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Matches 501 - 550 out of 2,779

Document Document Title
WO/1992/021683A1
New cephem compounds of formula (I), wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, and R3 is hydroxy or protected hydroxy, and pharmaceutically acceptable salts thereof which are useful as a me...  
WO/1992/021681A1
The present invention relates to a compound of general formula (I) wherein R1a is hydrogen atom or an amino-protecting group; R1b is a C1-C4 alkyl group or a group of formula (a) wherein R3 and R4, being the same or different from each o...  
WO/1992/018474A2
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.  
WO/1992/018508A1
New cephem compounds of formula (I) wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, R3 is lower alkyl, R4 is lower alkyl, A is lower alkylene, R5 is hydroxy or protected hydroxy, and R6 is carbox...  
WO/1992/017482A1
Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of formula (I) are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthr...  
WO/1992/016532A1
A halogenated beta-lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R1 represents optionally protected amino; R2 represents hydrogen or a carboxyl blocking group; R3 represents hydr...  
WO/1992/010502A1
Heterocyclic carboxylic esters or derivatives thereof, comprising a beta-lactam moiety linked by a carboxylic acid bridge to an imidazole moiety for use as antimicrobial agents are provided. Also methods for the preparation of these este...  
WO/1992/008463A1
A novel method for producing pills with 7-acylamino cephalosporanic acid derivatives by directly compressing a mixture containing said acid in an amount which represents 20-90 % by weight of the overall mass of the pill. The pills thereb...  
WO/1992/008721A1
The present invention relates to new cephalosporin compounds of formula (I), pharmaceutically acceptable non-toxic salts thereof, and physiologically hydrolyzable esters and solvates thereof, which have potent and broad antibacterial act...  
WO/1992/007840A1
A compound represented by general formula (I), which is useful as an intermediate for the production of (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-substitu ted cephalosporin derivatives having an excellent antibacterial activity...  
WO/1992/004353A1
beta-Lactam antibiotics of formula (I) or a salt thereof wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; L is -CH=...  
WO/1992/003445A1
The present invention provides a cephalosporin compound represented by formulas (I-S) and (I-R), wherein R1 is a C1-4 alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substituted with a C1-4 alkyl radical, phenyl, or 2-, 4- or 6- s...  
WO/1992/002523A1
A novel cephalosporin compound represented by general formula (I), which has a wide antibacterial spectrum, wherein A represents a group of the formula -N=CH-, -NHCO-(CH=CH)¿m?-, -CH¿2?- or -O-CH¿2?; m represents 0 or 1; R?1¿, R?2¿ ...  
WO/1992/001695A1
Compounds of formula (I) or a salt thereof, processes for their preparation, their use as antibiotics, and intermediates thereto, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially...  
WO/1992/001696A1
beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 repre...  
WO/1992/001061A1
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...  
WO/1992/000981A1
The present invention relates to novel cephalosporins of formula (I), wherein R¿1? represents A C¿1?$m(k)C¿4? alkyl group or ($g(a)), wherein R¿2? and R¿3?, independently, represent hydrogen or a C¿1?$m(k)C¿3? alkyl group and R¿4...  
WO/1991/017996A1
The present invention provides cephalosporin esters of formula (I), wherein R1 is a disulfide group, and R2 is the ending group for the esters. These compounds are useful as antibiotics for treating warm-blooded animals to combat pathoge...  
WO/1991/017997A1
There is provided a process for preparing a compound of formula (I), wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises reacting...  
WO/1991/017166A1
Du monohydrate de c�phalexine pr�par� par silylation de 7-ADCA peut �tre obtenu en grande quantit� et avec une puret� am�lior�e quand l'�tape de silylation est effectu�e par reflux dans un solvant ayant un point d'�...  
WO/1991/016310A1
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...  
WO/1991/016327A1
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cycli...  
WO/1991/014692A1
A group of 3-(optionally substituted N-aminopyridinium thiomethyl)cephalosporin derivatives and pharmaceutical compositions thereof are of use in antibacterial therapy.  
WO/1991/009038A1
Compound of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a), where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a...  
WO/1991/009037A1
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wher...  
WO/1991/009036A1
Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for t...  
WO/1991/007410A1
The invention relates to a compound represented by structural formula (I), which is a novel optically active compound useful as an agent for treating infectious diseases induced by bacteria, pharmaceutically acceptable salts and esters t...  
