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WO/1982/001705A1 |
4-substituted-2-oxoazetidine derivatives represented by the following general formula (I): (FORMULA) (wherein R1 represents a hydrogen atom, an alkyl group optionally having a hydroxy group, a phthalimido group or a halogen atom, R2 repr...
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WO/1981/001707A1 |
A novel process for the preparation of 6-aminopenicillanic acid-1,1-dioxide and its non-toxic, pharmaceutically acceptable salts by deacylation of a penicillin-1,1-dioxide or its salts of which the 3-carboxylic acid is protected by such ...
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WO/1980/000337A1 |
A primary alcohol or an aldehyde is reacted with ammonia or a primary or secondary amine together with a molecular oxygen-containing gas in the presence of a palladium or platinum catalyst under oxidative condition to prepare a correspon...
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JP7343602B2 |
An object of the present invention is to provide a pharmaceutical composition and a kit which exhibit strong antibacterial activity against Gram-negative bacteria and/or drug-resistant Gram-negative bacteria.A pharmaceutical composition ...
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JP2023521886A |
The present invention relates to methods and reagents for determining the presence or amount of an analyte in a sample.
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JP2023502026A |
The present invention relates to conjugates comprising an antibiotic and a nucleophilic derivatizing reagent, compositions comprising the conjugates, kits comprising the conjugates or compositions, and uses of the conjugates or compositi...
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JP7179919B2 |
A bioassembly system having a tissue/object modeling software component fully and seamlessly integrated with a robotic bioassembly workstation component for the computer-assisted design, fabrication and assembly of biological and non-bio...
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JP2022548067A |
The novel iron-chelating group-conjugated penam derivatives described herein exhibit antibacterial activity and can be used as antibacterial agents or as beta-lactamase inhibitors (BLI), which can be used in combination with other antiba...
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JP7092869B2 |
An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by ...
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JP7045795B2 |
A crystalline compound of formula (I):The compound of formula (I) is a β-lactamase inhibitor and may be administered in combination with an antibacterial agent for prevention or treatment of bacterial infection.
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JP7011242B2 |
The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for preparing alkenyl fluorides such as CF3-s...
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JP6986089B2 |
An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. According to the present i...
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JP6894498B2 |
The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension o...
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JP6891275B2 |
The present disclosure provides a composition consisting of ceftriaxone sodium and sulbactam sodium, a pharmaceutical formulation comprising the same and the application thereof. The composition is characterized by having an X-ray powder...
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JP2020125248A |
To provide a production method that makes it easy to remove and recover a catalyst and makes it possible to obtain a tazobactam key intermediate with a high conversion rate.A method for producing a triazole compound represented by the fo...
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JP6707512B2 |
High penetration comp1ositions (HPCs) or prodrugs (HPPs) of antimicrobials and antimicrobial-related compounds are provided. The HPCs/HPPs are capable of being converted to parent drugs or drug metabolites after crossing the biological b...
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JP6613303B2 |
A method of forming a compound of formula (II) in which a compound of formula (I) is reacted with less than a molar equivalent of a compound of formula (V): wherein R 1 in each occurrence is independently selected from H, halogen, amino,...
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JP2018039756A |
To provide an industrially advantageous production method of tazobactam sodium monohydrate crystal.The present invention is a production method of a 2 alpha-methyl-2 beta-(1,2,3-triazolyl-1-yl)-methylpenam-3 alpha-carboxylic acid 1,1-dio...
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JP2018039755A |
To provide an industrially advantageous production method of tazobactam sodium monohydrate crystal.The present invention is a production method of a 2 alpha-methyl-2 beta-triazolylmethyl penam-3-carboxylic acid 1,1-dioxide sodium monohyd...
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JPWO2016175223A1 |
Provided are a compound showing a strong antibacterial spectrum against various bacteria including Gram-negative bacteria and / or Gram-positive bacteria, and a pharmaceutical composition having antibacterial activity against carbapenem-...
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JP6256924B2 |
High penetration comp1ositions (HPCs) or prodrugs (HPPs) of antimicrobials and antimicrobial-related compounds are provided. The HPCs/HPPs are capable of being converted to parent drugs or drug metabolites after crossing the biological b...
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JP6186001B2 |
This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions.
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JP2016538244A |
[Task] The present invention provides a compound of formula I. ALB [In the formula, A is Zn2+Means a lipophilic chelating moiety that is selective for ions; L is a covalent bond or linker; B is a vector, said vector being found within a ...
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JP6035420B2 |
Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by dr...
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JP2016106157A |
To provide compounds that inhibit E1 activating enzymes.This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are u...
