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Patent Searching and Data


Matches 551 - 600 out of 2,761

Document Document Title
WO/1986/005184
Novel antibacterial compounds represented by general formula (I), wherein Ro represents a hydrogen atom, a nitrogen-containing heterocyclic group, an acyl group or an esterified carboxyl group, Z represents S, S$(1,3)$O, O or CH2, R4 rep...  
WO/1986/003204
Process for the production of cephalosporine derivatives by the silylization of 7-ACA or its derivatives followed by conversion of 3-iodomethyl derivatives with subsequent nucleophilic exchange in the 3-position.  
WO/1986/000070
Novel cephem compounds represented by general formula (I), wherein R1 represents an optionally protected amino group, R2 represents hydrogen or halogen, R3 represents hydrogen or an optionally substituted hydrocarbon residue, R4 represen...  
WO/1986/000071
Novel cephem compounds represented by general formula (I), wherein R1 represents an optionally protected amino group, R2 represents hydrogen or halogen, R3 represents hydrogen or an optionally substituted hydrocarbon residue, R4 represen...  
WO/1985/005360
A process for preparing cephalosporin derivatives represented by general formula (I), which comprises reacting a compound of general formula (II) or its reactive derivative with a compound of general formula (III) or eliminating an R1 gr...  
WO/1985/005107
Crystalline anhydrides, hemihydrates, monohydrates or trihydrates of (6R, 7R)-7- AD(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido BD-3-(1-quinuclidiniummethyl)-3-cephem-4-carboxylate or derivatives thereof.  
WO/1985/005106
Novel cephem compounds of general formula (I), wherein R1 represents an optionally protected amino group, R2 represents a hydrogen atom or a halogen atom, R3 represents a hydrogen atom or an optionally substituted hydrocarbon residue, R4...  
WO/1985/004879
Novel cephem compounds of general formula (I), wherein R1 represents and optionally amino group, R2 represents H or halogen, R3 represents H or an optionally substituted hydrocarbon residue, R4 represents H or methoxy, A represents an op...  
WO/1985/004878
Compounds of general formula (I), their pharmaceutically acceptable salts and in-vivo hydrolysable esters are antibacterial agents; in which R1 is optionally substituted phenyl or optionally substituted 5 or 6-membered heterocyclyl; R2 i...  
WO/1985/004659
Process for preparing intermediary products of cephalosporine having the formula (I) wherein R1 is an acyl group. Modification of a compound having the formula (IV) and/or (IVa) wherein R1 has the same meaning as hereabove and (A), respe...  
WO/1985/004404
A process for the preparation of compounds of formula (I), wherein R1 represents hydrogen or a hydroxy-protecting group, R2 represents hydrogen, a cation, the pivaloyloxymethyl group or a carboxy-protecting group and R3 represents hydrog...  
WO/1985/003938
Cephalosporin derivatives represented by formula (I), (wherein R1 represents a hydrogen atom or a protective group, R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl grou...  
WO/1985/003937
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula (I), and the non-toxic pharmaceutically acceptable salts thereof, wherein D is ...  
WO/1985/001046
Mandelic acid derivatives represented by general formula (I), wherein R1 represents a hydrogen atom or a hydroxy group, X represents a halogen atom or OR2 (wherein R2 represents a hydrogen atom, benzyl, benzhydryl, t-butyl, tetrahydropyr...  
WO/1984/004747
Cephem compounds represented by general formula (I), wherein R1 represents a hydrogen atom or an amino group-protecting group and R2 represents formula (II) or (III), wherein R3 represents a lower alkyl group and R4 represents a lower al...  
WO/1984/004096
Novel compounds of formula (I), a process for their preparation, pharmaceutical compositions containing the same as active ingredient and their use in therapy as antibiotics. The compounds of the formula (I) according to the invention st...  
WO/1984/002911
A compound of formula (I) or a salt thereof, wherein R1 and R3 are independently an in vivo hydrolysable group, or R1 and R3 together form an in vivo hydrolysable group, provided that R1 and R3 are not both C1-6 alkylcarbonyl; R7 is a hy...  
WO/1984/002703
A process for preparing novel aminothiazolylacetic acid derivatives useful as intermediates for synthesizing beta-lactam antibiotics, starting with diketene as shown in formula (I), wherein R represents lower alkyl or phenyl, R1 and R2 e...  
WO/1984/001949
Cephalosporin derivatives represented by the general formula (I), wherein R1 represents an alpha-, beta- or gamma-amino acid residue (bonded through an ester bond) whose amino group is optionally susbstituted by a lower alkyl group, R2 r...  
WO/1984/001950
Cephalosporin derivatives represented by formula (I) (wherein R represents -CH2-OCORa1 (wherein Ra1 represents an alkyl group),$(4,)$(wherein Rb1 represents an alkyl group),$(4,)$(wherein Rc1 represents an alkyl group),$(6,)$or phthalidy...  
WO/1984/001152
Azetidinone compounds represented by the general formula (I), wherein R1 represents a substituted or unsubstituted phenyl group, R2 represents a carboxyl-protecting group, X represents a hydrogen atom or a chlorine atom, Y represents$(7,...  
WO/1984/000965
2-Substituted cephem derivatives represented by the general formula (I), (wherein R1 represents substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, or substituted or unsubstituted phenoxymethyl, R2 represents ...  
WO/1984/000964
Cephalosporin compounds represented by the general formula (I), wherein R1 represents alkyl, alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylmethyl, or substituted or unsubstituted phenoxymethyl, and R2 repre...  
WO/1983/003968
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula: ADD-DHC BD (I), wherein ADD BD is a centrally acting drug species, and AD...  
WO/1982/001004
A process for preparing cephalosporin compounds represented by the following general formula (III): (FORMULA) (wherein R represents a hydrogen atom or a methyl group) or the pharmaceutically acceptable salts thereof, which comprises reac...  
WO/1980/000337
