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Matches 1 - 50 out of 9,233

Document Document Title
WO/2018/013770A1
Disclosed are compounds of Formula (I) to (IV): [INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof. Also disclosed are methods of using such compounds as PAR4 inhibi...  
WO/2018/013774A1
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted...  
WO/2018/011414A1
Derivatives of 1,2,4-Triazolo-[3,4-b]-1,3,4-thiadiazoles according to formula (I), processes for their production, pharmaceutical compositions containing them and their use in the treatment of cancer.  
WO/2018/011163A1
The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 and Q are as described above. The compounds may be useful for the treatment or prop...  
WO/2018/011823A1
Disclosed are compounds and methods for the preparation of Edoxaban. In particular, a camphor sulfonate salt of an amine-protected [(1R,2S,5S)-1,2-amino-5-[(dimethylamino)carbonyl] cyclohexane, an intermediate that may be formed in the s...  
WO/2018/007479A1
The invention relates to novel organic semiconducting compounds containing a polycyclic unit, to methods for their preparation and educts or intermediates used therein, to compositions, polymer blends and formulations containing them, to...  
WO/2018/007957A1
The present invention refers to novel thiazolo[5,4-d]pyrimidine derivatives that are inverse agonists of the adenosine A2A receptor, to a process for their preparation, to the pharmaceutical compositions containing them and to their use ...  
WO/2018/008984A1
The present invention relates to a pharmaceutical composition for preventing or treating pulmonary hypertension, the composition comprising: an epidithiodioxopiperazine (ETP) compound or a derivative thereof; or a pharmaceutically accept...  
WO/2018/008920A1
Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an a...  
WO/2018/007843A1
The compound 2-((4-Nitrophenyl)amino)-7,8,9,10-tetrahydrocyclohepta[4,5]t hieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6H)-one and method of synthesizing it, wherein the compound is effective to inhibit the growth and proliferation ...  
WO/2018/002437A1
Compounds of formula (I): wherein Ra and Rb are as defined in the claims, exhibit alpha2C antagonistic activity and are thus useful as alpha2C antagonists.  
WO/2018/003976A1
In agricultural and horticultural crop production, etc., damage by pests and the like remains devastating even today, and due to factors such as the occurrence of pests resistant to existing chemicals, there is a demand for the developme...  
WO/2017/222976A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2017/220925A1
The invention relates to a method for preparing substituted thiolactones of formula (I), new substituted thiolactones of formula (I') that can be obtained by carrying out said method, and the use of substituted thiolactones of formula (I...  
WO/2017/220477A1
The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as ...  
WO/2017/222466A1
The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compo...  
WO/2017/223474A1
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associ...  
WO/2017/216281A1
The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.  
WO/2017/216706A1
The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation...  
WO/2017/216283A1
The present invention relates to the following compounds, formula (I), wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.  
WO/2017/211759A1
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.  
WO/2017/211760A1
The present invention relates to novel antibacterial compounds (1) as defined below, pharmaceutical compositions containing them and their use as antimicrobials. A compound of formula (1): A-L1-Y-L2-R-B, wherein A is a cyclic group havin...  
WO/2017/214005A1
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.  
WO/2017/207395A1
The present invention relates to novel isothiazolopyridones (isothiazolopyridone derivatives), to processes for preparing these compounds, to compositions comprising these isothiazolopyridones, and to the use thereof as biologically acti...  
WO/2017/207462A1
The invention relates to the technical field of the herbicides and/or plant growth regulators. Specifically, the invention primarily relates to novel isothiazolopyridones, and compositions comprising said novel isothiazolopyridones. Furt...  
WO/2017/207387A1
The present invention covers diazaspiroalkylmethyl-indole compounds of general formula (I) in which R8, X and Y are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharm...  
WO/2017/201069A1
The present invention provides chimeric compounds of formula (II) that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CKl-alpha activity and cell-cell ad...  
WO/2017/195112A1
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infect...  
WO/2017/190345A1
Provided is the design, synthesis and applications of molecular fluorophores for bioimaging in the short wavelength infrared window (1000-1700 nm). The molecular fluorophores compound comprise structures with electron accepting aromatic ...  
WO/2017/192930A1
The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and comp...  
WO/2017/192961A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2017/177828A1
The present invention relates to a novel oxazolidinone-fluoroquinolone derivative and uses, and relates to the field of chemical drugs. The present invention also relates to a compound represented by formula (I), a pharmaceutically accep...  
WO/2017/177837A1
The present invention relates to a heterocyclic-substituted pyridinopyrimidinone derivative, and the use thereof as a therapeutically effective cyclin-dependent kinase (CDK) inhibitor. In particular, the present invention relates to the ...  
WO/2017/175068A1
The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.  
WO/2017/173313A1
Pateamine A derivatives, pharmaceutical compositions that include the derivatives, and methods for treating chronic lymphocytic leukemia using the derivatives.  
WO/2017/170759A1
Provided is a novel herbicide having a significant herbicidal activity against undesirable plants. A pyridazinone-type compound represented by general formula (I) (wherein X represents -O-, -S-, -SO-, -SO2- or -N(Y)-; Q represents a mono...  
WO/2017/157782A1
The invention relates to novel compounds containing one or more benzo[1,2-d;4,5-d']bisthiazole-4,8-diyl ("BBT") units, to methods for their preparation and educts or intermediates used therein, to mixtures and formulations containing the...  
WO/2017/160552A1
Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic too...  
WO/2017/160555A1
The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula: or a pharmaceutically accepta...  
WO/2017/153601A1
The present invention relates to the compounds of formula (I) that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synucl...  
WO/2017/155030A1
Provided is a tetrazolopyridine compound that is useful as an organic semiconductor material. This compound is characterized by being represented by any of formulas (1)-(3). [In formulas (1)-(3), Y1 and Y2 each independently represent a ...  
WO/2017/150477A1
The purpose of the present invention is to provide a compound having an excellent JAK1-inhibiting activity. The compound according to the present invention has a JAK1-inhibiting activity, and therefore has an immunesuppressing effect, an...  
WO/2017/144633A1
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2017/144639A1
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2017/147312A1
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.  
WO/2017/144341A1
The invention relates to novel compounds of formula (I), in which Aa, Ab, Ac, Ad, R1, R2, R3, Q and n have the meanings indicated in the description, to the use thereof as acaricides and/or insecticides for controlling animal pests, and ...  
WO/2017/147410A1
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharma...  
WO/2017/144637A1
The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.  
WO/2017/146220A1
The present invention addresses the problem of developing and providing a novel agricultural and horticultural insecticide because of factors such as existing devastation to crop production in agriculture, horticulture, etc., caused by i...  
WO/2017/142324A2
The present invention relates to a multisubstituted 4H-thiazolo[4,5-e][1,4]diazepine-5,8-dione derivative represented by chemical formula 1 and a use of the derivative, which is useful for a vascular inflammation-related infectious disea...  

Matches 1 - 50 out of 9,233