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Matches 551 - 600 out of 6,495

Document Document Title
WO/1994/010177A1
New cephem compounds of formula (I), wherein R1 is amino or protected amino, R2 is hydrogen, a hydroxy protective group, lower alkyl or mono(or di or tri)halo(lower)alkyl, R3 is carboxy or protected carboxy, and R4 is pyridylvinyl which ...  
WO/1994/007898A1
The present invention relates to novel cephalosporin derivatives or pharmaceutically acceptable non-toxic salts thereof useful as antibiotics and to processes for the preparation thereof. Formula (1) wherein: R1 is a hydrogen or an optio...  
WO/1994/006804A1
A cephem compound represented by general formula (I) and excellent in the bactericidal effect against various pathogenic bacteria, wherein Q represents CH or N; R1 represents carboxylate, etc.; R represents (II) or (III); R2 represents l...  
WO/1994/002491A1
A novel cephalosporin derivative represented by general formula (I), which has a potent antibacterial activity, a low toxicity and a high oral absorbability, and a nontoxic salt thereof, wherein R1 and R3 represent each hydrogen or lower...  
WO/1994/002489A1
A compound of formula (I) or a salt thereof, wherein: R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically...  
WO/1994/002490A1
A process for producing a cephem compound represented by general formula (3) which comprises reacting an allenyl-ss-lactam compound represented by general formula (1) with an organotin compound represented by general formula (2) in the p...  
WO/1994/000457A1
Compound of formula (I) or salts thereof wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically acce...  
WO/1993/024493A1
A novel cephalosporin compound represented by general formula (I), wherein R?1¿ represents -CX?1¿¿3?, X?1¿ representing H or halogen; R?2¿ represents -O-Q-Z?1¿, Q representing a C¿3?-C¿6? linking group present between O and Z?1¿...  
WO/1993/018044A1
Compounds of formula (I) or salts thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group or a pharmaceutically ac...  
WO/1993/016043A1
A $g(b)-lactam compound and a 2-(substituted methyl)-3-cephem compound, both being useful as an intermediate for the synthesis of cephem antibiotics and so forth. The lactam compound is represented by general formula (I), wherein R?1¿ r...  
WO/1993/016084A1
The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-y1]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-y1]-3-cephem-4-car...  
WO/1993/015084A1
The present invention relates to new cephalosporin compounds of formula (I), particularly 3-position of cephem rings thereof substituted with new thione compounds and pharmaceutically acceptable salts thereof, which have broad antibacter...  
WO/1993/013109A1
To provide a medicine with an excellent effect on both Gram-positive and negative bacteria. A cephalosporin derivative represented by general formula (I) and a nontoxic salt thereof, wherein R1 represents hydrogen or a protective group; ...  
WO/1993/013108A1
Certain 7-beta-[2-(2-amino-4-thiazolyl)-(Z)-2-(chloromethylene)aceta mido]-3-[(substituted)methyl]-ceph-3-em-4-carboxylic acids, pharmaceutically-acceptable salts thereof and conventional in vivo hydrolyzable esters thereof are valuable ...  
WO/1993/012250A1
The present invention relates to an improved method for the preparation of certain $g(b)-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate.  
WO/1993/011132A1
Described is a new method (systematic method) of preparing the antibiotic cefaclor of formula (I). Also described are new starting products and intermediates used in the method. The method is carried out as described in claim 1.  
WO/1993/011131A1
beta-lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy of formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2R3 is a carboxy group or a carboxylate anion, ...  
WO/1993/010123A1
A process for preparing beta-lactam derivatives of formula (I), wherein R1 represents hydrogen or a metal salt; and R2 represents hydrogen, acetoxy methyl, (2,5-dihydro-2-methyl-6-hydroxy-5-oxo-as-triazin-3-yl)thiome thyl or (1-methyl-1H...  
WO/1993/008287A1
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum)...  
WO/1993/002085A1
The present invention relates to a process for preparing a compound of formula (I), wherein R is an heterocyclic group which contains at least one nitrogen atom with or without oxygen or sulphur and R1 and R2 are both hydrogen atoms or o...  
WO/1993/000346A1
New antibacterially-active cephalosporins are disclosed having either two carboxyl groups, two protected carboxyl groups, or salts thereof, substituted at the carbon atom in the four position of the dihydrothiazine ring.  
WO/1992/022556A1
Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed ...  
WO/1992/021682A1
Compound of formula (I) or a salt thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a) where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a ...  
