Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 251 - 300 out of 2,761

Document Document Title
WO/2002/067943
The present invention relates to a stable pharmaceutical composition of cefpodoxime proxetil, for oral administration.  
WO/2002/060866
The present invention relates to an improved and industrially advantageous process for the preparation of pure 7-amino-3-alkoxymethyl-3-cephem-4-carboxylic acids, and salts thereof. In particular, the present invention relates to a proce...  
WO/2002/059272
Described are compounds having the formula: H1-Y-H2 where H1 is a substrate capable of selectively binding to a first receptor; where H2 is a substrate capable of selectively binding to and selectively forming a covalent bond with a seco...  
WO/2002/053563
The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), also, the invention provides a method for preparation of the thioester derivatives and reaction of the thioester derivatives ...  
WO/2002/046199
This invention relates a process for preparing a compound of formula (I) wherein R?1¿ is para-nitrobenzyl or allyl; and X is halo, which is useful to prepare 3-cyclic-ether-substituted cephalosporins, from trimethylphosphinic compounds....  
WO/2002/046198
This invention relates to a novel process for the preparation of 3-cyclic-ether-substituted cephalosporins of formula (I): wherein the group CO¿2?-R?1¿ is a carboxylic acid or a carboxylate salt and R2 has the formula (a): wherein A?1...  
WO/2002/042266
Ceftiofur in the form of a sodium salt which is practically free of organic solvent and a process for its production.  
WO/2002/024707
Cephem compounds of the general formula (I) or their pharmaceutically acceptable salts: (I) wherein R¿1? and R¿2? are each independently hydrogen, nitro, or cyano; R¿3? is optionally carboxylated C¿1-6? alkyl; R¿4? is hydrogen or am...  
WO/2002/024708
The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimin o)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid- 4-ylthio}-3-cephem-4-carbocyllic acid, where t...  
WO/2002/020532
Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.  
WO/2002/017854
The present invention relates to novel cephalosporin antibiotics, prodrugs thereof and pharmacologically acceptable salts of either, which are active against a wide spectrum of bacteria that are resistant to present clinical beta-lactam ...  
WO/2002/016372
Disclosed is a method for preparation of amorphous cefuroxime axetil. The amorphous cefuroxime axetil can be prepared by (a) obtaining a reaction mixture by reacting sodium cefuroxima with (R, S)-1-acetoxylethylbromide at -10 °C to 0 °...  
WO/2002/014332
New process for the preparation of bipyrrolidinyl compounds of formula I wherein * signifies an asymmetric centre with an (R) or (S) configuration and X represents chlorine, bromine or iodine. The compounds of formula I are important bui...  
WO/2002/014333
A cephem compound which is represented by the formula (1): (1) wherein X represents CH¿3?COOH, CH¿3?CH¿2?COOH or CH¿3?CN and n represents 0 to 5. The cephem compound (in particular, crystals thereof) is useful as an antibacterial age...  
WO/2002/006289
A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.  
WO/2002/004463
The present invention relates to a novel cephalosporin compound and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition containing the compou...  
WO/2002/004464
The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition containing the compo...  
WO/2002/000616
The present invention relates to a novel cephalosporin compound in which thiomethylthio chain is introduced into C-3 position of cephem ring and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, sol...  
WO/2001/098309
A novel industrial process for preparing 7-[2-(2- amino- thiazol-4-yl)-2-lower-alkoxycarbonylmethoxyiminoacetamido] 3-cephem compounds of the general formula (I) or salts thereof (wherein R?1¿ is an organic group; R?2¿ is carboxyl or p...  
WO/2001/092254
The problem of how to replace an organic solvent contained in clathrate crystals with water without causing transition of the crystals is solved by using a fluidizing means under a humidity-conditioned atmosphere, the clathrate crystals ...  
WO/2001/090111
The invention relates to a new process for the preparation of a vinyl-pyrrolidinone cephalosporine derivative of formula (I). The compound of formula (I), prepared according to the invention, can be used for the treatment and prophylaxis...  
WO/2001/087299
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is admin...  
WO/2001/087893
There is described a process for the preparation of a pure and pharmacopoeial amorphous form of cefuroxime axetil which involves dissolving crystalline cefuroxime axetil in acetic acid and recovering amorphous form of cefuroxime axetil f...  
WO/2001/083492
The present invention provides compositions comprising improved beta-lactam antibiotics and methods for applying these compositions to inhibit the growth of microbial infections. The improved antibiotics are capable of inhibiting the gro...  
WO/2001/083491
A process and intermediates in the production of cefotiam (hexetil).  
