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Matches 501 - 550 out of 6,537

Document Document Title
WO/1997/002024A1
Invented is a method of enhancing erythropoiesis in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human Stat 5 SH2 domain with a binding affinity greater than fif...  
WO1996030540A3  
WO/1996/040156A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/040190A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/038450A1
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO/1996/038451A1
Cephem compounds of the formula (I) wherein R1 is an optionally protected amino group; R2 is a fluoro-lower alkyl group; and the ring A may have further substituent(s), or their esters or salts, show broad and excellent antibacterial act...  
WO/1996/038448A1
The compounds of formulae A-D, wherein: X is selected from the group consisting of CH2, S, and O; T is selected from the group consisting of CH2 and O; U is selected from the group consisiting of CH2, S, O, and CH(alkyl), where alkyl is ...  
WO/1996/037499A1
Compounds represented by general formula (I) and having a 'beta'-(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad anti...  
WO/1996/035692A1
A compound of formula (I) wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.  
WO/1996/031516A1
A process for the removal of fluoride from spent liquors obtained in a process in the production of an organic compound in which boron trifluoride is used by conversion of fluoride into an isolatable salt of tetrafluoroborate.  
WO/1996/030540A2
Substrates for 'beta'-lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e., alkyl of...  
WO/1996/029334A1
A process for the preparation of an allenyl-'beta'-lactam compound which comprises reacting the hydroxyl group of a 'beta'-lactam compound of general formula (1) with a reactive functional derivative of a sulfonic acid of the general for...  
WO1992018474A3  
WO/1996/028453A1
A process for producing a 2-isocephem derivative which comprises treating, in a water-containing organic solvent, a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by general formula (1) with a thioacetic acid derivative...  
WO/1996/026943A1
Cephalosporin derivatives of general formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R4 and R5 are each independently hydrogen or lower alkyl, or R4 and R5 taken together form a cycloal...  
WO/1996/026209A1
The cephalosporin compound [6R, 7R]-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoxyimino)acetamido ]-3-[1-(methylamino)pyridinium-4-thiomethyl]-ceph-3-em-4-car boxylic acid chloride hydrochloride is provided as a mono-, di- or tri-hydrate. The...  
WO/1996/023798A1
A cephem compound of formula (1) wherein R1 is an optionally protected amino group; R2 is H or a group bonded through a carbon atom; A+ is an optionally substituted group of formula (2) or (3) (wherein B is a 6-membered aromatic heterocy...  
WO/1996/023797A1
Process for the recovery of a 'beta'-lactam antibiotic from a mixture containing the ammonium salt of the 'beta'-lactam antibiotic and the ammonium salt of the corresponding 'beta'-lactam core by subjecting the mixture to a physical trea...  
WO/1996/023897A1
The invention relates to a process for the preparation of a 'beta'-lactam antibiotic by enzymatic acylation of a 'beta'-lactam core by means of an acylation agent, with the molar ratio between the 'beta'-lactam core and the acylation age...  
WO/1996/023796A1
Process for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin b...  
WO/1996/022296A1
A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and s...  
WO/1996/020198A1
A process for the production of cefotaxime in acetone/water and its use in the production of a sodium salt of cefotaxime and a crystalline sodium salt of cefotaxime in form of rounded agglomerates and in form of needles.  
WO/1996/018609A1
The present invention is a method of protecting a sulfonic acid functional group in an organic molecule as a substituted or unsubstituted neopentyl sulfonate ester. The method allows the conversion of R-SO3-H to R'-SO3-H, wherein R and R...  
WO/1996/017847A1
A process for the preparation of cephalosporin compounds of formula (I) is disclosed, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; R3 is a pharmaceutica...  
WO/1996/017848A1
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of 'beta'-lactamases and are therefore useful in the treatment of penicillin resistant infections.  
WO/1996/017846A1
A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of formula (IV),...  
WO/1996/017849A1
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of 'beta'-lactamase enzymes.  
WO/1996/017850A1
This invention relates to a new use of a cephem compound of formula (I), wherein R1 is aryl(lower)alkyl which may have one or more suitable substituent(s), arylthio(lower)alkyl, lower alkenylthio(lower)alkyl which may have one or more su...  
WO/1996/016067A1
A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cephalosporanic acid by silylation in certain carboxylic acid esters and its use in the production of 6-alpha-aminoacyl-penicillins and 7-alpha-aminoacyl-desa...  
WO/1996/012712A1
The present invention relates to a novel reactive phosphate derivative of thiazolylacetic acid having general formula (II), which is useful as an intermediate for preparing cephalosporin derivatives: in which R represents hydrogen, C1-C4...  
WO/1996/007659A1
A novel crystal of 7'beta'-[2-(2-aminothiazol-4-yl)-2-Z-(hydroxyimino)acetamido ]-3-[(pyrazol-4-yl)-methylthio]-3-cephem-4-carboxylic acid or a salt thereof. The compound is a cephalosporin antibiotic having a potent antibacterial activi...  
WO/1996/005205A1
A cephalosporin derivative represented by general formula (I) wherein an (un)substituted 3-(imidazo[5,1-b]thiazolium-6-yl)-1-propenyl group is present as a substituent at the 3-position of the cephem ring, having an excellent antibacteri...  
WO/1996/004247A1
The present invention provides a process for making a compound having a structure according to formula (I) wherein A1, A2 and A3 are independently carbon or nitrogen and R1, R3, R4 and R6 are known quinolone substituents; and wherein one...  
WO/1996/004286A1
The present invention provides processes for making compounds of the structure (Q-L1)-L-(L2-B), wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiety; comprising the st...  
WO/1996/003373A1
Esters of 2-(2-azetidinon-N-yl)-2- and 3-butenoic acids of formula (I), wherein X is an acylamino group, Y is a S-substituted dithio group or a sulfonylthio group, or X and Y are joined to form a group (a), wherein R1 is the aliphatic, a...  
WO/1996/002548A1
Cephalosporin compounds of formula (I) are disclosed. The compounds are useful against MRSA/MRCNS. Compositions and methods of use are also included.  
WO1995035020A3  
WO/1995/035020A2
There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom; a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by a...  
WO/1995/034567A1
New 9,12-epoxycyclohexano[3,4-c]cephalosporins of formula (I) are prepared starting from the corresponding ester obtained reacting a 7-phenylacetamido-3-cephem-4-carboxylic acid having in position 3 a leaving group, with furan, optionall...  
WO/1995/033753A1
The invention relates to a process for the preparation of trihydrated cefixime by reacting a functional derivative of N-protected (Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimi no)acetic acid with 7-amino-3-vinyl-3-cepheme-...  
WO/1995/032210A1
Novel cephalosporin compounds of formula (I) exhibit potent and broad antibiotic activities against Gram-negative and Gram-positive bacteria and various resistant bacteria.  
WO/1995/029182A1
Intermediates in the production of cephalosporins of formula (IA) wherein either 'alpha') Ra denotes hydrogen or a silyl group; Rb denotes a group of formula -ORe, wherein Re denotes hydrogen or alkyl; and Rc and Rd together denote a bon...  
WO/1995/026966A1
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO1995019974A3  
WO/1995/025109A1
A cephem compound represented by general formula (1), which has an excellent antibacterial effect against various pathogenic bacteria, wherein Q represents CH or N; R1 represents carboxylate, etc.; R represents group (a) or (b); R3 repre...  
WO/1995/023153A1
Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions contain...  
WO/1995/019974A2
Calixarene-based compounds are described which have biological activity, particularly anti-bacterial, anti-fungal, anti-cancer and anti-viral activity. Some compounds have been found to have anti-HIV activity. The compounds are calixaren...  
WO/1995/015966A1
2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfone compounds, methods of treating patients for elastase inhibition, and processes for preparing such compounds.  
WO/1995/013281A1
A process for producing a 3-substituted cephem compound from an allenyl-'beta'-lactam compound which can readily be prepared from an inexpensive penicillin compound in a short reaction path. The process comprises reacting an allenyl-'bet...  
WO/1995/009171A1
A cephalosporin derivative as a cephem compound having an excellent antibacterial activity and being useful as a remedy for various bacterial infections. It has an (un)substituted 2-(5-thiazolyl)vinyl group at the 3-position and is repre...  

Matches 501 - 550 out of 6,537