Heterocyclic Compounds

Matches 751 - 800 out of 5,407	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >

Document	Document Title
WO/1998/050344A1	SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE Substituted cyanoenamines of general formula (I) wherein Z, R?1�, R?2� and R?3� are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment o...
WO/1998/050358A1	INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R?a� is a group of formula (i), in which P?1� is phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 t...
WO/1998/048800A1	ANTITHROMBOTIC AGENTS This application relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of ...
WO/1998/049157A1	FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES This invention concerns compounds of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R?1� and...
WO/1998/047933A1	GROUP 8-10 TRANSITION METAL OLEFIN POLYMERIZATION CATALYSTS Provided are certain transition metal complexes which are useful as catalysts in the polymerization of olefinic monomers. In particular, the invention provides complexes of certain bidentate ligands bonded to Ni, Pd, Co, or Fe, and optio...
WO/1998/047882A1	4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS The present invention provides a compound of formula (I), wherein ring A is an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic ring; ring B is an optionally substituted aromatic hydrocarbon ring or aromatic hete...
WO/1998/045275A1	COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. A preferred aspect of the invention are compounds of Formula (II) in which: the dashed lines...
WO/1998/045290A1	2-AMINOTHIAZOLEACETAMIDE DERIVATIVES 2-Aminothiazoleacetic acid derivatives of general formula (I), wherein R?1�, X and Y are each a specified organic group. These compounds are particularly useful for the acylation of some cephalosporin antibiotics.
WO/1998/043969A1	INDAZOLES OF CYCLIC UREAS USEFUL AS HIV PROTEASE INHIBITORS The present invention describes indazoles of cyclic ureas of formula (I): wherein X is a linker group and Y may be acyclic or cyclic, which are useful as inhibitors of HIV protease, and pharmaceutical compositions and diagnostic kits com...
WO/1998/043956A1	1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES Novel 1,4-substituted cyclic amine derivatives which have serotonin antagonism and serve as drugs having high clinical usefulness, especially an agent for the remedy/alleviation/prevention of spastic paralysis or a central muscle relaxan...
WO/1998/043970A1	AZOLE COMPOUNDS, THEIR PRODUCTION AND THEIR USE A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated $i(in vivo) and the substituent can be ...
WO/1998/042678A1	1-ALKYL-4-BENZOYL-5-HYDROXYPYRAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES 1-Alkyl-4-benzoyl-5-hydroxy-1H-pyrazole compounds in which the benzoyl moiety is substituted in the 2-position with groups such as halo or alkyl, in the 4-position with an alkylsulfonyl group, and in the 3-position with a cyclic or acycl...
WO/1998/041510A1	NOVEL BENZOLACTAM DERIVATIVES AND MEDICINAL COMPOSITIONS COMPRISING THE SAME Compounds represented by general formula (I), pharmaceutically acceptable salts thereof, or hydrates of these; pharmaceutical compositions comprising the same; a method for inhibiting feeding characterized by administering the same; a me...
WO/1998/040420A2	CATALYST COMPOSITIONS FOR THE POLYMERIZATION OF OLEFINS The present invention includes novel ligands which may be utilized as part of a catalyst system. A catalyst system of the present invention is a transition metal-ligand complex. In particular, the catalyst system includes a transition me...
WO/1998/040361A1	AMINOSULFONYLUREAS WITH HERBICIDAL ACTIVITY Aminosulfonylureas of general formula (I). The aminosulfonylureas of said formula are endowed with a high herbicidal activity against numerous weeds.
WO/1998/040374A2	OLEFIN POLYMERIZATION CATALYSTS CONTAINING GROUP 8-10 TRANSITION METALS, BIDENTATE LIGANDS, PROCESSES EMPLOYING SUCH CATALYSTS AND POLYMERS OBTAINED THEREFROM Methods for preparing olefin polymers, or oligomers catalysts for preparing olefin polymers and bidentate ligand used for preparing these catalysts are disclosed. The polymers can be prepared containing the corresponding monomers with a ...
WO/1998/039303A1	SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of structural formulas (a), (b), (c), (d), (e) an...
