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JP2006508985A |
A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject are disclosed. The modified compounds a...
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JP3755908B2 |
PURPOSE: To obtain crystals of the subject compound excellent in fluidity, filling property and pressure resistance regardless of origin of raw materials, its producing method, existence or absence, or king of an impurity and difference ...
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JP2006508093A |
The present invention relates to an improved process for the preparation of cefprozil DMF solvate of formula (I), which is useful for the preparation of cefprozil, comprising: i) reacting a compound of formula (VIII) with acetaldehyde to...
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JP2006507290A |
A process for preparation of ceftiofur of formula (I) having purity greater than 97% is disclosed. The process comprises reacting [2-(2-aminothiazol-4-yl)]-2-syn-methoxyimino acetic acid-2-benzothiazolyl thioester of formula (II), with 7...
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JP2006507289A |
The present invention provides an improved process to produce the chloromethylcephem derivatives of the formula (I), wherein R>1< represents a carboxy-protecting group viz., substituted methyl group, which can be deprotected easily, such...
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JP3751880B2 |
Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.
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JP3747328B2 |
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JP3747329B2 |
To obtain in a simple operation in high yield the subject compound useful as an intermediate for various cephalosporin-based antibiotics by continuously carrying out deacylation and chlorination during the deacylation process without iso...
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JP2006034950A |
To provide a method and an agent for efficiently cleaning an institution and/or facilities used for manufacturing a substance capable of chemically reacting with a nucleophilic agent and/or a medicine.This is a method for cleaning an ins...
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JP3743680B2 |
PURPOSE: To obtain a new compound useful as an antimicrobial agent exhibiting excellent antimicrobial potency and treating effect on infectious diseases by bacteria from gram-positive bacteria including staphylococcus to gram-negative ba...
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JP3742829B2 |
To improve the yield of the subject reaction and achieve smooth reaction to improve the operability by reacting an organic amine salt of a 7-acylamino-3-hydroxymethyl-3-cephem-4-carboxylic acid with a reactive derivative of carbamic acid...
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JP2006022042A |
To provide a new crystal of cefcapene pivoxil, and to provide a method for producing an antibacterial agent using the same.This crystal of a compound (I) represented by the formula or its solvate. The crystal, wherein the solvent of the ...
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JPWO2004026882A1 |
The present invention has the formula:(In the formula, R1And R2Are lower alkyls, each of which may be substituted independently; R3Is an amino protecting group; R is a compound represented by an anion, hydrogen or carboxy protecting grou...
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JP2006501305A |
Disclosed are salts of the general formula (I) wherein R1, R2 and B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the ...
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JP2006500356A |
A process for the production of cefdinir using 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetami
do]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt as an intermediate.
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JP2005536499A |
A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.
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JP2005536499A5 |
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JP3713282B2 |
Z-Isomers of compounds of general formula (IV): Äwherein R<1> is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R<1> is hydrogen or the like; R<3> is hydrogen, a carboxyl-protecting group or the like; and R<1> is a...
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JP2005530741A |
The present invention relates to a process for the preparation of cefdinir on an industrial scale.
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JP2005526112A |
The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I)which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using sodium borohydri...
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JP2005525399A |
Compounds of formula (I): wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-beta-lactamase enzymes, ...
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JP2005524611A |
The invention described herein relates to the treatment of a range of bacterial infecions in companion animals, in particular cats and dogs, with a DOLLAR (g)b-lactam derivative, compound of Fornula (1). The invention is also directed to...
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JP3675863B2 |
PURPOSE: To simply and efficiently obtain a product having a remarkably increased Z-isomer content or composed of a pure Z-isomer by crystallizing an amine salt of a Z/E mixture of cephalosporin to deplete the E-isomer in the mixture. CO...
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JP2005521692A |
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compo...
