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JP11302176 |
To obtain an anti-Helicobacter agent having a strong antibacterial action against a bacterium belonging to genus Helicobacter and useful as a medicine such as an antiulcer agent by including oxacephem or a specific cephem as an active co...
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JP11292882 |
To efficiently obtain the subject compound useful as an intermediate for synthesizing medicines, etc., in a high yield without using an organic solvent having the problems of safety and environmental pollution by reacting a specified ami...
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JP11279180 |
To obtain a new compound having strong antimicrobial activity to methicillin resistant Staphylococcus aureus and useful as a medicine, especially an antimicrobial agent to human and animals by binding a specific group to 3 position of ce...
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JP11255771 |
To obtain the subject new compounds useful for preventing, inhibiting or treating diseases caused by the uncontrolled release of a protease, especially emphysema or cystic fibrosis, as inhibitors against a protease, especially against hu...
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JP11255772 |
To obtain the subject new compound having a specific cationic group and a phosphonoamino-substituted five-membered cyclic group on a cephem skeleton, having water solubility, excellent antibacterial actions on (methicillin- resistant) St...
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JP11236386 |
To produce a 3-cephem compound having a wide range of antimicrobial spectra from a raw material that is readily available from inexpensive penicillin by allowing a β-lactam halide to react with an organic halide in the presence of a spe...
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JP11236387 |
To produce a 3-cephem compound that is a synthetic intermediate of an antimicrobial agent having a wide range of antimicrobial spectra from a raw material that is readily available from inexpensive penicillin through a shortened process ...
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JP11180985 |
To obtain the subject high pure compound having high reactivity at the 3-position of the cephalosporin skeleton, capable of exhibiting good storage stability under mild conditions and useful as an intermediate for synthesizing antibiotic...
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JP2938427 |
To economically produce the objective compound by a method of a two step process comprising a reaction of 4-chloro-butyroyl chloride with N-bromosuccinimide and further the reaction of the product with an amine. A reaction of 4-Chloro-bu...
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JP2939129 |
PURPOSE: To provide the subject intermediate being stable in a solution, not decomposing in the presence of a strong base, not forming an intramolecular lactone and being economically advantageous for the synthesis of cephalosporins. CON...
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JP2934809 |
PURPOSE: To provide a novel compd. excellent in antibacterial power and useful as an antibiotic. CONSTITUTION: This compd. is represented by formula I [wherein R1 is H or an amino protecting group; R2 and R3 are each H or an OH protectin...
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JP11140087 |
To obtain an antimicrobial composition capable of manifesting high effectiveness against methicillin-resistant Staphylococcus aureus(MRSA) and uniquely having a wide antimicrobially active spectrum for Gram-positive pathogenic bacteria a...
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JP11124384 |
To produce 3-halogenomethylcephem with industrial advantage that is useful as a starting substance for synthesis of 3-thiomethyl-cephem as an intermediate for antibiotic substance typified by cefazolin or cefatriaxon. 7-Amino-3-halogenom...
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JP11080164 |
To obtain the subject compound in high yield and purity by electrolytic oxidation of a 3-thiomethyl cephem compound with a lower alcohol. This 3-dialkoxymethyl cephem compound of formula II is obtained by electrolytic oxidation of a 3-th...
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JP11071351 |
To obtain a new compound having excellent antiulcer activity and useful for treating digestive ulcer. This new compound is shown by formula I [R1 is a (substituted) (hetero)aryl; R2 is H, an alkoxycarbonyl, substituted aminocarbonyl, cya...
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JP11060583 |
To obtain the subject reaction reagent from which a cephalosporin- based antibiotic is synthesized with a simple operation in high yield by essential including a cephalosporin derivative capable of being easily obtained. This reaction re...
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JP11049778 |
To obtain the subject intermediate by reaction of a cephalosporin derivative bearing methyl group on the 3-site with a specific compound to effect slight formation of byproduct Δ2-form on the cephem ring and also transform the methyl gr...
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JP11049779 |
To obtain the subject compound as E-form in high yield through few processes capable of producing cephalosporin derivatives having antibacterial action in an industrially advantageous way, by reaction of a specific compound with a disulf...
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JP11012276 |
To provide a process for producing a β-lactam derivative carboxylic acid without using expensive reagent in high efficiency by eliminating a carboxylic acid protecting group of a β-lactam derivative having protected carboxyl group in t...
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JP10338694 |
To readily obtain the subject compound used for intermediate, etc. for an antimicrobial agent in high yield by reacting a 3-chloromethylcephem compound with an iodizing reagent, an alkali metal hydroxide, an arylphosphine and an aldehyde...
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JP10316666 |
To obtain a new compound capable of acting as siderophore or a biological chelate and suitable for introducing an active ingredient, e.g. an antibiotic, into microbial cells through the microbial iron-transporting route. This compound is...
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JP10291991 |
To obtain the subject derivative for a raw material of an antibiotic, etc., by reacting a specific 7-aminocephalosporanic acid with hexamethyldisilazane in a solvent in the presence of a sulfur-containing acid (ammonium salt) or a Lewis ...
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JP10273481 |
To economically produce the objective compound by a method of a two step process comprising a reaction of 4-chloro-butyroyl chloride with N-bromosuccinimide and further the reaction of the product with an amine. A reaction of 4-Chloro-bu...
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JP10265477 |
To obtain a new compound useful for an antimicrobial agent for resistant microorganisms, having antibacterial activity against methicillin- resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, comprising a spec...
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JP10265488 |
To provide the subject new compound consisting of a specific phosphonocephem derivative, exhibiting antibacterial action on a wide variety of bacteria including methicillin resistant Staphylococcus aureus(MRSA), useful as an antibacteria...
