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Matches 1 - 50 out of 6,619

Document Document Title
WO/2018/059213A1
Provided are compounds interfering with SAICAR synthesis, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain co...  
WO/2017/153892A1
A synthesis process of precursors of derivatives of beta-lactam compounds, said beta-lactam compounds being selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, comprising the follo...  
WO/2017/153824A1
A process for alkylating the hydroxymethyl group at position -3 of 7-Amino-3- hydroxymethyl-3-cephem-4-carboxylic acid (D-7-ACA) using an alkylating agent, strong acid and a suitable solvent(s).  
WO/2017/140072A1
Disclosed are a novel polymorphic cefuroxime sodium compound and a preparation method for crystals thereof, where the novel polymorphic cefuroxime sodium compound is prepared by employing a particle process crystal product molecular asse...  
WO/2017/140074A1
Disclosed are a cefmenoxime hydrochloride new crystalline compound and crystallization preparation method thereof; said cefmenoxime hydrochloride new crystalline compound is formed using particle processing for molecular assembly and mor...  
WO/2017/140073A1
Disclosed in the present invention are a cefathiamidine novel crystal compound and a crystallisation preparation method therefor, the cefathiamidine novel crystal compound being prepared using particle process crystal product molecular a...  
WO/2017/136642A1
The present disclosure relates to compounds having antimicrobial activity, compositions comprising said compounds in combination with β-lactam antibiotics, and methods of using the compounds and compositions.  
WO/2017/046756A1
The present invention relates to compound of formula (II) wherein R = -OCH(CH3)2, -CH3; or a pharmaceutically acceptable salt thereof. The present invention further relates to substantially pure cefixime proxetil; substantially pure cefi...  
WO/2017/042188A1
The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7- ACA).  
WO/2017/027062A1
The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferr...  
WO/2017/021390A1
The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the ...  
WO/2017/002903A1
The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity against carbapenem-resistan...  
WO/2017/001364A1
The present invention relates to a process for the preparation of carbamoylamino pyrazole derivatives using diacetoxyiodobenzene (ΡhΙ(ΟΑc)2) in combination with a non-nucleophilic base.  
WO/2016/201905A1
Disclosed is a new industrial crystallisation technique for cefuroxime sodium, wherein a supercritical fluid extraction technique is combined with conventional crystallization techniques to realize the recrystallization of cefuroxime sod...  
WO/2016/175223A1
Provided are the following: compounds having a powerful anti-bacterial spectrum against a variety of bacteria, including gram-negative bacteria and gram-positive bacteria; and pharmaceutical compositions having antibacterial activity aga...  
WO/2016/142902A1
The present invention provides cefixime trihydrate (I) with surface area of less than 1.2 m2/gm containing impurity A1 less than 0.5% by area percentage of HPLC. The impurity A1 is one of the stereoisomers of impurity A as depicted below.  
WO/2016/128580A1
Provided is a synthesis of cephalosporin derivatives, characterized by the use of the new intermediates for the preparation of cephalosporin derivatives, a crystalline toluene hemi-solvate of benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-...  
WO/2016/123028A1
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these comp...  
WO/2016/109259A2
Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.  
WO/2016/107331A1
A new crystal form of a Cefathiamidine compound and a preparation method therefor. The method comprises: dissolving a Cefathiamidine compound with the purity greater than or equal to 98% in a solvent selected from methanol and the like t...  
WO/2016/095660A1
A new crystal form of cefamandole sodium compound and preparation method thereof, the method comprising: adding cefamandole sodium solid to an organic solvent to prepare a 0.04-0.3 g/ml suspension, stirring and suspending for a period of...  
WO/2016/088041A8
The present invention relates to a stable extended-release composition of cefpodoxime proxetil and a process for its preparation. The composition comprises cefpodoxime proxetil, a stabilizer, and a release-controlling agent, wherein the ...  
WO/2016/088041A1
The present invention relates to a stable extended-release composition of cefpodoxime proxetil and a process for its preparation. The composition comprises cefpodoxime proxetil, a stabilizer, and a release-controlling agent, wherein the ...  
