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WO/1992/008721A1 |
The present invention relates to new cephalosporin compounds of formula (I), pharmaceutically acceptable non-toxic salts thereof, and physiologically hydrolyzable esters and solvates thereof, which have potent and broad antibacterial act...
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WO/1992/008463A1 |
A novel method for producing pills with 7-acylamino cephalosporanic acid derivatives by directly compressing a mixture containing said acid in an amount which represents 20-90 % by weight of the overall mass of the pill. The pills thereb...
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WO/1992/007840A1 |
A compound represented by general formula (I), which is useful as an intermediate for the production of (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-substitu
ted cephalosporin derivatives having an excellent antibacterial activity...
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WO/1992/004353A1 |
beta-Lactam antibiotics of formula (I) or a salt thereof wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; L is -CH=...
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WO/1992/003445A1 |
The present invention provides a cephalosporin compound represented by formulas (I-S) and (I-R), wherein R1 is a C1-4 alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substituted with a C1-4 alkyl radical, phenyl, or 2-, 4- or 6- s...
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WO/1992/002523A1 |
A novel cephalosporin compound represented by general formula (I), which has a wide antibacterial spectrum, wherein A represents a group of the formula -N=CH-, -NHCO-(CH=CH)¿m?-, -CH¿2?- or -O-CH¿2?; m represents 0 or 1; R?1¿, R?2¿ ...
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WO/1992/001695A1 |
Compounds of formula (I) or a salt thereof, processes for their preparation, their use as antibiotics, and intermediates thereto, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially...
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WO/1992/001696A1 |
beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 repre...
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WO/1992/000981A1 |
The present invention relates to novel cephalosporins of formula (I), wherein R¿1? represents A C¿1?$m(k)C¿4? alkyl group or ($g(a)), wherein R¿2? and R¿3?, independently, represent hydrogen or a C¿1?$m(k)C¿3? alkyl group and R¿4...
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WO/1992/001061A1 |
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...
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WO/1991/017997A1 |
There is provided a process for preparing a compound of formula (I), wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises reacting...
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WO/1991/017996A1 |
The present invention provides cephalosporin esters of formula (I), wherein R1 is a disulfide group, and R2 is the ending group for the esters. These compounds are useful as antibiotics for treating warm-blooded animals to combat pathoge...
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WO/1991/017166A1 |
Du monohydrate de c�phalexine pr�par� par silylation de 7-ADCA peut �tre obtenu en grande quantit� et avec une puret� am�lior�e quand l'�tape de silylation est effectu�e par reflux dans un solvant ayant un point d'�...
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WO/1991/016310A1 |
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...
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WO/1991/016327A1 |
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cycli...
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WO/1991/014692A1 |
A group of 3-(optionally substituted N-aminopyridinium thiomethyl)cephalosporin derivatives and pharmaceutical compositions thereof are of use in antibacterial therapy.
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WO/1991/009036A1 |
Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for t...
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WO/1991/009037A1 |
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wher...
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WO/1991/009038A1 |
Compound of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a), where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a...
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WO/1991/007413A1 |
The invention relates to compounds represented by general formula (I) (wherein R1 represents hydrogen or an optionally substituted lower alkyl, lower alkynyl, lower alkynyl or aralkyl, A represents a single bond or a hetero atom selected...
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WO/1991/007411A1 |
A novel, optically active compound of formula (I) which is useful as a remedy for bacterial infection, a pharmaceutically acceptable salt or ester thereof, a crystal thereof, and production and uses thereof.
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WO/1991/007410A1 |
The invention relates to a compound represented by structural formula (I), which is a novel optically active compound useful as an agent for treating infectious diseases induced by bacteria, pharmaceutically acceptable salts and esters t...
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WO/1991/006549A1 |
Cephalosporin compounds represented by general formula (I), pharmacologically acceptable addition salts thereof, method for the production thereof, and medicinal uses thereof, wherein R1 represents hydrogen or lower alkyl, and R2 represe...
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WO/1991/005788A1 |
The present application discloses a process for the conversion of penicillin-1-(R)-sulfoxide(s) and/or cephalosporin-1-(R)-sulfoxides in solution, to their corresponding 1-(S)-sulfoxides comprising the step of treating said 1-(R)-sulfoxi...
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WO/1991/005789A1 |
Compounds represented by general formula (I) (wherein R1 represents a lower alkyl group optionally substituted by a halogen atom or atoms), process for their preparation, and use thereof as active ingredients for antifungal agents are di...
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WO/1991/004977A1 |
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.
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WO/1991/000865A1 |
The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.
