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WO/2008/036272A1 |
The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions ...
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WO/2008/009700A1 |
Bicyclic nitrogen containing compounds and their use as antibacterials.
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WO/2008/011406A2 |
The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-J]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and...
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WO/2008/007123A2 |
The invention provides a cyclin dependent kinase (e.g. cdk-4 kinase) inhibitor of the formula (I) or a salt, tautomer, solvate or N-oxide thereof; wherein R1 is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group co...
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WO/2007/139569A1 |
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or pr...
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WO/2007/122258A1 |
Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.
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WO/2007/087276A1 |
The present invention relates to chemical compounds having a general formula (I) wherein A1, A2, C1, C2, D, L1, L2, Z and R1-8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase recept...
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WO/2007/070984A1 |
The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. Th...
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WO/2007/071936A1 |
Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials .
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WO/2007/049798A1 |
Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or th...
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WO/2007/040166A1 |
Disclosed is a compound represented by the formula (1) below which is useful as a glucocorticoid receptor function regulating agent, an anti-inflammatory drug or an antidiabetic drug, or a pharmaceutically acceptable salt thereof. (1) [I...
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WO2006117800B1 |
The present invention relates to the syntheses of 3,4-propylenedioxythiophenes of the formula (I) wherein R represents a n-valent linear or branched, optionally substituted, aliphatic C1-Cn radical and Y represents a pendant functional g...
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WO/2007/018660A2 |
The present invention provides imidazobenzodiazepine derivatives and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes com...
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WO/2007/011809A1 |
The invention relates to a compound of a formula (I): , or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.
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WO/2006/116764A1 |
The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an inte...
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WO/2006/107273A1 |
The invention relates to compounds having progestogenic activity and to their use. The invention discloses a compound having the general formula (I) wherein Y, Y', X and X' are independently selected from the group consisting of O, S and...
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WO/2006/081264A1 |
Naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
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WO/2006/050435A1 |
NLO chromophores of the form of Formula (I) and the acceptable salts, solvates and hydrates thereof, wherein Z, X1-4, &pgr 1-2, D and A have the definitions provided herein.
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WO/2006/030452A1 |
The present invention relates to an improved process for the preparation of Levofloxacin hemihydrate by adjusting the moisture content of the solvent to about 12% to about 20% during crystallization.
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WO/2006/013914A1 |
A medicine for use in administration to the mouth mucosa which contains as an active ingredient either a spirooxathiolane-quinuclidine derivative represented by the following general formula (I) (wherein R1 and R2 may be the same or diff...
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WO/2006/003329A1 |
The invention concerns the use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R'1 represent in particular a hydrogen at...
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WO/2005/113561A1 |
The invention provides compounds of structure of formula (I), and methods of their synthesis and use. Preferred compounds are useful as therapeutic agents, particularly for protein kinase related disorders such as cancer.
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WO/2005/097802A1 |
The invention relates to the use of quinoline derivatives of formula (I), where the dotted bond is either a single- or double-bond and the substituents have the meaning given in the description, as plant treatment agents, in particular, ...
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WO/2005/056549A1 |
Etoposide analogs with improved water-solubility such as 4'-O-Demethyl-4'-(N', N'-dimethyl-glycyl)-4β-(4'-nitroanilino)-4-desoxy-podophyll
otoxin (8) and 4'-O-Demethyl-4'-(N', N'-dimethyl-glycyl)-4β-(4'-fluoroanilino)-4-desoxy-podophyl...
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WO/2005/056563A2 |
A method for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof; from a compound of the formula: (IV); wherein L represents a leaving group.
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WO/2005/054234A2 |
The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making ...
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WO/2005/012281A1 |
This invention relates to benzo[1,3]oxathiol-2-ones, derivatives, and precursors thereof, and their use as neuroprotective agents in the treatment and prevention of neuronal disorders of the central and peripheral nervous systems.
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WO/2005/007099A2 |
The invention is directed to biaryl compounds with two six membered rings fused wherein at least one six membered ring is substituted with a thiophenyl or furanyl ring. Useful in the inhibition of PKB kinase, the treatment of cancer, or ...
