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Patent Searching and Data


Matches 301 - 350 out of 7,108

Document Document Title
WO/2003/007946A1
The invention relates to novel compounds, namely secondary thiazolylsulfonamides, according to formula (I), to method for producing them and to the use thereof as drugs, especially as antiviral drugs.  
WO/2003/008391A1
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. Th...  
WO/2003/008398A1
This invention relates aryl substituted thiazolidinones of Formula I: (I) or a pharmaceutically acceptable salt, or solvate thereof, wherein $i(n) is an integer from 1 to 2; R1 is selected from the group consisting of: (I) where Y is alk...  
WO2002050066A3
This invention describes novel pyrazole compounds of formula (II ):wherein Z<1> is nitrogen or CR<8>; Q is -S-, -O-, -N(R<4>)-, or -CH (R<6>)-; R<1> is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ...  
WO/2003/006440A2
The present invention is directed to novel amide-containing compounds which have an improved solubility and a method of improving the solubility of amide-containing compounds. The amide-containing compounds include oxazolidinone compound...  
WO/2003/006436A1
The invention concerns novel azole or triazole derivatives of formula (Ia) or (Ib), wherein: X, Ar?1¿, Ar?2¿, Ar?3¿, A, B and R?1¿ are such as defined in the description, the method for preparing same and their use as fungicides.  
WO/2003/006456A1
Compound of general formula (I) in which Y is chosen from the following groups Y?1¿ to Y?3¿ (I*), the other substituents being as defined in the description, process for preparing this compound, fungicidal composition comprising this c...  
WO/2003/004493A1
The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compo...  
WO/2003/004512A1
A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1$g(l)?6¿-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The...  
WO/2003/004467A2
Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically ...  
WO/2003/004023A1
The invention relates to novel benzimidazole derivatives of general formula (I), wherein the groups R?1¿, R?2¿, R?3¿, A, B and Y are defined as per the definition and the claims. The invention also relates to the use of these compound...  
WO/2003/004027A1
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compou...  
WO/2003/002518A1
2,4-difluorobenzamide derivatives and their pharmaceutically acceptable salts, represented by following formula (1), are described in which the derivatives have excellent inhibitory effects on proliferation of hepatitis B virus (HBV) and...  
WO/2003/002542A1
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions ...  
WO2001072728B1
A compound of formula (I) or the pharmaceutically acceptable salt thereof; wherein a, b, c, d, e, j, R<1>, R<2>, R<3>, and R<4> ar e as defined above useful to treat inflammation and other immune disorders.  
WO/2003/002519A1
The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.  
WO/2003/002498A1
Novel halophenyl derivatives of the general formula (I), wherein R?1¿ is halogen, a leaving group or 1H-1,2,4-triazol-l-yl and R?2¿ is ethynyl or carboxy, X?1¿ is halogen and X?2¿ and X?3¿ are each independently hydrogen or halogen,...  
WO2002059111A3
This invention describes novel pyrazole compounds of formula (IIa): wherein R<1> is T-Ring D, wherein Ring D is 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R an...  
WO/2003/000664A1
The invention relates to uracils, methods for the production thereof, pharmaceutical compositions containing said uracils, and the use of the same for treating diseases affecting humans or animals. The inventive compounds are of general ...  
WO/2003/000180A2
Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (Formula I) are inhibitors of the dipep tidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and condi...  
WO/2003/000653A1
The invention relates to novel substituted N-acyl aniline derivatives of general formula (I), where R?1¿ to R?5¿, A, X, Y and Z are as defined in claim 1, the tautomers, stereoisomers, mixtures, prodrugs, derivatives with a group, nega...  
WO2002046170A8  
WO2002074753A3
The invention relates to 5-phenylpyrimidine of formula (I) wherein the substituents have the following designations: R<1> represents a five to ten-membered saturated, partially unsaturated or aromatic monocyclic or bicyclic heterocycle w...  