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WO/1990/011782A2 |
A drug delivery system is described in which an immunoconjugate and a prodrug are used in association with each other to deliver a drug to a host target site such as a tumour. The immunoconjugate comprises an antibody or antibody fragmen...
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WO/1990/008764A1 |
The asymmetrical ureas have the formula (I) wherein R2 and R3, similar or different, represent a hydrogen atom or a structural fraction susceptible of being bonded to a nitrogen atom, appropriate for forming part of a ring wherein the ni...
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WO/1990/007111A2 |
A molecular model of the interaction of various non beta-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial ...
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WO/1990/004595A1 |
Antimicrobial fluoroquinolonyl cephems of formula (I), wherein (1) R1 and R2 are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem; (2) R3 is a substituted or unsubstituted, nitrog...
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WO/1990/004591A1 |
Antimicrobial dithiocarbamoyl quinolone compounds of general formula (I), wherein A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobi...
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WO/1989/010926A1 |
There are provided compounds of formula (I), wherein A is a hydrogen atom or an organic group, R1 is hydrogen or halogen atom or an organic group, R2 is hydrogen or halogen atom, C1-C4 alkyl or acyloxy group, R3 is hydrogen atom, C1-C4 a...
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WO/1989/007600A1 |
Zinc ceftiofur complexes, e.g., zinc ceftiofur hydrochloride and zinc ceftiofur sodium complexes, have been found to provide the good antibiotic activity of ceftiofur while providing low dissolution rate and long half-like properties ena...
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WO/1989/004313A1 |
Cephalosporin compounds of formula (II), where R is hydrogen or a pharmaceutical cation, in which case R1 is not present, or R is hydrogen or a chemical bond when R1 is an acid addition salt anion, and R2 is (a) hydrogen, (b) a duplicate...
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WO/1989/000572A1 |
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be car...
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WO/1988/010263A1 |
Stable crystalline sulfate of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl
ethoxyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindol
inium)-methyl-3-cephem-4-carboxylate and its hydrate, process for their preparation, ...
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WO/1988/010262A1 |
Stable crystalline hydrate of (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyletho
xyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindoliniu
m)-methyl-3-cephem-4-carboxylate which is useful as an agent for treating diseas...
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WO/1988/010256A1 |
The present invention relates to a method for producing novel 4-[1-oxoalkyl]-2,5-oxazolidinediones, (4-1 OOD), and their use in a stereoselective method of producing beta-lactam-containing compounds which include several biologically act...
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WO/1988/005776A1 |
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein Y represents an optionally protected amino group; Z repre...
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WO/1988/005777A1 |
Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein X represents -CH= or -N=; Y represents an optionally prot...
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WO/1988/003924A1 |
Novel cephalosporin derivatives having formula (I) and their crystalline form, processes for preparing thereof, compositions for treating and/or preventing infectious diseases which comprise the novel cephalosporin derivatives as active ...
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WO/1988/002752A1 |
New process for manufacturing cephtazidime pentahydrate having formula (III), characterized in that the ester group of the compound of formula (Ia) or an acid addition salt thereof is decomposed by using exclusively aqueous hydrochloric ...
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WO/1988/002001A1 |
New stable crystalline forms of t-butyl ester of cephtazidime having formula (I), and their manufacture.
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WO/1987/006232A1 |
Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group,...
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WO/1987/005297A1 |
Antibacterial cephalosporin compounds of formula (I), wherein W is a pharmaceutically acceptable salt or ester radical, or a carboxyl-protecting group; n is an integer from 0 to 5; -X- is -X1- or -X2- where the X1 moieties are the same o...
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WO/1987/003876A1 |
Benzathine cephalothin for use in the treatment of bacterial infection in animals, in particular for the treatment or prophylaxis of mammary disorders and keratoconjunctivitis.
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WO/1987/003875A1 |
Cephalosporin derivatives represented by general formula (I), (wherein R1 represents a lower alkyl group, A represents (II) (wherein R2 and R3 may be the same or different and each represents a lower alkyl group, and R4 represents a subs...
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WO/1987/001117A2 |
Processes for the preparation of alkali metal salts of amino acids. Preferably, the present invention relates to solid phase alkali metal salts of cephalosporins of formula (III), wherein M is selected from the group consisting of sodium...
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WO/1987/001116A1 |
Processes for the preparation of stable, crystalline cephalosphorin intermediates of formula (I) and formula (II), wherein X is HI or HCl, and Nu and Nu + are certain N-containing heterocyclic rings attached via a sulfur atom or a ring n...
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