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Matches 1 - 50 out of 39,513

Document Document Title
WO/2018/170167A1
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...  
WO/2018/166993A2
Compounds of Formula (I) and methods of use as Janus kinase inhibitors are described herein.  
WO/2018/166932A1
The present invention relates to arylamine derivatives which are substituted with diazanaphthalene groups, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according to th...  
WO/2018/170214A1
The disclosure is directed to deutetrabenazine analogs, compositions comprising same and methods of detecting same in compositions comprising deutetrabenazine.  
WO/2018/167695A1
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular t...  
WO/2018/167113A1
The invention provides novel compounds having the general formulas (I), (II), wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.  
WO/2018/167690A1
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular t...  
WO/2018/170019A1
Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquin...  
WO/2018/169420A1
A method for the preparation of trazodone of formula III, in the reaction of 2-(3- halogenopropyl)[l,2,4]triazolo[4,3-a]pyridin-3(2H)-one of formula la or formula lb with l-(3-chlorophenyl)piperazine hydrochloride of formula II consists ...  
WO/2018/169880A1
Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.  
WO/2018/167276A1
The present invention relates to compounds of Formula (I) as defined herein, and salts, hydrates and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to the use ...  
WO/2018/166756A1
Compounds of formula (I) and their pharmaceutical and food grade acceptable salts, for use in the prevention and/or treatment of NAFLD (non-alcoholic fat liver disease) or NASH (non-alcoholic steatohepatitis), and related symptoms and/or...  
WO/2018/167203A1
The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where R1 has the meanings defined herein. The specification also relates to the use of compounds of Formula (I) and salts ther...  
WO/2018/167652A1
The present invention provides a process for the preparation of amorphous form of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]met hyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4yl- methyl)-amino]-phenyl}sulfonyl)-2...  
WO/2018/169700A1
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The in...  
WO/2018/167800A1
The present invention relates to fused bicyclic compounds that are inhibitors of GPR91, their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. T...  
WO/2018/167019A1
The present invention encompasses compounds of formula (I), wherein the groups R1 to R, A1 to A4 and n have the meanings given in the claims and specification, their use as inhibitors of PHGDH, pharmaceutical compositions which contain c...  
WO/2018/167176A1
A series of substituted fused pentacyclic imidazopyridine and imidazopyridazine derivatives, and analogues thereof, being potent modulators of human TNFα activiy, are accordingly of benefit in the treatment and/or prevention of various ...  
WO/2018/167147A1
Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK...  
WO/2018/162851A1
The invention relates to the use of a bis(pyridinium)-naphthalene diimide redox ionic compound as an active electrode material, in particular for an aqueous electrolyte battery, a negative electrode comprising at least said bis(pyridiniu...  
WO/2018/164191A1
The present invention provides a substituted pyrrolidine compound having orexin receptor type 2 agonist activity. A compound represented by the formula (in the formula, each symbol is as described in the specification) or a salt thereof ...  
WO/2018/164043A1
Provided is a labeled precursor compound represented by formula (2). (In the formula, S represents a substrate, L represents a C1-6 linear alkyl group which may contain an ether group, R1 and R2 each independently represent a C1-30 linea...  
WO/2018/163190A1
of the Invention The present invention relates to an improved process for the preparation of varenicline and salt thereof. The present invention also provides a process for the 2,7preparation of l-(4,5-dinitro-10-aza-tricyclo[6.3.1.0 ]do...  
WO/2018/163818A1
A compound represented by formula (5) can be obtained by the simultaneous and separate addition of a compound represented by formula (4) and methanesulfonyl chloride to a compound represented by formula (3). A compound represented by for...  
WO/2018/165142A1
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)- piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.  
WO/2018/163030A1
The present invention provides novel cyclic substituted imidazo[4,5- c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The ...  
WO/2018/165395A1
The invention provides compounds of formula (I): (I) where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutica...  
WO/2018/161910A1
Disclosed in the present invention is an aminopyrimidine five-membered heterocyclic compound, and an intermediate, preparation method, pharmaceutical composition and application thereof. The aminopyrimidine five-membered heterocyclic com...  
WO/2018/161871A1
Disclosed is a p53-MDM2 inhibitor compound having the structure of an imidazopyridine, and particularly disclosed are a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.  
WO/2018/161922A1
The present invention relates to a compound having PRMT5 inhibitory activity, a preparation for the compound, and applications thereof. Specifically, the compound of the present invention has a structure as represented by formula I, wher...  
WO/2018/165392A1
The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors...  
WO/2018/163066A1
The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R1, R2 and R3 are as defined in the specification. The invention is also directed to pha...  
WO/2018/162607A1
The invention relates to compounds of formula I: (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmac...  
WO/2018/158619A1
Compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, pharmaceutical compositions comprising such compounds and their use in treating and/or preventing bacterial infections are disc...  
WO/2018/160022A1
The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure comprises a specific combination of a light-emitting layer and an electron transport zone, thereby pr...  
WO/2018/160406A1
The present invention provides a compound of Formula I I wherein X is selected from the group consisting of CH and N; Q is selected from the group consisting of CH3 and H; R is selected from the group consisting of and; or a pharmaceutic...  
WO/2018/159964A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, it is possible to pro...  
WO/2018/158212A1
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases  
WO/2018/157801A1
The present invention relates to a cyano group-substituted fused bicyclic derivative, and a pharmaceutical composition comprising the compound. The compound or the pharmaceutical composition can be used for inhibiting xanthine oxidase an...  
WO/2018/157857A1
Provided are an amide derivative inhibitor, a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor and a pharmaceutica...  
WO/2018/160003A1
The present specification relates to a heterocyclic compound of chemical formula 1 and an organic light-emitting device comprising same.  
WO/2018/159970A1
The present disclosure relates to an organic electroluminescent device comprising a light-emitting layer and a hole transport zone. By comprising a specific combination of a light-emitting layer and a hole transport zone, it is possible ...  
WO/2018/158365A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2018/158620A1
The present invention provides processes for the preparation of active pharmaceutical ingredients and intermediates thereof in an aqueous designer smart surfactant solution.  
WO/2018/157232A1
Compositions comprising modulators of N-terminus activation of the androgen receptor, such as EPI-002 and EPI-506, and a second therapeutic agent are provided. Use of such compositions for treatment of various indications, including pros...  
WO/2018/160076A1
Fibroblast Growth Factor Receptor kinase inhibitors and prodrugs thereof of Formula (I) and their use for the treatment of hyper-proliferative diseases such as retinopathy, psoriasis, rheumatoid arthritis, osteoarthritis, septic arthriti...  
WO/2018/160552A1
lmidazo[4,5-c] ring compounds of formula I, (particularly imidazo4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5- c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine...  
WO/2018/157803A1
Venetoclax crystal forms and a preparation method therefor, the structural formula thereof is represented by formula (I), and such crystal forms may be directly obtained from crystallization in a solvent.  
WO/2018/157277A1
The present invention provides a compound of Formula (I), where in X is selected from the group consisting of CH and N; Q is selected from the group consisting of CH3 and H; R is selected from the group consisting of (II) and (III), or a...  
WO/2018/160522A1
Disclosed are small molecule inhibitors of ανβ6 integrin, and methods of using them to treat a number of specific diseases or conditions.  

Matches 1 - 50 out of 39,513