Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 251 - 300 out of 6,422

Document Document Title
WO/2002/086143A2
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula ...  
WO/2002/083692A1
A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl prote...  
WO/2002/083634A2
The present invention relates to an improved and cost effective process for the industrial preparation of cefpodoxime acid of Formula (I) and a pharmaceutically acceptable ester thereof.  
WO/2002/070017A1
The invention relates to novel conjugates of beta-lactam antibiotics of the general formula (I) with tetra- or hexadentate iron chelators or the acylated derivatives thereof as siderophore components, derived from amino acids or peptides...  
WO/2002/070016A2  
WO/2002/068678A2
Provided are fluorescent substrates for β-lactamases having general formula (I), in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, es...  
WO/2002/068428A1
High purity cephalosporin compound can be easily prepared in a high yield by a process comprising the steps of: reacting a cephem compound with a 4-hydroxyphenylglycine derivative.  
WO/2002/068429A1
The present invention relates to an improved and cost effective process for the industrial manufacture of cefpodoxime proxetil. More specifically, the present invention relates to the preparation of cefpodoxime proxetil of high purity an...  
WO/2002/067943A1
The present invention relates to a stable pharmaceutical composition of cefpodoxime proxetil, for oral administration.  
WO/2002/060866A2
The present invention relates to an improved and industrially advantageous process for the preparation of pure 7-amino-3-alkoxymethyl-3-cephem-4-carboxylic acids, and salts thereof. In particular, the present invention relates to a proce...  
WO/2002/059272A2
Described are compounds having the formula: H1-Y-H2 where H1 is a substrate capable of selectively binding to a first receptor; where H2 is a substrate capable of selectively binding to and selectively forming a covalent bond with a seco...  
WO/2002/053563A1
The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), also, the invention provides a method for preparation of the thioester derivatives and reaction of the thioester derivatives ...  
WO/2002/046199A1
This invention relates a process for preparing a compound of formula (I) wherein R?1¿ is para-nitrobenzyl or allyl; and X is halo, which is useful to prepare 3-cyclic-ether-substituted cephalosporins, from trimethylphosphinic compounds....  
WO/2002/046198A1
This invention relates to a novel process for the preparation of 3-cyclic-ether-substituted cephalosporins of formula (I): wherein the group CO¿2?-R?1¿ is a carboxylic acid or a carboxylate salt and R2 has the formula (a): wherein A?1...  
WO/2002/042266A2
Ceftiofur in the form of a sodium salt which is practically free of organic solvent and a process for its production.  
WO/2002/024707A1
Cephem compounds of the general formula (I) or their pharmaceutically acceptable salts: (I) wherein R¿1? and R¿2? are each independently hydrogen, nitro, or cyano; R¿3? is optionally carboxylated C¿1-6? alkyl; R¿4? is hydrogen or am...  
WO/2002/024708A1
The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimin o)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid- 4-ylthio}-3-cephem-4-carbocyllic acid, where t...  
WO/2002/020532A1
Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.  
WO/2002/017854A2
The present invention relates to novel cephalosporin antibiotics, prodrugs thereof and pharmacologically acceptable salts of either, which are active against a wide spectrum of bacteria that are resistant to present clinical beta-lactam ...  
WO/2002/016372A1
Disclosed is a method for preparation of amorphous cefuroxime axetil. The amorphous cefuroxime axetil can be prepared by (a) obtaining a reaction mixture by reacting sodium cefuroxima with (R, S)-1-acetoxylethylbromide at -10 °C to 0 °...  
WO/2002/014332A1
New process for the preparation of bipyrrolidinyl compounds of formula I wherein * signifies an asymmetric centre with an (R) or (S) configuration and X represents chlorine, bromine or iodine. The compounds of formula I are important bui...  
WO/2002/014333A1
A cephem compound which is represented by the formula (1): (1) wherein X represents CH¿3?COOH, CH¿3?CH¿2?COOH or CH¿3?CN and n represents 0 to 5. The cephem compound (in particular, crystals thereof) is useful as an antibacterial age...  
WO/2002/006289A1
A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.  
WO/2002/004463A1
The present invention relates to a novel cephalosporin compound and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition containing the compou...  
WO/2002/004464A1
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition containing the compo...  
WO/2002/000616A2
The present invention relates to a novel cephalosporin compound in which thiomethylthio chain is introduced into C-3 position of cephem ring and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, sol...  