WO/1991/007413A1
The invention relates to compounds represented by general formula (I) (wherein R1 represents hydrogen or an optionally substituted lower alkyl, lower alkynyl, lower alkynyl or aralkyl, A represents a single bond or a hetero atom selected...  
WO/1991/007411A1
A novel, optically active compound of formula (I) which is useful as a remedy for bacterial infection, a pharmaceutically acceptable salt or ester thereof, a crystal thereof, and production and uses thereof.  
WO/1991/006549A1
Cephalosporin compounds represented by general formula (I), pharmacologically acceptable addition salts thereof, method for the production thereof, and medicinal uses thereof, wherein R1 represents hydrogen or lower alkyl, and R2 represe...  
WO/1991/005788A1
The present application discloses a process for the conversion of penicillin-1-(R)-sulfoxide(s) and/or cephalosporin-1-(R)-sulfoxides in solution, to their corresponding 1-(S)-sulfoxides comprising the step of treating said 1-(R)-sulfoxi...  
WO/1991/005789A1
Compounds represented by general formula (I) (wherein R1 represents a lower alkyl group optionally substituted by a halogen atom or atoms), process for their preparation, and use thereof as active ingredients for antifungal agents are di...  
WO/1991/004977A1
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.  
WO/1991/000865A1
The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.  
WO/1990/011782A2
A drug delivery system is described in which an immunoconjugate and a prodrug are used in association with each other to deliver a drug to a host target site such as a tumour. The immunoconjugate comprises an antibody or antibody fragmen...  
WO/1990/008764A1
The asymmetrical ureas have the formula (I) wherein R2 and R3, similar or different, represent a hydrogen atom or a structural fraction susceptible of being bonded to a nitrogen atom, appropriate for forming part of a ring wherein the ni...  
WO/1990/007111A2
A molecular model of the interaction of various non beta-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial ...  
WO/1990/004591A1
Antimicrobial dithiocarbamoyl quinolone compounds of general formula (I), wherein A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobi...  
WO/1990/004595A1
Antimicrobial fluoroquinolonyl cephems of formula (I), wherein (1) R1 and R2 are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem; (2) R3 is a substituted or unsubstituted, nitrog...  
WO/1989/010926A1
There are provided compounds of formula (I), wherein A is a hydrogen atom or an organic group, R1 is hydrogen or halogen atom or an organic group, R2 is hydrogen or halogen atom, C1-C4 alkyl or acyloxy group, R3 is hydrogen atom, C1-C4 a...  
WO/1989/007600A1
Zinc ceftiofur complexes, e.g., zinc ceftiofur hydrochloride and zinc ceftiofur sodium complexes, have been found to provide the good antibiotic activity of ceftiofur while providing low dissolution rate and long half-like properties ena...  
WO/1989/004313A1
Cephalosporin compounds of formula (II), where R is hydrogen or a pharmaceutical cation, in which case R1 is not present, or R is hydrogen or a chemical bond when R1 is an acid addition salt anion, and R2 is (a) hydrogen, (b) a duplicate...  
WO/1989/000572A1
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be car...  
WO/1988/010263A1
Stable crystalline sulfate of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl ethoxyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindol inium)-methyl-3-cephem-4-carboxylate and its hydrate, process for their preparation, ...  
WO/1988/010256A1
The present invention relates to a method for producing novel 4-[1-oxoalkyl]-2,5-oxazolidinediones, (4-1 OOD), and their use in a stereoselective method of producing beta-lactam-containing compounds which include several biologically act...  
WO/1988/010262A1
Stable crystalline hydrate of (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyletho xyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindoliniu m)-methyl-3-cephem-4-carboxylate which is useful as an agent for treating diseas...  
WO/1988/005776A1
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein Y represents an optionally protected amino group; Z repre...  
WO/1988/005777A1
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein X represents -CH= or -N=; Y represents an optionally prot...  
WO/1988/003924A1
Novel cephalosporin derivatives having formula (I) and their crystalline form, processes for preparing thereof, compositions for treating and/or preventing infectious diseases which comprise the novel cephalosporin derivatives as active ...  
WO/1988/002752A1
New process for manufacturing cephtazidime pentahydrate having formula (III), characterized in that the ester group of the compound of formula (Ia) or an acid addition salt thereof is decomposed by using exclusively aqueous hydrochloric ...  

Matches 501 - 550 out of 2,779