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JP10251266 |
To obtain a new cephem compound capable of specifically expressing an excellent antibacterial action against bacteria belonging to the genus Helicobacter without producing side effects such as emesis and diarrhea by the administration of...
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JP10245387 |
To readily obtain the subject compound for antimicrobial agents, etc., having a wide range of antimicrobial spectrum by reacting a halogenomethylcephem compound with an alkenyltin compound in the presence of a cuprous halide and an aroma...
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JP10182655 |
To obtain a new cephem compound having an excellent antibacterial power, especially exhibiting a storing antibacterial activity against MRSA, high in solubility in water, low in toxicity and high in safety. For this cephen compound, a ce...
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JP10182657 |
To obtain the subject new compound useful of the therapy of infectious diseases caused by bacterial pathogens, especially methicillin-resistant staphylo coccus and Pseudomonas aeruginosa. This compound a cephalosporin derivative of formu...
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JP10182656 |
To obtain a new cephem compound having an excellent antibacterial power against gram-positive bacteria, especially metuicillin-resistant Staphylococcus aureus, high in solubility in water, low in toxicity, and high in safety. For this co...
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JP10175980 |
To efficiently obtain a compound useful as the subject intermediate in high purity and yield by deacylating a compound formed by reaction between each specific glutaryl aminocephalosporanic acid and thiol. In the form of an aqueous solut...
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JP10152490 |
To profitably obtain the subject compound useful as a medicine, especially an antibiotic, in water solvent having no problem on safety by reacting a specific 3-cephem-4-carboxylate (salt) with an acid chloride in the water. This method f...
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JP10139783 |
To obtain the subject new derivatives comprising specific vinylpyrrolidinone cephalosporin derivatives and useful for treatment and prevention, etc., of diseases due to gram-positive bacteria, especially sensitive and resistant staphyloc...
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JP10120687 |
To obtain the subject derivative, which is an antibiotic substance, comprising a specific cephalosporin pyridinium derivative, having a strong and a wide range of antimicrobial activities and especially effective against methicillin-resi...
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JP10101679 |
To simply obtian the subject compound useful for antibiotics, etc., by reacting a 7-protected amino-3-halogenomethyl-cephem carboxylic acid ester with a 5-mercaptothiazole compound and subsequently reacting the reaction product with a te...
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JP10101680 |
To obtain the subject new cephalosporin derivative having a wide antibacterial spectrum and a strong antibacterial activity, excellent in oral absorbability, low in toxicity, and useful as an antibacterial agent, etc., for human and anim...
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JP10087493 |
To obtain the subject medicine useful for preventing and curing cardiac infraction, cardiac failure, rheumatism, etc., by allowing to contain a specific new cephem-based compound. This chymase-inhibitor contains an oxycephem derivative e...
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JP10067784 |
To produce 7-acyl-3-substituted carbamoyloxycephem compound com prising a specific 7-acyl-3-substituted carbamoyloxycephem, having excellent effects as a medicine and useful as an antimicrobial agent such as antifungal agent capable of b...
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JP10059978 |
To obtain a cephem or isoxacephem derivative in high efficiency by acylating a specified cephem or isoxacephem derivative with an activated carboxylic acid derivative containing 2-aminothiazole group. The objective cephem or isoxacephem ...
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JP10053533 |
To provide a method useful for treatment and prevention of sepsis and acute respiratory disease syndrome of adult by independently administrating a specific chemokine or its fragment and simultaneously administrating it together with an ...
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JP10045766 |
To obtain a new cephalosprin derivative (salt) having a wide antibacte rial spectrum and a strong antibacterial activity, especially having a strong antibacterial activity against methicillin-resistant Staphylococcus aureus, low in toxic...
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JP10045765 |
To obtain new cephalosporins (salt) having a wide antibacterial spectrum and a strong antibacterial activity. A compound of formula I [R1 is a (substituted) alkylthio, an alkynylthio, an aryl(thio), etc.; R2 is (protected) carboxyl, carb...
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JP10036375 |
To obtain a new cephalosporin derivative being the specific one, having a wide range antimicrobial spectrum and a strong antibacterial activities and useful as an antimicrobial agent effective in methicillin resistant Staphylococcus aure...
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JP10029995 |
To obtain a new compound useful as an intermediate for producing a new cephalosporin antibiotic having a substituted benzyloximino group at the 7-position, exhibiting high antibacterial activities against gram-positive bacteria and gram-...
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JP2740497 |
To efficiently obtain the subject compound, useful as, e.g. a stock for production of a cephalosporin antibiotic by vinylating a ylide compound of 7-protected amino-3-cephem-4-carboxylic acid by the Witting reaction and then acylating th...
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JP10001482 |
To obtain the subject compound useful as pharmaceuticals in high purity and yield by reacting a halogenated β-lactam with a specific reagent in the presence of a specific metal compound. This 3-norcephem compound of formula II can be pr...
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JP2723088 |
PURPOSE: To obtain a crystal of a cephalosporin compound, capable of manifesting extremely strong antimicrobial activities, stable to heat or light and manifesting physically, chemically and pharmaceutically excellent properties and its ...
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JP09295982 |
To obtain an intermediate for synthesizing cephalosporin useful as e.g. an antibacterial agent, in a site-specific way and in high yield, by reaction of a specific 3-halomethyl-3-cephem-4-carboxylic acid compound with a specifically reac...
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JP09278779 |
To obtain the subject new compound, capable of manifesting distinct therapeutic effects on infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and useful as an antimicrobial agent, etc., by reacting a specifi...
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JP09278778 |
To obtain a new anti-MRSA [anti-methicillin-resistant Staphylococcus aureus (MRSA)] cephalosporin compound, having strong antimicrobial activities against the MRSA and high safety and useful as a therapeutic agent for infectious diseases...
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