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Patent Searching and Data


Matches 701 - 750 out of 9,721

Document Document Title
WO/2013/005354A1
The present invention provides: a heterocyclic derivative having an excellent inhibitory activity on the production of amyloid-β; and use of the heterocyclic derivative. A compound represented by formula (I) (wherein each symbol is as d...  
WO/2012/156756A3
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful i...  
WO/2013/000086A1
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating di...  
WO/2013/000084A1
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also prov...  
WO/2013/001498A1
The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C<; R1 represents H or -CH...  
WO/2013/000532A1
The invention relates to novel organic semiconducting compounds containing one or more dialkylidene-s-indacenodiheteroarene groups, methods for their preparation and educts or intermediates used therein, polymers, blends, mixtures and fo...  
WO/2013/000543A1
This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation ther...  
WO/2012/136356A8
The present invention relates to a compound of formula (1), a pharmaceutical composition containing the compound, a method for its preparation as well as the use of the compound as hypnotic agent or anesthetic agent.  
WO/2012/175702A1
The present invention provides radiolabelled RIF derivatives that are suitable for in vivo imaging of bacterial infection. The in vivo imaging agent of the invention is preferably provided as a radiopharmaceutical composition, which form...  
WO/2012/169605A1
In the present invention, a polymer compound containing a constitutional unit represented by formula (1), formula (2), formula (3) or formula (4) can be used to produce an organic thin film solar cell having a high open end voltage. (In ...  
WO/2012/163236A1
The present invention belongs to the field of medicine and relates to a pyridothiazepine derivative and a preparation method and uses therefor. Pyridothiazepine derivatives have a wide range of antineoplastic activity, said compounds exh...  
WO/2012/159262A1
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating di...  
WO/2012/162334A1
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein R1, R2, R3, R4, R5, and R6 are independently hydrogen, C1-C6 alkyl or C1-C6 cycloalkyl; Y and Z are independently a C6-C10- aryl...  
WO/2012/162580A2
The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.  
WO/2012/161799A1
Compositions containing epidithiodioxopiprazines and methods of their use are provided. Epidithiodioxopiprazines can be isolated from natural resources or synthesized de novo. Moreover, epidithiodioxopiprazines, including Verticillin A, ...  
WO/2012/162330A1
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: formula (I), wherein X is selected from the group of CH2, O, and NR2; m = 0 or 1; R1 at each instance is selected from the group of halo...  
WO/2012/156022A1
The invention relates to novel polymers containing one or more benzo[1,2-b:4,5-b']dithiophene-4,8-dione repeating units, methods for their preparation and monomers used therein, blends, mixtures and formulations containing them, the use ...  
WO/2012/158271A1
The invention is directed to amides of bicyclic amine compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.  
WO/2012/156756A2
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful i...  
WO/2012/153768A1
The problem addressed by the present invention is to provide a novel medicinal agent for the prevention and/or treatment of a viral infection. The present invention provides a medicinal agent for the prevention and/or treatment of a vira...  
WO/2012/154194A1
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)  
WO/2012/149102A1
This invention relates to the use of acylated alanine derivatives for the modulation, notably the inhibition of the activity of WIP1. Suitably, the present invention relates to the use of acylated alanine derivatives in the treatment of ...  
WO/2012/149567A1
This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer. The meth...  
WO/2012/143599A1
Compounds of formula (I) wherein Rx, Rz, R9, R10, R14, R14', R15, R15', A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective andro...  
WO/2012/143116A1
The present invention relates to 4-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.  
WO/2012/144478A1
The present invention relates to a compound represented by general formula (I) or a pharmacologically acceptable salt thereof, which has an excellent 11β-hydroxysteroid dehydrogenase 1 inhibitory effect. (In the formula, R1 represents a...  
WO/2012/143117A1
The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.  
WO/2012/139692A1
The present invention relates to an electronic device comprising one or more compounds of a formula (I) or (II). The invention further encompasses the use of a compound according to formula (I) or (II) in an electronic device, and the pr...  
WO/2012/139693A1
The present invention relates to a compound of a formula (I) or (II), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I) or (II). The invention further rel...  
WO/2012/016925A3
The present invention provides semiconducting compounds, oligomers and polymers of formula wherein A1 and A2 can be the same or different and are S or Se, E is selected from the group consisting of The compounds, oligomers and polymers o...  
WO/2012/136356A1
The present invention relates to a compound of formula (1), a pharmaceutical composition containing the compound, a method for its preparation as well as the use of the compound as hypnotic agent or anesthetic agent.  
WO/2012/136751A1
The invention relates to N-substituted hetero-bicyclic compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these N...  
WO/2012/138945A1
Embodiments of the invention relate to the treatment of schizophrenia in mammals. Embodiments of the invention include methods for treating schizophrenia and/or symptoms of schizophrenia and/or positive symptoms of schizophrenia in a psy...  
WO/2012/138776A1
The present invention relates to compounds of formula I or II, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diab...  
WO/2012/138590A1
In its many embodiments, the present invention provides provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compound...  
WO/2012/136385A1
The present invention relates to a compound of formula 1, a pharmaceutical composition containing the compound, a method for its preparation as well as the use of the compound as neuromuscular blocker or skeletal muscle relaxant.  
WO/2012/129802A1
Pyrano[3,2-d]thiazol derivatives of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds are provided. Methods of treating di...  
WO/2012/133607A1
[Problem] To provide a compound useful for the prevention of and/or as a therapeutic agent for schizophrenia, anxiety, Huntington's disease, drug dependence, and/or Alzheimer's disease. [Solution] The inventors studied compounds having P...  
WO/2012/130780A1
The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and i...  
WO/2012/020848A8
Provided is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor potentiating action. The...  
WO/2012/126084A1
The invention relates to therapeutic compounds that bind to HSP90. The compounds disclosed herein bind HSP90 and alter the chaperoning capability of HSP90 proteins. The invention also relates to pharmaceutical compositions comprising the...  
WO/2012/126091A1
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating di...  
WO/2012/125629A1
The present invention provides substituted diamino-pyrimidine and substituted diamino-pyridine derivatives of Formula I; wherein X, Y, R1, R2, and Ar are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) an...  
WO/2012/124502A1
Provided are an MRI imaging agent and a CT imaging agent capable of further increasing the relaxivity of water molecules and having low toxicity to the human body; also provided are metal nanoparticles used as the material of these imagi...  
WO/2012/124696A1
[Problem] To provide a compound which is useful as an active ingredient of a pharmaceutical composition, especially of a pharmaceutical composition for the prophylaxis and/or treatment of VAP-1 associated diseases. [Solution] As a result...  
WO/2012/121414A1
The present invention provides a novel photochromic compound having superior durability, a rapid fading speed, and a high color-emission density, and wherein the color tone during color emission exhibits an intermediate color. The chrome...  
WO/2012/078859A3
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharm...  
WO/2012/119883A1
The present invention relates to 1,4 Thiazepines/Sulfones of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. Th...  
WO/2011/092226A8
This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of t...  
WO/2012/117048A1
The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infe...  

Matches 701 - 750 out of 9,721