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JP2004043438A |
To obtain a 1-methylcarbapenemu compound exhibiting excellent antimicrobial activity.This medicine containing the 1-methylcarbapenemu derivative is a 1-methylcarbapenemu compound represented by formula (1) [wherein R1 is a group represen...
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JP2004504322A |
The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]me
thyl]tetrahydro-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-meth
yl-7-oxo-1-azabicy...
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JP2004035517A |
To provide an oral preparation containing an oral carbapenem antibiotic, having good disintegration property of the preparation, remarkably improved in releasing property of an active ingredient, having good stability of the active ingre...
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JP3483254B2 |
PCT No. PCT/EP94/01141 Sec. 371 Date Oct. 19, 1995 Sec. 102(e) Date Oct. 19, 1995 PCT Filed Apr. 13, 1994 PCT Pub. No. WO94/25442 PCT Pub. Date Nov. 10, 19943-(Het)arylcarboxylic acid derivatives of the formula I I where R is formyl, CO2...
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JP3479720B2 |
PURPOSE: To obtain carbapenems in high yield by reacting an azetidine derivative with imidazoles, then reacting the resultant compound with an inorganic salt, a dicarboxylic acid derivative, an azide compound and an acid, carrying out th...
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JP3476420B2 |
To obtain crystal of a methylcarbapenem compound (salt) improved in preservation stability and practically very useful medicines, in particular antimicrobial agent, by crystallizing a methylcarbapenem compound (salt). This compound is ob...
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JP3477206B2 |
A process for the preparation of antibacterial compound (I) or a salt thereof which comprises hydrogenolysis of the novel compound of formula (II) and if necessary or desired isolating the resultant carboxylic acid as a salt thereof.
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JP3461786B2 |
To obtain a medicinal composition useful in the treatment or prophylaxis of generalized microbisms on patients of human being or animal by including an antimicrobial specific heterocyclic derivative and at least one of specific carriers ...
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JP2003183280A |
To obtain a new carbapenem compound having excellent resistance to β-lactamase and kidney dehydropeptidase and strong antimicrobial activity.This carbapenem compound is represented by formula (I) (R1 is a hydrogen atom or a carboxy grou...
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JP2003183282A |
To obtain a new carbapenem compound having excellent resistance to β-lactamase and kidney dehydropeptidase and strong antimicrobial activity.This carbapenem compound is represented by formula (I) (R1 is a hydrogen atom or a carboxy grou...
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JP2003183281A |
To obtain a new carbapenem compound having excellent resistance to β-lactamase and kidney dehydropeptidase and strong antimicrobial activity.This carbapenem compound is represented by formula (I) (R1 is a hydrogen atom or a carboxy grou...
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JP2003171277A |
To provide a medicine-releasing time-controlling type solid preparation having a so-called pulse type releasing characteristic, i.e., exhibiting a prescribed lag time until the initiation of release of the medicine after administering an...
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JP3411589B2 |
PURPOSE: To provide the new antibiotic effective against various kinds of strains including Pseudomonas aeruginosa, excellent in the safety and stable also for hydroxylases such as dehydropeptitase. CONSTITUTION: A compound of formula I ...
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JP2003517427A |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH2-O- group. The compounds of the invention are represent...
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JP3406669B2 |
PURPOSE: To obtain a new compound useful as a synthetic intermediate for a β-lactam antibiotic substance having carbapenam or carbapenem skeleton. CONSTITUTION: An azetidinone derivative of formula I [R1 is H, (substituted) alkyl or (su...
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JP2003128674A |
To provide a method for efficiently producing carbapenem antibiotic in a short time which solves the problems that (1) a column chromatography must be applied and that (2) insoluble salts are required to be taken out once.Characteristica...
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JP3403173B2 |
The present invention relates to carbapenem derivatives of Formula I, wherein X is carbonyl or sulfonyl, and a preparation method thereof. The carbapenem derivatives of the invention have excellent antibacterial properties and are thus u...
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JP2003104986A |
To provide a methylcarbapenem compound having excellent absorbability through the digestive tracts by oral administration, exhibiting sufficiently high antibacterial property against a wide variety of bacterial strains in the form of an ...
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JP2003104893A |
To provide a 1-methylcarbapenem compound having excellent antimicrobial activity or pharmacologically acceptable prodrug and pharmacologically acceptable salt thereof.This antimicrobial agent contains a 1-methylcarbapenem compound that i...
