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Matches 501 - 550 out of 2,762

Document Document Title
WO/1992/001695
Compounds of formula (I) or a salt thereof, processes for their preparation, their use as antibiotics, and intermediates thereto, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially...  
WO/1992/001696
beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 repre...  
WO/1992/001061
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...  
WO/1992/000981
The present invention relates to novel cephalosporins of formula (I), wherein R¿1? represents A C¿1?$m(k)C¿4? alkyl group or ($g(a)), wherein R¿2? and R¿3?, independently, represent hydrogen or a C¿1?$m(k)C¿3? alkyl group and R¿4...  
WO/1991/017996
The present invention provides cephalosporin esters of formula (I), wherein R1 is a disulfide group, and R2 is the ending group for the esters. These compounds are useful as antibiotics for treating warm-blooded animals to combat pathoge...  
WO/1991/017997
There is provided a process for preparing a compound of formula (I), wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises reacting...  
WO/1991/017166
Du monohydrate de c�phalexine pr�par� par silylation de 7-ADCA peut �tre obtenu en grande quantit� et avec une puret� am�lior�e quand l'�tape de silylation est effectu�e par reflux dans un solvant ayant un point d'�...  
WO/1991/016310
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...  
WO/1991/016327
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cycli...  
WO/1991/014692
A group of 3-(optionally substituted N-aminopyridinium thiomethyl)cephalosporin derivatives and pharmaceutical compositions thereof are of use in antibacterial therapy.  
WO/1991/009038
Compound of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a), where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a...  
WO/1991/009037
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wher...  
WO/1991/009037
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wher...  
WO/1991/009036
Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for t...  
WO/1991/007410
The invention relates to a compound represented by structural formula (I), which is a novel optically active compound useful as an agent for treating infectious diseases induced by bacteria, pharmaceutically acceptable salts and esters t...  
WO/1991/007413
The invention relates to compounds represented by general formula (I) (wherein R1 represents hydrogen or an optionally substituted lower alkyl, lower alkynyl, lower alkynyl or aralkyl, A represents a single bond or a hetero atom selected...  
WO/1991/007411
A novel, optically active compound of formula (I) which is useful as a remedy for bacterial infection, a pharmaceutically acceptable salt or ester thereof, a crystal thereof, and production and uses thereof.  
WO/1991/006549
Cephalosporin compounds represented by general formula (I), pharmacologically acceptable addition salts thereof, method for the production thereof, and medicinal uses thereof, wherein R1 represents hydrogen or lower alkyl, and R2 represe...  
WO/1991/005788
The present application discloses a process for the conversion of penicillin-1-(R)-sulfoxide(s) and/or cephalosporin-1-(R)-sulfoxides in solution, to their corresponding 1-(S)-sulfoxides comprising the step of treating said 1-(R)-sulfoxi...  
WO/1991/005789
Compounds represented by general formula (I) (wherein R1 represents a lower alkyl group optionally substituted by a halogen atom or atoms), process for their preparation, and use thereof as active ingredients for antifungal agents are di...  
WO/1991/004977
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.  
WO/1991/000865
The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.  
WO/1990/011782
A drug delivery system is described in which an immunoconjugate and a prodrug are used in association with each other to deliver a drug to a host target site such as a tumour. The immunoconjugate comprises an antibody or antibody fragmen...  
WO/1990/008764
The asymmetrical ureas have the formula (I) wherein R2 and R3, similar or different, represent a hydrogen atom or a structural fraction susceptible of being bonded to a nitrogen atom, appropriate for forming part of a ring wherein the ni...  
WO/1990/007111
A molecular model of the interaction of various non beta-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial ...  
WO/1990/004591
Antimicrobial dithiocarbamoyl quinolone compounds of general formula (I), wherein A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobi...  
WO/1990/004595
Antimicrobial fluoroquinolonyl cephems of formula (I), wherein (1) R1 and R2 are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem; (2) R3 is a substituted or unsubstituted, nitrog...  
WO/1989/010926
There are provided compounds of formula (I), wherein A is a hydrogen atom or an organic group, R1 is hydrogen or halogen atom or an organic group, R2 is hydrogen or halogen atom, C1-C4 alkyl or acyloxy group, R3 is hydrogen atom, C1-C4 a...  
WO/1989/007600
Zinc ceftiofur complexes, e.g., zinc ceftiofur hydrochloride and zinc ceftiofur sodium complexes, have been found to provide the good antibiotic activity of ceftiofur while providing low dissolution rate and long half-like properties ena...  
WO/1989/004313
Cephalosporin compounds of formula (II), where R is hydrogen or a pharmaceutical cation, in which case R1 is not present, or R is hydrogen or a chemical bond when R1 is an acid addition salt anion, and R2 is (a) hydrogen, (b) a duplicate...  
WO/1989/000572
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be car...  
WO/1988/010263
Stable crystalline sulfate of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl ethoxyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindol inium)-methyl-3-cephem-4-carboxylate and its hydrate, process for their preparation, ...  
WO/1988/010256
The present invention relates to a method for producing novel 4-[1-oxoalkyl]-2,5-oxazolidinediones, (4-1 OOD), and their use in a stereoselective method of producing beta-lactam-containing compounds which include several biologically act...  
WO/1988/010262
Stable crystalline hydrate of (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyletho xyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindoliniu m)-methyl-3-cephem-4-carboxylate which is useful as an agent for treating diseas...  
WO/1988/005776
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein Y represents an optionally protected amino group; Z repre...  
WO/1988/005777
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein X represents -CH= or -N=; Y represents an optionally prot...  
WO/1988/003924
Novel cephalosporin derivatives having formula (I) and their crystalline form, processes for preparing thereof, compositions for treating and/or preventing infectious diseases which comprise the novel cephalosporin derivatives as active ...  
WO/1988/002752
New process for manufacturing cephtazidime pentahydrate having formula (III), characterized in that the ester group of the compound of formula (Ia) or an acid addition salt thereof is decomposed by using exclusively aqueous hydrochloric ...  
WO/1988/002001
New stable crystalline forms of t-butyl ester of cephtazidime having formula (I), and their manufacture.  
WO/1987/006232
Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group,...  
WO/1987/005297
Antibacterial cephalosporin compounds of formula (I), wherein W is a pharmaceutically acceptable salt or ester radical, or a carboxyl-protecting group; n is an integer from 0 to 5; -X- is -X1- or -X2- where the X1 moieties are the same o...  
WO/1987/003875
Cephalosporin derivatives represented by general formula (I), (wherein R1 represents a lower alkyl group, A represents (II) (wherein R2 and R3 may be the same or different and each represents a lower alkyl group, and R4 represents a subs...  
WO/1987/003876
Benzathine cephalothin for use in the treatment of bacterial infection in animals, in particular for the treatment or prophylaxis of mammary disorders and keratoconjunctivitis.  
WO/1987/001116
Processes for the preparation of stable, crystalline cephalosphorin intermediates of formula (I) and formula (II), wherein X is HI or HCl, and Nu and Nu + are certain N-containing heterocyclic rings attached via a sulfur atom or a ring n...  
WO/1987/001117
Processes for the preparation of alkali metal salts of amino acids. Preferably, the present invention relates to solid phase alkali metal salts of cephalosporins of formula (III), wherein M is selected from the group consisting of sodium...  
WO/1986/006723
A process for producing beta-lactam derivatives, which comprises reacting a beta-lactam derivative wherein the carboxyl group is protected and which is represented by the general formula: A-COO-X (wherein A represents a beta-lactam deriv...  
WO/1986/006376
Novel compounds represented by general formula (I) (wherein Ro represents a nitrogen-containing heterocyclic group, an acyl group or an esterified carboxyl group, Z represents S, S$(1,4)$O, O or CH2, R4 represents hydrogen, methoxy or fo...  
WO/1986/005786
Novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in ...  
WO/1986/005182
beta-Lactam compounds, which are represented by formula (I) wherein R1 represents a hydrogen atom or a protective group for an amino group, and W represents (II) ou (III) wherein R2 represents a hydrogen atom, a salt-forming cation, a pr...  
WO/1986/005183
A compound of formula (I), wherein R1 is an amino group which may be protected R3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S$(1,3)$O, O or CH2, R4 is a hydrogen atom, methoxy group or formamido group, ...  

Matches 501 - 550 out of 2,762