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Matches 751 - 800 out of 4,890

Document Document Title
JP4028607B2
To obtain a new cephalosporin derivative being the specific one, having a wide range antimicrobial spectrum and a strong antibacterial activities and useful as an antimicrobial agent effective in methicillin resistant Staphylococcus aure...  
JPWO2005085258A1
formula: [Chemical 1](In the formula, A may be substituted lower alkylene (substituent: mono or di-lower alkyl, lower alkylidene, or lower alkylene with 2 or more carbon atoms); Z+Is one of the following: [Chemical 2](In the formula, R1A...  
JP4022070B2
The present invention relates to a new crystalline aminothiazole derivative represented by the following formula (I) which is very useful for the preparation of cephalosporin antibiotics, including ceftazidime and cefixime, etc:wherein R...  
JP4018546B2
A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl prot...  
JPWO2005034957A1
According to the present invention, there is provided a solid dispersion composition which can maintain amorphous cefditoren pivoxil in a suspension for a long period of time. The present invention is a solid dispersion composition compr...  
JP2007533724A
A method of stabilizing pharmaceutical compositions containing cefovecin sodium salt which is in an amorphous or other disordered state is disclosed.  
JP2007532579A
The present invention relates to stable amorphous 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl- 3-cephem-4-carboxylic acid (syn isomer), methods for its preparation, and pharmaceutical compositions comprising stable amorph...  
JP2007529521A
Compositions, methods and kits are disclosed for improved staining of a cell or tissue with a dye-conjugate that binds specifically to a particular component of the cell or tissue. The compositions, methods and kits include a polymeric m...  
JP3994011B2
The invention relates to a new process for the preparation of a vinyl-pyrrolidinone cephalosporine derivative of the formula I The compound of the formula I, prepared according to the invention can be used for the treatment and prophylax...  
JP2007528386A
This invention relates a process for preparing a compound of formula (I) wherein R1 is para-nitrobenzyl or allyl; X is halo; as well as its isomers.  
JP3989832B2
A process for producing the compound (1'benzyl-2-oxo-[1,3']-(R)-bipyrrolidinyl-3-(R,S)-yl)-triphe nyl-phosphonium bromide which is an intermediate for antibacterial vinylpyrrolidinone-cephalosporin derivatives.  
JP2007238596A
To provide a process for obtaining cefepime dihydrochloride monohydrate from synthetic cefepime. A synthetic cefepime solution is bleached with carbon, sterilely filtered and treated with a concentrated hydrochloric acid to pH 0.4-0.6 at...  
JP3948628B2
PCT No. PCT/KR96/00250 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Dec. 26, 1996 PCT Pub. No. WO97/24358 PCT Pub. Date Jul. 10, 1997The present invention relates to a novel crystalline cefdinir intermediate having ...  
JP3927808B2
The present invention relates to a new, simple, and easy process for preparing cephalosporin antibiotics of the following formula (I), such as ceftazidime and cefixime. The process comprises acylating a 7-amino cephalosporanic acid deriv...  
JP3928086B2
A compound represented by the formula: (I) wherein Acyl represents an acyl group which can be used in the field of ß-lactams; T represents S, SO or O; the group represented by the formula: (Q) represents a heterocyclic group which may b...  
JP3927262B2
To produce a specific new cephem compound capable of manifesting excellent antimicrobial activities against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus(MRSA) and useful as an antimicrobi...  
JP2007131535A
To provide an agent for suppressing the formation of a modified protein, free from hypotensive action and inducing no vitamin B6 deficiency.The agent for suppressing the formation of a modified protein uses a compound having a free or sa...  
JP3920939B2
To obtain a new crystalline cephem acid addition salt with long half- life in the blood and excellent medicinal sustainability, useful for the treatment of bacterial infectious diseases. This compound is shown by formula I [(n) is 1 or 2...  
JP2007512261A
The present invention discloses the ²-lactamase resistant cephalosporin ester compounds represented by the following formula (I), characterized in that the structures of the compounds are composed by connecting methyl ester residue of s...  
JP2007119484A
To provide a new antibacterial agent of cephem compound expressing a wide antibacterial spectrum to various pathogenic bacteria.The compound is expressed by formula (I), wherein Acyl expresses an acyl applicable to the β-lactam field; T...  
JP3914276B2
To obtain a specific new cephalosporin derivative having a substituted sulfonylmethyl group bonded to the 3-site of cephem ring, having a broad antibacterial spectrum and strong antibacterial action and useful for an antibacterial agent,...  
JP3911124B2
A process for increasing the diastereoisomeric ratio (B/A+B), wherein B is the more apolar and A is the more polar of two diastereoisomers, of a mixture of diastereoisomers of a compound of formulathe diastereoisomers being with respect ...  
JP2007106684A
To provide a pharmaceutical preparation containing cefditoren pivoxil, having improved wettability with water and improved dissolution property and exhibiting high initial dissolution rate.The pharmaceutical composition comprises 0.1-10 ...  
JP2007510709A
The present invention relates to a process for preparation of highly pure amorphous and crystalline forms of cefditoren pivoxil and pharmaceutical compositions comprising highly pure amorphous and crystalline forms of cefditoren pivoxil....  
