Heterocyclic Compounds

Matches 1 - 50 out of 36,796	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2024/081939A2	GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF The present disclosure provides compounds of Formulae T-A, I-B. II-A. II-B. lll-A, III-B, IV-A. IV-B, V-A, V-B, Vl-A, and VI-B. and compounds shown in Table 13, Table 13 A, and Table 14, and pharmaceutically acceptable salts, solvates, h...
WO/2024/081775A1	SYNTHESIS OF 6-FLUORO-2-METHYLBENZO[D]THIAZOL-5-YL COMPOUNDS The present invention provides improved reaction schemes and novel reaction intermediates for the synthesis of molecules useful as O-GlcNAcase (OGA) inhibitors.
WO/2024/080330A1	SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD CONTROLLING COMPOSITION CONTAINING SAME The present invention provides a compound having an excellent control effect against harmful arthropods. A compound represented by formula (1) and an N oxide thereof have an excellent control effect against harmful arthropods. [In the fo...
WO/2024/078448A1	HPK1 KINASE INHIBITOR AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF Provided are an HPK1 kinase inhibitor, a preparation method therefor and the use thereof. The kinase inhibitor can adjust (for example, inhibit) HPK1 kinase activity, and thus can be used for treating various HPK1-related diseases includ...
WO/2024/078579A1	INDOLE PHTHALOCYANINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN TUMOR DIAGNOSIS IMAGING The present invention relates to an indole phthalocyanine compound, a preparation method therefor, and a use thereof in tumor diagnosis imaging. Specifically, the present invention relates to a compound having a structure represented by ...
WO/2024/081927A1	COMPOUNDS FOR IMPROVEMENT OF VIRAL PRODUCTION Provided herein are methods of improving (e.g., increasing) the production of viral particles (e.g., AAV) in mammalian cells (e.g., HEK293 or HEK293T cells) using selective HDAC6 inhibitors (e.g., compounds of Formula I, Formula II, or F...
WO/2024/080788A1	NOVEL TRICYCLIC DERIVATIVE COMPOUND AND USES THEREOF The present invention relates to a novel tricycle derivative compound and uses thereof, more specifically to a novel tricycle derivative compound having inhibitory activity for methionine adenosyltransferase 2A (MAT2A) and uses thereof.
WO/2024/080354A1	SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD-CONTROLLING COMPOSITION CONTAINING SAME The present invention provides a compound, or an N-oxide thereof, which has an excellent controlling effect with respect to harmful arthropods and which is represented by formula (I) (in the formula: Q denotes a group represented by form...
WO/2024/078581A1	SELECTIVE BCL-XL PROTAC COMPOUNDS AND USES THEREOF The present application relates to novel PROTAC compounds, and tautomers, stereoisomers, or pharmaceutically acceptable salts thereof, which degrade and/or inhibit the level or activity of BCL-XL proteins. The present application also re...
WO/2024/081889A1	4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES FOR TREATING CANCER This disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3Kα). These compounds are useful for treating a disease...
WO/2024/078628A1	METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATING OSTEOPOROSIS Provided is a method for treating osteoporosis, and further provided is a drug for treating osteoporosis, comprising: a therapeutically effective amount of ONT-380 or a pharmaceutically acceptable salt thereof, or a combination of ONT-38...
WO/2024/074497A1	PARG INHIBITORY COMPOUND The present invention relates to a compound of formula (I) or pharmaceutically acceptable salt thereof. The present invention further relates to the compound of formula (I) of the present invention for use in therapy. The compound is par...
WO/2024/076670A2	TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF The present disclosure provides compounds having activity as inhibitors of the G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and methods of treating certain disorders, such as cancer, including but not l...
WO/2024/077273A2	COMPOUNDS, COMPOSITIONS, AND METHODS The present disclosure relates generally to small molecule inhibitors of Sterile Alpha and TIR Motif containing 1 (SARM1) protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomer...
WO/2024/073802A1	METHOD OF DETECTION A method for detection of a nerve agent in a sample, which method comprises (a) irradiating an optical sensing element, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, and measuring the lumi...
WO/2024/074128A1	ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND USES THEREOF Described herein are ENPP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with ENPP1.
WO/2024/077236A1	COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS The present disclose includes, among other things, compounds that treat or lessen the severity of cancer, pharmaceutical compositions and methods of making and using the same.