WO/1992/021683A1
New cephem compounds of formula (I), wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, and R3 is hydroxy or protected hydroxy, and pharmaceutically acceptable salts thereof which are useful as a me...  
WO/1992/021681A1
The present invention relates to a compound of general formula (I) wherein R1a is hydrogen atom or an amino-protecting group; R1b is a C1-C4 alkyl group or a group of formula (a) wherein R3 and R4, being the same or different from each o...  
WO/1992/018474A2
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula (I), are provided which are useful as potent elastase inhibitors.  
WO/1992/018508A1
New cephem compounds of formula (I) wherein R1 is amino or protected amino, Z is N or CH, R2 is hydrogen or an organic group, R3 is lower alkyl, R4 is lower alkyl, A is lower alkylene, R5 is hydroxy or protected hydroxy, and R6 is carbox...  
WO/1992/017482A1
Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of formula (I) are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthr...  
WO/1992/016532A1
A halogenated beta-lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R1 represents optionally protected amino; R2 represents hydrogen or a carboxyl blocking group; R3 represents hydr...  
WO/1992/010502A1
Heterocyclic carboxylic esters or derivatives thereof, comprising a beta-lactam moiety linked by a carboxylic acid bridge to an imidazole moiety for use as antimicrobial agents are provided. Also methods for the preparation of these este...  
WO/1992/008463A1
A novel method for producing pills with 7-acylamino cephalosporanic acid derivatives by directly compressing a mixture containing said acid in an amount which represents 20-90 % by weight of the overall mass of the pill. The pills thereb...  
WO/1992/008721A1
The present invention relates to new cephalosporin compounds of formula (I), pharmaceutically acceptable non-toxic salts thereof, and physiologically hydrolyzable esters and solvates thereof, which have potent and broad antibacterial act...  
WO/1992/007840A1
A compound represented by general formula (I), which is useful as an intermediate for the production of (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-substitu ted cephalosporin derivatives having an excellent antibacterial activity...  
WO/1992/004353A1
beta-Lactam antibiotics of formula (I) or a salt thereof wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; L is -CH=...  
WO/1992/003445A1
The present invention provides a cephalosporin compound represented by formulas (I-S) and (I-R), wherein R1 is a C1-4 alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substituted with a C1-4 alkyl radical, phenyl, or 2-, 4- or 6- s...  
WO/1992/002523A1
A novel cephalosporin compound represented by general formula (I), which has a wide antibacterial spectrum, wherein A represents a group of the formula -N=CH-, -NHCO-(CH=CH)¿m?-, -CH¿2?- or -O-CH¿2?; m represents 0 or 1; R?1¿, R?2¿ ...  
WO/1992/001695A1
Compounds of formula (I) or a salt thereof, processes for their preparation, their use as antibiotics, and intermediates thereto, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially...  
WO/1992/001696A1
beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 repre...  
WO/1992/001061A1
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...  
WO/1992/000981A1
The present invention relates to novel cephalosporins of formula (I), wherein R¿1? represents A C¿1?$m(k)C¿4? alkyl group or ($g(a)), wherein R¿2? and R¿3?, independently, represent hydrogen or a C¿1?$m(k)C¿3? alkyl group and R¿4...  
WO/1991/017996A1
The present invention provides cephalosporin esters of formula (I), wherein R1 is a disulfide group, and R2 is the ending group for the esters. These compounds are useful as antibiotics for treating warm-blooded animals to combat pathoge...  
WO/1991/017997A1
There is provided a process for preparing a compound of formula (I), wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises reacting...  
WO/1991/017166A1
Du monohydrate de c�phalexine pr�par� par silylation de 7-ADCA peut �tre obtenu en grande quantit� et avec une puret� am�lior�e quand l'�tape de silylation est effectu�e par reflux dans un solvant ayant un point d'�...  
WO/1991/016310A1
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...  
WO/1991/016327A1
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cycli...  
WO/1991/014692A1
A group of 3-(optionally substituted N-aminopyridinium thiomethyl)cephalosporin derivatives and pharmaceutical compositions thereof are of use in antibacterial therapy.  
WO/1991/009038A1
Compound of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group of formula (a), where A3 is thiazolyl optionally substituted by an amino group, A4 is hydrogen or an organic residue; CO2R3 is a...  
WO/1991/009037A1
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wher...  
WO/1991/009036A1
Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for t...  
WO/1991/007410A1
The invention relates to a compound represented by structural formula (I), which is a novel optically active compound useful as an agent for treating infectious diseases induced by bacteria, pharmaceutically acceptable salts and esters t...  

Matches 551 - 600 out of 6,495