Heterocyclic Compounds

Matches 301 - 350 out of 33,973	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2023/009835A9	ANTIBODY CONJUGATES SPECIFIC FOR MUCIN-1 AND METHODS OF USE THEREOF The present disclosure provides antibody conjugates (e.g., antibody-drug conjugates (ADCs)) specific for MUC1. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same. Also provided ...
WO/2024/006559A1	MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS Compounds are provided for inhibiting NLRP3 inflammasome generally, or for treating a NLRP3 inflammasome dependent condition more specifically, by contacting the NLRP3 inflammasome or administering to a subject in need thereof, respectiv...
WO/2024/005516A1	HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF The present invention relates to a heteroaryl derivative and use thereof. The heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, and thus can be effectively used as a therapeutic agent for...
WO/2024/006971A2	ANTIMALARIAL COMPOUNDS Disclosed herein are compounds and compositions comprising the compounds of Formula I (I) wherein all variables are as defined herein. Further disclosed are methods for using the above compounds and compositions comprising the above comp...
WO/2024/006445A1	METHODS FOR TREATMENT OF CANCER The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions co...
WO/2024/006916A1	AZETIDINYL PYRIMIDINES AND USES THEREOF AS JAK INHIBITORS Provided herein are compounds useful as inhibitors of Janus kinase (JAK) proteins and in treating JAK-related diseases.
WO/2024/005339A1	CAMSYLATE SALT OF TRIAZOLOPYRAZINE DERIVATIVE The present invention relates to: a salt (camsylate salt) of D(+)10-camphorsulfonic acid and a triazolopyrazine derivative of chemical formula 1; a pharmaceutical composition comprising the salt; a method for preparing the salt; and a th...
WO/2024/002378A1	COMPOUND HAVING KINASE INHIBITORY FUNCTION, AND PREPARATION AND APPLICATION THEREOF The present invention provides an HPK1 kinase inhibitor, and the preparation and use thereof. Specifically, the present invention provides a compound represented by formula (I), where the definition of each group is as described in the d...
WO/2024/006970A2	ANTIMALARIAL COMPOUNDS Disclosed herein are compounds and compositions comprising said compounds as disclosed herein. Further disclosed are methods for using the above compounds and compositions comprising the above compounds for the prevention, amelioration, ...
WO/2024/006376A1	SOLID FORMS OF A NUCLEOSIDE ANALOGUE AND USES THEREOF The disclosure provides solid forms, e.g. salts and polymorphs, of the compound of Formula (I) and uses thereof. Also provided are the methods of making the solid forms and pharmaceutical formulations comprising the solid forms.
WO/2024/002263A1	AMINO-SUBSTITUTED HETEROARYL DERIVATIVE AND USE THEREOF Disclosed are a series of amino-substituted heteroaryl and use thereof, and in particular, disclosed are a compound represented by formula (IV) and a pharmaceutically acceptable salt thereof.
WO/2024/002377A1	CLASS OF PRMT5 INHIBITORS AND USE THEREOF Provided is a class of compounds with methyltransferase inhibitory activity. Specifically, provided is a class of compounds with PRMT5 inhibitory activity. The compounds can be used for preparing a pharmaceutical composition for treating...
WO/2024/002157A1	INHIBITORS OF FGFR2 AND FGFR3 AND USES THEREOF Provided are FGFR2 and FGFR3 inhibitors of Formula (I) and pharmaceutical compositions comprising said inhibitors. The compounds and compositions are useful for the treatment of a disease or disorder associated with FGFR2 and/or FGFR3.
WO/2024/003208A1	IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS The invention relates to a compound of formula (I) as SIK modulators for the treatment or prophylaxis of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cel...
WO/2024/001487A1	METHOD FOR SYNTHESIZING CYCLIC CARBONATE FROM CARBON DIOXIDE AND EPOXY COMPOUND AND CATALYST THEREOF The present invention relates to the technical field of green, clean and efficient catalysis, and in particular, to a method for synthesizing a cyclic carbonate from carbon dioxide and an epoxy compound by means of a catalytic reaction a...
WO/2024/006974A2	ANTIMALARIAL COMPOUNDS Disclosed herein are compounds and compositions comprising the compounds of Formula I (I) wherein all variables are as defined herein. Further disclosed are methods for using the above compounds and compositions comprising the above comp...
