Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 6,580

Document Document Title
WO/2017/027062A1
The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferr...  
WO/2017/021390A1
The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the ...  
WO/2017/002903A1
The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity against carbapenem-resistan...  
WO/2017/001364A1
The present invention relates to a process for the preparation of carbamoylamino pyrazole derivatives using diacetoxyiodobenzene (ΡhΙ(ΟΑc)2) in combination with a non-nucleophilic base.  
WO/2016/201905A1
Disclosed is a new industrial crystallisation technique for cefuroxime sodium, wherein a supercritical fluid extraction technique is combined with conventional crystallization techniques to realize the recrystallization of cefuroxime sod...  
WO/2016/175223A1
Provided are the following: compounds having a powerful anti-bacterial spectrum against a variety of bacteria, including gram-negative bacteria and gram-positive bacteria; and pharmaceutical compositions having antibacterial activity aga...  
WO/2016/142902A1
The present invention provides cefixime trihydrate (I) with surface area of less than 1.2 m2/gm containing impurity A1 less than 0.5% by area percentage of HPLC. The impurity A1 is one of the stereoisomers of impurity A as depicted below.  
WO/2016/128580A1
Provided is a synthesis of cephalosporin derivatives, characterized by the use of the new intermediates for the preparation of cephalosporin derivatives, a crystalline toluene hemi-solvate of benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-...  
WO/2016/123028A1
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these comp...  
WO/2016/109259A2
Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.  
WO/2016/107331A1
A new crystal form of a Cefathiamidine compound and a preparation method therefor. The method comprises: dissolving a Cefathiamidine compound with the purity greater than or equal to 98% in a solvent selected from methanol and the like t...  
WO/2016/095660A1
A new crystal form of cefamandole sodium compound and preparation method thereof, the method comprising: adding cefamandole sodium solid to an organic solvent to prepare a 0.04-0.3 g/ml suspension, stirring and suspending for a period of...  
WO/2016/088041A8
The present invention relates to a stable extended-release composition of cefpodoxime proxetil and a process for its preparation. The composition comprises cefpodoxime proxetil, a stabilizer, and a release-controlling agent, wherein the ...  
WO/2016/088041A1
The present invention relates to a stable extended-release composition of cefpodoxime proxetil and a process for its preparation. The composition comprises cefpodoxime proxetil, a stabilizer, and a release-controlling agent, wherein the ...  
WO/2016/065525A1
Disclosed is a use of oxopiperazinyl amide compounds as shown by formula I, and isomers, hydrates or salts thereof in the preparation of drugs for inhibiting PLK1 activity.  
WO/2016/046055A1
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...  
WO/2016/035845A1
The present invention provides an acid addition salt or sodium salt of a compound represented by formula (IA), a hydrate of the salt or a stable crystalline solid form of the salt. The salt or the crystalline solid form thereof is extrem...  
WO/2016/035847A1
The present intention provides compounds represented by formula (IV) (in the formula, R1 is a protecting group of an amino group, and R2 and R3 are each independently a protecting group of a carboxy group), pharmaceutically acceptable sa...  
WO/2016/027262A1
A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderop...  
WO/2016/025813A1
Described herein are crystalline forms of a compound of formula (ΙΙΓ), including toluene solvates ofT A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as cef...  
WO/2016/025839A1
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a p...  
WO/2016/004166A1
Boron-based prodrugs of phenol- or aromatic hydroxyl group -containing therapeutic molecules ("original drugs"), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged r...  
WO/2015/119962A1
Beta-Lactamase substrates and methods for using the substrates to detect beta-lactamase and to diagnose tuberculosis. In the method, a sample is contacted with a compound of the invention, and an optical signal generated from contacting ...  
WO/2015/109056A1
The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains th...  
WO/2015/021692A1
Provided is a bacteria culture medium, wherein the culture medium is prepared by adding one or more β-lactam antibiotics and/or salts thereof to an ordinary bacteria culture medium in advance, wherein the β-lactam antibiotics and/or sa...  