WO/2001/098309A1
A novel industrial process for preparing 7-[2-(2- amino- thiazol-4-yl)-2-lower-alkoxycarbonylmethoxyiminoacetamido] 3-cephem compounds of the general formula (I) or salts thereof (wherein R?1¿ is an organic group; R?2¿ is carboxyl or p...  
WO/2001/092254A1
The problem of how to replace an organic solvent contained in clathrate crystals with water without causing transition of the crystals is solved by using a fluidizing means under a humidity-conditioned atmosphere, the clathrate crystals ...  
WO/2001/090111A1
The invention relates to a new process for the preparation of a vinyl-pyrrolidinone cephalosporine derivative of formula (I). The compound of formula (I), prepared according to the invention, can be used for the treatment and prophylaxis...  
WO/2001/087299A1
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is admin...  
WO/2001/087893A1
There is described a process for the preparation of a pure and pharmacopoeial amorphous form of cefuroxime axetil which involves dissolving crystalline cefuroxime axetil in acetic acid and recovering amorphous form of cefuroxime axetil f...  
WO/2001/083492A1
The present invention provides compositions comprising improved beta-lactam antibiotics and methods for applying these compositions to inhibit the growth of microbial infections. The improved antibiotics are capable of inhibiting the gro...  
WO/2001/083491A1
A process and intermediates in the production of cefotiam (hexetil).  
WO/2001/079211A1
A process for the preparation of a 3-vinylcephem compound, characterized by treating a protected 3-vinylcephem derivative of the general formula (1) in an organic solvent in the presence of a perhalogenic acid and an organic protonic aci...  
WO/2001/079210A2
Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20 $...  
WO/2001/070749A1
The present invention relates to a new, simple, and easy process for preparing cephalosporin antibiotics of the formula (I), such as ceftazidime and cefixime. The process comprises acylating a 7-amino cephalosporanic acid derivative of t...  
WO/2001/066528A1
A method of improving the stability of a quaternary ammonium salt; and a process for efficiently producing the quaternary ammonium salt having improved stability.  
WO/2001/066532A1
The present invention relates to a new crystalline aminothiazole derivative represented by the following formula (I) which is very useful for the preparation of cephalosporin antibiotics, including ceftazidime and cefixime, etc: wherein ...  
WO/2001/064687A1
The present invention provides compositions and methods for targeting toxic anti-metabolites to inhibit the growth of antibiotic resistant microbial infections. It provides a means of taking advantage of a key disease resistance mechanis...  
WO/2001/060828A1
The present invention relates to novel processes for the preparation of 3-methylenecephams. More specifically, the present invention relates in part to the intramolecular cyclization of penicillin sulfoxide derived monocyclic azetidinone...  
WO/2001/054691A1
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.  
WO/2001/034611A1
Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.  
WO/2001/030783A1
Process for the preparation of a $g(b)-lactam antibiotic by acylation of a $g(b)-lactam nucleus with the aid of an acylating agent, use being made of a complexing agent, and the acylating agent containing L-isomer and an aldehyde being a...  
WO/2001/027117A1
7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfon...  
WO/2001/023393A1
A method for preparing crystals of a 3-cephem derivative, characterized in that it comprises subjecting a 3-cephem derivative in the form of an amorphous powder or an oil to a crystallization by the use of a good solvent and a poor solve...  
WO/2001/021622A1
A process for the preparation of 3-sulfonyloxy-3-cephem compounds of general formula (3), characterized by reacting a 3-hydroxy-3-cephem compound of general formula (1) with a sulfonic acid halide of general formula (2) :R?4¿SO¿2?x, in...  
WO/2001/021623A1
The present invention includes novel (7R)-7-acylamino-3-heteroarylthio-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts and prodrugs thereof, which exhibit antibiotic activity against a wide spectrum of organisms i...  
WO/2001/016140A1
A process for the preparation of 3-alkenylcephem or 3-norcephem compounds represented by general formula (3), characterized by treating a 3-cephem compound of general formula (1) in a solvent with an alkenyl halide of general formula (2)...  
WO/2001/010410A1
A non-crystalline cefuroxime axetil solid dispersant is prepared by (a) dissolving cefuroxime axetil and a surfactant in an organic solvent; (b) suspending a water-insoluble inorganic carrier in the resulting solution; and (c) drying the...  
WO/2001/009143A1
A novel process for the production of an improved amorphous form of cefpodoxime proxetil [(6R-[6$g(a), 7$g(b) (Z))]-7-{E(2-Amino-4-thiazolyl) (methoxy-imino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia- 1-azabicyclo [4.2.0] oct-2-ene-2-c...  

Matches 251 - 300 out of 6,422