WO/1998/039305A1	CRYSTALLINE FORM OF A BIS 1,2,4-TRIAZOLE COMPOUND Form II crystals having a melting point of 127 �C � 3 �C, of the compound represented by formula (I) are low in hygroscopicity and excellent in stability.
WO/1998/038172A1	PHENYL-AMINO-SULFONYL-UREA DERIVATIVES AS FUNGICIDES AND PESTICIDES, The invention relates to new phenyl-amino-sulfonyl-urea derivatives, a method for producing said derivatives, and the use thereof as fungicides.
WO/1998/038167A1	HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR Compounds of formula (I) wherein R?1� is optionally substituted (C�2?-C�9?)heteroaryl; R?2� is optionally substituted phenyl-(CH�2?)�m?-, naphthyl-(CH�2?)�m?-, (C�3?-C�10?)cycloalkyl-(CH�2?)�m?-, (C�1?-C�6?)al...
WO/1998/038168A1	ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS An isoquinolinone derivative of formula (I) wherein Ring A and Ring B are substituted or unsubstituted benzene, R?1� is (1) H, (2) substituted or unsubstituted lower alkyl, (3) substituted or unsubstituted cyclo-lower alkyl, (4) substi...
WO/1998/037079A1	$i(N)-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS $i(N)-Heterocyclic derivatives of formula (I) are described herein, as well as other $i(N)-Heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as ...
WO/1998/037070A1	FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Novel compounds which are compounds represented by general formula (I) or salts thereof having a steroid C�17-20? lyase inhibitory activity and being useful as preventives or remedies for tumors such as prostatism and mammary cancer. I...
WO/1998/035937A1	CETP ACTIVITY INHIBITORS CETP activity inhitors containing as the active ingredient compounds represented by general formula (I), prodrug compounds thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these, (wherein R represents linear...
WO/1998/035954A1	BICYCLIC HYDRAZONE HERBICIDES Compounds of Formula (I), and their $i(N)-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein Q is Q-1, Q-2, Q-3 or Q-4; and Q, Z, X, R?1� through R?20�, m, n, and r a...
WO/1998/034921A1	BICYCLIC INHIBITORS OF PROTEIN FARNESYL TRANSFERASE The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutical...
WO/1998/034923A1	PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS A class of 1-phenylbenzimidazole derivatives, substituted at the $i(meta) position of the phenyl ring by a methylene-, carbonyl- or thiocarbonyl-linked amine moiety, are selective ligands for GABA�A? receptors, in particular having hig...
WO/1998/034934A1	AMINO ACID ESTER CONTAINING AZOLE ANTIFUNGALS The present invention concerns novel compounds of formula (I), the $i(N)-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein -A-B- forms a bivalent radical of formula -...
WO/1998/033778A1	TRIAZOLE DERIVATIVES Triazole compounds represented by general formula (I) and excellent as an antimycotic, wherein Ar?1� represents a phenyl group which may be substituted, Ar?2� represents a naphthyl group which may be substituted, R?1� represents a ...
WO/1998/032744A1	PROCESS FOR MANUFACTURING FLUCONAZOLE The invention herein relates to a process for the manufacture of fluconazole, or more particularly, to the process for the manufacture of fluconazole of Formula (1) having superior antifungal activity with a high yield and purity, and it...
WO/1998/032741A1	INHIBITORS OF FARNESYL PROTEIN TRANSFERASE The present invention relates to inhibitors of ras farnesylation of Formula (I), wherein T is of Formula (1) or (2) or (3); A is aryl or heteroaryl; B is aryl or heteroaryl; X and Y represent hydrogen, or both X and Y can represent a sin...
WO/1998/032743A1	PHENYLSULPHONYL UREAS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS The invention concerns compounds of formula (I) and their salts, in the formula R?1�-R?9�, W and A being defined as in formula (I) according to claim 1. These compounds and salts are suitable as herbicides and plant-growth regulators...
