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JPH05500950A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH04178389A |
NEW MATERIAL:A compound shown by formula I [R1 is H or (substituted) hydrocarbon; COOR2 is (esterified) carboxyl; ring B is (substituted) cyclic group]. EXAMPLE: Sodium (5S,6S,7RS)-5-[(R)-hydroxyethyl]-4-oxo-3-aza-11 thiatricyclo[5,4,0,0...
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JPH0414116B2 |
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JPH03118370A |
NEW MATERIAL: A substituted 1H-indazole-3-carboxamide of formula I and its salt [R1 is a straight or branched 1-4C alkyl, a halogen or cyano; (n) is 0 or 1; R2 is H, a 1-6C alkyl, a 3-6C cycloalkyl, a 3-6C cycloalkyl-1-4C alkyl, phenyl, ...
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JPH0374387A |
NEW MATERIAL:A compound expressed by formula I. USE: A recording, memorizing, dimming, masking and temperature indicating materials and optical filters having photochromic and thermochromic properties. PREPARATION: A compound expressed b...
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JPH0366669A |
NEW MATERIAL:A compound shown by formula I [R1 and R2 are H, alkyl, phenyl or bonded to form 4- to 8-membered carbon ring; R3 is H or alkyl; R4 is H, halogen, NO2, alkyl, phenyl, OR5 (R5 is H, alkyl, carboxymethyl, etc.), etc.; R7 is H o...
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JPH0313235B2 |
This invention relates to new 1,3-dihydro-6-methyl-furo-(3,4-c)-pyridine derivatives of the general formula: wherein, each of A1 and A2 represents various hydrocarbon groups, to pharmaceutically acceptable salts of them, to a process for...
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JPH02262582A |
NEW MATERIAL: Compd. of formula I [wherein R is a phenyl substd. with 1-5F and arbitrarily substd. with methyl or Cl at para position, etc.; R1 and R2 are each H, a halo or a (substd.) 1-3C aliph.; R3 is a 3-18C group, R12 (wherein R12 i...
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JPH02247183A |
NEW MATERIAL:The compound of formula I [R1 is lower alkyl; R2 is H or lower alkyl; X is O or S; Y is O, S, so or SO2; when both X and Y are O, R2 is H and when X is O and Y is S, R2 is lower alkyl]. EXAMPLE: 3,8-Dimethyl-1-oxa-4-thia-8-a...
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JPH02218612A |
PURPOSE: To obtain an ophthalmic composition which contains an ACE inhibitor, in some cases, additionally a CA inhibitor and is used for treatment of glaucoma and for ocular hypertension accompanied thereby. CONSTITUTION: This ophthalmic...
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JPH0238595B2 |
An anomer or an asteric mixture of a compound of the formula wherein R is selected from wherein R1 to R4 may be the same or different and are selected from hydrogen, lower alkyl, lower alkenyl, lower haloalkyl, lower aminoalkyl, lower al...
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JPH02218683A |
NEW MATERIAL: Compounds of formula I [Me is Al, CR4 (R4 is H, 1-6C alkyl, halogen, phenyl, O-C1-6 alkyl)I, SiR4, Sn(IV)R4, P, P=O; X is O, S, NR5 (R5 is H, 1-6C alkyl, phenyl); R1 is H, 1-6C alkyl, tri-C1-4 alkylsilyl, (substituted) phen...
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JPH02197838A |
PURPOSE: To improve stability of the organic colored material against light by allowing a specified thiophenol compound to exist together with the organic colored material. CONSTITUTION: The compound to be used together with the organic ...
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JPH0230359B2 |
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JPH0272179A |
NEW MATERIAL: A speroazacyclic compd. represented by formula I (wherein Q is a residue of azabicyclo[2.2.1]heptane or azabicyclo [3.2.1] octane ring system which is substd. according to circumstances; and T is a residue of a saturated or...
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JPH01319474A |
NEW MATERIAL: Compound of formula I (R1, R9 are H, and both are CO, SO, CHNR2R3; R2, R3 are lower alkyl; R6, R7 are H, COR22, CONR4Z; R22, R4 are H, lower alkyl; Z is NR5R8, N=CR10R11; R5, R8 are H, lower alkyl, etc.; R10, R11 are lower ...
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JPH01290680A |
PURPOSE: To obtain the title high-purity cis type compound useful as a remedy for mammalian central nerve diseases, by firstly converting 2-methylspiro (1, 3-oxathiolane-5, 3') quinuclidine (MSOQ) into the perchlorate of MSOQ, adding a s...
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JPH01501866A |
The present invention relates to carbamoyloxylabdanes, intermediates and a process for the preparation thereof. The compounds of the invention exhibit intraocular pressure activity and can, therefore, be used as medicaments.
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JPH01100173A |
NEW MATERIAL: A compd. of formula I (R1 is H, a halogen, an O-, N-, P- or S-bonded org. group; R2 is H, F, OH, hydrocarbyl, etc.; R3, R4 are each H, a halogen, OH, hydrocarbyl, etc.; R5 is an aralkyl, an aryl, an alkyl, etc.; R6 is H, hy...