WO/2024/077137A1	CRYSTALLINE FORMS OF A PARP1 INHIBITOR Described herein are crystalline forms of 5-(4-((7-cyclopropyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl )methyl)piperazin-1-yl)-N-methylpicolinamide (compound 1), or a pharmaceutically acceptable salt or solvate thereof.
WO/2024/076672A1	HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF The present disclosure provides compounds having activity as inhibitors of the G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and methods of treating certain disorders, such as cancer, including but not l...
WO/2024/074611A1	PRMT5 INHIBITORS The present invention relates to compounds of formula (I) and salts, stereoisomers, atrop-isomers, rotamers, tautomers or N- oxides thereof that are useful as PRMT5 inhibitors. The present invention further relates to the compounds of fo...
WO/2024/074977A1	SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS This disclosure relates to compounds of Formula (I) (I), or a pharmaceutically acceptable salt thereof, in which R3, R4, L2, W, X, Y, and Z are as 5 defined herein, to pharmaceutical compositions comprising such compounds and salts; to p...
WO/2024/076680A1	CRYSTAL FORMS OF AN ANTI-SARS COV-2 AGENT The present invention features crystalline forms of Compound I, including polymorphs and pseudopolymorphs, which are useful in the preparation of pharmaceutical compositions.
WO/2024/075139A1	A PROCESS FOR PREPARATION OF FINERENONE AND INTERMEDIATES THEREOF The present application relates to an improved process for the preparation of finerenone and intermediates thereof, which is represented by the following structural formula-I.
WO/2024/077023A2	CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS The present disclosure provides compounds of Formula (I), which may be Bcl-xL and Bcl-2 dual inhibitors. The compounds may target and degrade Bcl-xL and Bcl-2. The present disclosure also provides pharmaceutical compositions, kits, and m...
WO/2024/075815A1	8-HYDROXYQUINOLINE COMPOUND AND USE THEREOF The present invention addresses the problem of providing a cMLCK activator which can enhance myocardial contraction without the need to increase the concentration of calcium in cells. The problem is solved by a cMLCK activator comprising...
WO/2024/075696A1	IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE The present invention addresses the problem of providing a novel compound having an SMG1 inhibitory activity and an anticancer effect, or a pharmaceutically acceptable salt thereof etc.　A compound represented by formula (1) or a pharma...
WO/2024/075051A1	HSD17B13 INHIBITORS AND/OR DEGRADERS Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD an...
WO/2024/075070A2	NOVEL BICYCLIC HETEROCYCLYL COMPOUNDS AND USE THEREOF The present invention relates to a compound represented by chemical formula 1 as an SOS1 inhibitor, optical isomers thereof, stereoisomers thereof, solvates thereof, isotopic variants thereof, tautomers thereof, or pharmaceutically accep...
WO/2024/077244A1	COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS The present disclose includes, among other things, compounds that treat or lessen the severity of cancer, pharmaceutical compositions and methods of making and using the same.
WO/2024/077036A1	METHODS FOR TREATING CANCER This disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compounds of Formula (II), and pharmaceutically acceptable salts thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3-kinase (...
WO/2024/071371A1	HETEROCYCLIC COMPOUND The present disclosure provides a heterocyclic compound.　The disclosure relates to a compound in which a ligand of a specific E3 ligase is bound to an intracellular target protein ligand via a linker. More specifically, the disclosure ...
WO/2024/067819A1	PIPERIDINE-CONTAINING POLYCYCLIC DERIVATIVE MODULATOR, PREPARATION METHOD THEREFOR, AND USE THEREOF A piperidine-containing polycyclic derivative modulator, a preparation method therefor, and use thereof. In particular, the present invention relates to a compound represented by general formula (II-a), a preparation method therefor, a p...
WO/2024/073559A1	BICYCLIC COMPOUNDS Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein)...
WO/2024/066986A1	2-AMINOPYRIMIDINE COMPOUND, AND USE AND PHARMACEUTICAL COMPOSITION THEREOF The present invention relates to a 2-aminopyrimidine compound, and a use and pharmaceutical composition thereof. The compound can inhibit CDK4 and CDK6 activity, in particular CDK4 activity with high selectivity, and treat or prevent hyp...
