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Matches 1 - 50 out of 9,327

Document Document Title
WO/2018/071794A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.  
WO/2018/065365A1
The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I), wherein the variables have the meaning defined in the claims. The compounds according to the present i...  
WO/2018/067786A1
Substituted 1 H-imidazo[4,5-b]pyridin-2(3H)-ones as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditio...  
WO/2018/060926A1
This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to meth...  
WO/2018/064545A1
This disclosure generally relates to dual CLK2/CDK1 inhibitors or more potent and specific CLK inhibitors to target CLK2 and CDKl kinases in the treatment of germ-line mutations of the spliceosome leading to the development of cancers an...  
WO/2018/059537A1
The present invention relates to a diazaspiro[5.5]undecane derivative and a use thereof. The derivative is a compound represented by general formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, e...  
WO/2018/060300A1
The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen; R may be the same or different, if n = 2 o...  
WO/2018/060218A1
The present invention relates to diazadibenzofurane or diazadibenzothiophene derivatives which are substituted with carbazole structures, in particular for use in electronic devices. The invention further relates to a method for producin...  
WO/2018/056453A1
The present invention provides a compound represented by formula (I) in which an indole ring or a pyrrolo[2,3-b]pyridine ring and a pyrazolopyridine skeleton are bonded using a substituent, or a salt of the compound; solvates thereof; an...  
WO/2018/052065A1
Provided is a heterocyclic compound that can have a PRS inhibitory effect and is expected to be of use as a prophylaxis or a therapeutic agent for PRS-related diseases, including cancer. A compound or a salt thereof, said compound being ...  
WO/2018/050684A1
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to fused bicyclic compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL pro...  
WO/2018/050686A1
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to spiro bicyclic compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL pro...  
WO/2018/050825A1
The invention relates to novel compounds of formula (I), in which Q, Aa, Ab, Ac, Ad, R1 and n are defined as in the description, to the use thereof as acaricides and/or insecticides for controlling animal pests, and to methods and interm...  
WO/2018/045971A1
The present invention provides a pyrido five-element aromatic ring compound, and a preparation method therefor and a use thereof. The compound provided in the present invention has an inhibitory effect on wild-type and/or mutant EZH2, an...  
WO/2018/039531A1
This application relates to substituted fused pyrrole compounds of formula I, and pharmaceutical compositions comprising them which inhibit HBV replication, and methods of making and using them. Formula (I)  
WO/2018/038265A1
The present invention provides: a novel use of a specific bicyclic nitrogenated heterocyclic compound as a PDE7 inhibitor; a novel bicyclic nitrogenated heterocyclic compound having a PDE7 inhibition activity, a method for producing the ...  
WO/2018/037230A1
Described herein is a molecule for use as a conductive coating, the molecule comprising pH neutral or substantially neutral functionalities and presenting chemical diversity, transparency in the UV-Vis spectrum and solubility in common o...  
WO/2018/032945A1
The present invention relates to a preparation method for a solution processable organic photovoltaic compound using benzothiophene (benzoselenophene) and thiophene (selenophene) as a π bridge, and use thereof, the structural formula of...  
WO/2018/035080A1
The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.  
WO/2018/033742A2
Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.  
WO/2018/034242A1
A compound represented by formula (1) (in formula (1), the dotted lines, A-D, and R1-R10 are as defined in the specification) yields a high-performance organic electroluminescent element.  
WO/2018/035391A1
seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.  
WO/2018/033455A1
The invention relates to novel compounds of formula (I), in which Aa, Ab, Ac, Ad, R1, Q and n are defined as in the description, to the use thereof as acaricides and/or insecticides for controlling animal pests, and to methods and interm...  
WO/2018/035006A1
The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined herein. The present invention also relates to ...  
WO/2018/028664A1
Provided are an FGFR4 inhibitor with the structure of formula (I) and a preparation method and use thereof. The series of compounds of formula (I) have a very strong inhibitory effect on the FGFR4 kinase activity, and have a very high se...  
