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Matches 51 - 100 out of 14,487

Document Document Title
WO/2020/180127A1
The present invention relates to a novel compound having excellent electron transport ability and luminescence, and an organic electroluminescent device which comprises same in one or more organic layers and thus has improved characteris...  
WO/2020/181025A1
The present disclosure relates to solid state forms of baloxavir marboxil, processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.  
WO/2020/178282A1
The specification relates to compounds of Formula (A) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them an...  
WO/2020/173417A1
The present invention relates to a novel acryloyl-containing compound, a preparation method for same, and uses thereof. Specifically, the present invention relates to an acryloyl-containing compound as represented by formula (1), a prepa...  
WO/2020/169804A1
Compounds of formula (I), wherein A, Z, E, R1, R2, m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2020/165776A1
The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and ph...  
WO/2020/167976A1
Described herein are compounds that regulate pyruvate kinase activity, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R2, L1-L2, U1-U7, m, ring A, and Q are as defined herein.  
WO/2020/161742A1
The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl]carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydr o-2H-pyrido[1',2':4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represent...  
WO/2020/163598A1
Disclosed herein, inter alia, are immunophilin binding compounds and methods of using the same.  
WO/2020/161744A1
Novel crystalline forms of Bictegravir sodium, pharmaceutical compositions containing said crystalline forms and the use of said crystalline forms in the treatment of HIV infection are disclosed. The present invention is further directed...  
WO/2020/163594A1
Described herein, inter alia, are immunophilin binding compounds and methods of treating CNS diseases, including co-administering outside the CNS of a subject an anti-CNS disease drug and a compound described herein.  
WO/2020/155613A1
The present invention provides a method for preparing an ecteinascidin compound and an intermediate thereof, and specifically provides a preparation method for a novel compound QT9, and a method of using QT9 to prepare an ecteinascidin c...  
WO/2020/160151A1
A compound having one of formula (1), formula (2), formula (3) and formula (4) or a pharmacologically acceptable salt thereof.  
WO/2020/156437A1
The present invention discloses an AKT inhibitor, and specifically relates to a compound represented by formula I or a pharmaceutically acceptable salt thereof. The present invention further provides a preparation method thereof, and the...  
WO/2020/157626A1
The invention relates to a compound of general formula (I) or a pharmaceutically acceptable enantiomer, tautomer, salt, solvate or prodrug of said compound, or a mixture thereof, and to the use of said compound as a drug, in particular a...  
WO/2020/157662A1
The invention relates to 2-methylbenzoxazole compounds of formula I which are analogues of the DNA alkylating subunit of the duocarmycins. Compounds of formula I can be used in the synthesis of DNA alkylating agents and antibody-drug con...  
WO/2020/157026A1
The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the µ-opioid receptor and more particularly to hydroxylated derivatives of 1-oxa-4,9-diazaspiro undecane compounds...  
WO/2020/154455A1
The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods...  
WO/2020/140005A3
The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors f...  
WO/2020/147802A1
Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are a...  
WO/2020/150113A1
The present invention provides compounds of Formula (I): Formula (I) wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorde...  
WO/2020/145250A1
[Problem] To provide a compound having a 15-PGDH inhibitory effect. [Solution] A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.  
WO/2020/135210A1
Disclosed are a substituted aryl compound or pharmaceutically acceptable salts thereof, a stereoisomer, a polymorphic substance, a solvate, a N-oxide, an isotopically labeled compound, a metabolite or a prodrug and a preparation method t...  
WO/2020/132819A1
Disclosed is a method for preparing (1R,3S)-3-aminocyclopentanol hydrochloride. The method comprises using amide formed by chiral carboxylic acid and hydroxylamine as a chiral source, quickly obtaining a chiral Diels-Alder reaction produ...  
WO/2020/139803A1
Disclosed herein are novel inhibitors of CD73. More specifically, the novel CD73 inhibitors are derived from benzothiadiazine. Further, the present disclosure is related to the use of said benzothiadiazine derivatives in the treatment of...  
WO/2020/138398A1
The present invention addresses the problem of providing a novel compound exhibiting a high LSD1-inhibiting activity, high selectivity for LSD1 inhibition, and/or having a useful therapeutic effect for various diseases. One embodiment pe...  
WO/2020/140005A2
The disclosure includes compounds of Formula (I), (I) wherein Z, Q1, Q3, Q4, Q5, Q6, Q7, R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, g, k, m, n, s, v, j, L, Z1, and, W are defined herein. Also disclosed is a method for treating a neopla...  
WO/2020/138015A1
The present invention provides: a novel compound that is useful for treating or preventing infections associated with viruses belonging to the subfamily Pneumovirinae, including respiratory syncytial virus (RSV), and that has an anti-RSV...  
WO/2020/135439A1
A deuterated dihydropyrimidine compound and use thereof as a drug, especially as a drug for treating and preventing hepatitis B. In particular, the present invention relates to a compound represented by general formula (I) or (Ia) or a s...  
WO/2020/125729A1
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.  
WO/2020/125513A1
The present invention relates to a macrocyclic compound as a CDK inhibitor, a preparation method therefor and the use thereof in medicine. Specifically, the present invention relates to a novel macrocyclic compound represented by a gener...  
WO/2020/126591A1
The present invention relates to substituted pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising such compounds. The invention also relates to methods and uses...  
WO/2020/128583A1
The present invention refers to a process for the manufacturing of a tablet of rifaximin starting from a pseudo-crystalline form of rifaximin, as well a tablet of rifaximin obtainable by such process.  
WO/2020/132483A1
The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureu...  
WO/2020/128861A1
The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making...  
WO/2020/125730A1
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.  
WO/2020/130681A1
The present invention relates to a novel compound and an organic electroluminescent device comprising same. As the compound according to the present invention is used in an organic material layer of an organic electroluminescent device, ...  
WO/2020/122092A1
The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I) [in the formula, each symbol is as described in the description] or a salt thereof has orexin ...  
WO/2020/122461A1
The present invention provides: a compound represented by chemical formula 1; an organic electric device comprising a first electrode, a second electrode, and an organic material layer between the first electrode and the second electrode...  
WO/2020/119592A1
The present invention relates to the field of medicinal chemistry. Disclosed are a three-ring fused structure compound, a preparation method therefor and use thereof. The compound of the present invention can be used as a selective inhib...  
WO/2020/122607A1
The present invention relates to the preparation of novel compounds 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demeth...  
WO/2020/124059A1
Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutcal compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated ...  
WO/2020/123850A1
The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of adm...  
WO/2020/122611A1
The present invention relates to a novel compound usable as a main ingredient of a composition for stimulating hair growth, and to a use of same in hair growth stimulation, wherein the compound is 9-deoxo-31-O-demethyl-prolyl-FK506, 9-de...  
WO/2020/115481A1
This invention relates to compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these compounds, for example in a method of treatmentof ca...  
WO/2020/116995A1
The present specification relates to a heterocyclic compound represented by chemical formula 1, and an organic light-emitting element including same.  
WO/2020/116660A1
A compound represented by the following formula (I): wherein each symbol in the formula is as described herein or a salt thereof has an NRF2 activating activity, and is expected to be useful as a preventive or therapeutic agent for disea...  
WO/2020/110008A1
The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):, or a pharmaceutically acceptable salt, hydrate, solvate, prod...  
WO/2020/111613A1
The present invention provides a novel compound and an organic light-emitting diode using same.  
WO/2020/111081A1
A purpose of the present invention is to provide, as a material for organic EL elements having high efficiency and high durability, an organic compound which has excellent characteristics including excellent electron injection/transport ...  

Matches 51 - 100 out of 14,487