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Matches 1 - 50 out of 40,408

Document Document Title
WO/2019/075402A1
The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, oral mucositis, mucositis, and proctitis by the administration of a compound ...  
WO/2019/071348A1
There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying exci...  
WO/2019/072978A1
The invention provides compounds of formula (I) or pharmaceutically acceptable salt thereof wherein ring A represents group A-I, A-II or A-III. Al represents -C(R4a)(R4a)-, -C(R4a)= -N(R4b)-, -N= -O- or -S-; A2 represents -C(R4c)(R4c)-, ...  
WO/2019/072785A1
The invention provides new heterocyclic compounds having general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufac...  
WO/2019/040106A3
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.  
WO/2019/075092A1
In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.  
WO/2019/075108A1
Provided herein are compound of Formula I-IV and pharmaceutically acceptable salts thereof which exhibit rearranged during transfection (RET) kinase inhibition. In particular, provided herein are novel crystalline forms of 4-(6-(4-((6-me...  
WO/2019/075243A1
Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl] pyrrolo[3,2-b]pyridin-3- yl)benzoic acid (Compound I) were prepared and characterized in the solid state: (I). Also provided are processes of manufacture and methods o...  
WO/2019/073251A1
This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compound...  
WO/2019/074824A1
The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proli...  
WO/2019/075291A1
The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compoun...  
WO/2019/072906A1
The invention relates to compounds of formula (I): wherein the variables are defined in the specification. The invention also relates to a pesticidal mixture comprising a compound of formula (I), and another agrochemically active ingredi...  
WO/2019/073102A1
The present invention relates to compounds of general formula (I) and to the use thereof in the production of medicinal products that can be used to treat human diseases, including, but not limited to, various types of cancer, infectious...  
WO/2019/068726A1
The present invention relates to a cellular transport system for bringing a sulfonic acid construct which carries a cargo into a cell and releasing the cargo in the cell's cytoplasm, the cellular transport system comprising: (i) a sulfon...  
WO/2019/069293A1
Compounds of Formula (I), specifically hepatitis B virus and/or hepatitis D virus inhibitors, more specifically compounds that inhibit HBe antigen and HBs antigen in a subject, for the treatment of viral infections, and methods of prepar...  
WO/2019/070043A1
The purpose of the present invention is to provide a heterocyclic compound that potentiates AMPA receptor function and can be expected to be useful as a preventive or therapeutic agent for depression, Alzheimer's disease, schizophrenia, ...  
WO/2019/071073A1
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical e...  
WO/2019/068613A1
The present invention encompasses compounds of formula (I) wherein the groups R1 to R5, A and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compou...  
WO/2019/068783A1
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.  
WO/2019/070044A1
A purpose of the present invention is to provide a heterocyclic compound that has an AMPA receptor function enhancing action, and can be expected to be useful as a prevention or treatment for depression, Alzheimer's disease, schizophreni...  
WO/2019/066607A1
The present invention relates to a heterocyclic compound represented by chemical formula 1 and an organic light emitting device comprising the same.  
WO/2019/064310A1
The present invention relates to an improved process for the preparation of Elbasvir compound of Formula-I through its novel salt.  
WO/2019/067591A1
The disclosure provides new, stable, pharmaceutically acceptable hydrochloride salt forms of 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-h exahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin- 8-yl)-butan-1-one, tog...  
WO/2019/062657A1
The present invention relates to a nitrogen heterocyclic derivative, a preparation method therefor, and a pharmaceutical use thereof. In particular, the present invention relates to a nitrogen heterocyclic derivative represented by the g...  
WO/2019/063414A1
The invention relates to a compound of formula (I): Formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein A is heteraryl selected from 1 H-benzimidazol...  
WO/2019/067511A1
Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, ara...  
WO/2019/061796A1
The present invention relates to an organic compound with triazine and quinoxaline as a core and application thereof in an OLED device. The compound of the present invention is high in glass transition temperature and molecular thermal s...  
