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Matches 1 - 50 out of 9,482

Document Document Title
WO/2018/215316A1
The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine ...  
WO/2018/210659A1
Heteroaryl compounds as agrochemical fungicides Formula (I) The present invention relates to heteroaryl compounds of formula (I) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer, an isotopic form...  
WO/2018/210661A1
The present invention relates to heteroaryl compounds of formula (I) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer, an isotopic form, a N-oxide, a S- oxide, a prodrug or mixture thereof. The p...  
WO/2018/210660A1
The present invention relates to heteroaryl compounds of formula (I) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer, an isotopic form, a N-oxide, a S-oxide, a prodrug or mixture thereof. The pr...  
WO/2018/210658A1
The present invention relates to heteroaryl compounds of formula (I) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer, an isotopic form, a N-oxide, a S-oxide, a prodrug or mixture thereof. The pr...  
WO/2018/207165A1
The present disclosure relates to a new class of antimicrobial agents. In particular, this disclosure provides the identification and characterization of novel spiro-lactam compoundsas anti-HIV/AIDS and anti-malarial agents. Furthermore,...  
WO/2018/202654A1
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, (formula X) wherein the variables of compound of formula X are as defined in the claims and the description.  
WO/2018/203302A1
This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of b...  
WO/2018/203235A1
Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: I  
WO/2018/203298A1
The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceuti...  
WO/2018/197541A1
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, X wherein the variables of compound of formula X are as defined in the claims or the description.  
WO/2018/197401A1
The present invention covers bicyclic pyrazole compounds of general formula (I) : in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, ph...  
WO/2018/189108A1
The application provides a modified process for the preparation of an imidazothiazolone of formula (I), or a stereoisomer thereof, or a stereoisomeric mixture thereof, wherein R1 is C1-10 alkyl or aryl, preferably phenyl; R2 is a protect...  
WO/2018/177970A1
The present invention relates to pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof, their mixtures and to compositions comprising such compounds or mixtures. The invention also relates to ...  
WO/2018/177302A1
Disclosed are a nitrogen containing heterocycle substituted benzoxazine oxazolidinone compound, a preparation method thereof and the use in the preparation of a drug for treating and/or preventing infectious diseases induced by Mycobacte...  
WO/2018/176343A1
Compounds of Formula (A), where the definition of the variables are as described in the description, as well as their preparation and uses, and pharmaceutical compositions comprising these compounds and their uses as modulators of dysfun...  
WO/2018/183679A1
The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In pa...  
WO/2018/183964A1
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1 -dependent disorders and enhancing an immune response. Also described are methods of inhibiting ...  
WO/2018/166934A1
The present invention relates to dibenzofuran and dibenzothiophene derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compound...  
WO/2018/165760A1
The present disclosure relates generally to antioxidants. More particularly, the present disclosure relates to lubricating compositions comprising an antioxidant.  
WO/2018/167506A1
Novel compounds having antimicrobial activitiy, in particular against Pseudomonas aeruginosa, Burkholderia cepaciaand/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.  
WO/2018/170201A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2018/167113A1
The invention provides novel compounds having the general formulas (I), (II), wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.  
WO/2018/170204A1
The present invention provides compounds, compositions thereof, and methods of using the same.  
WO/2018/170203A1
The present invention provides methods of preparing a MK2 inhibitor, and intermediates related thereto.  
WO/2018/162445A1
The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) (I) and (II) wherein the radicals are as defined in the specification. The invention is also directed to pharmaceu...  
WO/2018/162444A1
The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) (I) and (II) and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the sp...  
WO/2018/162443A1
The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the specification. ...  
WO/2018/160618A1
Substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, and anthrahydroquinones are disclosed herein. The substituted hydroquinones and catechols have the formula: while the substituted 1,4-quinones or 1,2-have ...  
WO/2018/159964A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, it is possible to pro...  
WO/2018/157800A1
Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated di...  
WO/2018/160003A1
The present specification relates to a heterocyclic compound of chemical formula 1 and an organic light-emitting device comprising same.  
WO/2018/153326A1
The present invention relates to a sulfonyl hydrazine compound and a use thereof as a medicament for use in treating hepatitis B. Specifically, the present invention discloses a compound which may act as an HBV inhibitor and which has th...  
WO/2018/153507A1
Compounds of formula (I), wherein R', R'', R, X, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2018/140578A1
Described herein are molecules for use in organic photovoltaic devices. Example molecules comprise at least one core moiety, two spacer moieties, and two terminal moieties. Values and preferred values of the core, spacer, and terminal mo...  
WO/2018/137614A1
Disclosed are a heteroarothiadiazide-2,2-dioxide derivative, and a preparation method therefor and an application thereof in medicament. Specifically, disclosed are a novel heteroarothiadiazide-2,2-dioxide derivative represented by formu...  
WO/2018/136890A1
The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLR...  
WO/2018/136265A1
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.  
WO/2018/130863A1
The invention relates to promoting authopagy in the treatment or prevention of autophagy related disorders, such as various forms of cancer; neurodegenerative disease, diabetes, immune deficiency, infection by intracellular microbes, tis...  
WO/2018/127526A2
The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidi n-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid f...  
WO/2018/127526A3
The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidi n-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid f...  
WO/2018/127525A1
The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment o...  
WO/2018/123207A1
The purpose of the present invention is to provide a naphthobischalcogenadiazole derivative which can be used as an intermediate for producing a naphthobischalcogenadiazole compound having a fluorine atom introduced therein. The naphthob...  
WO/2018/121267A1
A [1,3]thiazol-2-amine compound, an application, and a pharmaceutical composition. The present invention belongs to the field of BACE inhibitors. The [1,3]thiazol-2-amine compound is a compound represented by formula (I), or a pharmaceut...  
WO/2018/119221A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2018/119266A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2018/113538A1
The present invention relates to an organic compound with homobenzene as a core and the use thereof in an OLED device. The compound of the present invention has a higher glass transition temperature, a higher molecular heat stability, ap...  
WO/2018/119183A3
Provided herein are benzisothiazol, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives and related compounds as KRAS G12C inhibitors for treating e.g. lung cancer, pancre...  
WO/2018/119263A1
Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing o...  
WO/2018/118598A1
The present disclosure relates to bifunctional compounds, which find utility as modulators of FLT3 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Linda...  

Matches 1 - 50 out of 9,482