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WO/2013/057197 |
The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.
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WO/2013/057196 |
The present invention relates to a process for the preparation of cefamandole nafate from cefamandole and to the use thereof in the manufacture of a medicament for treatment of a bacterial disease.
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WO/2013/051597 |
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represent...
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WO/2013/041999 |
The present invention relates to an improved process for the preparation of cefpodoxime acid from 7-Amino cephalosporanic acid. Further the preparation of cefpodoxime proxetil from cefpodoxime acid is also described.
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WO/2013/034718 |
The present invention relates to a novel process for preparing ceftaroline fosamil as well as to a intermediates of formulae (1), (3) or (4) of this process.
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WO/2013/010297 |
A method for purifying ceftizoxime sodium, comprising (1) dissolving crude ceftizoxime sodium in water, extracting with cyclohexane or ethyl acetate, and acquiring an aqueous phase having ceftizoxime sodium; (2) introducing ammonia or am...
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WO/2013/010296 |
A method for purifying cefmenoxime hydrochloride, comprising specifically the following steps: 1) adding a cefmenoxime hydrochloride-insoluble solvent to a cefmenoxime hydrochloride raw material, removing impurities by filtering; 2) usin...
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WO/2013/002215 |
The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound repr...
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WO/2012/175587 |
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine...
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WO/2012/175587 |
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine...
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WO/2012/155203 |
Regulation of nitric oxide release and biofilm development Abstract The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate...
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WO/2012/150520 |
The present invention provides novel cephalosporin derivatives of formula (I), their analogues, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the prepar...
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WO/2012/147773 |
The present invention provides a novel compound having a wide antibacterial spectrum, and expressing strong antibacterial activity against beta-lactamase-producing gram-negative bacteria in particular. This invention provides the compoun...
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WO/2012/134184 |
The present invention relates to a novel cephalosporin derivative indicated in chemical formula 1 of the description. In the chemical formula 1, X, Y, L, R1, R2 are identical as defined in the detailed explanation. In addition, the prese...
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WO/2012/134184 |
The present invention relates to a novel cephalosporin derivative indicated in chemical formula 1 of the description. In the chemical formula 1, X, Y, L, R1, R2 are identical as defined in the detailed explanation. In addition, the prese...
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WO/2012/126147 |
Disclosed herein is a purification method of cefmetazole sodium including processing steps as follows: step 1), dissolve the raw material cefmetazole sodium into water, and extract it by adding water insoluble organic solvent, then disca...
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WO/2012/126148 |
A method for purifying cefotiam hydrochloride is provided, which comprises the following steps: step 1) dissolving raw material cefotiam hydrochloride in water, treating the solution with an acidic salt, then decreasing the temperature a...
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WO/2012/117038 |
The present invention relates to the degradation of β-lactam compounds such as penicillins in the presence of other β-lactam compounds such as cephalosporins. Furthermore the present invention relates to the use of sulfite in the degra...
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WO/2012/100383 |
Provide a process of refining cefamandole sodium comprising steps as follows: step 1), adsorbing cefamandole sodium by strong acid ion exchange resin, and collecting the eluant after eluting, then decompressing and concentrating to obtai...
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WO/2012/049576 |
The present invention relates to a novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of a novel polymorph of crystalline Ceftiofur sodium of formula (I).
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WO/2012/032040 |
The present invention relates to a composition comprising ≥85 wt% of an N-deacylated cephalosporin, a process for making the same and the use of said N-deacylated cephalosporin in the preparation of highly pure semi synthetic cephalosp...
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WO/2011/144021 |
A cefpiramide sodium hydrate, preparation method and uses thereof are disclosed. The cefpiramide sodium hydrate has better storage stability, and is applicable to produce medicaments for treating or preventing human or animals diseases o...
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WO/2011/141004 |
A cefodizime sodium hydrate, preparation method and uses thereof are disclosed. The said cefodizime sodium hydrate has better storage stability, and is applicable to pruduce medicaments for treating or preventing human or animals disease...
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WO/2011/141415 |
The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]...
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WO/2011/136268 |
Provided is a cephem compound represented by the following formula, having a broad antibacterial spectrum, and exhibiting strong antibacterial activity particularly with respect to β-lactamase producing gram-negative bacteria. Also prov...
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WO/2011/125967 |
Disclosed is a compound represented by formula (I) (wherein X represents -N=, -CH= or the like; W represents -CH2- or the like; U represents -S- or the like; R1 and R2 each independently represents a hydrogen atom, a halogen atom, an opt...
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WO/2011/125966 |
Disclosed are a compound shown by formula (I), an ester thereof, or a protected product thereof in which an amino group located on the ring in the 7-position side chain is protected, a pharmaceutically acceptable salt of the compound, es...
