Heterocyclic Compounds

Matches 251 - 300 out of 33,986	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2024/019103A1	HETEROCYCLIC COMPOUND THAT ACTS ON G12D MUTANT KRAS PROTEIN Provided is a compound that is effective as an active ingredient in a therapeutic pharmaceutical composition for pancreatic cancer.　Having studied compounds that are effective as active ingredients in a therapeutic pharmaceutical compo...
WO/2024/020380A1	QUINAZOLINE COMPOUNDS AND METHODS OF USE Substituted quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects,...
WO/2024/017880A1	IMIDAZOTRIAZINE DERIVATIVES AS IL-17 MODULATORS A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of Formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments,...
WO/2024/020522A1	COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 The present disclosure relates to compounds that act as degraders of IRAK-4 protein kinase; pharmaceutical compositions comprising compounds of Formula (I); and methods of treating diseases and disorders associated with cancer and inflam...
WO/2024/017877A1	HETEROARYL DERIVATIVES AS DDRs INHIBITORS The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions contai...
WO/2024/017365A1	PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH OF SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE DERIVATIVE AND USE THEREOF The present application relates to a pharmaceutically acceptable salt and polymorph of a substituted pyrazolo[1,5-a]pyrimidin-7-amine derivative as represented by formula (I), a pharmaceutical composition comprising same, a preparation m...
WO/2024/017144A1	SUBSTITUTED IMIDAZO [1, 2-A] PYRIDINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND PREVENTION OF FIBROSIS Provied are a class of substituted imidazo[1,2-a]pyridine compounds, pharmaceutical compositions containing the same, and use of the compounds in the treatment and prevention of fibrosis.
WO/2024/020419A1	AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE Substituted aza-quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspe...
WO/2024/017178A1	SUBSTITUTED HYDANTOIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS Provided herein are substituted hydantoin compounds, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms o...
WO/2024/020333A2	KINASE INHIBITORS Disclosed is a class of kinase inhibitors. Related pharmaceutical compositions and methods of making and using the kinase inhibitors are also disclosed.
WO/2024/020034A1	CBL-B INHIBITORS AND METHODS OF USE THEREOF Disclosed herein are compounds that are Cbl-b inhibitors having a structure according to Formula (II), and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment ...
WO/2024/020534A2	CYCLIC COMPOUNDS AND METHODS OF USING SAME The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and ph...
WO/2024/017294A1	PREPARATION AND USE OF QUINAZOLINONE DERIVATIVE AS KINASE INHIBITOR Disclosed are a compound represented by formula I, a stereoisomer, deuterated product or pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing same, as well as a use thereof as a BRAF modulator in the prepa...
WO/2024/017270A1	SPIRO COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present application relates to the technical field of chemical drugs, and to a spiro compound as represented by general formula (I), or an isomer, racemate, or pharmaceutically acceptable salt thereof, as a 3C-like protease inhibitor...
WO/2024/017857A1	NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES The invention relates to novel compounds having the general formula I wherein R1, R2, X1, X2,X3 and W are as described herein, composition including the compounds and methods of using the compounds.
WO/2024/013395A1	PYRROLOTRIAZINE AND IMIDAZOTRIAZINE DERIVATIVES AS MODULATORS OF THE NLRP3 INFLAMMASOME PATHWAY The application relates to pyrrolotriazine and imidazotriazine derivatives of the general formula (I) for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation...
WO/2024/015262A1	FUSED RING KRAS INHIBITORS FOR TREATING DISEASE The present disclosure relates to fused ring compounds targeting KRAS, pharmaceutical compositions containing the compounds, and methods of using such compounds to treat disease, such as cancer.
WO/2024/015229A1	PROTEASE/ENZYME CLEAVABLE LINKER-PAYLOADS AND PROTEIN CONJUGATES Provided herein are compounds, conjugate products thereof, methods, and pharmaceutical compositions for use in treatment and diagnosis.
WO/2024/015503A1	EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Provided are compounds of the Formula (I) or pharmaceutically acceptable salts thereof, which are useful for the inhibition of EBP and in the treatment of a variety of EBP mediated conditions or diseases, such as multiple sclerosis.