WO/2018/024225A1
Disclosed are a hydrochloride, citrate, phosphate or sulfate of compound 1, a crystal of the salt, a preparation method therefor, and applications of the salt and crystal in preparing a medicament for treating cerebral stroke or epilepsy.  
WO/2018/024602A1
The present invention covers 2,7-diazaspiro[4.4]nonane compounds of general formula (I): in which n, X, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing s...  
WO/2018/025554A1
The present invention addresses the problem of providing a nitrogen-containing heterocyclic compound production method by which a nitrogen-containing heterocyclic compound having a high purity can be obtained with a high yield. The nitro...  
WO/2018/025590A1
The present invention addresses the problem of providing a method for producing, with a high yield, a nitrogen-containing heterocyclic compound having a high purity, superior production suitability, and superior environmental suitability...  
WO/2018/021406A1
Provided are: a novel metal complex; and an electron-transporting material which uses said metal complex and can be formed by a wet process during the manufacture of an organic electroluminescent device having a multilayer structure. Thi...  
WO/2018/019917A1
The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation com...  
WO/2018/015289A1
The invention relates to novel compounds of formula (I), wherein Aa, Ab, Ac, Ad, R1, Q and n have the meanings indicated in the description, the use thereof as acaricides and/or insecticides for controlling animal pests, and methods and ...  
WO/2018/014863A1
The present invention discloses a crystal form and salt of a nitroimidazole compound, and a manufacturing method thereof. The invention further comprises an application of the crystal form and salt in preparing a pharmaceutical product f...  
WO/2018/013774A1
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted...  
WO/2018/012508A1
Provided are: a novel aromatic compound which has properties of a semiconductor showing excellent carrier mobility; an organic semiconductor material and a composition for thin film formation use, each of which contains the compound; an ...  
WO/2018/013776A1
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted...  
WO/2018/007479A1
The invention relates to novel organic semiconducting compounds containing a polycyclic unit, to methods for their preparation and educts or intermediates used therein, to compositions, polymer blends and formulations containing them, to...  
WO/2018/006530A1
A chloro-benzothiadiazole-containing conjugated polymer, a preparation method therefor and an organic solar cell device. The chloro-benzothiadiazole-containing conjugated polymer is represented by structural formula (1), wherein Ar is on...  
WO/2018/009938A1
Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure [Formula should be inserted here] and pharmaceutically acceptable salts, prodrugs and...  
WO/2018/001952A1
The present invention provides novel compounds having general formula (I), wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2018/003962A1
2- (Piperidin-1-yl) pyrimidin-4 (3H) -ones characterized by having a 1,8-diazaspiro [4.5] deca-3-ene, 1-oxa-8-azaspiro [4.5] deca-3-ene, 2,8-diazaspiro [4.5] deca-3-ene, 2-oxa-8-azaspiro [4.5] deca-3-ene, 2,9-diazaspiro [5.5] undeca-3-en...  
WO/2018/001330A1
Provided are porphyrin small molecules substitutes designed and synthesized for bulk hetero junction (BHJ) organic solar cells (OSOs). Provided are synthesized materials with strong and ordered self-assembly property, leading to form bic...  
WO/2018/005336A1
The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or e...  
WO/2018/001944A1
The present invention provides novel compounds having the general formula: wherein R1, R2, A and X are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2017/220670A1
The subject of the present invention is symmetric or dissymmetric azomethine direct dyes comprising at least one pyrazolopyridine unit of formula (I), a composition comprising said dyes, a process for treating keratin fibers using said d...  
WO/2017/219800A1
Selective mTOR inhibitors of formulas (I)-(III), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from abnormal cell growth, functions, or beh...  
WO/2017/223231A1
Disclosed herein is the use of a specific compound e.g. (S)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3H-pyrazino-[1,2-b]pyridazin-yl-isobutyrat e (RegNo 1674397-77-3) for use in a method of treating an influenza infect...  
WO/2017/216791A9
Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the...  
WO/2017/216706A1
The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation...  
WO/2017/216791A1
Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the...  

Matches 1 - 50 out of 9,327