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WO/2011/121389 |
A process for preparation of cefepime dihydrochloride monohydrate is provided. The process comprises condensing 7-amino-3-[(l -methyl- 1 -pyrrolidino)methyl]-3-cephem-4-carboxylate monohydrochloride dihydrate and 2-mercaptobenzothiazolyl...
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WO/2011/113361 |
Disclosed are a ceftizoxime sodium crystalline hydrate, preparation methods and uses thereof. The ceftizoxime sodium crystalline hydrate has high storage stability, and is suitable for preparing medicaments for treating or preventing dis...
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WO/2011/103686 |
The present invention relates to cephalosporin derivatives having β- lactamase inhibitory activity. The compounds are useful in preventing or treating bacterial resistance to an antibiotic, e.g. a β-lactam antibiotic. Disclosed herein ...
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WO/2011/093294 |
Provided is a process by which an objective cephalosporin derivative having a high Z-isomer content or an alkali metal salt thereof can be prepared via simple steps with industrial advantages. A process for the preparation of a cephalosp...
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WO/2011/078819 |
Present invention relates to pharmaceutically acceptable salts of cefdinir, specifically to primary, secondary and tertiary amine salts of cefdinir, preperation methods and pharmaceutical compositions comprising them.
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WO/2011/077217 |
The present invention relates to the preparation of cefpodoxime acid of formula (I) using alcoholic solvent in the presence or absence of water in a very safe, simple, economical, user-friendly and in an industrially viable manner.
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WO/2011/042775 |
Cefotaxime acid of formula (I) is prepared by using a kind of alcohol as the single solvent in presence of a base.
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WO/2011/042776 |
A process for the preparation of cefotaxime acid of formula (IV) and pharmaceutically acceptable salt thereof, such as cefotaxime sodium of formula (I) is provided, which comprises condensing the compound of formula (II) with the compoun...
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WO/2011/012965 |
The preparation of ceftriaxone disodium hemiheptahydrate of formula (I) using alcoholic solvent in a very safe, simple, economical, user-friendly and in an industrially viable manner is provided.
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WO/2011/009827 |
Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solu...
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WO/2010/136423 |
The invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazole-3-yl)-2-hydroxy
imino-acetylamino]-8-oxo-3-[(E)-(R)-1'-(5-methyl-2-oxo-[1,3]
-dioxol-4-ylmethoxy...
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WO/2010/136422 |
The invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazole-3-yl)-2-hydroxy
imino-acetylamino]-8-oxo-3-[(E)-(R)-1'-(5-methyl-2-oxo-[1,3]
-dioxol-4-ylmethoxy...
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WO/2010/097675 |
The present invention relates to an improved process for the preparation of cefpodoxime proxetil of formula (I) from cefpodoxime acid (II) by reacting 1 -iodoethyl isopropyl carbonate (III) in an aprotic solvent in presence of a mixture ...
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WO/2010/089729 |
The present invention relates to processes for the preparation of cefozopran of Formula (I), its salts and polymorphic forms thereof.
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WO/2010/083725 |
Compounds of formula I, pharmaceutically acceptable salts, esters, isomers or solvates thereof, wherein R1 and R2 are independently hydrogen, C1-6 alkyl or amino- protecting group; X is N and the like; R3 is H and the like；ring B is a ...
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WO/2010/082108 |
An improved process for the preparation of 7-phenylacetamido-3-vinyl cephalosporanic acid-p-methoxybenzyl ester of formula (I), which is a key intermediate of cephalosporin antibiotics and is extremely useful in their synthesis, is provi...
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WO/2010/075765 |
The invention provides an acid double salt of cefdinir. The acid double salt is obtained by reacting cefdinir with acid and alkali metal element or ammonium (including ammonia) compound or with acid salt. The cefdinir sulfate double salt...
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WO/2010/075765 |
The invention provides an acid double salt of cefdinir. The acid double salt is obtained by reacting cefdinir with acid and alkali metal element or ammonium (including ammonia) compound or with acid salt. The cefdinir sulfate double salt...
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WO/2010/072672 |
A compound of formula (I) in a crystalline form, which has a X-ray diffraction pattern comprising, when measured using Cu- Kα1 radiation, a diffraction line, having a relative intensity (rl) of 100 percent at about 11.6, 12.9, 14.7, 22....
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WO/2010/050468 |
Disclosed is a cephem compound represented by formula (I) [wherein X represents N, CH, or C-Cl; T represents S, or the like; A and G independently represent a lower alkylene, or the like; B represents a single bond, or the like; D repres...
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WO/2010/030858 |
The present invention discloses compounds of formula (I), or its β-L enantiomer, or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof: Formula (I) which inhibit, preventing or tr...
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WO/2010/020871 |
The present invention relates to novel polymorphs of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).
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WO/2010/020871 |
The present invention relates to novel polymorphs of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).
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