monomer, wherein the method occurs at temperatures less than 250° C and NDI monomers are produced safely.  
WO/2019/021059A1
The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hea...  
WO/2019/020993A1
Salts of cytisine have been prepared and incorporated in stable pharmaceutical compositions, including compositions comprising lactose. The salts are prepared by adding acid stock solutions to solutions of cytisine with heating, followed...  
WO/2019/023468A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.  
WO/2019/023216A1
The present disclosure relates to salts and crystalline forms of a compound having the formula (I) : Also described are processes for the production of the salts and crystalline forms described herein.  
WO/2019/023635A1
Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,5-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1 ) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for makin...  
WO/2019/020981A1
The present invention relates to substituted pyrazole, isoxazole andisothiazole compounds which are of use in the field of agriculture as fungicides.  
WO/2019/018975A1
The salts and crystalline forms of a compound having the formula (1) and processes for the production of the salts and crystalline forms are disclosed.  
WO/2019/023207A1
The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.  
WO/2019/023278A1
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions,...  
WO/2019/022061A1
This fungicide for agricultural and horticultural use includes a compound represented by formula (I) (in the formula, X represents a halogen group, etc.; n represents any integer of 0-4; when n is 2 or higher, X may be the same or differ...  
WO/2019/015559A1
The present invention belongs to the field of medical chemistry, and relates to a class of heterocyclic compounds acting as ASK inhibitors and the use thereof. Specifically, provided are compounds as shown in formula A or isomers, pharma...  
WO/2019/015689A1
Provided are a chiral 3-quinuclidone compound, a preparation method, and a use. In particular, the present invention provides a compound shown in general formula I-A or I-B or a pharmaceutically acceptable salt, isomer or a mixture there...  
WO/2019/015608A1
Disclosed are a class of isoquinoline compounds acting as RHO protein kinase inhibitors, and the use thereof in the preparation of a drug for treating diseases associated with RHO protein kinase. Particularly disclosed are compounds as s...  
WO/2019/015593A1
Provided is a pyridopyrimidinone or pyridopyridone compound having a structure of the formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof or a prodrug molecule thereof. Such compounds can inhibit the activ...  
WO/2019/016071A1
The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I), in which A, X, R1, R2a, R2b, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations compris...  
WO/2019/015672A1
Disclosed are a pyridoimidazole compound and the use of the same as an IDH mutant inhibitor. In particular, disclosed are the compound as shown in formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof.  
WO/2019/015463A1
The present invention provides a new crystal form of a N-phenyl‑2‑aminopyrimidine compound, a crystal form of a pharmaceutically acceptable salt of said compound, and a preparation method for these crystal forms and use thereof. The ...  
WO/2019/018354A1
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.  
WO/2019/018539A1
(-)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.  
WO/2019/018583A1
1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may fin...  
WO/2019/016269A1
The present invention relates to derivatives of formula (I) which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR.  
WO/2019/014513A1
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat diseases, such as cancer.  
WO/2019/014514A1
This disclosure relates to compounds that are CBP inhibitor and methods of using such compounds in the treatment and diagnosis of diseases and disorders.  
WO/2019/011336A1
The invention relates to a crystal form of a compound (I), a preparation method and use thereof, a pharmaceutical composition containing said crystal form, and the use of the crystal form in preparing the prostaglandin D2 receptor 2 anta...  
WO/2019/014300A1
The present invention provides compounds of Formula (I): Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitor...  
WO/2019/013562A1
The present invention relates to a novel 1H-pyrazolopyridine derivative and a pharmaceutical composition containing the same. The 1H-pyrazolopyridine derivative and the pharmaceutical composition containing the same can be effectively us...  
WO/2019/014296A1
Provided herein are mechanically interlocked air-stable persistent organic radicals. The radical compositions may access a multiplicity of radical, cationic redox states as well as a fully cationic redox state. A composition comprises a ...  
WO/2019/013273A1
The present invention provides: a compound represented by formula (I), which is highly effective in controlling harmful arthropods; an intermediate of the compound; and a production method for the compound. [In formula (I), A1 represents...  
WO/2019/013312A1
The present invention provides a compound represented by formula (I). (In formula (I), (2) is, for example, (3); R1 is a hydrogen atom; R2a and R2b have been bonded to each other to form a ring B, which is (5); R3a is a hydrogen atom; R3...  

Matches 1 - 50 out of 40,136