WO/2024/002934A1	8-HETEROCYCLIC-3-(PHENYLSULFONYL)-[1,2,3]TRIAZOLO[1,5A]QUINAZOLIN-5(4H)-ONE DERIVATIVES AS ANTI-BACTERIALS The present invention relates to 8-heterocyclic-3-(phenylsulfonyl)-[1,2,3] triazolo[1,5a]quinazolin-5(4H)-one derivatives and pharmaceutical compositions thereof as well as to their uses in methods of reducing the virulence of bacteria (...
WO/2024/006879A1	USP1 INHIBITORS AND USES THEREOF Provided herein are inhibitors of ubiquitin-specific-processing Protease 1 (USP1), their pharmaceutical compositions, and methods of use for treating diseases or disorders, such as cancers described herein.
WO/2024/006016A1	METHOD OF PREPARING FUNCTIONAL POLYMERS An apparatus may include: a flow path defined by a conduit; and a functional polymer disposed in the conduit, wherein the functional polymer comprises a polymer and a macrocycle, wherein the macrocycle is grafted to the polymer by an ami...
WO/2024/006461A1	SOLID FORMS OF A NUCLEOSIDE ANALOGUE AND USES THEREOF The present disclosure relates to solid forms (e.g. crystalline forms, solvates, and crystalline forms thereof) of a compound which is ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)- 5-cyano-3,4-dihydroxytetrahydrofuran-2-yl...
WO/2024/005343A1	MESYLATE OF TRIAZOLOPYRAZINE DERIVATIVE The present invention relates to salts (mesylates) of a methanesulfonic acid and a triazolopyrazine derivative of chemical formula 1, a pharmaceutical composition comprising same, a preparation method for the salt, and therapeutic use of...
WO/2024/006781A1	ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF The application relates to bifunctional compounds of the general formula I-3' which act as degraders of the estrogen receptor alpha(ERα) and are useful for treating disorders associated with ERα-mediated transcription regulation such a...
WO/2024/002935A1	3-(PHENYLSULFONYL)-[1,2,3]TRIAZOLO[1,5A]QUINAZOLIN-5(4H)-ONE DERIVATIVES The present invention relates to 3-(phenylsulfonyl)-[1,2,3] triazolo[1,5a]quinazolin- 5(4H)-one derivatives and pharmaceutical compositions thereof as well as to their uses in methods of reducing the virulence of bacteria (preferably Sta...
WO/2024/002024A1	TRICYCLIC COMPOUNDS AND USES THEREOF The present invention provides a class of compounds represented by formula (I), or tautomers, stereoisomers, or pharmaceutically acceptable salts thereof. The compounds of the present invention have a strong MAT2A inhibitory effect and h...
WO/2024/004619A1	CURABLE COMPOSITION, METHOD FOR PRODUCING CURED PRODUCT, FILM, OPTICAL ELEMENT, IMAGE SENSOR, SOLID-STATE IMAGING ELEMENT, IMAGE DISPLAY DEVICE, AND RADICAL POLYMERIZATION INITIATOR An embodiment of the present invention provides: a curable composition containing a radical polymerization initiator represented by formula (1) and a radically polymerizable compound; a method for producing a cured product; a film; an op...
WO/2024/002289A1	PROTEIN DEGRADATION COMPOUNDS AND METHODS OF USE This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the degrading target proteins a...
WO/2024/002376A1	PRMT5 INHIBITORS AND USE THEREOF The present invention provides a class of compounds with inhibitory activity against methyltransferases. Particularly, the present invention provides a class of compounds with inhibitory activity against PRMT5. The compounds can be used ...
WO/2024/006883A1	POLYMORPHIC COMPOUNDS AND USES THEREOF The present invention provides salt forms, and compositions and methods thereof, useful for treating various conditions, such as cancer, by the administration of small molecule therapeutics acting as kinase inhibitors.
WO/2024/002373A1	SUBSTITUTED PYRIMIDINE-FUSED RING INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF The present invention relates to a substituted pyrimidine-fused ring inhibitor, a method for preparing same, and use thereof. Specifically, the compound of the present invention has a structure represented by formula (I). Further disclos...
WO/2024/006287A2	ANTIVIRAL COMPOUNDS USEFUL AGAINST SARS-COV-2 Disclosed herein are compound of Formula I, Formula II, or Formula III: or a pharmaceutically acceptable salt and/or solvate of any one or more thereof, pharmaceutical compositions including such compounds, and methods of treating diseas...
