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JP4054376B2 |
The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals...
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JP2008502689A |
Compounds of formula (I) and derivatives thereof: compositions containing them, their preparation and their use as antibacterials.
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JP2007532503A |
The present filing of an invention relates to the use of quinoline derivatives of the formula in which the dashed bond is a single or double bond and the substituents have the definition given in the disclosure, as crop treatment composi...
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JP3935201B2 |
PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in th...
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JP2007512302A |
The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provi...
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JP3881165B2 |
To provide a method for producing a compound having high HIV activity. A process for the preparation of enantiomerically pure β-D-(-)- dxoxolane-nucleosides (e.g. a compound represented by formula 2 when thymine is used as a base) compr...
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JP3802050B2 |
Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XIII: I II III IV V VI AGE> X XI XII XIII wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unb...
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JP2006516610A |
The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) inter...
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JP2006511622A |
Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
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JP2006070027A |
To provide a medicine used for prophylaxis and/or treatment of xerostomia, rapidly exhibiting excellent sialogogic effects and reducing or avoiding adverse effects on digestive organs.A medicine is used for, e.g. prophylaxis and/or treat...
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JP2006506375A |
Benzo(e)(1,4)oxazino(3,2-g)isoindole derivatives (I), and their enantiomers, diastereoisomers, N-oxides and addition salts with acids and bases are new. Benzo(e)(1,4)oxazino(3,2-g)isoindole derivatives of formula (I), and their enantiome...
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JP2005535669A |
The present invention relates to novel macrocycles of the general formula (I) and to the use thereof in the treatment of cancer diseases.
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JP2005532327A |
The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especia...
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JP3691856B2 |
PURPOSE: To obtain a compound useful as an antifungal agent effective for therapy of dermatomycosis, visceral mycosis, etc. CONSTITUTION: This compound is represented by the formula (A is =CH-or =N-; L and M are H, a halogen; R1 is a fiv...
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JP3654939B2 |
PURPOSE: To obtain a low-toxic medicine for dry vagina free from side effects, acting on exocrine gland, esp. capable of promoting the secretion of various secretions from the vagina and vulva through stimulating muscarinic M3-type recep...
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JP2004535405A |
Compound of formula (I): wherein: represents a single or double bond, represents a ring system selected from R6a, R6b, R6c, R6d, X and Y are as defined in the description, R1 represents a hydrogen atom or a group selected from aryl, hete...
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JP2004529191A |
A compound of formula (I): wherein: represents a single or double bond, represents a ring system selected from R9a, R9b, R9c, X and Y are as defined in the description, R1 represents a group selected from hydrogen, aryl, heteroaryl, cycl...
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JP2004231659A |
To provide a method for preparing triethylenediamine (TEDA) solution in an alcohol and/or an ether.The method for preparing TEDA solutions containing solvents selected from a group consisting monohydric alcohols and ethers of monohydric ...
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JP3555032B2 |
A compound of general formula (I) is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.
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JP2004518613A |
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.
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JP2004161741A |
To provide a ligand system capable of changing stereospecific characteristics and electronic characteristics easily and especially enabling not only a high enantio-selectivity but also a high conversion rate with the transition metal com...
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JP2004149543A |
To provide a enantiomerically pure dioxolane nucleoside having excellent anti-HIV activity.The method and a composition for therapeutic treatment of an infected human with HIV (human immunodeficiency virus) include administration of an H...
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JP3519736B2 |
A method and composition for the treatment of humans infected with HIV that includes administration of an HIV treatment amount of an enantiomerically pure beta -D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, or ...
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JP2003535096A |
This invention relates to novel dihydropyridine soft drugs of the formula PhiOOR1, where Phi is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constr...
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JP2003523360A |
This invention provides novel benzoethers of the following formulae:These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pha...
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JP3421335B2 |
The present invention provides enantiomerically pure ²-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of...
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JP2003519693A |
The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8, or a chemical bo...
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JP2003128667A |
To provide an alkylation method of 3,4-dihydroxythiophene-2,5- dicarboxylic acid ester or an alkali metal salt or an alkaline earth metal salt thereof, which is easy to carry out and with which corresponding 3,4- dialkoxythiophene-2,5-di...
