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Matches 701 - 750 out of 2,769

Document Document Title
JP11236387
To produce a 3-cephem compound that is a synthetic intermediate of an antimicrobial agent having a wide range of antimicrobial spectra from a raw material that is readily available from inexpensive penicillin through a shortened process ...  
JP11180985
To obtain the subject high pure compound having high reactivity at the 3-position of the cephalosporin skeleton, capable of exhibiting good storage stability under mild conditions and useful as an intermediate for synthesizing antibiotic...  
JP2938427
To economically produce the objective compound by a method of a two step process comprising a reaction of 4-chloro-butyroyl chloride with N-bromosuccinimide and further the reaction of the product with an amine. A reaction of 4-Chloro-bu...  
JP2939129
PURPOSE: To provide the subject intermediate being stable in a solution, not decomposing in the presence of a strong base, not forming an intramolecular lactone and being economically advantageous for the synthesis of cephalosporins. CON...  
JP2934809
PURPOSE: To provide a novel compd. excellent in antibacterial power and useful as an antibiotic. CONSTITUTION: This compd. is represented by formula I [wherein R1 is H or an amino protecting group; R2 and R3 are each H or an OH protectin...  
JP11140087
To obtain an antimicrobial composition capable of manifesting high effectiveness against methicillin-resistant Staphylococcus aureus(MRSA) and uniquely having a wide antimicrobially active spectrum for Gram-positive pathogenic bacteria a...  
JP11124384
To produce 3-halogenomethylcephem with industrial advantage that is useful as a starting substance for synthesis of 3-thiomethyl-cephem as an intermediate for antibiotic substance typified by cefazolin or cefatriaxon. 7-Amino-3-halogenom...  
JP11080164
To obtain the subject compound in high yield and purity by electrolytic oxidation of a 3-thiomethyl cephem compound with a lower alcohol. This 3-dialkoxymethyl cephem compound of formula II is obtained by electrolytic oxidation of a 3-th...  
JP11071351
To obtain a new compound having excellent antiulcer activity and useful for treating digestive ulcer. This new compound is shown by formula I [R1 is a (substituted) (hetero)aryl; R2 is H, an alkoxycarbonyl, substituted aminocarbonyl, cya...  
JP11060583
To obtain the subject reaction reagent from which a cephalosporin- based antibiotic is synthesized with a simple operation in high yield by essential including a cephalosporin derivative capable of being easily obtained. This reaction re...  
JP11049778
To obtain the subject intermediate by reaction of a cephalosporin derivative bearing methyl group on the 3-site with a specific compound to effect slight formation of byproduct Δ2-form on the cephem ring and also transform the methyl gr...  
JP11049779
To obtain the subject compound as E-form in high yield through few processes capable of producing cephalosporin derivatives having antibacterial action in an industrially advantageous way, by reaction of a specific compound with a disulf...  
JP11012276
To provide a process for producing a β-lactam derivative carboxylic acid without using expensive reagent in high efficiency by eliminating a carboxylic acid protecting group of a β-lactam derivative having protected carboxyl group in t...  
JP10338694
To readily obtain the subject compound used for intermediate, etc. for an antimicrobial agent in high yield by reacting a 3-chloromethylcephem compound with an iodizing reagent, an alkali metal hydroxide, an arylphosphine and an aldehyde...  
JP10316666
To obtain a new compound capable of acting as siderophore or a biological chelate and suitable for introducing an active ingredient, e.g. an antibiotic, into microbial cells through the microbial iron-transporting route. This compound is...  
JP10291991
To obtain the subject derivative for a raw material of an antibiotic, etc., by reacting a specific 7-aminocephalosporanic acid with hexamethyldisilazane in a solvent in the presence of a sulfur-containing acid (ammonium salt) or a Lewis ...  
JP10273481
To economically produce the objective compound by a method of a two step process comprising a reaction of 4-chloro-butyroyl chloride with N-bromosuccinimide and further the reaction of the product with an amine. A reaction of 4-Chloro-bu...  
JP10265477
To obtain a new compound useful for an antimicrobial agent for resistant microorganisms, having antibacterial activity against methicillin- resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, comprising a spec...  
JP10265488
To provide the subject new compound consisting of a specific phosphonocephem derivative, exhibiting antibacterial action on a wide variety of bacteria including methicillin resistant Staphylococcus aureus(MRSA), useful as an antibacteria...  
JP10251266
To obtain a new cephem compound capable of specifically expressing an excellent antibacterial action against bacteria belonging to the genus Helicobacter without producing side effects such as emesis and diarrhea by the administration of...  
JP10245387
To readily obtain the subject compound for antimicrobial agents, etc., having a wide range of antimicrobial spectrum by reacting a halogenomethylcephem compound with an alkenyltin compound in the presence of a cuprous halide and an aroma...  
JP10182655
To obtain a new cephem compound having an excellent antibacterial power, especially exhibiting a storing antibacterial activity against MRSA, high in solubility in water, low in toxicity and high in safety. For this cephen compound, a ce...  
JP10182657
To obtain the subject new compound useful of the therapy of infectious diseases caused by bacterial pathogens, especially methicillin-resistant staphylo coccus and Pseudomonas aeruginosa. This compound a cephalosporin derivative of formu...  
JP10182656
To obtain a new cephem compound having an excellent antibacterial power against gram-positive bacteria, especially metuicillin-resistant Staphylococcus aureus, high in solubility in water, low in toxicity, and high in safety. For this co...  
JP10175980
To efficiently obtain a compound useful as the subject intermediate in high purity and yield by deacylating a compound formed by reaction between each specific glutaryl aminocephalosporanic acid and thiol. In the form of an aqueous solut...  
