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Matches 251 - 300 out of 6,577

Document Document Title
WO/2004/056834A1
A process for the preparation of cefpodoxime proxetil of formula (I), of high purity conforming to pharmacopoeial specifications is disclosed. The process comprises a) adding hydrogen halide to a solution of impure cefpodoxime proxetil i...  
WO/2004/050663A2
The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).  
WO2003040116A8
A process for the preparation of salts of organic nitrogen bases with carboxylic acids of general formula (I), wherein Q and R have the meanings defined in the disclosure, useful for the preparation of cephalosporins side chains.  
WO/2004/048387A1
An improved process for the preparation of cefpodoxime proxetil of the formula (I) the said process comprises reacting cefpodoxime acid with 1-haloethyl isopropyl carbonate of the formula (VI) where X represents halogen atom such as chlo...  
WO/2004/046154A1
A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of :i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XII...  
WO/2004/046153A1
The invention relates to prodrug esters of ceftriaxone. The invention also relates to processes for preparing prodrug esters of ceftriaxone, pharmaceutical compositions that include the prodrug esters and to methods for using the prodrug...  
WO/2004/045536A2
A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject are disclosed. The modified compounds a...  
WO/2004/045533A2
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious par...  
WO/2004/041831A1
The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).  
WO/2004/039814A1
The present invention relates to a compound of the formula [I]: wherein R¿1? is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R¿2? is hydrogen or amino protecting group, or R¿1? and R¿2? are bonded together and form lower...  
WO/2004/039997A1
A process for preparing the 7-(1-H-tetrazol-1-yl) acetamide-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cep hem-4-carboxylic acid or cefazolin, comprising catalysing the acylation of the amino β-lactam, the 7-amino-3-[5methyl-1,3,4-t...  
WO/2004/039813A1
The present invention provides an improved process to produce the chloromethylcephem derivatives of the formula (I), wherein R¿1? represents a carboxy-protecting group viz., substituted methyl group, which can be deprotected easily, suc...  
WO/2004/039811A2
A process for preparation of ceftiofur of formula (I) of high purity and substantially free from impurities is disclosed. The process comprises reacting [2-(2-aminothiazol-4-yl)]-2-syn-methoxyimino acetic acid-2-benzothiazolyl thioester ...  
WO/2004/039812A1
The present invention relates to an improved process for the preparation of 3-propenyl cephalosporin DMF solvate, more particularly, the present invention relates to an improved process for the preparation of cefprozil DMF solvate of the...  
WO/2004/037163A2
6(7)-β-substituted β-lactam compounds as inhibitors of β-lactamase activity.  
WO/2004/037833A1
The present invention more particularly relates to a process for the preparation of cephalosporin antibiotics of the formula (I) wherein R¿1? represents hydrogen, trityl, CH¿3?, CR¿a?R¿b?COORY¿c? where R¿a? and R¿b? independently ...  
WO/2004/037832A1
The present invention provides an improved process for the preparation of cefixime of formula (I) from the corresponding alkyl ester, with an improved quality having/possessing better color and solubility. The ester hydrolysis is carried...  
WO/2004/035593A1
The present invention relates to an improved process for the preparation of cefadroxil of the Formula (I), more particularly, the present invention relates to an improved process for the preparation of cefadroxil having water content in ...  
WO/2004/035800A2
Disclosed are salts of the general formula (I) wherein R1, R2 and as defined in the description and a process for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.  
WO/2004/033464A1
The invention relates to a process for enrichment of the (Z)-isomer amount in a mixture of the (Z)- and (E)- isomers of 7-amino-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid.  
WO2003093278A3
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...  
WO/2004/026882A1
The invention provides both a process for the preparation of compounds represented by the general formula (I), pharmaceutically acceptable salts thereof, or solvates of both: (I) [wherein R1 and R2 are each independently optionally subst...  
WO/2004/016623A1
7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetami do]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this inventi...  
WO/2004/013097A1
The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula (I), wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * rep...  
WO/2004/011471A1
The present invention relates to a process for the preparation of cephem esters.  
WO/2004/007505A1
A compound of formula (IA) or of formula (IB), wherein the substituents have various meanings, useful as a pharmaceutical.  
WO/2004/000848A1
The present invention relates to a new process for the preparation of cephalosporin derivative of formula (I) wherein R¿1? represents p-methoxybenzyl, p-nitrobenzyl, o-chlorobenzyl or diphenylmethyl; R¿2? represents CH¿3? or CR?a¿R?b...  
WO/2004/000323A1
A medicinal composition for injection characterized by containing the following ingredients (A) and (B). It is useful as a highly practical injection which has high storage stability and does not become turbid upon re-dissolution. A comp...  
WO2003011871A3
A salt of PACA with an amidine and its use in the production of cefprozil. [6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]ami no]-8-oxo-3-(1-propenyl)-3-thia-1-azabicyclo[4.2.0]oct-2-ene -2carboxylic acid; (Formula I).  
WO2002068678A3
Provided are fluorescent substrates for beta-lactamases having general formula (I), in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ...  
WO/2003/099826A1
The present invention provides a process for the preparation of Cefditoren of formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV), where R3 is hydrogen or trimethylsilyl with thioester deriva...  
WO/2003/093278A2
The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), its pharmaceutically acceptable salt such as sodium or hydrochloride and also provides two new intermediates of formulae (V) and (VI) whe...  
WO/2003/091230A1
The present invention provides a process for the preparation of 4−methyl−5−formyl−thiazole of the formula (I), which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodi...  
WO/2003/091261A1
The present invention relates to a process for the preparation of cefdinir on an industrial scale.  
WO/2003/089406A1
The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) wherein R1 represents CH3, CRaRbCOORc where Ra and Rb independently represent hydrogen or methyl and Rc rep...  
WO/2003/087105A1
Compounds of formula (I): wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-ß-lactamase enzymes, fo...  
WO2002083634A3
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.  
WO/2003/080543A1
A process for producing a cyclic compound, i.e., a ß-lactam compound, represented by the following formula (3), which comprises the step of reacting a compound represented by the following formula (1) with 2 to 5 mol of a trialkyl phosp...  
WO/2003/078440A1
Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T ...  
WO/2003/076640A3
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/076640A2
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...  
WO/2003/072582A1
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compo...  
WO2003031449A3
This invention provides cross-linked glycopeptide cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...  
WO/2003/064430A1
A crystalline hydrochloride of the compound 7-&lcub [5-amino-1,2,4-thiadiazol-3-yl-(fluoromethoxy-imino)acetyl]a mino&rcub -3-[(imino-1-piperazinylmethyly)methylhydrazano]-methyl-3-ce phem-4carboxylic acid and the pharmaceutical use ther...  
WO/2003/059914A1
The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxyli c acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) repre...  
WO/2003/059908A1
The present invention provides new thioester derivatives of thiazolyl acetic acid of general formula (I), wherein, R¿1? represents H, trityl, CH¿3?, CR¿a?R¿b?COOR¿2? (R¿a? and R¿b? independently of one another represents hydrogen ...  
WO/2003/055892A1
The invention relates to a process for the stabilization of an acidic aqueous phase comprising cephradine, HCl, water and residual dichloromethane in solution, wherein the aqueous phase is subjected to a vacuum distillation. The inventio...  
WO/2003/055893A1
The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl) thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presenc...  
WO/2003/053522A1
The invention described herein relates to the treatment of a range of bacterial infecions in companion animals, in particular cats and dogs, with a $(g)b-lactam derivative, compound of Fornula (1). The invention is also directed to pharm...  
WO/2003/050125A1
The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base. Formula (I)  

Matches 251 - 300 out of 6,577