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Matches 551 - 600 out of 6,422

Document Document Title
WO/1988/002001A1
New stable crystalline forms of t-butyl ester of cephtazidime having formula (I), and their manufacture.  
WO/1987/006232A1
Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group,...  
WO/1987/005297A1
Antibacterial cephalosporin compounds of formula (I), wherein W is a pharmaceutically acceptable salt or ester radical, or a carboxyl-protecting group; n is an integer from 0 to 5; -X- is -X1- or -X2- where the X1 moieties are the same o...  
WO/1987/003875A1
Cephalosporin derivatives represented by general formula (I), (wherein R1 represents a lower alkyl group, A represents (II) (wherein R2 and R3 may be the same or different and each represents a lower alkyl group, and R4 represents a subs...  
WO/1987/003876A1
Benzathine cephalothin for use in the treatment of bacterial infection in animals, in particular for the treatment or prophylaxis of mammary disorders and keratoconjunctivitis.  
WO/1987/001116A1
Processes for the preparation of stable, crystalline cephalosphorin intermediates of formula (I) and formula (II), wherein X is HI or HCl, and Nu and Nu + are certain N-containing heterocyclic rings attached via a sulfur atom or a ring n...  
WO/1987/001117A2
Processes for the preparation of alkali metal salts of amino acids. Preferably, the present invention relates to solid phase alkali metal salts of cephalosporins of formula (III), wherein M is selected from the group consisting of sodium...  
WO/1986/006723A1
A process for producing beta-lactam derivatives, which comprises reacting a beta-lactam derivative wherein the carboxyl group is protected and which is represented by the general formula: A-COO-X (wherein A represents a beta-lactam deriv...  
WO/1986/006376A1
Novel compounds represented by general formula (I) (wherein Ro represents a nitrogen-containing heterocyclic group, an acyl group or an esterified carboxyl group, Z represents S, S$(1,4)$O, O or CH2, R4 represents hydrogen, methoxy or fo...  
WO/1986/005786A1
Novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in ...  
WO/1986/005182A1
beta-Lactam compounds, which are represented by formula (I) wherein R1 represents a hydrogen atom or a protective group for an amino group, and W represents (II) ou (III) wherein R2 represents a hydrogen atom, a salt-forming cation, a pr...  
WO/1986/005183A1
A compound of formula (I), wherein R1 is an amino group which may be protected R3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S$(1,3)$O, O or CH2, R4 is a hydrogen atom, methoxy group or formamido group, ...  
WO/1986/005184A1
Novel antibacterial compounds represented by general formula (I), wherein Ro represents a hydrogen atom, a nitrogen-containing heterocyclic group, an acyl group or an esterified carboxyl group, Z represents S, S$(1,3)$O, O or CH2, R4 rep...  
WO/1986/003204A1
Process for the production of cephalosporine derivatives by the silylization of 7-ACA or its derivatives followed by conversion of 3-iodomethyl derivatives with subsequent nucleophilic exchange in the 3-position.  
WO/1986/000070A1
Novel cephem compounds represented by general formula (I), wherein R1 represents an optionally protected amino group, R2 represents hydrogen or halogen, R3 represents hydrogen or an optionally substituted hydrocarbon residue, R4 represen...  
WO/1986/000071A1
Novel cephem compounds represented by general formula (I), wherein R1 represents an optionally protected amino group, R2 represents hydrogen or halogen, R3 represents hydrogen or an optionally substituted hydrocarbon residue, R4 represen...  
WO/1985/005360A1
A process for preparing cephalosporin derivatives represented by general formula (I), which comprises reacting a compound of general formula (II) or its reactive derivative with a compound of general formula (III) or eliminating an R1 gr...  
WO/1985/005107A1
Crystalline anhydrides, hemihydrates, monohydrates or trihydrates of (6R, 7R)-7- AD(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido BD-3-(1-quinuclidiniummethyl)-3-cephem-4-carboxylate or derivatives thereof.  
WO/1985/005106A1
Novel cephem compounds of general formula (I), wherein R1 represents an optionally protected amino group, R2 represents a hydrogen atom or a halogen atom, R3 represents a hydrogen atom or an optionally substituted hydrocarbon residue, R4...  
WO/1985/004879A1
Novel cephem compounds of general formula (I), wherein R1 represents and optionally amino group, R2 represents H or halogen, R3 represents H or an optionally substituted hydrocarbon residue, R4 represents H or methoxy, A represents an op...  
WO/1985/004878A1
Compounds of general formula (I), their pharmaceutically acceptable salts and in-vivo hydrolysable esters are antibacterial agents; in which R1 is optionally substituted phenyl or optionally substituted 5 or 6-membered heterocyclyl; R2 i...  
