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JPH11236387A |
To produce a 3-cephem compound that is a synthetic intermediate of an antimicrobial agent having a wide range of antimicrobial spectra from a raw material that is readily available from inexpensive penicillin through a shortened process ...
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JPH11236386A |
To produce a 3-cephem compound having a wide range of antimicrobial spectra from a raw material that is readily available from inexpensive penicillin by allowing a β-lactam halide to react with an organic halide in the presence of a spe...
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JP2939129B2 |
PURPOSE: To provide the subject intermediate being stable in a solution, not decomposing in the presence of a strong base, not forming an intramolecular lactone and being economically advantageous for the synthesis of cephalosporins. CON...
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JP2936052B2 |
A p-toluenesulphonic acid salt of 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroximinoacetamido]-3-N,N
-dimethylc arbamoyloxymethyl-3- cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester, e.g. of formula its use in the production of other...
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JP2938427B2 |
To economically produce the objective compound by a method of a two step process comprising a reaction of 4-chloro-butyroyl chloride with N-bromosuccinimide and further the reaction of the product with an amine. A reaction of 4-Chloro-bu...
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JP2934809B2 |
PURPOSE: To provide a novel compd. excellent in antibacterial power and useful as an antibiotic. CONSTITUTION: This compd. is represented by formula I [wherein R1 is H or an amino protecting group; R2 and R3 are each H or an OH protectin...
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JPH11508601A |
A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform ...
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JPH11180985A |
To obtain the subject high pure compound having high reactivity at the 3-position of the cephalosporin skeleton, capable of exhibiting good storage stability under mild conditions and useful as an intermediate for synthesizing antibiotic...
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JPH11507062A |
Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and prefera...
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JP2905775B2 |
Trimethylsilyl 7-trimethylamino-3-iodomethylceph-3-em-4-carboxylate, its use as an intermediate for the preparation of cephalosporin derivatives, and a process for the preparation of cephalosporin derivatives using this intermediate.
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JP2904810B2 |
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JPH11506429A |
A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent
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JP2898029B2 |
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JP2898054B2 |
Cephalosporin derivatives of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives and of the pharmaceutical...
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JP2895900B2 |
The present invention provides a process for preparing a 3-formylcephem derivative represented by the formula (2) which comprises oxidizing in the presence of oxygen a 3-halomethylcephem derivative represented by the formula (1) wherein ...
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JPH11505514A |
PCT No. PCT/GB96/00373 Sec. 371 Date Aug. 14, 1997 Sec. 102(e) Date Aug. 14, 1997 PCT Filed Feb. 19, 1996 PCT Pub. No. WO96/26209 PCT Pub. Date Aug. 29, 1996The cephalosporin compound [6R, 7R]-7-[2-(2-Amino-4-thiazolyl)-2-(Z)-(methoxyimi...
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JPH11124384A |
To produce 3-halogenomethylcephem with industrial advantage that is useful as a starting substance for synthesis of 3-thiomethyl-cephem as an intermediate for antibiotic substance typified by cefazolin or cefatriaxon. 7-Amino-3-halogenom...
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JP2888638B2 |
PCT No. PCT/GB92/02231 Sec. 371 Date Jun. 1, 1994 Sec. 102(e) Date Jun. 1, 1994 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/11131 PCT Pub. Date Jun. 10, 1993 beta -lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen,...
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JP2883173B2 |
A method for deactivation of esterase enzyme and an improved enzymatic process for the oxidation of Cephalosporin C to glutaryl-7-ACA.
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JP2881746B2 |
Trimethylsilyl 7-trimethylamino-3-iodomethylceph-3-em-4-carboxylate, its use as an intermediate for the preparation of cephalosporin derivatives, and a process for the preparation of cephalosporin derivatives using this intermediate.
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JPH11503408A |
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any s...
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JPH1180164A |
To obtain the subject compound in high yield and purity by electrolytic oxidation of a 3-thiomethyl cephem compound with a lower alcohol. This 3-dialkoxymethyl cephem compound of formula II is obtained by electrolytic oxidation of a 3-th...
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JP2875170B2 |
A process for etherifying the hydroxymethyl group in position 3 of a cephalosporin by reaction of a 3-hydroxymethyl cephalosporin with an dioxycarbenium-tetrafluoroborate.
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JP2875015B2 |
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: wherein (1) A<1>, A<2>, A<3>, R<1>, R<3>, R<4>, and R<6> form any of a variety of quinolone and related heterocyclic structures similar to those known in the art t...
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JP2874987B2 |
7 beta -[2-(aminothiazolyl and thiadiazolyl)-2-oxyiminoacetamido]cephalosporin derivatives having a 3-[N-(optionally substituted) aminopyridiniumthiomethyl] substituent have antibacterial activity and are of use in antibacterial therapy....
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JPH1171351A |
To obtain a new compound having excellent antiulcer activity and useful for treating digestive ulcer. This new compound is shown by formula I [R<1> is a (substituted) (hetero)aryl; R<2> is H, an alkoxycarbonyl, substituted aminocarbonyl,...
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JP2867438B2 |
A method for producing 3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and besides in good yield, characte...
