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Matches 251 - 300 out of 6,533

Document Document Title
WO/2004/037163A2
6(7)-β-substituted β-lactam compounds as inhibitors of β-lactamase activity.  
WO/2004/037833A1
The present invention more particularly relates to a process for the preparation of cephalosporin antibiotics of the formula (I) wherein R¿1? represents hydrogen, trityl, CH¿3?, CR¿a?R¿b?COORY¿c? where R¿a? and R¿b? independently ...  
WO/2004/037832A1
The present invention provides an improved process for the preparation of cefixime of formula (I) from the corresponding alkyl ester, with an improved quality having/possessing better color and solubility. The ester hydrolysis is carried...  
WO/2004/035593A1
The present invention relates to an improved process for the preparation of cefadroxil of the Formula (I), more particularly, the present invention relates to an improved process for the preparation of cefadroxil having water content in ...  
WO/2004/035800A2
Disclosed are salts of the general formula (I) wherein R1, R2 and as defined in the description and a process for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.  
WO/2004/033464A1
The invention relates to a process for enrichment of the (Z)-isomer amount in a mixture of the (Z)- and (E)- isomers of 7-amino-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid.  
WO2003093278A3
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...  
WO/2004/026882A1
The invention provides both a process for the preparation of compounds represented by the general formula (I), pharmaceutically acceptable salts thereof, or solvates of both: (I) [wherein R1 and R2 are each independently optionally subst...  
WO/2004/016623A1
7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetami do]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this inventi...  
WO/2004/013097A1
The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula (I), wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * rep...  
WO/2004/011471A1
The present invention relates to a process for the preparation of cephem esters.  
WO/2004/007505A1
A compound of formula (IA) or of formula (IB), wherein the substituents have various meanings, useful as a pharmaceutical.  
WO/2004/000848A1
The present invention relates to a new process for the preparation of cephalosporin derivative of formula (I) wherein R¿1? represents p-methoxybenzyl, p-nitrobenzyl, o-chlorobenzyl or diphenylmethyl; R¿2? represents CH¿3? or CR?a¿R?b...  
WO/2004/000323A1
A medicinal composition for injection characterized by containing the following ingredients (A) and (B). It is useful as a highly practical injection which has high storage stability and does not become turbid upon re-dissolution. A comp...  
WO2003011871A3
A salt of PACA with an amidine and its use in the production of cefprozil. [6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]ami no]-8-oxo-3-(1-propenyl)-3-thia-1-azabicyclo[4.2.0]oct-2-ene -2carboxylic acid; (Formula I).  
WO2002068678A3
Provided are fluorescent substrates for beta-lactamases having general formula (I), in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ...  
WO/2003/099826A1
The present invention provides a process for the preparation of Cefditoren of formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV), where R3 is hydrogen or trimethylsilyl with thioester deriva...  
WO/2003/093278A2
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...  
WO/2003/091230A1
The present invention provides a process for the preparation of 4−methyl−5−formyl−thiazole of the formula (I), which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodi...  
WO/2003/091261A1
The present invention relates to a process for the preparation of cefdinir on an industrial scale.  
WO/2003/089406A1
The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) wherein R1 represents CH3, CRaRbCOORc where Ra and Rb independently represent hydrogen or methyl and Rc rep...  
WO/2003/087105A1
Compounds of formula (I): wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-ß-lactamase enzymes, fo...  
WO2002083634A3
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.  
WO/2003/080543A1
A process for producing a cyclic compound, i.e., a ß-lactam compound, represented by the following formula (3), which comprises the step of reacting a compound represented by the following formula (1) with 2 to 5 mol of a trialkyl phosp...  
WO/2003/078440A1
Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T ...  
WO/2003/076640A3
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/076640A2
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/072582A1
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compo...  
WO2003031449A3
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...  
WO/2003/064430A1
A crystalline hydrochloride of the compound 7-&lcub [5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxy-imino)acetyl]a mino&rcub -3-[(imino-1-piperazinylmethyly)methylhydrazano]-methyl-3-ce phem-4carboxylic acid and the pharmaceutical use ther...  
WO/2003/059914A1
The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxyli c acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) repre...  
WO/2003/059908A1
The present invention provides new thioester derivatives of thiazolyl acetic acid of general formula (I), wherein, R¿1? represents H, trityl, CH¿3?, CR¿a?R¿b?COOR¿2? (R¿a? and R¿b? independently of one another represents hydrogen ...  
WO/2003/055892A1
The invention relates to a process for the stabilization of an acidic aqueous phase comprising cephradine, HCl, water and residual dichloromethane in solution, wherein the aqueous phase is subjected to a vacuum distillation. The inventio...  
WO/2003/055893A1
The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presenc...  
WO/2003/053522A1
The invention described herein relates to the treatment of a range of bacterial infecions in companion animals, in particular cats and dogs, with a $(g)b-lactam derivative, compound of Fornula (1). The invention is also directed to pharm...  
WO/2003/050125A1
The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base. Formula (I)  
WO/2003/050124A1
The present invention relates to a novel crystalline cefdinir potassium dihydrate, to a process for its preparation and to a method of preparing pure cefdinir via the crystalline salt.  
WO2002046199A8
This invention relates a process for preparing a compound of formula (I) wherein R<1> is para-nitrobenzyl or allyl; and X is halo, which is useful to prepare 3-cyclic-ether-substituted cephalosporins, from trimethylphosphinic compounds. ...  
WO/2003/042219A1
The compounds of the general formula (I) wherein R?1¿ denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R?2¿ denotes a pharmaceutically acceptable group which is ...  
WO2003020732A3
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta -lactamase enzymes, for enhancing the ...  
WO/2003/040116A1
A process for the preparation of salts of organic nitrogen bases with carboxylic acids of general formula (I), wherein Q and R have the meanings defined in the disclosure, useful for the preparation of cephalosporins side chains.  
WO/2003/040148A1
A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido] -3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).  
WO/2003/031451A1
The present invention relates to a method for preparing crystals of 7-aminocephalosporanic acid from 7-aminocephalosporanic acid solution by using additive and acid. The crystals of 7-aminocephalosporanic acid prepared according to the p...  
WO/2003/031450A1
The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.  
WO/2003/031449A2
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...  
WO/2003/024977A1
The present invention relates to a process for the preparation of crystalline cefuroxime axetil with high purity lecel and optimal diastereomeric ratio. Said process, which comprises the use of a dimethyl carbonate for isolating crystall...  
WO/2003/020732A2
The invention provides compounds of formula (I): wherein: R¿1?-R¿4? and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting $g(b)-lactamase enzymes, for enhancin...  
WO2002059272A3
Described are compounds having the formula: H1-Y-H2 where H1 is a substrate capable of selectively binding to a first receptor; where H2 is a substrate capable of selectively binding to and selectively forming a covalent bond with a seco...  
WO/2003/014126A1
A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent l-acetoxyethyl bromide and responsible for the formation o...  
WO2002070016A8  

Matches 251 - 300 out of 6,533