WO/2024/011316A1	SALTS OF N-[4-(4-[[2-(DIMETHYLAMINO)ETHYL]AMINO]-3-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-Y L)-2-FLUOROPHENYL]-2,5-DIFLUOROBENZENESULFONAMIDE AND CRYSTALLINE FORMS THEREOF Compound of Formula (II) is provided: (II) A crystalline form of the compound of Formula (II) is provided. The compound of Formula (II), and crystalline form thereof can be used for the treatment of several conditions linked to the inhib...
WO/2024/012549A1	PYRIMIDO-FIVE-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present invention relates to a pyrimido-five-membered heterocyclic compound, a preparation method therefor and a use thereof, and a pharmaceutical composition comprising same. Specifically, the present invention relates to a compound...
WO/2024/014536A1	REAGENT FOR DETECTING SARS-RELATED CORONAVIRUS The present invention relates to a compound represented by a general formula (1) or a salt or a solvate thereof. [In the formula, R1, R2, and R3 are as defined in the description.]
WO/2024/011307A1	PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER Compounds of Formula I: Formula I and pharmaceutically acceptable salts thereof are provided for as inhibitors of SGK-1 for example for the treatment of conditions such as Long QT syndrome, heart failure, arrhythmia, ischemic injury, isc...
WO/2024/012519A1	PAN-KRAS INHIBITOR Provided in the present invention are a fused ring aromatic compound having a broad-spectrum inhibition effect on KRAS mutation, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof. As shown in formula ...
WO/2024/013206A1	HETEROCYCLE COMPOUNDS FOR THE TREATMENT OF CANCER The present invention relates to compounds of formula (I), wherein R1 to R3, M, A, Y and W are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the com...
WO/2024/011450A1	SYNTHETIC METHODS FOR PREPARING A PYRIDINECARBOXAMIDE COMPOUND Described herein are synthetic methods to prepare N- [4- [4- (4-morpholinyl) -7H-pyrrolo [2, 3-d] pyrimidin-6-yl] phenyl] -4- [ [3- [ (1-oxo-2-propen-1-yl) amino] -1-piperidinyl] methyl] -2-pyridinecarboxamide, an irreversible covalent i...
WO/2024/015889A2	SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES The present disclosure relates to compounds, and to their pharmaceutical compositions, that inhibit dipeptidyl peptidase IV (DPP4). The compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in th...
WO/2024/012425A1	HETEROCYCLIC COMPOUND AS RIPK1 INHIBITOR The present invention relates to a compound, a pharmaceutical composition containing same, a preparation method therefor, and the use thereof as an RIPK1 inhibitor. The compound is a compound as represented by formula (I), or an optical ...
WO/2023/280638A9	VINYL THIANTHRENIUM COMPOUND, PROCESS FOR ITS PREPARATION AND ITS USE FOR TRANSFERRING A VINYL GROUP The application relates to vinyl thianthrenium compounds Vinyl- TT+X- of the Formula (I), a process for preparing the same and the use thereof for vinylating organic compounds.
WO/2024/015409A1	CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Described herein are compounds of Formula (I) and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses (e.g., as estrogen receptor degraders).
WO/2024/014885A1	NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF The present invention provides a novel compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof. With an excellent inhibitory activity against PIKfyve, the novel compound of the...
WO/2024/011883A1	WEE1 INHIBITOR, PREPARATION THEREFOR AND USE THEREOF The present invention relates to a WEE1 inhibitor, preparation therefor and a use thereof. The structure of the WEE1 inhibitor is represented by formula (I). The present invention relates to a compound of formula (I), or a stereoisomer t...
WO/2024/009215A1	NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein c...
WO/2024/008128A1	SULFOXIMINE COMPOUND HAVING FGFR INHIBITORY EFFECT, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF Provided are a sulfoximine compound having an FGFR inhibitory effect, a pharmaceutical composition comprising said sulfoximine compound, and a use thereof. Specifically provided are a sulfoximine compound as represented by formula (I) wh...
WO/2024/010015A1	PYRIMIDINE DERIVATIVES Compounds represented by general formula (1), the compounds having strong inhibitory action against mPGES-1 and being useful as active ingredients for pharmaceuticals for the treatment of inflammation and the like.