A primary alcohol or an aldehyde is reacted with ammonia or a primary or secondary amine together with a molecular oxygen-containing gas in the presence of a palladium or platinum catalyst under oxidative condition to prepare a correspon...  
JP2013047267
To provide new antibiotics that are highly effective against antibiotic-resistant strains.This invention provides a novel cross-linked glycopeptide-cephalosporin compound useful as an antibiotic and a pharmaceutically-acceptable salt the...  
JP2011063616
To provide a process for producing 7-amino-3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxy lic acid or its salt having a high Z-isomer content and a low content of phenylacetic acid or its derivative as an impurity.Enzymatic reactio...  
JP2010254697
To provide a new antibiotic highly effective against antibiotic-resistant bacterial strains.There are provided a crossrinked glycopeptide-cephalosporin compound and a pharmaceutically acceptable salt thereof which are useful as antibioti...  
JP2010184925
To provide a new crystalline form of cefdinir having higher stability and lower solubility than the well-known crystalline form of cefdinir.The new crystalline form of cefdinir having specific X-ray diffraction spectra is obtained by the...  
JP2010119382
To provide a method for fluorescently labeling a protein labeling in vivo molecules.The method for fluorescently labeling the protein includes to obtain a fused protein of a target protein with a variant -lactamase and to fluorescently l...  
JP2010077115
To provide a method for selectively producing Z isomer of a cephem compound useful as a synthetic intermediate for a cephalosporin antibiotic substance in high yield.A 3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem compound (A) expressed by ...  
JP2010024148
To further increase the content of a Z isomer compared to an E isomer in the manufacture of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-c arboxylic acid or an alkali salt thereof.The content of 7-amino-3-[(Z)-2-(4-methylth...  
JP2009249380
To provide a new intermediate compound effectively usable in producing cefdinir, and a method for effectively producing the cefdinir using the same.Provided is the method for producing a cefdinir of general formula (7) characterized by c...  
JP2009143962
To provide cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof, which are useful as antibiotics.Pharmaceutical compositions containing the compounds, methods for treating bacterial infections i...  
JP2009114202
To provide a new cephem compound having excellent antimicrobial action, stability and oral absorption property, to provide a method for producing the compound, and to provide an agent containing the compound.The present invention provide...  
JP2009040795
To provide cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics.The invention also provides pharmaceutical compositions containing such compounds, methods for tre...  
JP2008189688
To provide a crystalline acid-addition salt from cefdinir; to provide a production method of the acid-addition salt; and to provide a cefdinir production method using the acid-addition salt.High purity cefdinir can be produced by a metho...  
JP2007131535
To provide an agent for suppressing the formation of a modified protein, free from hypotensive action and inducing no vitamin B6 deficiency.The agent for suppressing the formation of a modified protein uses a compound having a free or sa...  
JP2007119484
To provide a new antibacterial agent of cephem compound expressing a wide antibacterial spectrum to various pathogenic bacteria.The compound is expressed by formula (I), wherein Acyl expresses an acyl applicable to the β-lactam field; T...  
JP2007106684
To provide a pharmaceutical preparation containing cefditoren pivoxil, having improved wettability with water and improved dissolution property and exhibiting high initial dissolution rate.The pharmaceutical composition comprises 0.1-10 ...  
JP2007077137
To provide an industrial method for directly converting cefepime being a cephalosporin having a wide action spectrum into sterilized cefepime dihydrochloride monohydrate.The method for producing sterilized cefepime dihydrochloride monohy...  
JP2007077123
To provide a cefdinir which solves a problem that conventional crystalline cefdinir is slightly soluble in water, and has high solubility in water.The present invention relates to amorphous cefdinir which does not contain crystalline cef...  
JP3927262
To produce a specific new cephem compound capable of manifesting excellent antimicrobial activities against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus(MRSA) and useful as an antimicrobi...  
JP3920939
To obtain a new crystalline cephem acid addition salt with long half- life in the blood and excellent medicinal sustainability, useful for the treatment of bacterial infectious diseases. This compound is shown by formula I [(n) is 1 or 2...  
JP3914276
To obtain a specific new cephalosporin derivative having a substituted sulfonylmethyl group bonded to the 3-site of cephem ring, having a broad antibacterial spectrum and strong antibacterial action and useful for an antibacterial agent,...  
JP2007023046
To provide new cepham compounds having antimicrobial activities, their production method, intermediates and a pharmaceutical composition containing the cepham compounds.The antibacterial compounds are expressed by formula I [in the formu...  
JP3868008
PURPOSE: To obtain a new temp. and moisture stable compd. useful as a compsn. for injection. CONSTITUTION: This dihydrate of 7-[α-(2-aminothiazol-4-yl)-α-(Z)- methoxyiminoacetamide)-3-[(1-methyl-1-pyrrolidino)methyl]-3- cephem-4- carbo...  
JP3856807
To provide a beta-lactamase as a reporter gene, a beta-lactamase substrate compound and uses thereof for particularly monitoring expression from a pair of expression control sequences to screen a biochemical activity. Disclosed is a reco...  
JP3850692
To provide a method of preparing a cephalosporin compound and an intermediate for preparation of these compound. This method cyclizes a compound of formula (III) to obtain a compound expressed by formula (II). [R1 is H, a methoxy or form...  

Matches 551 - 600 out of 2,761