WO/1998/032740A1	PROCESS FOR PRODUCING OPTICALLY ACTIVE IMIDAZOLE COMPOUNDS, INTERMEDIATES FOR SYNTHESIZING THE SAME, AND PROCESS FOR PRODUCING THE SAME A process for producing optically active 4-[$g(a)-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimeth ylbenzoic acid or pharmacologically acceptable salts thereof which comprises optically resolving compounds represented by general formu...
WO/1998/031672A1	METHOD OF PRODUCING N,N'-DIAZOLE COMPOUNDS Describes a method of producing N,N'-diazole compounds, e.g. N,N'-carbonyldiimidazole, by reacting in an inert solvent, e.g., toluene, a 1-unsubstituted 1H-azole compound, e.g., 1H-imidazole, and a dihalide compound, e.g., phosgene, in t...
WO/1998/031675A1	NEW TRIAZOLES AS THERAPEUTIC AGENTS FOR FUNGAL INFECTIONS A compound of formula (I), or an optical isomer or pharmaceutically acceptable salt thereof, is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.
WO/1998/030558A2	TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE Novel tricyclic compounds of Formula (1.0) are disclosed. Compounds of Formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R?1�, R?3� and R?4� are each independently selected from halo. Also disclosed ...
WO/1998/028269A1	NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH�2?, which are useful ...
WO/1998/028257A1	AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT Compounds represented by general formula (1) which have NOS inhibitory activities and are useful as drugs, for example, remedies for cerebrovascular disorders, wherein R�1? and R�2? represent each hydrogen, etc.; R�3? and R�4? re...
WO/1998/027059A1	NOVEL TETRAHYDROBENZINDOLONE DERIVATIVES Compounds represented by general formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same. Because of having an inhibitory activity on the bonding of progesterone to its receptor, these compounds are ...
WO/1998/027108A2	NEW AMIDE COMPOUNDS AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inh...
WO/1998/027086A1	NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagoni...
WO/1998/025883A1	KETOBENZAMIDES AS CALPAIN INHIBITORS, The invention concerns ketobenzamides of formula (I) in which R?1�, R?2�, R?3�, R?4�, X and n have the meanings given in the description. The invention further concerns their preparation. The novel compounds are suitable for comb...
WO/1998/025467A1	SUBSTITUTED THIENYL(AMINO)SULPHONYL(THIO)UREAS AS HERBICIDES, The invention concerns novel substituted thienyl(amino)sulphonyl(thio)ureas of formula (I), in which A stands for nitrogen or a CH group; E stands for a single bond or an NH group; Q stands for oxygen or sulphur; R?1� and R?2�, indep...
WO/1998/025912A1	HERBICIDAL HETEROCYCLIC AMIDES Compounds for Formula (I), and their $i(N)-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein A, W, R?1�, R?2�, R?3�, and m are as defined in the disclosure. Also d...
WO/1998/024771A1	BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I) wherein R?1� is aryl optionally substituted with lower alkoxy, etc., R?2� is lower alkyl, etc...
WO/1998/024785A1	INDOLE-UREA DERIVATIVES WITH 5-HT ANTAGONIST PROPERTIES A compound of formula (I) wherein R?1� and R?2� are each hydrogen or linked together to form ethylene, R?3� is hydrogen or lower alkyl, R?4� is heterocyclic group, R?5� is hydrogen or nitro, and X is CH or N, and pharmaceutical...
WO/1998/023597A1	4,5-DIAMINOPYRIMIDINE DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF Novel 4,5-diamino pyrimidine derivatives having the inhibitory activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase and tumor necrosis factor, physiologically acceptable salt, solvate or metabolically readily conversible es...
WO/1998/021963A1	QUARTERNARY AMMONIUM SALTS AND THEIR USE IN AGRICULTURAL FORMULATIONS Novel agrichemical quaternary salts, compositions and a method to prepare them are disclosed.
WO/1998/021204A1	2R,4S,S,S- AND 2S,4R,S,S-HYDROXYITRACONAZOLE A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two $i(cis) dioxolane diastereomers of the $i(sec)-butyl (S,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceuti...
WO/1998/021186A1	BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.

Matches 751 - 800 out of 5,407	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >