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Patent Searching and Data


Matches 701 - 750 out of 10,054

Document Document Title
WO/2014/086601A1
The present invention relates to substituted 1,4-dithiine derivatives of formula I as defined in the description,and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to t...  
WO/2014/083038A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticidesand can be prepared...  
WO/2014/082380A1
Provided are fused tricyclic compounds effective to inhibit the function of the NS5A protein of formula (I), wherein X, X', Y, Y', A, A',Q1, Q2, R1-R4, X4, R5a, f and W are defined as in the description. Also provided herein are pharmace...  
WO/2014/081047A1
The present invention relates to an improved and industrially advantageous process for the preparation of (1S, 4S, 5S) -4-bromo-6-oxabicyclo [3.2.1] octan-7-one represented by the following formula (I) which is a key intermediate in the ...  
WO/2014/078372A1
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C...  
WO/2014/074932A1
The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.  
WO/2014/074657A1
Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a bicyclic heterocycle, and R1, R3, R4, R5 and R6 are as defined herein, that are useful as kinase modulators, incl...  
WO/2014/067003A1
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also prov...  
WO/2014/066132A1
The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease : wherein A is selected from the group consisting of; of; R1 is H or F; R2 is H, -OCH3, C1-C3 alkyl,; R3 is H, -...  
WO/2014/066435A1
Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.  
WO/2014/062811A2
The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods ...  
WO/2014/062044A1
Invention is related to novel compounds - fluorinated benzenesulfonamides of general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participa...  
WO/2014/059185A1
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, inde...  
WO/2014/059202A1
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikre...  
WO/2014/055548A1
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.  
WO/2013/163244A8
The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherei...  
WO/2014/022378A3
Synthesis of new class of conjugated molecules comprising electron accepting subunits that comprise, for example, naphthobisthiazole-, or naphthobisoxazole-diimides. The naphthobisazole molecules are useful for manufacturing organic elec...  
WO/2014/045162A1
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of trea...  
WO/2014/015167A3
The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth o...  
WO/2014/036105A2
Proteases such as memapsin 2 are important enzymes, playing roles in a variety of diseases including Alzheimer's Disease. The inventors have developed inhibitors of memapsin 2 and methods of use therefore in the treatment of disease.  
WO/2014/031282A1
A composition having the structure comprising formula (A): wherein Z is a halogen; wherein X is selected from the group consisting of N, O, P, S, and Se; wherein Y is selected from the group consisting of N, O, P, S and Se; and wherein R...  
WO/2014/029251A1
Disclosed are a benazepine compound and an application thereof. The benazepine compound, as a synthon for preparing a novel compound with an anti-tumor activity, results in a compound that has a significantly improved ex vivo enzyme-inhi...  
WO/2014/029250A1
Provided are a benazepine compound, a composition containing the compound and a use of the compound in the preparation of anti-tumor drugs. The benazepine compound is a compound shown in formula (I) or a pharmaceutically acceptable salt ...  
WO/2014/029832A1
P01-2864-ff 32/132 -132- ABSTRACT This invention relates to substituted 4-pyridones of formula R 1a R 7 R 6 R R 3 N O O N H R 4 R 2 R 1b A 1 and their use as inhibitors ofneutrophil elastase activity, pharmaceutical compositions containi...  
WO/2014/030743A1
Provided is a compound which has an excellent FLAP inhibitory activity and is useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, or a salt of the compound. The present invention relates to a compound represe...  
WO/2014/029684A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared...  
WO/2014/026881A1
The invention relates to imidazo[2,1-b]thiazol-3-one derivatives of formula (I) wherein the variables are as defined in the claims. It has been shown that the present compounds may be used for binding and imaging tau aggregates and relat...  
WO/2014/026244A1
The present invention relates to photoactive optoelectronic devices, such as organic photovoltaic devices, and transistor devices, and to organic compounds for use in the optoelectronic and transistor devices. The present invention also ...  
WO/2014/023815A1
The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions compris...  
WO/2014/026009A2
The application describes targets and methods that can inhibit bacterial growth in Gram-positive and Gram-negative bacteria. A bacterial enzyme, 2-epimerase, is common to both Gram-positive and Gram-negative bacteria and contains an allo...  
WO/2014/021281A1
Provided is a compound which is represented by general formula (I') and has an excellent PHD2-inhibiting activity or a pharmaceutically acceptable salt thereof. (In the general formula (I'), W, Y, R2, R3, R4 and Y4 are as defined in the ...  
WO/2014/021337A1
The present invention provides a compound and pharmaceutical composition for a neuropsychological disorder or malignant tumor, the use thereof, and a method for preventing, improving, inhibiting the progression of and/or treating a neuro...  
WO/2014/017802A1
The present invention provides a fused ring compound containing furan or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and a use thereof. Since the fused ring compo...  
WO/2014/017803A1
The present invention provides a fused ring compound containing furan or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and a use thereof. The fused ring compound co...  
WO/2012/158933A9
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.  
WO/2013/174930A3
The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diasiereomer or ...  
WO/2014/015291A1
Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as opti...  
WO/2014/015125A1
New salts of a fused aminodihydrothiazine derivative, and pharmaceutical uses thereof.  
WO/2014/013076A1
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R9 are as defined in the specification and which compound has an Αβ production inhibitory effect and may be useful as a prophylactic or therapeutic ...  
WO/2014/010325A1
The present invention is a polymerizable compound (I), a polymerizable composition containing the polymerizable compound and a polymerization initiator, a polymer obtained by polymerizing the polymerizable compound or polymerizable compo...  
WO/2014/009447A1
Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of maki...  
WO/2014/009293A1
The present invention relates to substituted thiadiazoles and the salts thereof and the use of these compounds for combating phytopathogenic fungi, and to seeds coated with at least one such compound.  
WO/2014/006402A1
The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disor...  
WO/2014/006130A1
The present invention relates to new imidazo[2,1-b]thiazole derivatives (I) having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them...  
WO/2014/006585A1
The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Y, Z, R1, R2, R3 and R4 are as described in the description and their use as prostaglandin receptor modulators, most particularly ...  
WO/2014/001782A1
The present invention relates to certain tetramic acid derivatives and, in particular, bicyclic tetramic acid derivatives that are suitable for use in the preparation and development of antimicrobial (e.g. antibacterial or antifungal) co...  
WO/2014/002969A1
A method for producing a naphtho bis thiadiazole acquires a naphtho bis thiadiazole by means of the reaction of a sulfurizing agent with a tetraamino naphthalene or a salt thereof. It is possible to industrially produce a naphtho bis thi...  
WO/2014/000686A1
Disclosed in the present invention are a Pyrimidobenzoazepine compound and the use thereof as an antitumour drug. The advantage of the present invention consists in that the compound and the pharmaceutical agent thereof have good effects...  
WO/2014/003098A1
To provide a novel compound which inhibits GSK3 and is useful for the treatment of diseases associated with GSK. Provided is a compound represented by genera formula (1) or a salt thereof. (In the formula, R1, R2, R3, R4, X1 and X2 are a...  
WO/2014/003336A1
The present invention relates to a novel compound, to an electro-organic device using same, and to an electronic device thereof. According to the present invention, the light-emitting efficiency, the color purity, and the life of a devic...  

Matches 701 - 750 out of 10,054