Heterocyclic Compounds

Matches 801 - 850 out of 5,407	< 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 >

Document	Document Title
WO/1998/021205A1	$i(2R,4S,R,R-) AND $i(2S,4R,R,R-)HYDROXYITRACONAZOLE A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two $i(cis) dioxolane diastereomers of the $i(sec)-butyl $i(R,R)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceu...
WO/1998/021203A1	$i(2R,4S,S,R-) AND $i(2S,4R,S,R-)HYDROXYITRACONAZOLE A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two $i(cis) dioxolane diastereomers of the $i(sec)-butyl (S,R)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceuti...
WO/1998/021199A2	PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES Compounds of formula (I) in which A is =N- or (a); W is a group (W1), (W2) or (W3); R�11? is hydrogen, fluorine, chlorine, bromine or methyl; and R�1? to R�5?, R�13?,n�1? and n�13? are as defined in claim 1, and the pyrazole ...
WO/1998/021213A2	2$i(R),4$i(S),$i(R),$i(S)- AND 2$i(S),4$i(R),$i(R),$i(S)-HYDROXYITRACONAZOLE- AND HYDROXYSAPERCONAZOLE DERIVATIVES A substantially pure single enantiomer of a compound of formula (1), wherein X?1¿ and X?2¿ are independently chlorine or fluorine and R is hydrogen, -P(O)(OH)¿2? or -SO¿3?H, or a salt thereof. A method of preparation of optically pur...
WO/1998/017631A2	SUBSTITUTED OXIME-ETHERS AND THEIR USE AS PESTICIDES The invention relates to novel pesticidally active compounds of formula (1) and to their possible isomers and mixtures of isomers, wherein: R�1? is hydrogen, C�1?-C�5?alkyl, C�3?-C�6?alkenyl, C�3?-C�6?alkynyl, or Ar-C�1?-...
WO/1998/017643A1	HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS The present invention is directed to compound of formula (I), wherein R�1?, R�2?, R�3?, R�4?, R�5?, X, Y and (Ia) are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contactin...
WO/1998/017267A1	COMPOSITIONS AND METHODS FOR TREATING BONE DEFICIT CONDITIONS Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...
WO/1998/015274A1	NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
WO/1998/013350A1	QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF The invention relates to the use of compounds of formula (I) wherein: R?2� represents hydroxy, halogeno, C�1-3?alkyl, C�1-3?alkoxy, C�1-3?alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0 to 5; Z represe...
WO/1998/011091A2	TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE Novel tricyclic compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R?1�, R?3� and R?4� are each independently selected from halo. Also disclosed ...
WO/1998/010761A1	CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH�2? group. The naphthosultam is further substituted with various ...
WO/1998/007702A1	DIAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME Diamide derivatives represented by general formula (1), wherein A represents optionally substituted phenyl, etc.; B represents -CH=CH-, -C$m(Z)C-, -(CH=CH)�2?-, -C$m(Z)C-CH=CH-, -CH=CH-C$m(Z)C-, phenylene, etc.; and W represents (a) or...
WO/1998/006725A1	PALLADIUM CATALYZED INDOLIZATION We have found that 2-unsubstituted indoles of structural formula (IV) can be cost-effectively synthesized in high yield by the palladium-catalyzed coupling/ring closure of a 2-halo or 2-trifluoromethylsulfonyloxy aniline (I) and an acyl ...
WO/1998/006399A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
WO/1998/005607A2	NEW NITRIFICATION INHIBITORS AND THE USE OF POLYACIDS TO TREAT MINERAL FERTILIZERS CONTAINING A NITRIFICATION INHIBITOR The use of anorganic or organic polyacids to treat mineral fertilizers, in particular the use of polyacids as a mixture with at least one nitrification inhibitor to treat mineral fertilizers. The invention also concerns the use of select...
WO/1998/005646A1	1,2-DIHYDROQUINOLINE DERIVATIVES HAVING FUNGICIDAL ACTIVITY This invention provides compounds of formula (1) wherein X is CR?5�, where R?5� is H, Cl or CH�3?; Y is CR?5'� where R?5'� is H, Cl, or Br; Z is O, S, SO, SO�2?, CH�2?, CH�2?CH�2?, NR?6�; B is (i, ii, iii, iv, or v) w...
WO/1998/005648A1	NOVEL ISOQUINOLINE DERIVATIVES Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the ap...
WO/1998/004545A1	NOVEL TRICYCLIC N-CYANOIMINES USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abn...
WO/1998/004528A2	SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS Substituted pyridines of formula (IA) are produced by reaction of suitably substituted pyridylaldehydes with Grignard or Witting reagents, and the resulting products are appropriately reduced. The pyridines of formula (IA) are suitable a...
