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Matches 1 - 50 out of 1,597

Document Document Title
WO/2018/010974A1
201600080 17 Process for preparing a carbapenem Abstract Process for preparing a carbapenem or precursors thereof (I) by cleaving one or more protecting groups of a substance (II) 5 comprising the steps of: a) hydrogenating with hydrogen...  
WO/2017/132321A1
New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they...  
WO/2017/008034A1
The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.  
WO/2016/148439A3
The present invention relates to a method of preparing a crystalline doripenem. According to the present invention, it is possible to prepare the crystalline doripenem in a simple way without additional special equipment. In addition, al...  
WO/2016/148439A2
The present invention relates to a method of preparing a crystalline doripenem. According to the present invention, it is possible to prepare the crystalline doripenem in a simple way without additional special equipment. In addition, al...  
WO/2015/167148A1
The present invention relates to a novel crystal of doripenem, a solvate thereof, and a preparation method therefor. More specifically, the novel crystal is an anhydrous crystal of doripenem, and the present invention relates to a method...  
WO/2015/145161A1
The present invention provides a process for the preparation of a carbapenem, said process comprising the step of treating a solution of a protected carbapenemwith hydrogen gas in the presence of a heterogeneous catalystto form the carba...  
WO/2015/078218A1
The present invention discloses a polymer containing a carboxyl group, a method for preparing same and a use thereof, and a method for preparing a supported catalyst and a penem antibiotic intermediate. The polymer is made by polymerizin...  
WO/2014/144285A1
The present invention provides novel derivative of β-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, ta...  
WO/2014/097221A1
The present invention relates to a process for the purification of biapenem.  
WO/2014/094659A1
Disclosed is a process for preparation of meropenem trihydrate crystals, comprising: 1) dissolving crude meropenem in an alkali solution, thus forming a saturated solution of meropenem; 2) adding activated carbon into the saturated solut...  
WO/2014/082226A1
The present invention relates a purification method of ertapenem sodium. Specifically, disclosed is a preparation method of low-chroma ertapenem sodium, which comprises steps of: providing an aqueous solution comprising a raw material of...  
WO/2014/057079A1
The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertape...  
WO/2014/019282A1
Disclosed in the present invention is a bulk drug of meropenem, characterized in that the meropenem content in the bulk drug is 98.5%~101.0% based on the anhydrous substances; the impurities A and B in the related substances of the bulk ...  
WO/2013/157583A1
The purpose of the invention is to provide a compound having excellent antimicrobial activity and oral absorbability, and comprising a crystal form having storage stability that permits practical use as a pharmaceutical ingredient. The i...  
WO/2013/150550A2
The present invention provides an improved process for the preparation Ertapenem monosodium of formula (I) having purity greater than 98.5% and having pharmaceutically acceptable level of palladium and residual solvent. (I)  
WO/2013/150550A3
The present invention provides an improved process for the preparation Ertapenem monosodium of formula (I) having purity greater than 98.5% and having pharmaceutically acceptable level of palladium and residual solvent. (I)  
WO/2013/143266A1
The present invention provides a doripenem intermediate compound shown by formula (XIV), wherein PNB is p-nitrobenzyl, and HX is an acid; and when HX is a monoacid, n = 1; and when HX is a polyacid, n = 2. The present invention also prov...  
WO/2013/121279A2
The present invention relates to a novel process for the preparation of Ertapenem of formula (I) or salt thereof.  
WO/2013/121279A3
The present invention relates to a novel process for the preparation of Ertapenem of formula (I) or salt thereof, using hydrogenation catalyst in presence of N-methylmorpholine, 2,6-Lutidine or mixture thereof.  
WO/2013/067878A1
Disclosed are an Ertapenem sodium crystal and preparation method thereof, the Ertapenem sodium crystal has a powder X-ray diffraction spectrum as shown in Fig. 1. The Ertapenem sodium crystal is of low residual solvent content and high s...  
WO/2013/068910A1
The present invention relates to a process for the preparation of polymorphs of doripenem.  
WO/2013/034087A1
Disclosed are a doripenem hydrate crystal and preparation method therefor. The X-ray diffraction spectrogram of the crystal powder is basically as represented in figure 1, and the measured water content is 4.4 to 5.5%. The doripenem hydr...  
WO/2013/029293A1
Provided is a method for preparing ertapenem sodium. In the method provided by the invention, ertapenem sodium is prepared by directly catalytic hydrogenation of an undried ertapenem intermediate or by catalytic hydrogenation of the erta...  
WO/2012/139414A1
Disclosed is a method for preparing carbapenem antibiotics, pharmaceutically acceptable salts or hydrates thereof. In particular, disclosed is a method for preparing carbapenem antibiotics, pharmaceutically acceptable salts or hydrates t...  
