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Matches 501 - 550 out of 6,588

Document Document Title
WO1997013772A3  
WO/1997/017353A1
A process for the preparation of 3-halogenocephem derivatives of general formula (2), characterized by reacting an allenyl-'beta'-lactam of general formula (1) with a halogenating agent in the presence of a cuprous or cupric salt: [where...  
WO/1997/017352A1
An efficient process for de-esterification has been provided for by application of special tetrahalogenides. By applying this process a new compound, viz. cefesone, and especially the E-isomer thereof, has been prepared.  
WO/1997/013772A2
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO/1997/012890A1
A compound of general formula (I) wherein R1 is amino or protected amino, R2 is hydrogen or hydroxy protective group, R3 is carboxy or protected carboxy, R4 is hydrogen, lower alkenyl, acyloxy(lower)alkenyl, optionally substituted hetero...  
WO/1997/009052A1
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vi...  
WO/1997/007805A1
The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or ...  
WO/1997/008174A1
The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or ...  
WO/1997/007121A1
Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.  
WO/1997/007112A1
A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crytalline structure of uniform s...  
WO/1997/003990A1
A process for the production of 7-trialkylsilylamino-3(E)-3-(acetoxy-1-propen-1-yl)-3-cephem -4-carboxylic acid trialkylsilyl esters and their use in the production of highly active vinyl-cephalosporin antibiotics, such as cefluprenam of...  
WO/1997/002268A1
The present invention provides compounds of formulae (Ia) and (Ib) and pharmaceutically or veterinarily salts thereof; wherein A, R1, R2 and R3 are hydrogen, halogen or an organic group; Q and W are appropriate substituents and X is eith...  
WO/1997/002024A1
Invented is a method of enhancing erythropoiesis in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human Stat 5 SH2 domain with a binding affinity greater than fif...  
WO1996030540A3  
WO/1996/040156A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/040190A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/038450A1
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO/1996/038451A1
Cephem compounds of the formula (I) wherein R1 is an optionally protected amino group; R2 is a fluoro-lower alkyl group; and the ring A may have further substituent(s), or their esters or salts, show broad and excellent antibacterial act...  
WO/1996/038448A1
The compounds of formulae A-D, wherein: X is selected from the group consisting of CH2, S, and O; T is selected from the group consisting of CH2 and O; U is selected from the group consisiting of CH2, S, O, and CH(alkyl), where alkyl is ...  
WO/1996/037499A1
Compounds represented by general formula (I) and having a 'beta'-(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad anti...  
WO/1996/035692A1
A compound of formula (I) wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.  
WO/1996/031516A1
A process for the removal of fluoride from spent liquors obtained in a process in the production of an organic compound in which boron trifluoride is used by conversion of fluoride into an isolatable salt of tetrafluoroborate.  
WO/1996/030540A2
Substrates for 'beta'-lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e., alkyl of...  
WO/1996/029334A1
A process for the preparation of an allenyl-'beta'-lactam compound which comprises reacting the hydroxyl group of a 'beta'-lactam compound of general formula (1) with a reactive functional derivative of a sulfonic acid of the general for...  
WO1992018474A3  
WO/1996/028453A1
A process for producing a 2-isocephem derivative which comprises treating, in a water-containing organic solvent, a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by general formula (1) with a thioacetic acid derivative...  
WO/1996/026943A1
Cephalosporin derivatives of general formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R4 and R5 are each independently hydrogen or lower alkyl, or R4 and R5 taken together form a cycloal...  
WO/1996/026209A1
The cephalosporin compound [6R, 7R]-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoxyimino)acetamido ]-3-[1-(methylamino)pyridinium-4-thiomethyl]-ceph-3-em-4-car boxylic acid chloride hydrochloride is provided as a mono-, di- or tri-hydrate. The...  