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JP2016516813A |
An artificial tricatecolate siderophore with a tripod backbone and its complex with ampicillin and amoxicillin were synthesized. Both complexes showed significantly enhanced in vitro antibacterial activity against Gram-negative species, ...
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JP5795343B2 |
To permit transdermal administration (topical application) of β-lactam antibiotic substances through skin barrier by increasing permeability of the β-lactam antibiotic substances.Novel positively-charged prodrugs of the β-lactam antib...
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JP5791498B2 |
Disclosed is a process for producing a 4-chloroazetidinone compound, which is a compound useful as an intermediate for the synthesis of a carbapenem antibiotic, with high efficiency and in a high yield. Also disclosed is an intermediate...
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JP5686385B2 |
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JP2014132111A |
To provide a method for forming an active material-containing coating on a substrate.A method comprises: (i) a step of introducing one or more kinds of atomized liquid or solid coating formation materials reacting to form a chemical bond...
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JP5324463B2 |
The novel positively charged pro-drugs of beta-lactam antibiotics in the general 'Structure 4' were designed. The positively charged amino group of the pro-drug not only makes the drugs soluble in water, but also bonds to the negative ch...
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JP5300713B2 |
The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic ...
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JP5232083B2 |
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...
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JP5231212B2 |
The invention relates to a method for producing isotopically labelled secondary metabolic products of fungi or bacteria in a liquid synthetic culture medium. According to said method, the synthesis is carried out by immobilizing the fung...
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JP5173842B2 |
Disclosed are a novel crystal of piperacillin sodium which has diffraction angles of 3.7°, 5.5°, 7.3°, 11.6°, 14.5° and 18.0° and a novel crystal of piperacillin sodium which has diffraction angles of 5.6°, 7.8°, 12.3°, 15.5°, ...
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JP4949826B2 |
The present invention relates to a product of amoxicillin trihydrate, having a free water content of less than 0.1 wt.%, preferably less than 0.07 wt.%, more preferably less than 0.05 wt.%, measured at an equilibrium relative humidity of...
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JP4949827B2 |
The present invention relates to a product of amoxicillin trihydrate, having a free water content of less than 0.1 wt.%, preferably less than 0.07 wt.%, more preferably less than 0.05 wt.%, measured at an equilibrium relative humidity of...
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JP2012511027A |
The invention provides compositions or pharmaceutical compositions of novel high penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capabl...
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JP2012507502A |
The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to ...
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JP2012012384A |
To provide a new crystal of piperacillin sodium having a pharmaceutically excellent effect, and to provide a preparation for injection filled with the same.A new crystal of piperacillin sodium 2.5-hydrate having diffraction angles of 5.4...
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JP4841129B2 |
The present invention provides novel 2±-methyl-2²-[(1,2,3-triazol-1-yl)methyl]penam-3±-carboxy
lic acid benzhydryl ester (TMPB)-acetone crystals for use in the production of 2±-methyl-2²-[(1,2,3-triazol-1-yl)methyl]penam-3±-carboxy...
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JP2011225552A |
To provide a new crystal of piperacillin sodium having an excellent function as a medicine, and to provide a preparation for injection filled therewith.This invention relates to a crystal (2S, 5R, 6R)-6-((2R)-2-((4-ethyl-2, 3-dioxo piper...
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JP4731777B2 |
With the purpose of developing a widely applicable technique capable of preparing oral granular formulations having good handling properties and rapidly disintegrating or dissolving in the mouth during administration or when they are dis...
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JP4716708B2 |
An object of the invention is to provide an industrially advantageous process capable of remarkably suppressing the generation of an undesirable by-product cepham compound to thereby efficiently produce a desired 2±-methyl-2²-[(1,2,3-t...
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JP4698773B2 |
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...
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JP2010518010T5 |
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JP4602759B2 |
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
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JP2010275289A |
To provide a mixture formulation for treating tuberculosis containing ertapenem and a β-lactamase inhibitor as effective ingredients.The mixture formulation produced by mixing ertapenem or a salt thereof and various β-lactamase inhibit...
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JP2010536750A |
In its many embodiments, the present invention relates to a novel class of 6-substituted sulfonyl-1,3,3-trialkyl-6-azabicyclo[3.2.1]octane compounds useful to inhibit 11beta-hydroxysteroid dehydrogenase type-I, pharmaceutical composition...
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JP2010215652A |
To provide one group of bicyclic heteroaryl substitution 6-alkylidene-penems which have beta-lactamase inhibiting properties and antibacterial properties.The present invention provides a compound shown by formula (I), pharmaceutical comp...
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