WO/2024/073475A1	CEREBLON LIGANDS AND USES THEREOF Described herein are compounds of Formula II or conjugates of Formula II' and their pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses (e.g., as cereblon-binding agents or degraders for certain p...
WO/2024/068851A1	A PROCESS FOR THE MANUFACTURE OF SALTS AND CRYSTALLINE FORMS OF 1-(8-BROMOPYRIDO[2,3-E][1,2,4]TRIAZOLO[4,3-A]PYRAZIN-4-YL)-N-METHYLAZETIDIN-3-AM INE AND NOVEL CRYSTALLINE FORMS A novel process for preparation of crystalline forms and novel crystalline forms of 1-(8- bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-N-meth ylazetidin-3-amine salts is provided along with pharmaceutical compositions comprising...
WO/2024/070371A1	COMPOSITION, OPTICAL FILTER, AND SOLID-STATE IMAGING ELEMENT The present invention addresses the problem of providing a composition capable of forming an optical filter that has fewer aggregates.　The present invention relates to a composition comprising a near-infrared absorbing dye, an alkali-s...
WO/2024/067465A1	KIF18A INHIBITOR Provided are a compound useful as a KIF18A inhibitor, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, a pharmaceutical composition and a preparation comprising the compound or the pharmaceutically acceptable salt,...
WO/2024/073658A1	HYDANTOIN MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION The subject matter described herein is directed to myelin-promoting compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of admin...
WO/2024/071216A1	PYRAZOLE COMPOUND AND PEST CONTROL AGENT CONTAINING SAME AS ACTIVE INGREDIENT The present invention addresses the problem of providing a novel compound for controlling pests. A pyrazole amide compound according to the invention is a novel compound that can control pests. The pyrazole amide compound according to th...
WO/2024/071439A1	FUSED RING COMPOUND AND PHARMACEUTICAL CONTAINING SAME The present invention provides a novel compound that has an STAT6 inhibitory effect and is efficacious in treating inflammatory diseases and allergic diseases such as atopic dermatitis. A compound represented by general formula (I) and h...
WO/2024/068976A1	AZOLE DERIVATIVES AS SHP2 INHIBITORS The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also re...
WO/2024/067445A1	NOVEL PRMT5 INHIBITOR AND USE THEREOF Provided are a compound of formula (I) having inhibitory activity for protein arginine methyltransferase 5, and a method for synthesis and use of the compound.
WO/2024/067820A1	TRICYCLIC COMPOUNDS AS CDK INHIBITORS AND METHODS OF USING SAME Provided are novel tricyclic compounds as CDK inhibitors, which are useful for treating diseases or conditions mediated by CDKs, particularly cancers and other diseases caused by abnormal cell proliferation. Preparation methods, pharmace...
WO/2024/072793A1	PYRIDINE CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS The invention provides pyridine carboxamide compounds, pharmaceutical compositions, and their use in treating medical conditions.
WO/2024/073283A1	HETEROCYCLES AS MODULATORS OF NSD ACTIVITY Disclosed herein are amino bicyclic nitrogen heterocyclic ring system compounds which inhibit nuclear receptor-binding SET domain proteins (NSD's), such as 6-amino-9H-purin-9-yl, 8-amino imidazo[1,2-a]pyrazin-3-yl, imidazo[2,1-f][1,2,4]t...
WO/2024/067433A1	NOVEL PRMT5 INHIBITOR AND USE THEREOF The present invention describes a novel molecule with inhibitory activity against protein arginine methyltransferase 5 and methods for synthesis and use of the compound. Specifically, the present invention describes a compound of formula...
WO/2024/073507A1	MACROCYCLIC COMPOUNDS AND USES THEREOF Described herein are macrocyclic compounds of Formulas (Al), (BI), and (CI) which can inhibit kinases such as EGFR, including mutant forms such as T790M EGFR mutants. Also described herein are pharmaceutical compositions comprising a com...
WO/2024/073587A1	N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF Compounds and methods for inhibiting Nrf2 by activating KEAP1.
WO/2024/067691A1	NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF Disclosed are a nitrogen-containing heterocyclic compound and pharmaceutical use thereof. Specifically, disclosed are a nitrogen-containing heterocyclic compound represented by general formula (I), a preparation method therefor, a pharma...

Matches 1 - 50 out of 36,796	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >