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WO/1995/023153A1 |
Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions contain...
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WO/1995/019974A2 |
Calixarene-based compounds are described which have biological activity, particularly anti-bacterial, anti-fungal, anti-cancer and anti-viral activity. Some compounds have been found to have anti-HIV activity. The compounds are calixaren...
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WO/1995/015966A1 |
2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfone compounds, methods of treating patients for elastase inhibition, and processes for preparing such compounds.
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WO/1995/013281A1 |
A process for producing a 3-substituted cephem compound from an allenyl-'beta'-lactam compound which can readily be prepared from an inexpensive penicillin compound in a short reaction path. The process comprises reacting an allenyl-'bet...
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WO/1995/009171A1 |
A cephalosporin derivative as a cephem compound having an excellent antibacterial activity and being useful as a remedy for various bacterial infections. It has an (un)substituted 2-(5-thiazolyl)vinyl group at the 3-position and is repre...
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WO/1995/007912A1 |
A compound represented by general formula (I), i.e., a cephem derivative having an (un)substituted imidazo[5,1-b]thiazolium-6-yl group at the 3-position of the ring, wherein X represents CH or N; R1 represents H, alkyl, alkenyl, etc.; an...
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WO/1995/007283A1 |
New cephem compounds of formula (I), wherein R1 is amino or protected amino, R2 is hydrogen, lower alkyl or hydroxy protective group, R3 is carboxy or protected carboxy, R4 is 3-pyridyl, 4-pyridyl or optionally substituted heteromonocycl...
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WO/1995/004739A1 |
A compound of formula (I) is disclosed. R13 represents hydrogen, NH2, C1-4 alkyl, C1-4 alkylamino or di(C1-4) alkylamino-; Y represents CH or N; Y" represents (a) CRgamma'Rz' with Rgamma' and Rz' hydrogen, C1-6 alkyl, C3-8 cycloalkyl or ...
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WO/1995/004740A1 |
L-valylamides and L-homovalylamides of 7alpha-amino-1,1-dioxo-3-cefem of formula (I), the process for obtaining them and the pharmaceutical compositions which contain them are described. The above-mentioned compounds are active in chroni...
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WO/1995/002603A2 |
The present invention relates to the use of known cephem derivatives of formula (I), wherein n is zero, one or two; R1 is hydrogen or an organic radical, R2 represents halo or an organic radical or R1 and R2 taken together with the C-2 c...
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WO/1994/029320A1 |
A cephalosporin compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, a process for producing the same, and a medicinal use thereof, especially, as a preventive or remedy for infectious diseases, wher...
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WO/1994/029321A1 |
The present invention relates to novel cephem compounds having formula (I) wherein Q is a carbon or nitrogen atom; X is an oxygen atom, or a nitroalkylenyl or cyanoimine group, with the proviso that X cannot be an oxygen atom when Q is a...
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WO/1994/028003A1 |
The present invention provides compounds of formula (I) and pharmaceutically or veterinarily salts thereof; wherein R1 is hydrogen or halogen or an organic group; R2 is hydrogen or an optionally substituted C1-C6 alkyl, C3-C6 cycloalkyl,...
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WO/1994/022874A1 |
A cephalosporin derivative represented by general formula (I) or a salt thereof, wherein R1 represents hydrogen, lower alkenyl, lower alkynyl, cycloalkyl, hydroxyl-protecting group, or (un)substituted lower alkyl; R2 represents hydrogen,...
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WO/1994/021649A1 |
A new salt form of cefonicid and its method of preparation is disclosed.
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WO/1994/020504A1 |
The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof, wherein n is one or two; A and B are both or each independently hydrogen or an organic radical; R1 ...
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WO/1994/020505A1 |
Anhydrous and crystalline free acid form of the cephalosporin antiobiotic ceftiofur, processes for its manufacture, and pharmaceutical compositions containing it are provided.
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WO/1994/018209A1 |
Provided is a process for isolating cefaclor from an acylation reaction mixture by adding anthraquinone-1,5-disulfonic acid to the mixture. The acid highly selectively precipitates with cefaclor so that isolation and recovery is streamli...
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WO/1994/014818A1 |
This invention relates to a compound of formula (I) and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a method for preventing and/or treating infecti...
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WO/1994/012504A1 |
A method of obtaining high-purity 7-aminocephalosporanic acid from an aqueous solution thereof contaminated with alpha-aminoadipic acid, which comprises treating the aqueous solution with a strongly basic styrene-base anion-exchange resi...
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WO/1994/010177A1 |
New cephem compounds of formula (I), wherein R1 is amino or protected amino, R2 is hydrogen, a hydroxy protective group, lower alkyl or mono(or di or tri)halo(lower)alkyl, R3 is carboxy or protected carboxy, and R4 is pyridylvinyl which ...
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WO/1994/007898A1 |
The present invention relates to novel cephalosporin derivatives or pharmaceutically acceptable non-toxic salts thereof useful as antibiotics and to processes for the preparation thereof. Formula (1) wherein: R1 is a hydrogen or an optio...
