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Matches 401 - 450 out of 7,108

Document Document Title
WO/2002/066459A1
The present invention relates to compounds of formula (I) which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention ...  
WO/2002/066469A2
The invention relates to heterocyclic substituted amide derivatives of formula (I) that display selective binding to dopamine D¿3? receptors. In another aspect, the invention relates to a method for treating central nervous system disor...  
WO/2002/066465A1
A triazole compound represented by the general formula (I) (I) [wherein X represents such a group that the compound represented by the formula X-OH has antifungal activity; L represents -(C¿6-10? aryl)CH¿2?- in which the aryl has subst...  
WO/2002/064559A2
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)-N(R?25¿)CH(R?30¿)- wherein the nitrogen atom is attached to R?1...  
WO/2002/064568A1
Selective MMP-13 inhibitors are pyridine derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R?1¿ and R?2¿ independently are hydrogen, halo, hydroxy, C¿1?-C¿6? alkyl, C¿1?-C¿6? alkoxy, C¿2?-C¿6?...  
WO/2002/062301A2
In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids...  
WO/2002/062295A2
The present invention provides a genus of pyridine-substituted benzanilides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.  
WO/2002/062768A1
Compounds of Formula I, and their agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein R?1¿ is C¿1?-C¿3? alkyl, C¿1?-C¿2? haloalkyl, C¿2?-C¿3? alkenyl, cyclopropyl or NR?3¿R?4...  
WO/2002/062789A1
This invention describes novel pyrazole compounds of formula (IIIC): wherein R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; ...  
WO2002014269A3
Disclosed are compounds of the formula (I) or pharmaceutically acceptable salts thereof wherein: (i) represents: (ii, iii, iv, v) and A, B, G, D, E, Ra, Rb, W, and Z are defined herein. These compounds are agonists, antagonists or invers...  
WO2002010140A3
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.  
WO2002032900A3
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof, wherein Y<1>, Y<2>, Y<3>, and Y<4> are independently selected from N, CH, etc.; R<1> is H, C1-8 alkyl, etc.; Q<1> is a 5-12 membered...  
WO/2002/060877A1
The invention related to compounds of the general formula (I), wherein the substituents are defined in claim 1. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key...  
WO/2002/060879A2
The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to met...  
WO2002008211A3
Compounds, pharmaceutical compositions, and methods for the treatment of a hyperlipidemic condition in a subject. The compounds of the present invention are apical sodium co-dependent bile acid transport inhibitors and are 1,4-benzothiaz...  
WO/2002/059074A1
A compound represented by the general formula (I) (wherein R?1¿ represents C¿1-6? alkyl, etc.; R?2¿ and R?3¿ are the same or different and each represents hydrogen, etc.; R?a¿ represents C¿1-6? alkyl, etc.; Arom represents aryl, et...  
WO/2002/058632A2
Primary intermediates for hair coloring compositions for oxidative of hair are compounds of the formula (1): where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5? mono o...  
WO/2002/058653A1
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R¿1? and R¿2? are aech independently selected from hydrogen atoms, a C¿1? to C¿5? alkyl or hydroxyalkyl group...  
WO/2002/059085A1
The present invention relates to the alkylation of N-methyl triazole to form 5-alkyl-1-methyl triazoles.  
WO/2002/059080A2
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...  
WO2002012190A3
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.  
WO/2002/058654A1
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1), where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5?...  
WO/2002/058695A1
Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.  
WO/2002/059112A2
This invention describes novel pyrazole compounds of formula III:wherein Z?1¿, Z?2¿, and Z?3¿ are described in the specification; Q is -S-, -O-, -N (R?4¿) -, or -CH (R?6¿) -; is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ...  
WO/2002/059111A2
This invention describes novel pyrazole compounds of formula (IIa): wherein R?1¿ is T-Ring D, wherein Ring D is 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x...  
WO2001090091A8
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparat...  
WO/2002/056884A2
Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing an...  
WO/2002/057259A2
This invention describes novel pyrazole compounds of formula (IIIa), wherein R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; ...  
WO2002032422A3
The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhi...  
WO2001072728A3
A compound of formula (I) or the pharmaceutically acceptable salt thereof; wherein a, b, c, d, e, j, R<1>, R<2>, R<3>, and R<4> ar e as defined above useful to treat inflammation and other immune disorders.  
WO/2002/055012A2
Provided herein is a compound having the formula (I) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, a...  
WO2002040455A8
The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.  
WO/2002/055492A2
An improved method for preparing dimethylamino-methyl-carbazolone and ondansetron base. A recrystallization process for preparing pure ondansetron hydrochloride dihydrate with a purity of at least 99.0% is also disclosed.  
WO2002012224A3
Substituted N-substituted alkoxyphenyl compounds, compositions containing them, and methods of making and using them.  
WO/2002/055013A2
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sl...  
WO/2002/055014A2
Provided herein is a compound represented by the Formula (I) wherein said compounds are useful for the treatment of migraine. Also provided are processes for the preparation of compounds of Formula (I) and intermediates.  
WO2002003912A3
Novel C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions. These novel C-4 substituted all-trans retinoic acid analogs inhibit all-trans retinoic ac...  
WO2002036734A3
Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatme...  
WO/2002/053543A1
A compound having an affinity for a cannabinoid 2-type receptor. It is represented by the formula (I): (I) wherein R?1¿ represents a group represented by the formula -Y?1¿-Y?2¿-Y?3¿-Ra (wherein Y?1¿ is a single bond, etc.; Y?2¿ is ...  
WO2002022602A3
This invention describes novel triazole compounds of formula (IX): wherein Z<1> is nitrogen or CR<9> and Z<2> is nitrogen or CH, provided that at least one of Z<1> and Z<2> is nitrogen; G is Ring C or Ring D; Ring C is selected from a ph...  
WO2001018171A3
The present invention provides the compound having formula (I), wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridin...  
WO/2002/050066A2
This invention describes novel pyrazole compounds of formula (II ):wherein Z?1¿ is nitrogen or CR?8¿; Q is -S-, -O-, -N(R?4¿)-, or -CH (R?6¿)-; R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicy...  
WO2001095856A3
The present invention relates to a novel urea derivative which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer c...  
WO/2002/049993A2
The invention includes low molecular weight, non-peptidic, non-peptidommetic, organic molecules that can act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also suc...  
WO/2002/050065A2
This invention describes novel pyrazole compound of formula (IIc): wherein R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?...  
WO2001092215A3
The invention provides a compounds comprising a [N(O)NO] functional group and a superoxide-generating moiety, wherein said compound is capable of generating nitric oxide and superoxide. The invention also provides compositions comprising...  
WO/2002/050046A1
Compound of formula (I), wherein X is C¿1-6? alkylene or C¿2-6? alkenylene, each of which is optionally substituted by one or more flluorine atoms; R is aryl or C¿3-8? cycloalkyl optionally substituted by one or more fluorine atoms; W...  
WO2002012214A3
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.  
WO/2002/048121A1
The invention relates to cyclohexenone derivatives of benzazolons of general formula (I), wherein the variables R?1¿, R?2¿, R?3¿, A and Hex have the meaning as cited in claim 1, and the salts thereof, and the use thereof for controlli...  
WO/2002/046151A1
The invention relates to novel delta 1-pyrrolines of formula (I), in which R?1¿, R?2¿, R?3¿, m and Q have the meanings as cited in the description, to a number of methods for producing these substances, and to their use for controllin...  

Matches 401 - 450 out of 7,108