WO/1998/003476A1	ANILINOPEPTIDE DERIVATIVES The invention relates to compounds of formula (I), in which R�1? and R�2? are, independently of each other, lower alkyl or lower alkoxy-lower alkyl; R�3? and R�4? are, independently of each other, sec-lower alkyl or tert-lower al...
WO/1998/003504A1	AMINOCYCLOHEXANE DERIVATIVES AS 5-HT RECEPTOR AGONISTS A class of substituted aminocyclohexane derivatives are selective agonists of 5-HT�1?-like receptors, being potent agonists of the human 5-HT�1D$g(a)? receptor subtype whilst possessing at least a 10-fold selective affinity for the 5...
WO/1998/003505A2	HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE Heterocyclic compounds represented by general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, -C(=O)- or -CH(OH)-; Y stands for CH or N...
WO/1998/003506A1	SUBSTITUTED PYRAZOLYL-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS AGENTS WITH A HERBICIDAL EFFECT The invention concerns novel substituted pyrazole derivatives of general formula (I) in which R?1� - R?6� have the meanings given in the description. The invention also concerns a process for their preparation and their use as agents...
WO/1998/002415A2	METHOD FOR INHIBITING CORROSION AND PROCESS FOR PREPARING 1-AMIDOALKYLIMIDAZOLES The invention relates to the use of at least one compound of general formula (I), in which R�1?, R�2? and R�3? independently of one another represent a hydrogen atom or an alkyl or alkenyl radical; R�4? represents an alkyl or alk...
WO/1998/002422A1	SUBSTITUTED AROMATIC CARBONYL COMPOUNDS AND THEIR DERIVATIVES, New substituted aromatic carbonyl compounds and their derivatives have the general formula (I), in which Q stands for oxygen, sulphur or imino (NH); R?1� stands for hydrogen or halogen; and R?2� stands for the group -A?1�-A?2�-A?...
WO/1998/000420A1	NOVEL THIOPHENE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME Thiophene derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds act as an anti-PCP agonist, thus being useful as psychotropic or antischizophrenic agents and so on. In said formula R�1? is -A...
WO/1998/000408A1	N-PHENYLIMINO HETEROCYCLIC DERIVATIVES AND THEIR USE AS HERBICIDES Compounds of the formula (I), in which -A- is a group (A�1?), (A�2?) or (A�3?) where the bonding of -A- to the nitrogen atom takes place via the carbon atom; R�1? is halogen, C�1?-C�4?alkyl, C�1?-C�4?haloalkyl, C�1?-C�...
WO/1998/000389A1	2-HYDROXYPROPIONIC ACID DERIVATIVE AND ITS MANUFACTURING METHOD This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so th...
WO/1998/000430A1	IMIDAZOL DERIVATIVES USEFUL AS NITROGEN MONOXIDE SYNTHASE INHIBITORS Compounds having the formulas (I) and (Ia) are disclosed, as well as their preparation and use in medicaments.
WO/1998/000399A1	NICKEL CATALYZED ADDITION OF -NH- CONTAINING COMPOUNDS TO VINYL AND ARYL HALIDES A process for producing unsaturated nitrogen containing compounds such as enamides, enamines and aryl amines/amides is disclosed. A vinyl halide or aryl halide is reacted with an -NH- containing compound in the presence of a catalytic am...
WO/1997/049399A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to the use of phenyl ureas of formula (I) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of formula (I) are defined herein.
WO/1997/049704A1	N-[4-(HETEROARYLMETHYL)PHENYL]-HETEROARYLAMINES The present invention is concerned with compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hyd...
WO/1997/048676A1	TRIPHENYLALKYL ANTIMICROBIAL AGENTS The invention relates to triphenylalkyl antibacterial compounds of general formula (1) pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action...
WO/1997/047608A1	PROCESS FOR PRODUCING 2-(1H-1,2,4-TRIAZOL-1-YL)ACETOPHENONES A novel process for producing 2-(1H-1,2,4-triazol-1-yl)acetophenones of general formula (I) which are useful as the starting materials in the production of antifungal agents and pesticides wherein R1 and R2 are the same or different and ...
WO/1997/046555A1	IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES Substituted imidazolylquinoxalinedione derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof and medicinal compositions comprising these compounds or salts thereof and pharmaceutically acceptable car...
WO/1997/045425A1	NEW INDOLYL AND BENZOFURANYL CARBOXAMIDES AS INHIBITORS OF NITRIC OXIDE PRODUCTION A compound of formula (I) wherein R1 is indolyl or benzofuranyl; R2 is hydrogen, lower alkylthio(lower)alkyl or a group of formula (1) in which R5 is hydrogen, lower alkoxy or halogen; R3 is hydrogen, quinolyl or phenyl which may have a ...