WO/2001/079211
A process for the preparation of a 3-vinylcephem compound, characterized by treating a protected 3-vinylcephem derivative of the general formula (1) in an organic solvent in the presence of a perhalogenic acid and an organic protonic aci...  
WO/2001/079210
Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20 $...  
WO/2001/070749
The present invention relates to a new, simple, and easy process for preparing cephalosporin antibiotics of the formula (I), such as ceftazidime and cefixime. The process comprises acylating a 7-amino cephalosporanic acid derivative of t...  
WO/2001/066528
A method of improving the stability of a quaternary ammonium salt; and a process for efficiently producing the quaternary ammonium salt having improved stability.  
WO/2001/066532
The present invention relates to a new crystalline aminothiazole derivative represented by the following formula (I) which is very useful for the preparation of cephalosporin antibiotics, including ceftazidime and cefixime, etc: wherein ...  
WO/2001/064687
The present invention provides compositions and methods for targeting toxic anti-metabolites to inhibit the growth of antibiotic resistant microbial infections. It provides a means of taking advantage of a key disease resistance mechanis...  
WO/2001/060828
The present invention relates to novel processes for the preparation of 3-methylenecephams. More specifically, the present invention relates in part to the intramolecular cyclization of penicillin sulfoxide derived monocyclic azetidinone...  
WO/2001/054691
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.  
WO/2001/034611
Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.  
WO/2001/030783
Process for the preparation of a $g(b)-lactam antibiotic by acylation of a $g(b)-lactam nucleus with the aid of an acylating agent, use being made of a complexing agent, and the acylating agent containing L-isomer and an aldehyde being a...  
WO/2001/027117
7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfon...  
WO/2001/027117
7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfon...  
WO/2001/023393
A method for preparing crystals of a 3-cephem derivative, characterized in that it comprises subjecting a 3-cephem derivative in the form of an amorphous powder or an oil to a crystallization by the use of a good solvent and a poor solve...  
WO/2001/021622
A process for the preparation of 3-sulfonyloxy-3-cephem compounds of general formula (3), characterized by reacting a 3-hydroxy-3-cephem compound of general formula (1) with a sulfonic acid halide of general formula (2) :R?4¿SO¿2?x, in...  
WO/2001/021623
The present invention includes novel (7R)-7-acylamino-3-heteroarylthio-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts and prodrugs thereof, which exhibit antibiotic activity against a wide spectrum of organisms i...  
WO/2001/016140
A process for the preparation of 3-alkenylcephem or 3-norcephem compounds represented by general formula (3), characterized by treating a 3-cephem compound of general formula (1) in a solvent with an alkenyl halide of general formula (2)...  
WO/2001/010410
A non-crystalline cefuroxime axetil solid dispersant is prepared by (a) dissolving cefuroxime axetil and a surfactant in an organic solvent; (b) suspending a water-insoluble inorganic carrier in the resulting solution; and (c) drying the...  
WO/2001/009143
A novel process for the production of an improved amorphous form of cefpodoxime proxetil [(6R-[6$g(a), 7$g(b) (Z))]-7-{E(2-Amino-4-thiazolyl) (methoxy-imino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia- 1-azabicyclo [4.2.0] oct-2-ene-2-c...  
WO/2001/009135
An industrially excellent novel process for the preparation of addition salts of basic antibiotics with inorganic acids (such as hydrochloric acid), by subjecting a basic antibiotic-oxalic acid addition salt (II) to salt-exchange with an...  
WO/2001/007443
A process for the preparation of Cefuroxime acid or of a corresponding pharmaceutically acceptable salt or ester, by reaction of a 3-hydroxymethylceph-3-em precursor thereof with activated isocyanates in carbonic acid esters.  
WO/2001/004127
The invention is concerned with cephalosporin derivatives of general formula (I) wherein X is chlorine, bromine, fluorine, trifluoromethyl, methyl, carboxy or hydroximethyl; R?1¿ is hydrogen or lower alkanoyl; R?2¿ is hydrogen or an in...  
WO/2001/004126
A method for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethyl formamide solvate using a mixture of a lower alkanol and water.  
WO/2000/071547
A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclose...  
WO/2000/068234
A new process is described for the preparation of cefpodoxime acid, which may then be converted into cefpodoxime proxetil by methods known in the art.  
WO/2000/066594
Crystalline 7-[2-(2-formylaminothiazol-4-yl)- 2-(Z)-(methoxyimino)acetamido]- 3-methoxy-methyl-3- cephem-4-carboxylic acid- 1-(isopropoxycarbonyloxy)ethyl ester and its use.  

Matches 251 - 300 out of 2,761