WO/2024/009977A1	5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE AND CRYSTAL OF SALT THEREOF Provided is a type-I crystal of a free form of 4-(4-(3-((2-(tert-butylamino)ethyl)amino)-6-(5-(trifluoromet hyl)-1,3,4-oxadiazol-2-yl)piperidin-2-yl)piperidin-1-yl)-5,5 -dimethyl-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one that has, in a powder...
WO/2024/010782A1	PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W arc as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a pr...
WO/2024/011136A1	CRYSTALLINE FORMS OF A TYK2 INHIBITOR Described herein are crystalline forms of 1-(5-((7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)amino)-7 -(methylamino)pyrazolo[1,5-a]pyrimidin-3-yl)-3-((1R,2S)-2-fl uorocyclopropyl)urea adipate, and solvates thereof.
WO/2024/007520A1	ORGANIC COMPOUND AND USE THEREOF Provided are an organic compound and use thereof. The organic compound has a structure of H-L-Ar, wherein H has a structure represented by formula 1-1 or formula 1-2. In formula 1-1 and formula 1-2, A1 and A2 are identically or different...
WO/2024/008909A1	INHIBITORS OF CORONAVIRUS The present invention relates to novel compounds of Formula (I) (cyanophenyl/cyanopyridinyl- 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine amide compounds) for treating and/or preventing infection or diseases caused by coronavirus. The...
WO/2024/007883A1	CLASS OF THIAZOLAMINE-DIAZABICYCLOOCTANONE CONJUGATED DERIVATIVES AND USE THEREOF The present invention belongs to the field of medicines and provides a class of thiazolamine-diazabicyclooctanone conjugated derivatives and use thereof. The compound provided by the present invention has good and broad-spectrum inhibiti...
WO/2024/008196A1	CLASS OF AMIDE COMPOUNDS AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF The present invention provides a class of compounds of general formula I and a preparation method therefor, and a pharmaceutical composition and the use thereof. Specifically, the present invention provides a compound having a structure ...
WO/2024/008722A2	TREM2 MODULATORS The present invention relates to compounds useful for modulating Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). The invention also relates to the compounds for use in treatment of conditions related to loss of function of TR...
WO/2024/008122A1	PI3K INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF The present invention belongs to the field of chemical pharmaceuticals, and provided are a PI3K inhibitor, a preparation method therefor, and a use thereof. The PI3K inhibitor of the present invention is a compound as represented by form...
WO/2024/008178A1	KRAS G12D INHIBITOR AND APPLICATION THEREOF IN MEDICINE Provided are a compound of formula (I), and a stereoisomer, tautomer, deuterated product or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and an application...
WO/2024/009308A1	TRPV2 CHANNEL BLOCKERS AND USE THEREOF The present invention involves novel TRPV2 blockers, pharmaceutical compositions comprising the same and uses thereof for the treatment of inflammatory response in inflammation mediated disease processes.
WO/2024/008088A1	COMPOUNDS AS TRK INHIBITORS AND/OR RET INHIBITORS AND USE THEREOF Disclosed are a class of compounds as TRK inhibitor drugs or RET inhibitor drugs and use thereof. Specifically, disclosed is use of a compound represented by formula (G), or an isotope-labeled compound thereof, or an optical isomer, a ge...
WO/2024/007976A1	COMPOUND CONTAINING GEM-DIFLUORO GROUP, PREPARATION METHOD THEREFOR AND USE THEREOF A compound represented by formula (I), a chiral enantiomer thereof or pharmaceutically acceptable salts thereof, and a preparation method therefor, an intermediate used for preparing the compound represented by formula (I), the chiral en...
WO/2024/002206A1	BIFUNCTIONAL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE BIFUNCTIONAL COMPOUND, AND METHOD FOR TREATING ANDROGEN RECEPTOR RELATED DISEASES BY USING THE SAME Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I) : ABM-L-CLM (I); wherein: ABM is an androgen rec...
WO/2024/002205A1	BIFUNCTIONAL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE BIFUNCTIONAL COMPOUND, AND METHOD FOR TREATING ANDROGEN RECEPTOR RELATED DISEASE BY USING THE SAME Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I) : ABM-L-CLM (I); wherein: ABM is an androgen rec...

Matches 251 - 300 out of 33,986	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >