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Matches 1 - 50 out of 9,585

Document Document Title
WO/2018/183964A1
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1 -dependent disorders and enhancing an immune response. Also described are methods of inhibiting ...  
WO/2018/183956A1
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating ...  
WO/2018/174266A1
Provided is a novel compound which has high antitumor activity, while having low toxicity to normal cells. A pyridone carboxylic acid derivative represented by formula (1) or a salt thereof. (In the formula, R1 represents a hydrogen atom...  
WO/2018/174283A1
Provided is a sustained-release formulation of evocalcet or a pharmacologically acceptable salt thereof. A polyethylene glycol derivative of evocalcet or a pharmacologically acceptable salt thereof is used.  
WO/2018/175474A1
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of di...  
WO/2018/168232A1
[Problem] A problem was presented in that conventional photochromic compounds cannot be considered adequate in terms of the coloring/decoloring rate and durability, and the production process therefor has many steps. The present inventio...  
WO/2018/168292A1
The purpose of the present invention is to provide: an organic EL element material and a compound, each of which has high luminous efficiency; and an organic EL element, a display device and a lighting device, in each of which the organi...  
WO/2018/167113A1
The invention provides novel compounds having the general formulas (I), (II), wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.  
WO/2018/167690A1
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular t...  
WO/2018/161910A1
Disclosed in the present invention is an aminopyrimidine five-membered heterocyclic compound, and an intermediate, preparation method, pharmaceutical composition and application thereof. The aminopyrimidine five-membered heterocyclic com...  
WO/2018/163066A1
The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R1, R2 and R3 are as defined in the specification. The invention is also directed to pha...  
WO/2018/157874A1
Disclosed are a dihydroartemisinin diploid derivative, a pharmaceutical composition thereof, and an application. The derivative is an artemisinin diploid, used for drugs treating or preventing malaria caused by plasmodium, drugs treating...  
WO/2018/153970A1
The present invention covers different solid forms of 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl) -8-(1H-pyrazol-5-yl)-1,7-naphthyridine of formula (I).  
WO/2018/154133A1
The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of ...  
WO/2018/154501A1
The present invention relates to a compound of formula (I), wherein R1, R2, R3 and R4 are each independently hydrogen or Ra, with proviso that a pair of two substituents selected from R1 and R2, R2 and R3, and R3 and R4 is linked to one ...  
WO/2018/153373A1
An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of...  
WO/2018/149960A1
The invention relates to aryloxazolidinone compounds of formula I: wherein Y represents hydrogen or certain chemical groups. These compounds are useful antimicrobial agents effective against a variety of pathogens including inter alia Gr...  
WO/2018/152368A1
Provided is a compound of Formula (I), wherein the variable groups are defined herein.  
WO/2018/148576A1
This invention is a benzothiophene estrogen receptor modulator or its pharmaceutically acceptable salt or a pharmaceutically acceptable composition thereof to treat an estrogen-related medical disorder.  
WO/2018/143403A1
Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce au...  
WO/2018/144605A1
The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.  
WO/2018/138039A1
The present invention relates to carbazole derivatives, particularly for use in electronic devices. The invention further relates to a method for producing the compounds according to the invention and to electronic devices comprising the...  
WO/2018/140435A1
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.  
WO/2018/138293A1
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use the...  
WO/2018/133151A1
The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibito...  
WO/2018/134148A1
The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (A) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compou...  
WO/2018/134335A1
The present invention relates to substituted imidazopyridinpyrimidine compounds of general formula (I) which inhibit MKNK1 and MKNK2 kinase (also known as MAP Kinase interacting Kinase, Mnkl and Mnk2), to methods of preparing said compou...  
WO/2018/134352A1
The present invention relates to a compound according to formula (I) wherein R1 represents alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, -SO2Ra, -SO2NRbRc, –C(O)Rb, phenyl and 5-and 6-membered heteroa...  
WO/2018/134127A1
The present invention relates to compounds of formula (I), wherein the variables are defined as given in the description and claims (e.g. R5 is halogene; R6 is halogene; R7 and R8 together with the carbon atoms to which they are bound fo...  
WO/2018/136265A1
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.  
WO/2018/127465A1
The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.  
WO/2018/124128A1
In crop production, such as agriculture and horticulture, there is continuing substantial damage by pests and so forth, and the development of novel agricultural/horticultural insecticides is desired due to factors such as the emergence ...  
WO/2018/125746A1
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the d...  
WO/2018/121766A1
The invention discloses a nitrogen-containing fused heterocyclic compound, a preparation method therefor, and an intermediate, a composition, and an application thereof. The compound of the present invention has a high inhibitory activit...  
WO/2018/125992A1
Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.  
WO/2018/114999A1
The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where R1 and R2 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts...  
WO/2018/119286A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2018/113771A1
The present invention relates to benzimidazole compounds useful in treating for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention of one or more symptoms of cancer, transplant r...  
WO/2018/117151A1
The present invention relates to: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitor; a cocrystal of the derivative; a method for producing the cocrystal; and a method for pu...  
WO/2018/117152A1
The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the int...  
WO/2018/115067A1
The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also p...  
WO/2018/116072A1
The present invention relates to compounds of the general formula (1) wherein the variables are defined as given in the description and claims. The invention further relates to uses of and to, processes and intermediates related to compo...  
WO/2018/108125A1
The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions th...  
WO/2018/108167A1
Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and th...  
WO/2018/108083A1
A heterocyclic compound as a Syk inhibitor and/or a Syk-HDAC dual inhibitor, or pharmaceutically acceptable salts, prodrugs, deuterated derivatives, hydrates, and solvates thereof. Specifically, the present invention relates to a compoun...  
WO/2018/109097A1
The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.  
WO/2018/108079A1
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, X, Y, P, W, and Ar are as defined in the description. The compound of formula (I) o...  
WO/2018/108084A1
Provided is a compound containing a tricyclic heteroaryl group. Specifically, provided are a compound (the definitions of groups are as stated in the description) having a structure as shown in formula (I), a pharmaceutical composition c...  
WO/2018/104766A1
The present invention relates to compounds of Formula (I), and Formula (II), wherein B is benzotriazolyl, phenyl, triazolopyridinyl, or -(CH2)2-triazolyl each of which may be unsubstituted or substituted by 1, 2, or 3 substituents indepe...  
WO/2018/104195A1
The present invention relates to nitrogen-containing heterocycles which are substituted with carbazole groups, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according t...  

Matches 1 - 50 out of 9,585