WO/2016/065525A1
Disclosed is a use of oxopiperazinyl amide compounds as shown by formula I, and isomers, hydrates or salts thereof in the preparation of drugs for inhibiting PLK1 activity.  
WO/2016/046055A1
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...  
WO/2016/035845A1
The present invention provides an acid addition salt or sodium salt of a compound represented by formula (IA), a hydrate of the salt or a stable crystalline solid form of the salt. The salt or the crystalline solid form thereof is extrem...  
WO/2016/035847A1
The present intention provides compounds represented by formula (IV) (in the formula, R1 is a protecting group of an amino group, and R2 and R3 are each independently a protecting group of a carboxy group), pharmaceutically acceptable sa...  
WO/2016/027262A1
A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderop...  
WO/2016/025813A1
Described herein are crystalline forms of a compound of formula (ΙΙΓ), including toluene solvates ofT A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as cef...  
WO/2016/025839A1
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a p...  
WO/2016/004166A1
Boron-based prodrugs of phenol- or aromatic hydroxyl group -containing therapeutic molecules ("original drugs"), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged r...  
WO/2015/119962A1
Beta-Lactamase substrates and methods for using the substrates to detect beta-lactamase and to diagnose tuberculosis. In the method, a sample is contacted with a compound of the invention, and an optical signal generated from contacting ...  
WO/2015/109056A1
The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains th...  
WO/2015/021692A1
Provided is a bacteria culture medium, wherein the culture medium is prepared by adding one or more β-lactam antibiotics and/or salts thereof to an ordinary bacteria culture medium in advance, wherein the β-lactam antibiotics and/or sa...  
WO/2014/189308A1
The present invention relates to: a novel crystal form of cefditoren pivoxil readily convertible into an amorphous form, to be used as an active ingredient of a drug, and having high cefditoren pivoxil purity; and a preparation method th...  
WO/2014/168105A1
A compound represented by formula (I) (In the formula, W is -CH2-, etc., U is -S-, etc., R1 is a substituted or unsubstituted carbocyclic group, etc., R2A and R2B together form an oxo, a substituted or unsubstituted methylidyne or a subs...  
WO/2014/165126A3
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive...  
WO/2014/165126A2
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive...  
WO/2014/158952A1
The present invention relates to a compound of formula I wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; a...  
WO/2014/152763A1
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.  
WO/2014/128538A1
The invention relates to an in-situ process for the preparation of amoxicillin trihydrate from sugarcane juice without isolation of the intermediates produced during the reaction sequence viz penicillin G and 6-aminopenicillanic acid. Th...  
WO/2014/104148A1
A compound represented by formula (I) (in the formula, W is -CH2- or the like, U is -S- or the like, R1 is a substituted or unsubstituted carbocyclic group or the like, R2A and R2B are a) or b) described in the description, R3 is a hydro...  
WO/2014/068388A1
The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram nega...  
WO/2014/069649A1
The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a sa...  
WO/2014/040239A1
Disclosed is a cefuroxime sodium crystal compound and a composition powder injection thereof, wherein the crystal form of cefuroxime sodium is amorphous and the preparation method thereof is as follows: reacting cefuroxime acid with sodi...  
WO/2014/026143A1
Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular t...  
WO/2014/012849A1
The present invention relates to a new crystal form of cefoperazone sodium and the method for making said crystal form. The new crystal form has the following characteristics: orthorhombic crystal, space group F222, unit cell dimensions ...  
WO/2013/173519A1
β-Lactamase substrates and methods for using the substrates to detect β-lactamase diagnose tuberculosis.  
WO/2013/114319A1
The present invention concerns a direct process, without the need to isolate any intermediate, for the preparation of Cefepime dihydrochloride monohydrate of sterile quality (for injective use) comprising a preliminary decolorization ste...  
WO/2013/109927A2
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide ("AMP") and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain...  

Matches 1 - 50 out of 6,619