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JP2005519070A |
A crystalline hydrochloride of the compound 7-{[5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxyimino)acetyl
)amino)-3-((imino-1-piperazinylmethyly)methylhydrazono]-meth
yl-3-cephem-4carboxylic acid and the pharmaceutical use thereof.
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JP2005162696A |
To provide a cefditoren pivoxil pharmaceutical preparation in which large improvement of dissolution property is obtained by adding a small amount of the pharmaceutical preparation and the production method is ready.The cefditoren pivoxi...
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JP2005146249A |
To provide a method for removing porogen from a temperature-sensitive macroreticular polymer, using steam under reduced pressure.The improved method for producing a resin comprises conducting steam stripping of the porogen from the polym...
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JP3658000B2 |
A process in the isolation of 7-aminocephalosporanic acid (7-ACA) of formula (I) from an alkaline, neutral or slightly acidic medium in the presence of an additive, e.g. selected from the group comprising organic carboxylic acid esters, ...
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JP2005516011A |
The present invention relates to a novel crystalline cefdinir potassium dihydrate, to a process for its preparation and to a method of preparing pure cefdinir via the crystalline salt.
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JP2005511480A |
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.
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JP3639449B2 |
To easily obtain in high yield the subject compound useful as a pharmaceutically active substance or intermediate for producing agrochemicals by converting a specific compound to a pyrrolidine derivative in the presence of a specific pri...
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JP2005509039A |
The compounds of the general formula (I) wherein R<1 >denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R<2 >denotes a pharmaceutically acceptable group which is bo...
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JP3636663B2 |
A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. wherein, X is N or CY and Y is H or halogen; R<1> is amino or protected amino; R<2> is hydrogen or optionally subst...
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JP2005508387A |
A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]
-3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).
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JP2005508385A |
A process for the preparation of salts of organic nitrogen bases with carboxylic acids of general formula (I), wherein Q and R have the meanings defined in the disclosure, useful for the preparation of cephalosporins side chains.
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JP3633940B2 |
Substrates for beta -lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e. alkyl of 1...
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JP2005047827A |
To provide a method for directly producing the crystals of a 3-chloromethyl-3-cephem derivative in a high yield in high purity by a reaction.This method for producing the crystals of the 3-chloromethyl-3-cephem derivative represented by ...
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JP2005502651A |
A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent 1-acetoxyethyl bromide and responsible for the formation o...
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JP2005502687A |
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta-lactamase enzymes, for enhancing the a...
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JP2005501806A |
Provided are fluorescent substrates for beta-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal...
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JP2004538265A |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:- into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative o...
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JP2004537985A |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:- into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative o...
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JP2004536870A |
A process for preparation of cefuroxime axetil of formula (I) of at least 96% purity and substantially free of analogous Delta2-isomer of formula (II) and other impurities. The process comprises reacting cefuroxime acid of formula (III) ...
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JP2004525862A |
The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimin
o)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid-
4-ylthio}-3-cephem-4-carbocyllic acid, where t...
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JPWO2002088147A1 |
The present invention provides sulfates of cefem compound (I) of the following formula, solvates thereof or crystals of the same, which are of high quality and useful as medicines such as an injection.
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JP2004522782A |
The present invention relates to a stable pharmaceutical composition of cefpodoxime proxetil, for oral administration.
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JP3547141B2 |
Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.
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JP3543016B2 |
PURPOSE: To safely, mildly and simply obtain an intermediate product of an antibiotic substance having a carbapenam or a carbapenem skeleton in β-lactam- based medicines which are antibiotic substances by cyclizing a new azetidinone der...
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JP2004520336A |
The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I),wherein, R1 represents H, trityl, CH3, or CRaRbCOOR3, in which Ra and Rb, independently of one another, represents hydrogen or...
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JP2004520293A |
A process for the preparation of 3-cyclic-ether-substituted cephalosporins of formula I wherein the group CO2R1 is a carboxylic acid or a carboxylate salt and R2 has the formula: wherein A1 and A2 have the meanings given in the specifica...
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