WO/2019/067623A1
The present technology provides compounds according to Formula I: (I) expected to be useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a c...  
WO/2019/065568A1
The present invention provides: a compound represented by formula (I) that has an excellent controlling effect against harmful arthropods [in the formula, A1 represents NCH3 or the like, A2 represents a nitrogen atom or the like, R1 repr...  
WO/2019/062686A1
Disclosed in the present invention are a compound with cyanobenzene as the core, and an application of the compound in OLED devices. The compound has cyanobenzene as the core and a carbazole cyclic group as a branched chain. The compound...  
WO/2019/064066A1
The present invention relates to a process for producing crystalline and amorphous forms of a diazabicyclooctane derivative represented by Compound (I) and methods for producing the same.  
WO/2019/063996A1
Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preve...  
WO/2019/063596A1
The present invention relates to novel heterocyclic compounds. The invention is also directed to compounds which are modulators of the metabotropic glutamate receptors (m Glu R), preferably of the metabotropic glutamate receptor subtype ...  
WO/2019/062329A1
Provided are a 4,6,7-trisubstituted 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3-one derivative and a preparation method and pharmaceutical use thereof. In particular, the present invention relates to a compound of formula (I) or a pharma...  
WO/2019/065794A1
The present invention relates to an analgesic drug containing: a compound represented by formula (I) or (II) (where, R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; R is an indazolyl group substituted with a ...  
WO/2019/064071A1
The present invention relates to crystalline forms of a diazabicyclooctane derivative represented by Compound I, the process for producing the same and methods for using the same: (I).  
WO/2019/065570A1
The present invention provides: a compound having an excellent controlling effect against a harmful arthropod and represented by formula (I); and a composition containing the compound, wherein, in formula (I), Q represents a group repres...  
WO/2019/062328A1
The present invention relates to a 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3-one derivative substituted by N-(3-aminophenyl)acrylamide and a preparation method and pharmaceutical use thereof. In particular, the present invention relate...  
WO/2019/056932A1
Disclosed in the present invention is an imidazole derivative. The imidazole derivative has a structural formula as represented by formula I: (I). Also disclosed in the present invention are a material comprising the imidazole derivative...  
WO/2019/057660A1
The present invention relates to heteroaryl compounds of formula (Ia) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer,an isotopic form, a N-oxide or a S-oxide thereof. The present invention furt...  
WO/2019/056163A1
Disclosed are a degradable impurity, i.e. N-formyl palbociclib, in a palbociclib solid preparation, a preparation method therefor, and a use thereof in prescription studies and impurity detection for the palbociclib solid preparation. Al...  
WO/2019/057740A1
The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2 - b]pyridazin-6-yl)pyrido[l,2-a]pyrimidin-4-one derivatives useful pharmaceutically active compounds.  
WO/2019/058393A1
Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compo...  
WO/2019/058132A1
This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the gene...  
WO/2019/056990A1
A 1,2-dihydro-1,6-naphthyridine derivative, a preparation method therefor, and an application thereof in medicine. Specifically provided are a 1,2-dihydro-1,6-naphthyridine derivative as represented by formula (I), a preparation method t...  
WO/2019/060770A1
The present disclosure provides compounds comprising a tetrapyrrole (e.g., a tetrapyrrole group) linked via a linker to one or more ligands and uses of the compounds. The compounds may be used as imaging agents (e.g., MRI contrast agents...  
WO/2019/057158A1
Provided are a condensed heteroaryl derivative, a preparation method therefor, and application thereof in medicines. Specifically, provided are a condensed heteroaryl derivative represented by general formula (I), a preparation method th...  
WO/2019/057053A1
Provided are a compound of formula (I) having FGFR4 inhibitory activity, a preparation process therefor, and use thereof in the manufacture of a medicament for treating a disease associated with FGFR4.  
WO/2019/055877A1
The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For inst...  
WO/2019/053010A1
Compounds of the formula (I) wherein the subsitiuents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and t...  

Matches 1 - 50 out of 40,408