JP10152490
To profitably obtain the subject compound useful as a medicine, especially an antibiotic, in water solvent having no problem on safety by reacting a specific 3-cephem-4-carboxylate (salt) with an acid chloride in the water. This method f...  
JP10139783
To obtain the subject new derivatives comprising specific vinylpyrrolidinone cephalosporin derivatives and useful for treatment and prevention, etc., of diseases due to gram-positive bacteria, especially sensitive and resistant staphyloc...  
JP10120687
To obtain the subject derivative, which is an antibiotic substance, comprising a specific cephalosporin pyridinium derivative, having a strong and a wide range of antimicrobial activities and especially effective against methicillin-resi...  
JP10101679
To simply obtian the subject compound useful for antibiotics, etc., by reacting a 7-protected amino-3-halogenomethyl-cephem carboxylic acid ester with a 5-mercaptothiazole compound and subsequently reacting the reaction product with a te...  
JP10101680
To obtain the subject new cephalosporin derivative having a wide antibacterial spectrum and a strong antibacterial activity, excellent in oral absorbability, low in toxicity, and useful as an antibacterial agent, etc., for human and anim...  
JP10087493
To obtain the subject medicine useful for preventing and curing cardiac infraction, cardiac failure, rheumatism, etc., by allowing to contain a specific new cephem-based compound. This chymase-inhibitor contains an oxycephem derivative e...  
JP10067784
To produce 7-acyl-3-substituted carbamoyloxycephem compound com prising a specific 7-acyl-3-substituted carbamoyloxycephem, having excellent effects as a medicine and useful as an antimicrobial agent such as antifungal agent capable of b...  
JP10059978
To obtain a cephem or isoxacephem derivative in high efficiency by acylating a specified cephem or isoxacephem derivative with an activated carboxylic acid derivative containing 2-aminothiazole group. The objective cephem or isoxacephem ...  
JP10053533
To provide a method useful for treatment and prevention of sepsis and acute respiratory disease syndrome of adult by independently administrating a specific chemokine or its fragment and simultaneously administrating it together with an ...  
JP10045766
To obtain a new cephalosprin derivative (salt) having a wide antibacte rial spectrum and a strong antibacterial activity, especially having a strong antibacterial activity against methicillin-resistant Staphylococcus aureus, low in toxic...  
JP10045765
To obtain new cephalosporins (salt) having a wide antibacterial spectrum and a strong antibacterial activity. A compound of formula I [R1 is a (substituted) alkylthio, an alkynylthio, an aryl(thio), etc.; R2 is (protected) carboxyl, carb...  
JP10036375
To obtain a new cephalosporin derivative being the specific one, having a wide range antimicrobial spectrum and a strong antibacterial activities and useful as an antimicrobial agent effective in methicillin resistant Staphylococcus aure...  
JP10029995
To obtain a new compound useful as an intermediate for producing a new cephalosporin antibiotic having a substituted benzyloximino group at the 7-position, exhibiting high antibacterial activities against gram-positive bacteria and gram-...  
JP2740497
To efficiently obtain the subject compound, useful as, e.g. a stock for production of a cephalosporin antibiotic by vinylating a ylide compound of 7-protected amino-3-cephem-4-carboxylic acid by the Witting reaction and then acylating th...  
JP10001482
To obtain the subject compound useful as pharmaceuticals in high purity and yield by reacting a halogenated β-lactam with a specific reagent in the presence of a specific metal compound. This 3-norcephem compound of formula II can be pr...  
JP2723088
PURPOSE: To obtain a crystal of a cephalosporin compound, capable of manifesting extremely strong antimicrobial activities, stable to heat or light and manifesting physically, chemically and pharmaceutically excellent properties and its ...  
JP09295982
To obtain an intermediate for synthesizing cephalosporin useful as e.g. an antibacterial agent, in a site-specific way and in high yield, by reaction of a specific 3-halomethyl-3-cephem-4-carboxylic acid compound with a specifically reac...  
JP09278779
To obtain the subject new compound, capable of manifesting distinct therapeutic effects on infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and useful as an antimicrobial agent, etc., by reacting a specifi...  
JP09278778
To obtain a new anti-MRSA [anti-methicillin-resistant Staphylococcus aureus (MRSA)] cephalosporin compound, having strong antimicrobial activities against the MRSA and high safety and useful as a therapeutic agent for infectious diseases...  
JP2708724
PURPOSE: To obtain a new amino-β-lactam acid salt useful for producing monolactam bicyclic antibiotics. CONSTITUTION: A compound of formula I [R2 is H, methyl, ethyl, benzyl, an aryl; (m), (n) are each 1-4 to form a ring, or (m), (n) ar...  
JP09268128
To obtain an inhalation preparation containing a specific cephem compound having an antibacterial action or its salt as an inhalation agent and capable of expressing an extremely high therapeutic effect by the administration of a small a...  
JP09249643
To obtain an allenyl β-lactam compound and a 3-halocephem compound in a simple operation and in high purity by using a halogenated β-lactam compound as a starting material and solely changing reaction conditions. An allenyl β-lactam c...  
JP09249983
To obtain a 3-alkoxymethylcephem of high purity in a simple process with high production yield by electrolyzing and oxidizing 3-alkoxymethylcephem compd. in the presence of a lower alcohol. A 3-thiomethylcephem compd. expressed by formul...  
JP2689412
PURPOSE: To provide a method for removing a protecting group in which a tri-substituted silyl group can efficiently be removed under mild conditions and the objective compound can be obtained in high yield at a low cost. CONSTITUTION: Th...  
JP2675539
To obtain a new cephalosporin compound showing strong antibacterial activity against Gram-negative and Gram-positive bacteria, and useful as, e.g. antibiotic by reacting a 3-halopropenylcephalosporin derivative with a specific tertiary a...  

Matches 701 - 750 out of 2,769