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JPS6471870A |
PURPOSE: To produce the title compound in high yield under mild conditions, by effecting reactions between a halotrimethylsilylmethyl sulfide, a carbonyl compound and a fluoride ion source in acetonitrile or tetrahydrofuran. CONSTITUTION...
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JPS6447787A |
NEW MATERIAL: The compd. expressed by formula I [R is 1 to 4C (substd.) alkoxy, 2 to 20C (substd.) nonaromatic hydrocarbyl, etc.; R1, R2 are H, halo, cyano, 1 to 4C alkoxy, etc.; A is 2 to 12C (substd.) nonaromatic hydrocarbyl, CH2O, etc...
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JPS6366808B2 |
The preparation of 6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza
zepines is described by direct bromination of the nucleus.
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JPS63185974A |
The present invention relates to carbamoyloxylabdanes, intermediates and a process for the preparation thereof. The compounds of the invention exhibit intraocular pressure activity and can, therefore, be used as medicaments.
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JPS63154682A |
Derivatives of formula (I), in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7- tetrahydro-5H-oxathiinno[1,4][2,3C]pyrrole or 2,3,6,7-tetrahydro-5H- dithiinno[1,4][2,3C]pyrrole nucleus a...
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JPS6388175A |
The present invention relates to oxolabdanes and to a process for their preparation. The compounds of the invention are able to reduce intraocular pressure and can, therefor, be used as medicaments.
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JPS6225658B2 |
The preparation of 6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza
zepines is described by direct bromination of the nucleus.
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JPS62116585A |
Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo-[2,2,3]-nonanes, having 2 or 3 ring hetero atoms selected from 0, s and n substituted at the 1-position by a carbocyclic group other than an alkynylphenyl group, and substitut...
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JPS6296492A |
PURPOSE: To industrially and advantageously obtain the titled compound useful as an intermediate raw material for producing optically active natural type biotin, by reacting a specific alkyl nonanoate with an alkali hydroxide. CONSTITUTI...
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JPS61210081A |
The present invention relates to novel labdanes, intermediates and processes for the preparation thereof. The compounds have the ability to reduce elevated intraocular pressure and can, therefore, be used as medicaments.
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JPS6141919B2 |
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JPS61167691A |
The invention relates to compounds of the formula I in which R1, R2, R3, m and n have the meaning given in Claim 1, and to their preparation. The compounds of the formula I can be used as medicines.
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JPS61145178A |
The present invention relates to aminoacyllabdanes of the formula and to pharmaceutically acceptable acid addition salts thereof, further to intermediates and a process for their preparation. The compounds are useful for reducing intraoc...
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JPS6125697B2 |
The preparation of 6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza
zepines is described by direct bromination of the nucleus.
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JPS6125035B2 |
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JPS6111954B2 |
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...
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JPS6029716B2 |
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...
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JPS6019312B2 |
PURPOSE:To prepare the title cpds. easily, useful as intermediates for 1-oxadithia-3cephem-4-carboxylic acid having an optional substituent at the 3-methyl gp. as antibacterials, by halogenation or substituent interchange of the correspo...
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JPS59511B2 |
1473591 Vinylic and acetylenic pyridines and their N-oxides MERCK & CO Inc 11 June 1974 [15 June 1973 18 April 1974 26 April 1974] 25858/74 Headings C2C and C2P The invention comprises novel compounds (I) and their pharmaceutically accep...
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JPS58177993A |
New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: and salts thereof, wherein R1 and R2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lo...
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JPS5747189B2 |
S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from py...
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JPS5634682A |
Process for preparing intermediates of spectinomycin and analogs thereof. Also provides novel intermediates for making spectinomycin and analogs thereof.
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JPS562075B2 |
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JPS5594357A |
Mercapto acyl compounds, having hypotensive activity, have the formula:- or are salts thereof, wherein R is hydrogen or lower alkyl, R1 and R2 are various defined organic groups or R1 and R2 together complete a ring, X1 and X2 are oxygen...
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JPS558508B2 |
Heterocyclic compounds of the formula: wherein the pyrroline ring and the symbols R1 and R2 together form an isoindoline, 6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-1,4-oxathiino-[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H...
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JPS553355B1 |
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JPS5422996B2 |
Heterocyclic compounds of the formula: wherein the pyrroline ring and the symbols R1 and R2 together form an isoindoline, 6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-1,4-oxathiino-[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H...
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JPS5317994B2 |
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JPS5193218A |
1528179 spiroimidazolines AGFAGEVAERT AG 18 Dec 1975 [20 Dec 1974 28 June 1975] 51808/75 Heading C2C [Also in Divisions G2-G3] Spiroimidazolidine compounds of the formula in which R and R1 which may be the same or different, represent hy...
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JPS5032181A |
S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from py...
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JPS5032180A |
S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from py...
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