WO2002070473A3
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators o...  
WO/2002/100813A2
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH¿2?-or-CH¿2?CH¿2?-; W is a substituted or unsubstituted alkylene or a substituted or unsubsti...  
WO2002059080A3
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...  
WO2002042248A3
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2NH, P(O)OCH3, P(O)OH, NH, N(CH3), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH2NH, C(=NH); R<1> is aryl or heteroaryl; R...  
WO/2002/098849A2
Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...  
WO/2002/098844A1
The invention relates to a method for producing perfluoroalkanesulfonic acid esters and for further transforming the same into the salts thereof. The invention also relates to the use of the produced compounds in electrolytes, batteries,...  
WO/2002/098848A1
The present invention provides antitumor compounds of the formula(I), and antitumor methods.  
WO/2002/098424A1
Compounds useful as HCV anti-infectives having the formula: wherein the formula variables are as defined herein, are disclosed. Also disclosed are methods of making and using the same.  
WO/2002/098852A2
The invention concerns compounds of general formula (I), wherein, in particular: W represents H, SO¿2?R¿5?, CO(CH¿2?)¿n?R¿5?, (CH¿2?)¿n?R¿6?, CS(CH¿2?)¿n?R¿5?; X represents S or NH; Y represents (CH¿2?)¿p?, CO, (CH¿2?)¿p?C...  
WO/2002/098363A2
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian re...  
WO/2002/096910A1
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins o...  
WO/2002/096905A1
The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. ...  
WO/2002/096361A2
The present invention relates to certain 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating d...  
WO/2002/096902A1
The invention relates to novel carbazole derivatives, their use for the preparation of a pharmaceutical composition for the treatment of eating and metabolic disorders such as obesity, bulimia nervosa, anorexia nervosa, of sleep disturba...  
WO/2002/096883A1
There is provided compounds of formula (I), wherein X¿1?, X¿2?, X¿3?, X¿4?, Y¿1?, Y¿2?, Y¿3?, Y¿4?, Z¿1?, Z¿2?, R?4¿ and R?5¿ have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compou...  
WO/2002/096888A1
The invention relates to the pyrimidine derivatives of general formula (1), wherein R?1¿, R?2¿, X, A and B are defined as in the description, for use as inhibitors of the cyclin-dependent kinase. The invention further relates to the pr...  
WO/2002/094817A1
The invention relates to a method for the production of triazolylmethylepoxide isomers of formula (I), where A and B independently = C¿1?-C¿4? alkyl, phenyl-(C¿1?-C¿2? alkyl), C¿3?-C¿6? cycloalkyl, C¿3?-C¿6? cycloalkenyl, tetrahy...  
WO/2002/094883A2
This invention describes a one pot, single-step process for the preparation of halide-free hydrophobic salts comprising polyalkylated imidazolium cations and various anions in accordance with the following structure, where R?1¿ and R?3...  
WO/2002/094796A2
The present invention relates to benzo[g]quinoxaline derivatives of the general formula (I), processes for manufacturing said benzo[g]quinoxaline derivatives, the use of the benzo[g]quinoxaline derivatives as pharmaceutically active agen...  
WO/2002/094819A1
The invention relates to a method for producing triazolyl methyl oxiranes of formula I wherein A and B are the same or different and independently represent C¿1?-C¿4?-alkyl, phenyl-C¿1?-C¿2?-alkyl, C¿3?-C¿6?-cycloalkyl, C¿3?-C¿6?...  
WO/2002/092608A2
The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comp...  
WO/2002/092575A1
The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmi...  
WO/2002/092571A1
The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.  
WO/2002/090350A1
The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar1, Ar3, A, R1, R5, R6, R7 and B are such as defined in the description, their preparation method and their use as antifungal medicines.  
WO/2002/089800A2
This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2 or 3; p represents 0 or 1; X is O, S C=O, SO2, or -CH=C...  
WO2002055012A3
Provided herein is a compound having the formula (I) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, a...  
WO2002055013A3
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sl...  

Matches 301 - 350 out of 7,108