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WO/2005/002577A1 |
The use of compounds of the general formula wherein the substituents are as described in claim 1 or pharmaceutically active acid-addition salts thereof for the preparation of medicaments for the treatment of schizophrenia.
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WO2004096805A9 |
Sulfoderivatives of perylenetetracarboxylic acid dibenzimidazole are provided. These compounds form liquid crystal systems possessing high quality optical properties. The resulting liquid crystal systems are readily applicable onto a sub...
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WO/2004/096139A2 |
The present invention provides a compound of Formula (I) or Formula (II): enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compoun...
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WO/2004/087650A2 |
A novel process is provided for the preparation of chiral beta-amino acid amide inhibitors of the dipeptidyl peptidase-IV and the useful intermediates obtained therein. The products resulting from the instant process are inhibitors of di...
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WO/2004/069149A2 |
The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) inter...
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WO/2004/060308A2 |
Novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, as well as novel methods for treating viral infections, including HCV, by administering the compounds and compositions, and novel method...
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WO/2004/058144A2 |
Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
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WO/2004/056879A2 |
Spirotetrathiocarbamates (STOCs) or oxa substituted compounds (SOTOCs) of Formula (I): (Formula (I)) or bisSTOC or bisSOTOC compounds of Formula (II): (Formula (II)) wherein X1, X2, X3, X4, X5, X6, X7, and X8, are independently O or S; a...
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WO/2004/037830A1 |
The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1...
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WO/2004/018481A2 |
The invention relates to derivatives of gossypol and, more specifically, thioderivatives, such as 1,3-dithiolane and 1,3-dithiane, of gossypol, gossypolone and methyl ethers of gossypol. The invention also relates to the methods of produ...
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WO/2004/007476A1 |
The invention relates to 5-thiapethilones and 15-disubstituted epothilones according to formula I (I) with the following meanings: X= >C = O or >S = O R1 = C1-6 alkyl or C2-6 alkenyl R2 = H or C1-6 alkyl Y - Z = >C=C< or >C-O-C< (epoxide...
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WO/2004/007483A1 |
The invention relates to novel macrocycles of general formula (1) and to the use thereof in the treatment of cancer diseases.
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WO/2004/007492A1 |
The present invention relates to new Macrocycles of Formula (I), and their use for the treatment of cancer.
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WO/2004/000859A2 |
Etoposide analogs such as 4'-O-demethyl-4β-[4''-(methyl-L-tyrosine-N-carbonyl)-anilin
o]-4-desoxy-podophyllotoxin (12) and 4'-O-demethyl-4β-[4''-(methyl-L-tryptophan-N-carbonyl)-anil
ino]-4-desoxypodophyllotoxin (13) are described, alo...
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WO/2003/097649A2 |
The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especia...
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WO/2003/082830A1 |
Novel fused quinazoline compound having the structure, formula (I) pharmaceutical composition and method of use for treating tyrosine kinase-mediated disorders.
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WO/2002/094830A2 |
Dihydropyrroloindoles and tetrahydropyridoindoles are prostaglandin receptor antagonists useful for the treatment of prostaglandin-mediated diseases such as allergic rhinitis, nasal congestion and asthma.
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WO/2002/094835A1 |
The invention concerns a compound of formula (I), wherein (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv), (v), (vi) and (vii). The inventive compounds, besides their novelty, exhibit ...
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WO/2002/094840A2 |
The invention concerns a compound of formula (I), wherein: (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv) and (v); R¿9a?, R¿9b?, R¿9c?, X and Y are such as defined in the descripti...
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WO/2002/010140A2 |
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
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WO/2001/098306A1 |
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharma-ceutically acceptable acid addition salt thereof, wherein -a?1¿=a?2¿-a?3¿=a?4¿- is a bivalent radic...
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WO/2001/092267A2 |
This invention relates to novel dihydropyridine soft drugs of the formula $g(F)OOR¿1?, where $g(F) is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho...
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