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JP2003515601A |
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or imroved recognition domains are disclosed, including methods of preparing and utilizing the same.
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JP2003073367A |
To provide a new agrochemical, especially a germicical agent and an insecticidal agent.The tricyclic heterocyclic imino compound represented by formula (1) [wherein, G is -CH2COOMe or the like; A is a ring formed by 5-7 atoms arbitrarily...
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JP2003506468A |
Heterocyclic spiro compounds of formula (I) or salts thereof, wherein the symbols have the meaning given in the description, are useful for combatting animal pest.
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JP3377227B2 |
This invention relates to derivatives of formula wherein A is =H2, =O, =(H) (OH), NOR1, or with n being 2 or 3, X and Y are O or S, R1 is H or alkyl, R2 is H, halogeno, alkyl, alkoxy, OH, -CN or C(O)NH2, Z is O, S or NR1, Q is a heterocy...
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JP2003505465A |
Anticonvulsant compounds of the general formula I:where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal inj...
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JP2003505388A |
The present invention relates to certain spirooxindole derivatives of the formula I, and pharmaceutically acceptable salts thereof, which exhibit good analgesic properties and are particularly effective in the treatment of chronic pain.
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JP2003504373A |
This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharm...
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JP2002179673A |
To provide a method for the organic synthesis of salacinol having inhibiting action on glucotase and a cyclic sulfonium compound analogous to salacinol, and to obtain a cyclic sulfonium compound and its analogous compound produced by the...
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JP2002512238A |
The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
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JP2002114681A |
To obtain a new therapeutic agent for anorthosis, having an excellent effect on the anorthosis, useful as a medicine especially slightly affecting on the heart.This therapeutic agent for anorthosis comprises a spirooxathiolane quinuclidi...
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JP2002114792A |
To obtain both a new [18]annulene-based compound and an optical information recording medium suitable for excellent recording and regeneration in a laser having 350-500 nm wavelength by using the same.This optical information recording m...
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JP3268098B2 |
PURPOSE: To obtain a new antimicrobial compound useful as a medicine, an animal medicine, an aquatic medicine, an antimicrobial preservative, etc. CONSTITUTION: A compound of formula I [X1 and X2 are halogen; R1 is H, OH, thiol, 1-6C alk...
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JP2002506072A |
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as P...
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JP2001520638A |
Combinatorial libraries are disclosed which are represented by Formula I: wherein: is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula whic...
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JP3220711B2 |
To obtain a new compound capable of bonding to the surface of gold in a lot of points and easily forming a stable self-organized film on the surface of gold by introducing a disulfide group in phthalocyanine. This new compound of phthalo...
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JP3208140B2 |
A compound of formula or a pharmaceutically acceptable salt form thereof, is useful as a retrovial protease inhibitor for treating HIV infections.
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JP3175940B2 |
The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical a...
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JP3157831B2 |
A process for the production of ambergris-type labdane spiroketals of general formulae I and II I and/or II where R represents oxygen or sulphur, useful in the perfumery industry, the said process being characterized by the intramolecula...
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JP3117217B2 |
A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a beta -dioxolanyl purine nucleoside of the formula: wherein R is OH, Cl, NH2, or H, or a pharmaceutica...
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JP3113078B2 |
PURPOSE: To prepare the subject new compds. effective as insecticides, miticides, herbicides and fungicides. CONSTITUTION: A compd. of formula I [X is an alkyl, a halogen, an alkoxy or a halogenoalkyl; Y is H or X; Z is an alkyl, a halog...
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JP3110461B2 |
PCT No. PCT/CA94/00311 Sec. 371 Date Feb. 2, 1995 Sec. 102(e) Date Feb. 2, 1995 PCT Filed Jun. 7, 1994 PCT Pub. No. WO94/29301 PCT Pub. Date Dec. 22, 1994The present invention relates to a process for producing predominantly pure cis nuc...
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JP2000509718A |
(57) [Summary] Compounds represented by formula (I), as well as their N-oxides and agriculturally suitable salts, are disclosed which are useful in controlling unwanted vegetation. In equation (I) above, Q is (Q-1), (Q-2) or (Q-3); and A...
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