WO/2012/139424A1
Disclosed are two crystalline forms of tebipenem, preparation methods and uses thereof in the preparation of medicines. The crystalline forms of tebipenem have good stability, fine color (white), high purity, low heavy metal residue and ...  
WO/2012/112061A1
The subject of the present invention is a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate co...  
WO/2012/097471A1
Provided is a preparation method of compound shown by formula (I), which comprises the following steps: in the presence of alkali, reacting compound of formula (III) with compound of formula (IV) in organic solvents to obtain compound of...  
WO/2012/089058A1
Provided is a crystalline form E of ertapenem sodium. Further provided is a method for preparing a crystalline form E of ertapenem sodium, characterized by using an aqueous ertapenem sodium solution at a low concentration as a raw materi...  
WO/2012/079504A1
Disclosed is a process for preparing Tebipenem Pivoxil and analogues thereof. The process uses a carbapenem compound salt of the formula II as a raw material to obtain a carbapenem compound ester of the formula I, wherein the carbapenem ...  
WO/2012/079504A8
Disclosed is a process for preparing Tebipenem Pivoxil and analogues thereof. The process uses a carbapenem compound salt of the formula II as a raw material to obtain a carbapenem compound ester of the formula I, wherein the carbapenem ...  
WO/2012/079289A1
The present invention relates to an amorphous powder, a solvate, and a polymorph of a carbapenem derivative (4R,55,6S)3-[(3S,5S)-5-[(furan-2-ylmethyl)amino-formyl]3-pyr rolidine]thio-6-[(R)-1-hydroxyethyl]4-methyl-7-oxo-1-oxabicy clo[3.2...  
WO/2012/081033A8
The present invention relates to a novel cost effective and commercially viable process for the preparation of pure crystalline Imipenem monohydrate by dissolving crude imipenem in carbonated water and morpholinopropane sulphonic acid (M...  
WO/2012/066492A1
The present invention relates to processes for the preparation of carbapenem antibiotic compositions, involving the preparation of the compound of formula II from a compound of formula I and a composition comprising the compound of formu...  
WO/2012/062035A1
Disclosed is a synthesis method for meropenem, the reaction chain whereof is represented below: [Formula IV] → [Formula V] → [Formula II] [Formula VI] → [Formula III] – Wittig → [Formula VII] → [Formula VIII] → [Formula I] ...  
WO/2012/052978A1
The present invention relates to a process for the preparation of pure meropenem trihydrate.  
WO/2012/038979A2
The present invention relates to a novel process for the preparation of 1 β- methylcarbapenem antibiotic, Ertapenem of formula I. The process comprises isolation of monoprotected Ertapenem acid or its monosodium salt and further deprote...  
WO/2012/027951A1
The invention relates to an intermediate used for preparation of imipenem medicine, a preparation method and use thereof. The said intermediate is shown in the structure of formula (I), wherein R1 is C1- C3 lower alkyl, nitryl, halogen, ...  
WO/2012/003955A4
Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or disubstituted heterocyclic aromatic group, are useful compounds for the detection of...  
WO/2012/003955A1
Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or disubstituted heterocyclic aromatic group, are useful compounds for the detection of...  
WO/2011/160020A3
The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The inventio...  
WO/2011/160020A2
The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The inventio...  
WO/2011/150679A1
Crystalline form of carbapenem derivative shown as formula (I) or its hydrates characterized by an X-ray powder diffraction pattern given in the specification are disclosed. The preparation methods and uses of the crystalline form of car...  
WO/2011/143935A1
Disclosed are a crystalline of carbapenem derivative represented by formula (I) (4R,5S,6S)-3-[(3S,5S)-5-[(4-aminosulfonylphen-1-yl)methyl)am inoformyl]-3-pyrrolidinyl]thio-6-[(R)-1-hydroxyethyl]-4-meth yl-7-oxo-1-azabicyclo[3.2.0]hept-2-...  
WO/2011/141847A1
The present invention provides an improved process for the preparation of methyl carbapenem derivative of formula (I) or its pharmaceutically acceptable salts or hydrates thereof in a pure form.  
WO/2011/097958A1
Disclosed are oral carbapenem compounds containing aminosulfonyl azetidinyl represented by general formula (I), their stereoisomers, or their pharmaceutically acceptable salts or solvates, which belongs to the technical field of medicine...  
WO/2011/072287A3
The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydrox...  
WO/2011/072287A2
The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydrox...  
WO/2010/146449A1
A process for the preparation of Imipenem (formula (I)) or its hydrates comprising (i) deprotection of a carboxylic ester via catalytic hydrogenation in the presence of a catalyst deactivating agent and/or (ii) rapid dissolution of Imipe...  
WO/2010/124531A1
Intermediates of carbapenem of formula 2a, wherein Np represents (I) or (II), and P1 and P2 represent carboxyl protecting groups, and their preparation methods are disclosed. The solid form of the compounds 2a prepared by the present met...  

Matches 1 - 50 out of 1,597