WO/1985/004659A1
Process for preparing intermediary products of cephalosporine having the formula (I) wherein R1 is an acyl group. Modification of a compound having the formula (IV) and/or (IVa) wherein R1 has the same meaning as hereabove and (A), respe...  
WO/1985/004404A1
A process for the preparation of compounds of formula (I), wherein R1 represents hydrogen or a hydroxy-protecting group, R2 represents hydrogen, a cation, the pivaloyloxymethyl group or a carboxy-protecting group and R3 represents hydrog...  
WO/1985/003938A1
Cephalosporin derivatives represented by formula (I), (wherein R1 represents a hydrogen atom or a protective group, R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl grou...  
WO/1985/003937A1
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula (I), and the non-toxic pharmaceutically acceptable salts thereof, wherein D is ...  
WO/1985/001046A1
Mandelic acid derivatives represented by general formula (I), wherein R1 represents a hydrogen atom or a hydroxy group, X represents a halogen atom or OR2 (wherein R2 represents a hydrogen atom, benzyl, benzhydryl, t-butyl, tetrahydropyr...  
WO/1984/004747A1
Cephem compounds represented by general formula (I), wherein R1 represents a hydrogen atom or an amino group-protecting group and R2 represents formula (II) or (III), wherein R3 represents a lower alkyl group and R4 represents a lower al...  
WO/1984/004096A1
Novel compounds of formula (I), a process for their preparation, pharmaceutical compositions containing the same as active ingredient and their use in therapy as antibiotics. The compounds of the formula (I) according to the invention st...  
WO/1984/002911A1
A compound of formula (I) or a salt thereof, wherein R1 and R3 are independently an in vivo hydrolysable group, or R1 and R3 together form an in vivo hydrolysable group, provided that R1 and R3 are not both C1-6 alkylcarbonyl; R7 is a hy...  
WO/1984/002703A1
A process for preparing novel aminothiazolylacetic acid derivatives useful as intermediates for synthesizing beta-lactam antibiotics, starting with diketene as shown in formula (I), wherein R represents lower alkyl or phenyl, R1 and R2 e...  
WO/1984/001949A1
Cephalosporin derivatives represented by the general formula (I), wherein R1 represents an alpha-, beta- or gamma-amino acid residue (bonded through an ester bond) whose amino group is optionally susbstituted by a lower alkyl group, R2 r...  
WO/1984/001950A1
Cephalosporin derivatives represented by formula (I) (wherein R represents -CH2-OCORa1 (wherein Ra1 represents an alkyl group),$(4,)$(wherein Rb1 represents an alkyl group),$(4,)$(wherein Rc1 represents an alkyl group),$(6,)$or phthalidy...  
WO/1984/001152A1
Azetidinone compounds represented by the general formula (I), wherein R1 represents a substituted or unsubstituted phenyl group, R2 represents a carboxyl-protecting group, X represents a hydrogen atom or a chlorine atom, Y represents$(7,...  
WO/1984/000965A1
2-Substituted cephem derivatives represented by the general formula (I), (wherein R1 represents substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, or substituted or unsubstituted phenoxymethyl, R2 represents ...  
WO/1984/000964A1
Cephalosporin compounds represented by the general formula (I), wherein R1 represents alkyl, alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylmethyl, or substituted or unsubstituted phenoxymethyl, and R2 repre...  
WO/1983/003968A1
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula: ADD-DHC BD (I), wherein ADD BD is a centrally acting drug species, and AD...  
WO/1982/001004A1
A process for preparing cephalosporin compounds represented by the following general formula (III): (FORMULA) (wherein R represents a hydrogen atom or a methyl group) or the pharmaceutically acceptable salts thereof, which comprises reac...  
WO/1980/000337A1
A primary alcohol or an aldehyde is reacted with ammonia or a primary or secondary amine together with a molecular oxygen-containing gas in the presence of a palladium or platinum catalyst under oxidative condition to prepare a correspon...  
JP2014513700A  
JP2014513116A  
JP5498393B2  
JP2014510750A  
JP2014065732A
To provide a cephem compound having wide antibacterial spectrum against various bacteria including gram-negative bacterium and/or gram-positive bacterium, and to provide a pharmaceutical composition containing the same.There are provided...  
JP5451743B2  
JP5230934B2  
JP2013526502A  
JP5161269B2  
JP2013047267A
To provide new antibiotics that are highly effective against antibiotic-resistant strains.This invention provides a novel cross-linked glycopeptide-cephalosporin compound useful as an antibiotic and a pharmaceutically-acceptable salt the...  
JP2012533596A  
JP2012529443A  

Matches 551 - 600 out of 6,422