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JP2867192B2 |
A compound represented by the following formula (1a): a process for the preparation thereof, an antibacterial composition comprising the same and the use thereof for the preparation of a medicament and for the synthesis of related cephem...
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JPH1149779A |
To obtain the subject compound as E-form in high yield through few processes capable of producing cephalosporin derivatives having antibacterial action in an industrially advantageous way, by reaction of a specific compound with a disulf...
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JPH1149778A |
To obtain the subject intermediate by reaction of a cephalosporin derivative bearing methyl group on the 3-site with a specific compound to effect slight formation of byproduct Δ2-form on the cephem ring and also transform the methyl gr...
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JP2857532B2 |
An aminothiazolyl- or aminothiadiazolylcephalosporin derivative represented by the following general formula (I) which has a condensed-ring thio group as a 3-positioned substituent group that contains a thiazolylthio group, an oxazolylth...
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JP2851021B2 |
Transformation of Cephalosporin C or its derivatives and salts into 7-aminocephalosporanic acid or its derivatives by an enzymatic two stage process with enzymes immobilized on a solid matrix.
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JP2851429B2 |
beta -Lactam antibiotics of formula (I) or a salt thereof wherein R<1> is hydrogen, methoxy or formamido; R<2> is an acyl group; CO2R<3> is a carboxy group or a carboxylate anion, or R<3> is a readily removable carboxy protecting group; ...
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JP2851428B2 |
beta -Lactam antibiotics of formula (I) or a salt thereof, wherein R<1> is hydrogen, methoxy or formamido; R<2> is an acyl group; CO2R<3> is a carboxy group or a carboxylate anion, or R<3> is a readily removable carboxy protecting group;...
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JPH11501017A |
PCT No. PCT/EP96/00667 Sec. 371 Date Jul. 25, 1997 Sec. 102(e) Date Jul. 25, 1997 PCT Filed Feb. 16, 1996 PCT Pub. No. WO96/26943 PCT Pub. Date Sep. 6, 1996Compounds of formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl...
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JP2847693B2 |
PURPOSE:To efficiently remove a protecting group by treating a beta-lactam compound having carboxyl protected with a substituted or unsubstituted allyl with a Pd catalyst in the presence of an allyl group scavenger. CONSTITUTION:A p-lact...
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JPH11500755A |
The present invention relates to cephem-derivatives and to a process for their preparation, having proper substituents at C-2 position, i.e. heterocyclylthio or acyloxy group. They are potent protease inhibitors, in particular human leuc...
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JP2845752B2 |
Cephalosporin derivatives of the general formula wherein R<1> is an acyl group derived from a carboxylic acid; R<2> is hydrogen, hydroxy, lower alkyl-Qm, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl-Qm, a...
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JP2846186B2 |
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JP2839914B2 |
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JP2840286B2 |
There are provided compounds of the formula Ia and Ib wherein A is hydrogen atom or an organic residue, R<1> is halogen atom, or an organic group, R<2> is hydrogen or halogen atom, C1-C4 alkyl or alkoxy group R<3> is hydrogen atom, C1-C4...
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JP2834771B2 |
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JP2834578B2 |
PCT No. PCT/GB93/01310 Sec. 371 Date Jan. 25, 1995 Sec. 102(e) Date Jan. 25, 1995 PCT Filed Jun. 21, 1993 PCT Pub. No. WO94/00457 PCT Pub. Date Jan. 6, 1994 (I) (a) Compound of formula (I) or salts thereof wherein R1 is hydrogen, methoxy...
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JPH10512585A |
Invented is a method of enhancing erythropoiesis in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human Stat 5 SH2 domain with a binding affinity greater than fif...
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JPH10316666A |
To obtain a new compound capable of acting as siderophore or a biological chelate and suitable for introducing an active ingredient, e.g. an antibiotic, into microbial cells through the microbial iron-transporting route. This compound is...
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JP2825655B2 |
The invention relates to a new process for the production of pharmaceutically active cephalosporines by depletion of 7-amino-3-Ä(E)-1-propen-1-ylÜ-3- cephem-4-carboxylic acid in mixtures of 7-amino-3-Ä(Z)-1-propen-1-ylÜ-3- cephem-4-c...
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JPH10291991A |
To obtain the subject derivative for a raw material of an antibiotic, etc., by reacting a specific 7-aminocephalosporanic acid with hexamethyldisilazane in a solvent in the presence of a sulfur-containing acid (ammonium salt) or a Lewis ...
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JPH10511377A |
PCT No. PCT/EP95/05088 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/20198 PCT Pub. Date Jul. 4, 1996A process for the production of cefotaxime in acetone/water and its use in the pr...
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JP2817203B2 |
A compound of the formula : wherein R<1> is amino or a protected amino group, Z is N or CH, R<2> is an organic group, and R is a group of the formula : (in which R<3> and R<4> are each lower alkyl, or R<3> and R<4> are linked together to...
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JPH10265477A |
To obtain a new compound useful for an antimicrobial agent for resistant microorganisms, having antibacterial activity against methicillin- resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, comprising a spec...
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