JP2007077123A
To provide a cefdinir which solves a problem that conventional crystalline cefdinir is slightly soluble in water, and has high solubility in water.The present invention relates to amorphous cefdinir which does not contain crystalline cef...  
JP2007077137A
To provide an industrial method for directly converting cefepime being a cephalosporin having a wide action spectrum into sterilized cefepime dihydrochloride monohydrate.The method for producing sterilized cefepime dihydrochloride monohy...  
JP2007503447A
The treatment of neurological disorders using cefazolin compositions and pharmaceutical compositions including oral dosage forms that include cefazolin compositions are described.  
JP3884063B2
A process for producing cefcapene pivoxil methanesulfonate and, with the use thereof as an intermediate, corresponding hydrochloride. There is provided methanesulfonate of the compound of the formula (?).  
JP2007023046A
To provide new cepham compounds having antimicrobial activities, their production method, intermediates and a pharmaceutical composition containing the cepham compounds.The antibacterial compounds are expressed by formula I [in the formu...  
JP3872955B2
The present invention is concerned with new compounds of formula (I) wherein R<1> is hydrogen, C1-6-alkyl, optionally substituted by fluoro, or C3-6-cycloalkyl; R<2> is hydrogen or a group selected from -CH2C(=CHR)-COOR, -CH2OCOR, -CH(R)...  
JP3868008B2
PURPOSE: To obtain a new temp. and moisture stable compd. useful as a compsn. for injection. CONSTITUTION: This dihydrate of 7-[α-(2-aminothiazol-4-yl)-α-(Z)- methoxyiminoacetamide)-3-[(1-methyl-1-pyrrolidino)methyl]-3- cephem-4- carbo...  
JP2006528970A
The present invention is concerned with a novel cephem compound, with a process for the production of this compound, which process may contain or consist of fermentative steps, chemical steps, and/or biotransformation steps. A cephem com...  
JP3863915B2
A new salt form of cefonicid and its method of preparation is disclosed.  
JP3860750B2
7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfon...  
JP3856807B2
To provide a beta-lactamase as a reporter gene, a beta-lactamase substrate compound and uses thereof for particularly monitoring expression from a pair of expression control sequences to screen a biochemical activity. Disclosed is a reco...  
JP3852946B2
PCT No. PCT/US94/01862 Sec. 371 Date Sep. 11, 1995 Sec. 102(e) Date Sep. 11, 1995 PCT Filed Mar. 7, 1994 PCT Pub. No. WO94/20505 PCT Pub. Date Sep. 15, 1994Anhydrous and crystalline free acid form of the cephalosporin antiobiotic ceftiof...  
JP3850692B2
To provide a method of preparing a cephalosporin compound and an intermediate for preparation of these compound. This method cyclizes a compound of formula (III) to obtain a compound expressed by formula (II). [R1 is H, a methoxy or form...  
JP2006525340A
The present invention relates to carbacephem antibiotics and pharmaceutically acceptable salts thereof useful for the treatment of bacterial infections, in particular infections caused by methicillin-resistant Staphylococcus spp. bacteria.  
JP3837439B2
To obtain a new cephem compound having an excellent antibacterial power, especially exhibiting a storing antibacterial activity against MRSA, high in solubility in water, low in toxicity and high in safety. For this cephen compound, a ce...  
JP3836675B2
A method for preparing an alpha-oxolactam comprising, reacting a corresponding alpha-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding alpha-oxolactam.  
JP2006206529A
To provide a method for producing a compound represented by formula (1).The compound represented by formula (2) and its salts are found out as efficient synthetic intermediates of the above-mentioned compound. [Wherein, R is H, an alkyl ...  
JPWO2004085443A1
7- [2- (2-Aminothiazole-4-yl) -2-hydroxyiminoacetamide] -3-vinyl-3-cephem-4 showing a peak at the diffraction angle shown in the table below in the powder X-ray diffraction pattern. -A novel crystal (B-type crystal) of a carboxylic acid ...  
JP3791941B2
PURPOSE: To obtain the subject high-purity compound important as an intermediate for cephem-based antibiotic substances useful as an oral agent in high yield according to safe and simple operations by using a specific arenyl β-lactam co...  
JP2006515633A
A pharmaceutically active compound having a carboxylic acid group -COOH as a part of its chemical structure which -COOH group is in the form of a carboxylic acid ester.  
JP3777191B2
A cephalosporin derivative which has a substituted or unsubstituted 2-(5-thiazolyl)vinyl group at the 3-position and is represented by the following formula (I) wherein X is CH or N, R<1> is an amino group or a protected amino group, R<2...  
JP3775836B2
To safely and easily produce a compound useful as a production intermediate for cephem antibiotics for oral administration in high yield and purity by reacting a specific allenyl β-lactam compound with a halogenation reagent in the pres...  
JP3775819B2
PURPOSE: To obtain the subject high-purity compound useful as an antimicrobial agent having a wide range of antimicrobial spectra in high yield according to simple operations by using a specific halomethylcephem compound as a starting ra...  
JP2006096679A
To provide a new inexpensive manufacturing method of cefditoren.The manufacturing method of 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamide]-3-[2-(4- methylthiazol-5-yl)vinyl]-3-cefem-4-carboxylic acid (cefditoren) represented by form...  
JP2006511561A
Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir inter...  
JP2006508984A
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious par...  

Matches 751 - 800 out of 4,890