WO/2023/249968A1	BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-DJPYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY The present disclosure provides certain bifunctional compounds that cause degradation of Cyclin-dependent kinase 2 (CDK2) via ubiquitin proteasome pathway and are therefore useful for the treatment of diseases mediated by CDK2. Also prov...
WO/2023/249563A1	COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION The disclosure provides for compounds and methods for inhibiting protein kinase, membrane associate tyrosine/threonine 1 (PKMYT1).
WO/2023/246656A1	SOS1 PROTEOLYSIS TARGETING CHIMERA, AND COMPOSITION, PREPARATION AND USE THEREOF The present invention belongs to the technical field of medicinal chemistry, and relates to an SOS1 proteolysis targeting chimera and a composition, a preparation and the use thereof. Specifically, the general formula structure of the ch...
WO/2023/247552A1	MICROBIOCIDAL BICYCLIC HETEROCYCLIC CARBOXAMIDE DERIVATIVES A compound of formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
WO/2023/250156A1	4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof...
WO/2023/249994A1	METHODS AND MATERIALS FOR TREATING CANCER This document relates to methods and materials involved in treating a mammal (e.g., a human) having cancer. For example, bifunctional molecules (e.g., protein targeting chimeras (PROTACs)) that include (a) a targeting moiety that binds t...
WO/2023/249980A1	METHODS OF MAKING MODIFIED BTK INHIBITORS Provided herein are BTK inhibitors containing piperidine modified at the 3-position. Further disclosed are methods of making and using said BTK inhibitors.
WO/2023/250083A1	SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecule compounds having a 6,6-heterocyclic structure (e.g., compounds having a naphthyridine, pyrido-pyridazine, pyrido...
WO/2023/247670A1	NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS The present invention provides compounds of formula (I) CB (I) or pharmaceutically acceptable salts thereof, wherein R3 to R5, R4a, B and C are as described herein, compositions including the compounds, processes of manufacturing the com...
WO/2023/250335A1	1,4-DIPHENYL-1 H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1 H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER The present disclosure relates to compounds of Formula (I): The compounds disclosed herein are useful for modulating PD-1 activity, PD-L1 activity (programmed cell death protein 1), and/or the PD-1/PD-L1 interaction and may be used in th...
WO/2023/247595A1	PYRAZOLOPYRAZINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS The disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.
WO/2023/250084A1	USP1 INHIBITORS AND USES THEREOF The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
WO/2023/250431A2	MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain ...
WO/2023/247592A1	5-(4-FLUOROPHENYL)-2,3-DIHYDRO-1H-IMIDAZO[1,2-A]IMIDAZOLE DERIVATIVES AS ALK INHIBITORS FOR THE TREATMENT OF FIBROSIS The present invention relates to 5-(4-fluorophenyl)-2,3-dihydro-1H- imidazo[1,2-a]imidazole derivatives of formula (I) as ALK5 inhibitors (transforming growth factor 3 (TGF3) type 1 receptor) for the treatment of fibrosis, such as e.g. p...
WO/2023/247593A1	PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS The disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.
WO/2023/249370A1	NOVEL HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING SAME The present invention relates to: a novel aromatic heterocyclic compound that can be used in an organic light-emitting diode; and an organic light-emitting diode including same.
WO/2023/246631A1	PREPARATION METHOD FOR DIAZABICYCLO PEPTIDOMIMETIC DERIVATIVE AND USE THEREOF Disclosed are a preparation method for a diazabicyclo peptidomimetic derivative and use thereof. The preparation method comprises: using an intramolecular nucleophilic substitution reaction in which sulfonamide is taken as a nucleophilic...
WO/2023/247590A1	TRIAZOLOPYRIDINE AND BENZOISOXAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.
WO/2023/250181A1	TRIAZOLE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR D Provided is a compound having the structure of Formula (1) or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, Ri, R2, R3, R4, R5, R6, R7, m, 11, p, and y are as defined herein, for use in methods fo...
WO/2023/246846A1	NON-CHELATING AND NON-REDUCING FERROPTOSIS INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF The present invention provides a compound represented by formula (I), a method for preparing same, and use thereof. The compound or a pharmaceutically acceptable salt thereof or a stereoisomer thereof is non-chelating and non-reducing, a...

Matches 301 - 350 out of 33,973	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >