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Matches 1 - 50 out of 2,900

Document Document Title
WO/2017/153892A1
A synthesis process of precursors of derivatives of beta-lactam compounds, said beta-lactam compounds being selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, comprising the follo...  
WO/2017/117882A1
Disclosed is a pharmaceutical composition of piperacillin sodium and sulbactam sodium, comprising 2-4 parts by weight of piperacillin sodium and 1 part by weight of sulbactam sodium having a specific rotation of +230° to +235°. By opti...  
WO/2017/096472A1
Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or...  
WO/2017/059062A1
Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti- angiogenic and/or anti-inflammatory activity. Certain embodiments of the disclosed compounds are no...  
WO/2017/021390A1
The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the ...  
WO/2016/175223A1
Provided are the following: compounds having a powerful anti-bacterial spectrum against a variety of bacteria, including gram-negative bacteria and gram-positive bacteria; and pharmaceutical compositions having antibacterial activity aga...  
WO/2016/139373A1
Molecular storage materials for incorporating small molecules in solid matrices may find applications in structure elucidation, decontamination, and slow release of active ingredients. The syntheses of 1,3,5,7-tetrakis(2,4-dimethoxypheny...  
WO/2016/046055A1
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...  
WO/2016/027262A1
A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderop...  
WO/2015/173378A2
A method of forming a compound of formula (IIIa); wherein: R1 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R2 in each occurrence is independently selected from H, halogen...  
WO/2015/173378A3
A method of forming a compound of formula (IIIa); wherein: R1 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R2 in each occurrence is independently selected from H, halogen...  
WO/2015/067787A1
A crystalline compound of formula (I): Formula (I). The compound of formula (I) is a β-lactamase inhibitor and may be administered in combination with an antibacterial agent for prevention or treatment of bacterial infection.  
WO/2015/061630A3
A compound is provided, comprising: an Fe(III)-binding or an Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; a drug; and an Fe(III) to Fe(II) reduction triggered linker bound to the drug and th...  
WO/2015/032711A1
The present invention relates to amoxicillin trihydrate compositions having a surface area of from 1.0 to 2.5 m2.g-1 that are free of organic contaminants such as dichloromethane, isopropanol, pivalic acid and triethyl amine and that hav...  
WO/2015/021692A1
Provided is a bacteria culture medium, wherein the culture medium is prepared by adding one or more β-lactam antibiotics and/or salts thereof to an ordinary bacteria culture medium in advance, wherein the β-lactam antibiotics and/or sa...  
WO/2015/012158A1
A method for providing a vascular system in biological tissue in vitro, the method comprising cocultivation of the biological tissue with vascular cells and mesenchymal cells. Biological tissue in which a vascular system has been provide...  
WO/2014/171971A1
An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negat...  
WO/2014/072843A1
The present invention relates to a process for the preparation of isoxazolyl penicillins from sugarcane juice. The invention focuses on in-situ synthesis of isoxazolyl penicillins without isolation of the intermediates like Penicillin G ...  
WO/2014/040280A1
Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and a preparation method therefor, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by...  
WO/2014/037893A1
The present invention relates to an improved process for the preparation of Tazobactam of formula (I) having reduced content of cresol. (Formula I) (I)  
WO/2013/109927A2
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide ("AMP") and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain...  
WO/2013/010102A2
The present invention provides compositions and methods for the administration and targeted delivery, release and/or formation of a drug compound from a halogenated phenol starting compound of the present invention at site(s) within the ...  
WO/2013/000277A1
Provided is a method for preparing ticarcillin disodium with less side reaction and strong controllability in mild reaction condition using fewer steps, which comprises (1) reacting 3-thiophene malonic acid with N-hydroxyl succinimide in...  
WO/2012/164355A1
Disclosed is an improved process for the preparation of isoxazolyl penicillins of formula (I), wherein X1 and X2 can be independently selected from the group comprising hydrogen, chlorine or fluorine, and its pharmaceutically suitable sa...  
WO/2012/105596A1
[Problem] To provide a method for the fluorescent labeling of a protein that can even be used for the fluorescent labeling of a biological molecule (protein) in vivo. [Solution] A method for the fluorescent labeling of a target protein, ...  
WO/2012/000421A1
Disclosed are gossypol derivatives, preparation methods and uses thereof in the manufacture of antitumor medicaments. Pharmaceutical compositions containing the said gossypol derivatives and preparation methods thereof are also disclosed.  
WO/2011/158133A1
An improved process for preparing sterile amoxicillin and an alkali metal salt thereof, wherein the said process involves the steps of: i) dissolving amoxicillin trihydrate in methyl acetate, methanol and triethylamine; ii) Passing the r...  
WO/2011/040386A1
Disclosed is a novel crystal of piperacillin sodium monohydrate, which has diffraction angles represented by 2θ of 6.6, 10.9, 14.6, 17.0, 18.2, 19.8 and 24.9° in powder X-ray diffraction. The crystal has a low analogous substance conte...  
WO/2010/095617A1
Disclosed is a process for producing a 4-chloroazetidinone compound, which is a compound useful as an intermediate for the synthesis of a carbapenem antibiotic, with high efficiency and in a high yield. Also disclosed is an intermediate...  
WO/2010/049899A1
The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to ...  
WO/2010/028458A1
The present invention relates to prodrugs of isoxazolyl penicillins, pharmaceutical compositions comprising same and their use in the treatment of microbial infections such as mastitis.  
WO/2009/053256A3
An improved process for the production of Sulbactam Sodium characterised in that aqueous Isopropyl Alcohol is used as crystallisation medium. The crystals thus obtained can be smoothly dried, giving a content of residual solvent lower th...  
WO/2009/053256A2
An improved process for the production of Sulbactam Sodium characterised in that aqueous Isopropyl Alcohol is used as crystallisation medium. The crystals thus obtained can be smoothly dried, giving a content of residual solvent lower th...  
WO/2009/016170A1
The present invention relates to a process for the silylation of a β-lactam compound in an organic solvent comprising one or more silylating agents characterized in that the process is carried out in the presence of an effective amount ...  
WO/2009/016171A1
The present invention relates to a composition comprising at least 90 wt% of a β-lactam compound characterized in that it contains between 0.02 and 5 wt% ammonium chloride and/or a corresponding amount of the HCI salt of an organic amine.  
WO2008059367A8
The invention relates to prodrugs of sulopenem of formula (I): wherein R1 is -(C2
WO/2008/111487A1
Disclosed is a method for producing a 6-hydroxyethylpenam compound represented by the general formula (2) below with high yield. Specifically, a 6-hydroxyethylpenam compound represented by the general formula (2) below is produced with h...  
WO/2008/093650A1
Disclosed are a novel crystal of piperacillin sodium which has diffraction angles of 3.7°, 5.5°, 7.3°, 11.6°, 14.5° and 18.0° and a novel crystal of piperacillin sodium which has diffraction angles of 5.6°, 7.8°, 12.3°, 15.5°, ...  
WO/2008/086971A2
The invention relates to novel formulations which are to be dissolved in water, contain a β-lactam antibiotic and urea, and have a pH value ranging from 4.5 to 8 after being dissolved in water. Said formulations are particularly suitabl...  
WO/2008/086971A9
The invention relates to novel formulations which are to be dissolved in water, contain a β-lactam antibiotic and urea, and have a pH value ranging from 4.5 to 8 after being dissolved in water. Said formulations are particularly suitabl...  
WO/2008/086971A3
The invention relates to novel formulations which are to be dissolved in water, contain a β-lactam antibiotic and urea, and have a pH value ranging from 4.5 to 8 after being dissolved in water. Said formulations are particularly suitabl...  
WO/2008/059367A1
The invention relates to prodrugs of sulopenem of formula (I): wherein R1 is -(C2-C8)alkyl, or a solvate or hydrate thereof. The invention also relates to the preparation, formulation, and use of the prodrugs of sulopenem to treat a diso...  
WO/2008/035153A3
Novel process for the preparation of the Faropenem of formula (I) where, R is hydrogen, alkali metal salts such as sodium or potassium, or prodrug residue.  
WO/2008/035153A2
Novel process for the preparation of the Faropenem of formula (I) where, R is hydrogen, alkali metal salts such as sodium or potassium, or prodrug residue.  
WO/2008/012830A1
The present invention provides solid form of faropenem free acid, its hydrates and processes for their preparation thereof. Thus, for example, dissolving an alkali metal salt of faropenem in water, adjusting the pH of the solution formed...  
WO/2008/010048A3
Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions ...  
WO/2008/010048A2
Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions ...  
WO/2008/001212A2
Orally bioavailable prodrugs of sulopenem, e.g., Formula (I) and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans.  
WO/2008/001212A3
Orally bioavailable prodrugs of sulopenem, e.g., Formula (I) and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans.  
WO/2007/128213A1
Solid powder of penicillin sodium salt, especially ticarcillin sodium salt and carbenicillin sodium salt, with high purity and/or content, its drug composition comprising it and its manufacture are disclosed in the present invention.  

Matches 1 - 50 out of 2,900