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Patent Searching and Data


Matches 251 - 300 out of 6,498

Document Document Title
WO/2003/099826A1
The present invention provides a process for the preparation of Cefditoren of formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV), where R3 is hydrogen or trimethylsilyl with thioester deriva...  
WO2003011871A3
A salt of PACA with an amidine and its use in the production of cefprozil. [6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]ami no]-8-oxo-3-(1-propenyl)-3-thia-1-azabicyclo[4.2.0]oct-2-ene -2carboxylic acid; (Formula I).  
WO2002068678A3
Provided are fluorescent substrates for beta-lactamases having general formula (I), in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ...  
WO/2003/093278A2
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...  
WO/2003/091261A1
The present invention relates to a process for the preparation of cefdinir on an industrial scale.  
WO/2003/091230A1
The present invention provides a process for the preparation of 4−methyl−5−formyl−thiazole of the formula (I), which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodi...  
WO/2003/089406A1
The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) wherein R1 represents CH3, CRaRbCOORc where Ra and Rb independently represent hydrogen or methyl and Rc rep...  
WO/2003/087105A1
Compounds of formula (I): wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-ß-lactamase enzymes, fo...  
WO2002083634A3
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.  
WO/2003/080543A1
A process for producing a cyclic compound, i.e., a ß-lactam compound, represented by the following formula (3), which comprises the step of reacting a compound represented by the following formula (1) with 2 to 5 mol of a trialkyl phosp...  
WO/2003/078440A1
Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T ...  
WO/2003/076640A3
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/076640A2
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/072582A1
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compo...  
WO2003031449A3
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...  
WO/2003/064430A1
A crystalline hydrochloride of the compound 7-&lcub [5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxy-imino)acetyl]a mino&rcub -3-[(imino-1-piperazinylmethyly)methylhydrazano]-methyl-3-ce phem-4carboxylic acid and the pharmaceutical use ther...  
WO/2003/059908A1
The present invention provides new thioester derivatives of thiazolyl acetic acid of general formula (I), wherein, R¿1? represents H, trityl, CH¿3?, CR¿a?R¿b?COOR¿2? (R¿a? and R¿b? independently of one another represents hydrogen ...  
WO/2003/059914A1
The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxyli c acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) repre...  
WO/2003/055893A1
The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presenc...  
WO/2003/055892A1
The invention relates to a process for the stabilization of an acidic aqueous phase comprising cephradine, HCl, water and residual dichloromethane in solution, wherein the aqueous phase is subjected to a vacuum distillation. The inventio...  
WO/2003/053522A1
The invention described herein relates to the treatment of a range of bacterial infecions in companion animals, in particular cats and dogs, with a $(g)b-lactam derivative, compound of Fornula (1). The invention is also directed to pharm...  
WO/2003/050125A1
The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base. Formula (I)  
WO/2003/050124A1
The present invention relates to a novel crystalline cefdinir potassium dihydrate, to a process for its preparation and to a method of preparing pure cefdinir via the crystalline salt.  
WO2002046199A8
This invention relates a process for preparing a compound of formula (I) wherein R<1> is para-nitrobenzyl or allyl; and X is halo, which is useful to prepare 3-cyclic-ether-substituted cephalosporins, from trimethylphosphinic compounds. ...  
WO/2003/042219A1
The compounds of the general formula (I) wherein R?1¿ denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R?2¿ denotes a pharmaceutically acceptable group which is ...  
WO2003020732A3
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta -lactamase enzymes, for enhancing the ...  
WO/2003/040148A1
A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido] -3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).  
WO/2003/040116A1
A process for the preparation of salts of organic nitrogen bases with carboxylic acids of general formula (I), wherein Q and R have the meanings defined in the disclosure, useful for the preparation of cephalosporins side chains.  
WO/2003/031451A1
The present invention relates to a method for preparing crystals of 7-aminocephalosporanic acid from 7-aminocephalosporanic acid solution by using additive and acid. The crystals of 7-aminocephalosporanic acid prepared according to the p...  
WO/2003/031450A1
The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.  
WO/2003/031449A2
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...  
WO/2003/024977A1
The present invention relates to a process for the preparation of crystalline cefuroxime axetil with high purity lecel and optimal diastereomeric ratio. Said process, which comprises the use of a dimethyl carbonate for isolating crystall...  
WO/2003/020732A2
The invention provides compounds of formula (I): wherein: R¿1?-R¿4? and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting $g(b)-lactamase enzymes, for enhancin...  
WO2002070016A8  
WO2002059272A3
Described are compounds having the formula: H1-Y-H2 where H1 is a substrate capable of selectively binding to a first receptor; where H2 is a substrate capable of selectively binding to and selectively forming a covalent bond with a seco...  
WO/2003/014126A1
A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent l-acetoxyethyl bromide and responsible for the formation o...  
WO/2003/011871A2
A salt of PACA with an amidine and its use in the production of cefprozil. [6R-[6&agr ,7β(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-( 1-propenyl)-3-thia-1-azabicyclo[4.2.0]oct-2-ene-2carboxylic acid; (Formula I).  
WO/2003/010170A1
An improved method for synthesis of cefuroxime axetil of formula (I) in high purity substantially free of the corresponding 2-cephem($g(D)?2¿)-ester of formula (II) and other impurities. The compound produced is valuable as a prodrug es...  
WO2002085914A3
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula (III) into a 3-thiolated- alpha -ketoadipyl-7-aminocephalosporanic acid derivative...  
WO/2003/004477A1
Compounds of formula (I) wherein X is halogen and R1 is alkyl or phenyl, are useful for the preparation of cephalosporins of the formula (VI) through acylation and thiourea cyclisation.  
WO2002086143A3
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula ...  
WO/2002/098884A1
High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt o...  
WO/2002/096430A1
The invention relates to a compound and/or pharmaceutically acceptable salts, esters, hydrates or solvates thereof, having the structural formula (1) or (2): (Please insert formulas 1 and 2)wherein:- X and Y are independently selected fr...  
WO/2002/090364A1
The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R?1¿ is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, ...  
WO/2002/088147A1
A high-quality sulfate of a cephem compound (I) represented by the following formula; a solvate of the sulfate; or crystals of the sulfate or solvate. The sulfate is useful as a medicine, e.g., an injection. (I)  
WO/2002/085913A1
A penicillin and cephalosporin compound having a phenylacetic acid or phenoxyacetic acid content of 100 ppm or lower; and a process for producing a penicillin and cephalosporin compound which comprises extracting two or more times phenyl...  
WO/2002/085914A2
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula (III) into a 3-thiolated-$g(a)-ketoadipyl-7-aminocephalosporanic acid derivative o...  
WO/2002/086143A2
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula ...  
WO/2002/083692A1
A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl prote...  
WO/2002/083634A2
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.  

Matches 251 - 300 out of 6,498