WO/2014/189308A1
The present invention relates to: a novel crystal form of cefditoren pivoxil readily convertible into an amorphous form, to be used as an active ingredient of a drug, and having high cefditoren pivoxil purity; and a preparation method th...  
WO/2014/168105A1
A compound represented by formula (I) (In the formula, W is -CH2-, etc., U is -S-, etc., R1 is a substituted or unsubstituted carbocyclic group, etc., R2A and R2B together form an oxo, a substituted or unsubstituted methylidyne or a subs...  
WO/2014/165126A3
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive...  
WO/2014/165126A2
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive...  
WO/2014/158952A1
The present invention relates to a compound of formula I wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; a...  
WO/2014/152763A1
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.  
WO/2014/128538A1
The invention relates to an in-situ process for the preparation of amoxicillin trihydrate from sugarcane juice without isolation of the intermediates produced during the reaction sequence viz penicillin G and 6-aminopenicillanic acid. Th...  
WO/2014/104148A1
A compound represented by formula (I) (in the formula, W is -CH2- or the like, U is -S- or the like, R1 is a substituted or unsubstituted carbocyclic group or the like, R2A and R2B are a) or b) described in the description, R3 is a hydro...  
WO/2014/068388A1
The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram nega...  
WO/2014/069649A1
The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a sa...  
WO/2014/040239A1
Disclosed is a cefuroxime sodium crystal compound and a composition powder injection thereof, wherein the crystal form of cefuroxime sodium is amorphous and the preparation method thereof is as follows: reacting cefuroxime acid with sodi...  
WO/2014/026143A1
Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular t...  
WO/2014/012849A1
The present invention relates to a new crystal form of cefoperazone sodium and the method for making said crystal form. The new crystal form has the following characteristics: orthorhombic crystal, space group F222, unit cell dimensions ...  
WO/2013/173519A1
β-Lactamase substrates and methods for using the substrates to detect β-lactamase diagnose tuberculosis.  
WO/2013/114319A1
The present invention concerns a direct process, without the need to isolate any intermediate, for the preparation of Cefepime dihydrochloride monohydrate of sterile quality (for injective use) comprising a preliminary decolorization ste...  
WO/2013/109927A2
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide ("AMP") and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain...  
WO/2013/084171A1
The present invention relates to a process for the preparation of ceftaroline salts or hydrates thereof.  
WO/2013/057197A1
The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.  
WO/2013/057196A1
The present invention relates to a process for the preparation of cefamandole nafate from cefamandole and to the use thereof in the manufacture of a medicament for treatment of a bacterial disease.  
WO/2013/051597A1
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represent...  
WO/2013/041999A1
The present invention relates to an improved process for the preparation of cefpodoxime acid from 7-Amino cephalosporanic acid. Further the preparation of cefpodoxime proxetil from cefpodoxime acid is also described.  
WO/2013/041999A4
The present invention relates to an improved process for the preparation of cefpodoxime acid from 7-Amino cephalosporanic acid. Further the preparation of cefpodoxime proxetil from cefpodoxime acid is also described.  
WO/2013/034718A1
The present invention relates to a novel process for preparing ceftaroline fosamil as well as to a intermediates of formulae (1), (3) or (4) of this process.  
WO/2013/010296A1
A method for purifying cefmenoxime hydrochloride, comprising specifically the following steps: 1) adding a cefmenoxime hydrochloride-insoluble solvent to a cefmenoxime hydrochloride raw material, removing impurities by filtering; 2) usin...  
WO/2013/010297A1
A method for purifying ceftizoxime sodium, comprising (1) dissolving crude ceftizoxime sodium in water, extracting with cyclohexane or ethyl acetate, and acquiring an aqueous phase having ceftizoxime sodium; (2) introducing ammonia or am...  

Matches 1 - 50 out of 6,580