WO/1996/023798A1
A cephem compound of formula (1) wherein R1 is an optionally protected amino group; R2 is H or a group bonded through a carbon atom; A+ is an optionally substituted group of formula (2) or (3) (wherein B is a 6-membered aromatic heterocy...  
WO/1996/023797A1
Process for the recovery of a 'beta'-lactam antibiotic from a mixture containing the ammonium salt of the 'beta'-lactam antibiotic and the ammonium salt of the corresponding 'beta'-lactam core by subjecting the mixture to a physical trea...  
WO/1996/023897A1
The invention relates to a process for the preparation of a 'beta'-lactam antibiotic by enzymatic acylation of a 'beta'-lactam core by means of an acylation agent, with the molar ratio between the 'beta'-lactam core and the acylation age...  
WO/1996/023796A1
Process for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin b...  
WO/1996/022296A1
A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and s...  
WO/1996/020198A1
A process for the production of cefotaxime in acetone/water and its use in the production of a sodium salt of cefotaxime and a crystalline sodium salt of cefotaxime in form of rounded agglomerates and in form of needles.  
WO/1996/018609A1
The present invention is a method of protecting a sulfonic acid functional group in an organic molecule as a substituted or unsubstituted neopentyl sulfonate ester. The method allows the conversion of R-SO3-H to R'-SO3-H, wherein R and R...  
WO/1996/017847A1
A process for the preparation of cephalosporin compounds of formula (I) is disclosed, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; R3 is a pharmaceutica...  
WO/1996/017848A1
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of 'beta'-lactamases and are therefore useful in the treatment of penicillin resistant infections.  
WO/1996/017846A1
A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of formula (IV),...  
WO/1996/017849A1
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of 'beta'-lactamase enzymes.  
WO/1996/017850A1
This invention relates to a new use of a cephem compound of formula (I), wherein R1 is aryl(lower)alkyl which may have one or more suitable substituent(s), arylthio(lower)alkyl, lower alkenylthio(lower)alkyl which may have one or more su...  
WO/1996/016067A1
A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cephalosporanic acid by silylation in certain carboxylic acid esters and its use in the production of 6-alpha-aminoacyl-penicillins and 7-alpha-aminoacyl-desa...  
WO/1996/012712A1
The present invention relates to a novel reactive phosphate derivative of thiazolylacetic acid having general formula (II), which is useful as an intermediate for preparing cephalosporin derivatives: in which R represents hydrogen, C1-C4...  
WO/1996/007659A1
A novel crystal of 7'beta'-[2-(2-aminothiazol-4-yl)-2-Z-(hydroxyimino)acetamido ]-3-[(pyrazol-4-yl)-methylthio]-3-cephem-4-carboxylic acid or a salt thereof. The compound is a cephalosporin antibiotic having a potent antibacterial activi...  
WO/1996/005205A1
A cephalosporin derivative represented by general formula (I) wherein an (un)substituted 3-(imidazo[5,1-b]thiazolium-6-yl)-1-propenyl group is present as a substituent at the 3-position of the cephem ring, having an excellent antibacteri...  
WO/1996/004247A1
The present invention provides a process for making a compound having a structure according to formula (I) wherein A1, A2 and A3 are independently carbon or nitrogen and R1, R3, R4 and R6 are known quinolone substituents; and wherein one...  
WO/1996/004286A1
The present invention provides processes for making compounds of the structure (Q-L1)-L-(L2-B), wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiety; comprising the st...  
WO/1996/003373A1
Esters of 2-(2-azetidinon-N-yl)-2- and 3-butenoic acids of formula (I), wherein X is an acylamino group, Y is a S-substituted dithio group or a sulfonylthio group, or X and Y are joined to form a group (a), wherein R1 is the aliphatic, a...  
WO/1996/002548A1
Cephalosporin compounds of formula (I) are disclosed. The compounds are useful against MRSA/MRCNS. Compositions and methods of use are also included.  
WO1995035020A3  
WO/1995/035020A2
There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom; a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by a...  

Matches 501 - 550 out of 6,588