WO/1997/045402A1	PHENYLSULFONAMIDE DERIVATIVES Phenylsulfonylamide derivatives represented by general formula (I) and salts thereof, (wherein R1 is hydrogen or alkyl; R2 is COOR3 or CONHOR4; E is vinylene or ethylene; A is hydrogen, alkyl, carbocycle or heterocycle; J is single bond ...
WO/1997/044323A1	MERCAPTO-IMIDAZOLYL DERIVATIVES AND THEIR USE AS MICROBICIDES The invention concerns novel mercapto-imidazolyl derivatives of formula (I), in which R and R1 have the meanings given in the description, as well as their acid addition salts and metallic salt complexes. The invention further concerns a...
WO/1997/044332A1	SULPHONYL-MERCAPTO-TRIAZOLYL DERIVATIVES AND THEIR USE AS MICROBICIDES The invention concerns sulphonyl-mercapto-triazolyl derivatives of formula (I-'alpha') or (I-'beta') in which R stands for alkyl, optionally substituted aralkyl and optionally substituted aryl, and R1 stands for various groups, as well a...
WO/1997/044330A1	PROCESS FOR PREPARING BIOLOGICALLY ACTIVE DERIVATIVES OF 1,2,4-TRIAZOL AND INTERMEDIARIES USEFUL IN THIS PROCESS There is disclosed a process for the preparation of fluconazol which is a well-known antifungic agent, as well as pharmaceutically acceptable salts thereof, wherein a new compound having the formula (IV) in which R is H, benzyl, tripheny...
WO/1997/042822A1	(HETERO)ARYL SULPHONYL UREAS WITH AN IMINOFUNCTION, THE PREPARATION AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS The invention relates to compounds of the formula (I) and the salts thereof, in which formula A is a (hetero)aromatic or heterocyclic bridge which is connected to the group SO2 via a direct bond or O, S, NH, CH2, or via alkylated NH or a...
WO/1997/042956A1	DIDHYDROPYRIMIDINES AND USES THEREOF This invention is directed to dihydropyrimidine compounds which are selective antagonists for human 'alpha'1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol ...
WO/1997/043248A1	'alpha'-SUBSTITUTED BENZYL ETHER DERIVATIVES AND PESTICIDES COMPRISING THE SAME AS ACTIVE INGREDIENTS Compounds of general formula (I); salts of the compounds; and hydrates of them, wherein R1 is an optionally substituted heterocyclic group, CO2R6 (wherein R6 is alkyl) or CONR7R8 (wherein R7 and R8 are each independently hydrogen or alky...
WO/1997/043269A1	TRIAZOLYL DISULPHIDES The invention relates to novel triazolyl disulphides of formula (I), in which R1 has the meanings given in the description. It also relates to the acid addition salts and metal salt complexes of said triazolyl disulphides, a process for ...
WO/1997/042178A1	ACYL MERCAPTO-TRIAZOLYL DERIVATIVES AND THE USE THEREOF AS MICROBICIDES The invention relates to acyl mercapto-triazolyl derivatives of the formula (I) in which R is alkyl, alkyl halide, optionally substituted aryl, optionally substituted aralkyl, alkoxy, alkylamino or optionally substituted arylamino, and R...
WO/1997/042189A1	AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES AS 5-HT RECEPTOR AGONISTS A class of compounds of formula (I) wherein Z, E, Q, T, U, V, W, M, R1, R7 and R8 are as defined herein; are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D'alpha' receptor subtype whilst possessing ...
WO/1997/042175A1	SUBSTITUTED IMIDAZOLIUM SALTS AND THEIR USE FOR THE INHIBITION OF PROTEIN AGEING The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein ageing). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhib...
WO/1997/042187A1	OXINDOLE DERIVATIVES The invention relates to compounds of formula (I), wherein: R2 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino, nitro, C2-4alkanoyl, C1-4alkanoylamino, C1-4alkoxycarbonyl, C1-4alkylthio...
WO/1997/041104A1	QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS This invention relates to a compound of formula (I) wherein R1 is lower alkyl, R2 is heterocyclic group, etc., R3 is hydrogen, lower alkyl or halogen, R4 is lower alkyl or halogen, R5 is amino substituted with substituent(s) selected fro...
WO/1997/041112A1	SULFONYLUREA SALTS AS HERBICIDES Compounds of formula (I), wherein R1 is hydrogen, methyl or trifluoromethyl, R2 is methyl or methoxy, A is C1-C4-haloalkyl, M is an alkali metal or alkaline earth metal atom and n is 1 or 2, are suitable for use as herbicides.

Matches 801 - 850 out of 5,407	< 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 >