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WO/1994/006804A1 |
A cephem compound represented by general formula (I) and excellent in the bactericidal effect against various pathogenic bacteria, wherein Q represents CH or N; R1 represents carboxylate, etc.; R represents (II) or (III); R2 represents l...
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WO/1994/002490A1 |
A process for producing a cephem compound represented by general formula (3) which comprises reacting an allenyl-ss-lactam compound represented by general formula (1) with an organotin compound represented by general formula (2) in the p...
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WO/1994/002489A1 |
A compound of formula (I) or a salt thereof, wherein: R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically...
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WO/1994/002491A1 |
A novel cephalosporin derivative represented by general formula (I), which has a potent antibacterial activity, a low toxicity and a high oral absorbability, and a nontoxic salt thereof, wherein R1 and R3 represent each hydrogen or lower...
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WO/1994/000457A1 |
Compound of formula (I) or salts thereof wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically acce...
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WO/1993/024493A1 |
A novel cephalosporin compound represented by general formula (I), wherein R?1¿ represents -CX?1¿¿3?, X?1¿ representing H or halogen; R?2¿ represents -O-Q-Z?1¿, Q representing a C¿3?-C¿6? linking group present between O and Z?1¿...
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WO/1993/018044A1 |
Compounds of formula (I) or salts thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically ac...
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WO/1993/016043A1 |
A $g(b)-lactam compound and a 2-(substituted methyl)-3-cephem compound, both being useful as an intermediate for the synthesis of cephem antibiotics and so forth. The lactam compound is represented by general formula (I), wherein R?1¿ r...
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WO/1993/016084A1 |
The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-y1]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-y1]-3-cephem-4-car...
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WO/1993/015084A1 |
The present invention relates to new cephalosporin compounds of formula (I), particularly 3-position of cephem rings thereof substituted with new thione compounds and pharmaceutically acceptable salts thereof, which have broad antibacter...
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WO/1993/013108A1 |
Certain 7-beta-[2-(2-amino-4-thiazolyl)-(Z)-2-(chloromethylene)aceta
mido]-3-[(substituted)methyl]-ceph-3-em-4-carboxylic acids, pharmaceutically-acceptable salts thereof and conventional in vivo hydrolyzable esters thereof are valuable ...
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WO/1993/013109A1 |
To provide a medicine with an excellent effect on both Gram-positive and negative bacteria. A cephalosporin derivative represented by general formula (I) and a nontoxic salt thereof, wherein R1 represents hydrogen or a protective group; ...
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WO/1993/012250A1 |
The present invention relates to an improved method for the preparation of certain $g(b)-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate.
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WO/1993/011132A1 |
Described is a new method (systematic method) of preparing the antibiotic cefaclor of formula (I). Also described are new starting products and intermediates used in the method. The method is carried out as described in claim 1.
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WO/1993/011131A1 |
beta-lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy of formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2R3 is a carboxy group or a carboxylate anion, ...
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WO/1993/010123A1 |
A process for preparing beta-lactam derivatives of formula (I), wherein R1 represents hydrogen or a metal salt; and R2 represents hydrogen, acetoxy methyl, (2,5-dihydro-2-methyl-6-hydroxy-5-oxo-as-triazin-3-yl)thiome
thyl or (1-methyl-1H...
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WO/1993/008287A1 |
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum)...
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WO/1993/002085A1 |
The present invention relates to a process for preparing a compound of formula (I), wherein R is an heterocyclic group which contains at least one nitrogen atom with or without oxygen or sulphur and R1 and R2 are both hydrogen atoms or o...
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WO/1993/000346A1 |
New antibacterially-active cephalosporins are disclosed having either two carboxyl groups, two protected carboxyl groups, or salts thereof, substituted at the carbon atom in the four position of the dihydrothiazine ring.
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WO/1992/022556A1 |
Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed ...
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WO/1992/021682A1 |
Compound of formula (I) or a salt thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a) where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a ...
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WO/1992/021681A1 |
The present invention relates to a compound of general formula (I) wherein R1a is hydrogen atom or an amino-protecting group; R1b is a C1-C4 alkyl group or a group of formula (a) wherein R3 and R4, being the same or different from each o...
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WO/1992/021683A1 |
New cephem compounds of formula (I), wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, and R3 is hydroxy or protected hydroxy, and pharmaceutically acceptable salts thereof which are useful as a me...
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WO/1992/018508A1 |
New cephem compounds of formula (I) wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, R3 is lower alkyl, R4 is lower alkyl, A is lower alkylene, R5 is hydroxy or protected hydroxy, and R6 is carbox...
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WO/1992/018474A2 |
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.
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WO/1992/017482A1 |
Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of formula (I) are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthr...
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WO/1992/016532A1 |
A halogenated beta-lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R1 represents optionally protected amino; R2 represents hydrogen or a carboxyl blocking group; R3 represents hydr...
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WO/1992/010502A1 |
Heterocyclic carboxylic esters or derivatives thereof, comprising a beta-lactam moiety linked by a carboxylic acid bridge to an imidazole moiety for use as antimicrobial agents are provided. Also methods for the preparation of these este...
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