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Matches 1 - 50 out of 9,448

Document Document Title
WO/2018/127465A1
The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.  
WO/2018/124128A1
In crop production, such as agriculture and horticulture, there is continuing substantial damage by pests and so forth, and the development of novel agricultural/horticultural insecticides is desired due to factors such as the emergence ...  
WO/2018/125746A1
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the d...  
WO/2018/121766A1
The invention discloses a nitrogen-containing fused heterocyclic compound, a preparation method therefor, and an intermediate, a composition, and an application thereof. The compound of the present invention has a high inhibitory activit...  
WO/2018/125992A1
Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.  
WO/2018/114999A1
The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where R1 and R2 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts...  
WO/2018/119286A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2018/113771A1
The present invention relates to benzimidazole compounds useful in treating for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention of one or more symptoms of cancer, transplant r...  
WO/2018/117151A1
The present invention relates to: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitor; a cocrystal of the derivative; a method for producing the cocrystal; and a method for pu...  
WO/2018/117152A1
The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the int...  
WO/2018/115067A1
The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also p...  
WO/2018/116072A1
The present invention relates to compounds of the general formula (1) wherein the variables are defined as given in the description and claims. The invention further relates to uses of and to, processes and intermediates related to compo...  
WO/2018/108125A1
The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions th...  
WO/2018/108167A1
Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and th...  
WO/2018/108083A1
A heterocyclic compound as a Syk inhibitor and/or a Syk-HDAC dual inhibitor, or pharmaceutically acceptable salts, prodrugs, deuterated derivatives, hydrates, and solvates thereof. Specifically, the present invention relates to a compoun...  
WO/2018/109097A1
The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.  
WO/2018/108079A1
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, X, Y, P, W, and Ar are as defined in the description. The compound of formula (I) o...  
WO/2018/108084A1
Provided is a compound containing a tricyclic heteroaryl group. Specifically, provided are a compound (the definitions of groups are as stated in the description) having a structure as shown in formula (I), a pharmaceutical composition c...  
WO/2018/104766A1
The present invention relates to compounds of Formula (I), and Formula (II), wherein B is benzotriazolyl, phenyl, triazolopyridinyl, or -(CH2)2-triazolyl each of which may be unsubstituted or substituted by 1, 2, or 3 substituents indepe...  
WO/2018/104195A1
The present invention relates to nitrogen-containing heterocycles which are substituted with carbazole groups, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according t...  
WO/2018/103749A1
Provided are a triazine fused ring compound, and an organic mixture, composition and organic electronic device comprising the same and application thereof. The triazine fused ring compound comprises a triazine structure having three stro...  
WO/2018/104194A1
The invention relates to compounds of formula (1) which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.  
WO/2018/103060A1
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).  
WO/2018/102315A1
Disclosed are crystalline forms of sepiapterin free base selected from polymorphs A, B, C, D, E, F, and G, and combinations thereof, as well as crystalline polymorphs of salts of sepiapterin. Also disclosed are pharmaceutical composition...  
WO/2018/100070A1
The invention provides novel compounds having the general formula I: (I) wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.  
WO/2018/095386A1
Disclosed in the present invention are a fused ring compound and applications thereof in organic electronic components, particularly in organic electroluminescent diodes. Also disclosed in the present invention are an organic electronic ...  
WO/2018/097297A1
The purpose of the present invention is to provide a compound that has excellent CDK 4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.  
WO/2018/095422A1
Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a bio...  
WO/2018/097239A1
The present invention addresses the problem of providing a clearing agent which is capable of, after administering a fusant of a streptavidin mutant with a molecular probe, preventing the localization of the fusant at a target site such ...  
WO/2018/087688A1
Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an i...  
WO/2018/089695A1
The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such ...  
WO/2018/086593A1
Disclosed are a nitrogen-containing heterocyclic compound, a preparation method, an intermediate, a pharmaceutical composition and a use. The nitrogen-containing heterocyclic compound of the present invention has a novel structure, relat...  
WO/2018/082444A1
The present invention relates to the pyrazolopyrimidine compound of formula (I) and a pharmaceutically-acceptable salt thereof. Such compounds can be used to inhibit the activity of a fat kinase PI3K, and can also be used to treat diseas...  
WO/2018/083098A1
The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for p...  
WO/2018/083085A1
Compounds of Formula I and methods of use as Interleukin-1 Receptor Associated Kinase 4 (IRAK4) inhibitors are described herein.  
WO/2018/083157A1
The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage ma...  
WO/2018/081612A1
Substituted hydrazone compounds, methods of making such compounds and metal complexes thereof, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds and metal complexes to treat, preve...  
WO/2018/079459A1
This organic electroluminescence element includes, in the order given, the following: a positive electrode; a plurality of organic functional layers including a light-emitting layer; and a negative electrode. The organic functional layer...  
WO/2018/081091A1
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further rel...  
WO/2018/079759A1
The present invention provides a compound having a TrkA inhibitory activity or a pharmaceutically acceptable salt of the compound. The present invention relates to: a compound represented by formula (I) or a pharmaceutically acceptable s...  
WO/2018/073193A1
The invention provides novel compounds having the general formula (I) wherein R1, X, Zlto Z5, L, n, the A ring, and the B ring, are as described herein, pharmaceutical compositions including the compounds and methods of using the compoun...  
WO/2018/071794A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.  
WO/2018/065365A1
The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I), wherein the variables have the meaning defined in the claims. The compounds according to the present i...  
WO/2018/067786A1
Substituted 1 H-imidazo[4,5-b]pyridin-2(3H)-ones as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditio...  
WO/2018/060926A1
This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to meth...  
WO/2018/064545A1
This disclosure generally relates to dual CLK2/CDK1 inhibitors or more potent and specific CLK inhibitors to target CLK2 and CDKl kinases in the treatment of germ-line mutations of the spliceosome leading to the development of cancers an...  
WO/2018/059537A1
The present invention relates to a diazaspiro[5.5]undecane derivative and a use thereof. The derivative is a compound represented by general formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, e...  
WO/2018/060300A1
The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen; R may be the same or different, if n = 2 o...  
WO/2018/060218A1
The present invention relates to diazadibenzofurane or diazadibenzothiophene derivatives which are substituted with carbazole structures, in particular for use in electronic devices. The invention further relates to a method for producin...  
WO/2018/056453A1
The present invention provides a compound represented by formula (I) in which an indole ring or a pyrrolo[2,3-b]pyridine ring and a pyrazolopyridine skeleton are bonded using a substituent, or a salt of the compound; solvates thereof; an...  

Matches 1 - 50 out of 9,448