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JP3386452B2 |
Novel crystalline carbapenem intermediate compounds of formula (I) wherein R1 represents CH3 or H; and P and P' independently represent H or a protecting group; and efficient process for synthesis thereof.
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JP3384768B2 |
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JP3382267B2 |
PURPOSE:To selectively obtain one of steric isomers of a lactam by radiating light to a clathrate compound consisting of a specific compound and an optically active host compound. CONSTITUTION:A clathrate compound consisting of a compoun...
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JP3375084B2 |
A novel crystal of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-Ä(1R)-1-hydroxyethylÜ-4-methyl-7-oxo-3 ÄÄ(3S,5S)-5-(sulfamoylaminometh...
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JP2003026679A |
To provide a new carbapenem compound having an antimicrobial activity.This compound is represented by formula (I) [wherein, R1 denotes hydrogen atom or methyl group; R2 denotes hydrogen atom or a protecting group of hydroxy group; R3 den...
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JP3367126B2 |
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JP3367104B2 |
PCT No. PCT/JP93/00469 Sec. 371 Date Sep. 21, 1994 Sec. 102(e) Date Sep. 21, 1994 PCT Filed Apr. 9, 1993 PCT Pub. No. WO93/21186 PCT Pub. Date Oct. 28, 1993A compound of the formula: in which R1 is carboxy or protected carboxy, R2 is 1-h...
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JP2002338572A |
To provide a method for industrially advantageously producing carbapenems.This method for producing the compound (VIII) in the formula comprises reacting a compound (I) (R1 is a protective group of OH) in the formula with (i) N,N'-carbon...
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JP3344662B2 |
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JP2002316977A |
To provide an industrially advantageous method for safely producing a high-quality optically active 1H-3-aminopyrrolidine compound at low cost by using an optically active aspartic acid as a raw material.This method for producing the opt...
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JP3317649B2 |
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JP3317604B2 |
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JP3317603B2 |
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JP2002525275A |
The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other beta -lactams, which are useful in treating and preventing enterococc...
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JP3313366B2 |
PCT No. PCT/GB93/00603 Sec. 371 Date Nov. 26, 1993 Sec. 102(e) Date Nov. 26, 1993 PCT Filed Mar. 24, 1993 PCT Pub. No. WO93/19070 PCT Pub. Date Sep. 30, 1993.The present invention relates to carbapenems and provides a compound of the for...
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JP2002212182A |
To obtain a 1-methylcarbapenem compound capable of exhibiting an excellent antimicrobial activity.This 1-methylcarbapenem compound is represented by the general formula (I) [wherein, R1 denotes a group represented by the formula: COOR3 (...
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JP2002520326A |
The invention describes an improved process for synthesizing 1-beta-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH...
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JP3296845B2 |
PURPOSE: To provide the subject new compound exhibiting excellent antibacterial action on Gram-negative bacteria and useful as an antibacterial agent, a bactericide, etc. CONSTITUTION: The compound of formula I [R is (substituted)amino; ...
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JP2002179679A |
To obtain a new carbapenem compound having an alkenyl group and to provide a method for producing the compound.This compound is represented by formula (1) (wherein, R1 denotes hydrogen atom or methyl group; R2 denotes hydrogen atom or a ...
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JP2002518496A |
Compounds of formula I:as well as pharmaceutically acceptable salts thereof and compositions useful as carbapenem antibacterial agents are disclosed.
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JP2002518497A |
Compounds of formula I:as well as pharmaceutically acceptable salts thereof useful as carbapenam antibacterial agents are disclosed wherein X is CR2R2, NR2, or O.
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JP2002518402A |
A process of synthesizing a carbapenem compound of formula (6) is disclosed, wherein R represents H or methyl, P and P* independently represent H or protecting groups and each R1 is independently selected from: H, halo, OH, OP wherein P ...
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JP2002518498A |
Compounds of formula I:as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed wherein X is CH2 or C=O.
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JP2002518447A |
Compounds of formula I:as well as pharmaceutically acceptable salts therefor and compositions useful as carbapenem antibacterial agents are disclosed.
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JP2002518446A |
Compounds of formula I:as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed.
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JP2002517394A |
The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least ...
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JP2002517395A |
The present invention relates to tricyclic carbapenem antibacterial agents wherein X is CH2, CHRa, CHRb, C=CHRa, C=CHRb, O, S, SO, SO2, CO, COO
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JP2002517422A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002516902A |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2 -position with a iodophenoxy linked through a group -Z-CH2-; The compound is further substituted with various substi...
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JP2002515882A |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is further substituted with various subs...
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