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WO/1996/005160A1 |
'beta'-Carotene, lycopene and canthaxanthin, as representative carotenoids, and to a lesser extent, retinoic acid, a representative retinoid, undergo extensive oxidation to yield substances, insofar as oxidized 'beta'-carotene is a model...
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WO/1996/000230A1 |
The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed. In particular, the present invention ...
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WO/1995/031990A1 |
The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
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WO/1995/029923A1 |
This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be 1,22-bis-[2-(trimethylammonium)ethylphosphatyl] docosan...
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WO/1995/026344A1 |
The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnoniella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention al...
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WO/1995/025748A1 |
A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as being free of detectable levels of lipid enveloped virus activity, free of prothrombin complex and active thrombin, and contains no p...
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WO/1995/023812A1 |
Novel antibiotic stalobacins H and I having physico-chemical properties as shown in Table 1 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.
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WO/1995/001984A1 |
A process for the extraction and purification of alkaloids from plant material wherein the first extraction is conducted with an aqueous solution of a strong acid and the acid extract is clarified by flocculation. The alkaloid is recover...
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WO/1995/000157A1 |
A method for the treatment of an inflammatory complaint including the step of administration of a compound of general formulae (I to XII) described herein in figure or mixtures thereof to a subject suffering from said inflammatory compla...
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WO/1994/027562A1 |
Foaming shampoo compositions which contain no anionic surfactant and are mild to the skin and eyes are comprised of alkyl polyglycosides, betaines, and polymeric slip agents.
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WO/1994/028006A1 |
In order to produce new non-ionic emulsifiers, sugar or aqueous starch hydrolysis products and primary alcohols in a molar ratio from 1:2 to 1:8 are acetalysed in a manner known per se with an acid catalyst, the reaction is interrupted w...
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WO/1994/026726A1 |
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or ary...
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WO/1994/020511A1 |
Doliculide is obtained in pure form from the visceral organ of Dollabella auricularia by extraction with an organic solvent followed by chromatographic separation. This compound has a potent growth inhibitor effect against HeLa S3 (human...
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WO/1994/014838A1 |
The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A (I), B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the tr...
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WO/1994/013684A1 |
Dolastatin C obtained in pure form by extracting the visceral organ of Dolabella auricularia with an organic solvent followed by chromatographic separation and purification. It has a potent activity of inhibiting the growth of HeLa S3 (h...
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WO/1994/012510A1 |
In the low temperature processing of natural shark cartilage into a substantially 100 % pure finely divided state, the cartilage is separated from any residual shark tissue, then chopped into particles of about 1/4 inch and dried. The dr...
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WO/1994/009799A1 |
The invention relates to an anti-inflammatory factor isolated from milk and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress th...
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WO/1994/009824A1 |
This invention relates to a preparation of allergenic (antigenic) extracts useful in a systematic approach to diagnosis, immunotherapy and the monitoring thereof of allergic patients, and also to be used in diagnosis of other immunologic...
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WO/1994/010324A1 |
This invention relates to novel compounds, WS79089 substances or salts thereof, having endothelin converting enzyme inhibiting activity, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
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WO/1994/009630A1 |
The present invention relates to a factor that potentiates the pesticidal activity of a Bacillus related pesticide as well as methods for isolating and identifying said factor. The invention further relates to pesticidal compositions com...
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WO/1994/008563A1 |
Certain phosphocholine derivatives having substantial antifungal therapeutic activity are disclosed. The phosphocholine derivatives may be chemically synthesized, enzymatically prepared or extracted from the plant Irlbachia alata. The ph...
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WO/1994/005639A1 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...
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WO/1994/005305A1 |
A human cataractous lens nuclei methanolic extract consists essentially of substances having a molecular weight lower than 3,000 daltons. The substances inhibit ATP hydrolysis by Na+, K+-ATPase and have affinity to the ouabain binding si...
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WO/1993/024502A1 |
The invention is a process for reducing the fatty alcohol content of a mixture of fatty alcohol and fatty glycoside product by passing the mixture through a forced circulation evaporation zone to form a mixture of fatty alcohol and fatty...
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WO/1993/024643A1 |
Low-molecular-weight farnesyltransferase inhibitors, OH-4652A, OH-4652B, OH-4652C, OH-4652D, OH-4652E and/or OH-4652F (collectively referred to as OH-4652 substances), and a process for producing OH-4652 by culturing an OH-4652-producing...
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WO/1993/021117A1 |
The chlorine content in chlorinated hydrocarbons in an environment which admits the presence of air and moisture can be reduced by bringing the chlorinated hydrocarbon into contact wih a dechlorination reagent which comprises (i) a compl...
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WO/1993/015748A1 |
The present invention relates to an improved method for isolating brush border membranes from insects. The method can be used to isolate brush border membranes from small insects.
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WO/1993/015094A1 |
A product of modification of a vegetable raw material is a product obtained by treating the vegetable raw material with alkaline solution while feeding oxygen or air in the presence of compounds of transition metals chosen from the 4th r...
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WO/1993/015188A1 |
Disclosed is a method for reducing the allergenicity of psyllium seed husk by treatment with an enzyme. An aqueous slurry of psyllium seed husk is treated with the enzyme under conditions sufficient to inactivate the allergenic protein t...
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WO/1993/011114A1 |
Disclosed is an antidegradant for highly unsaturated natural and synthetic rubbers and elastomers made as the reaction product of a) a first component comprising a reaction product of a diarylamine, such as diphenylamine, and a dialkyl k...
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WO/1993/007160A1 |
A process for preparing high detergency or surfactant alkyl polyglycoside compositions and a purified alkyl monoglycoside and to compositions employing the polyglycosides for various end use applications. The process involves removal of ...
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WO/1993/007249A1 |
An improved alkylpolyglycoside surfactant composition, and method of preparing same, by selecting an average chain length of the alkyl moiety of the composition and mixing two or more of at least binary components having an average alkyl...
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WO/1993/005131A1 |
Overbased metal phenate sulfides, having a higher alkalinity, reflected by the total base number (TBN), and having good viscosity characteristics, are synthesized with a dispersant comprising a dialkyl metal sulfosuccinate or combination...
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WO/1993/004689A1 |
The invention relates to active principles having an antitumoral activity extracted from plants of the family Palma, the subfamily Phoenicoideae and the species Phoenix, and pharmaceutical preparations containing at least one of the subs...
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WO/1993/003051A1 |
Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalys...
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WO/1993/002203A1 |
A new FR901451 substance which is produced by culturing an FR901451 substance-producing strain of the genus Flexibacter in a nutrient medium, this new substance possessing a human leukocyte elastase-inhibiting activity.
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WO/1993/002092A2 |
Galacturonic acid derivatives of formula (I); R1 being a linear or branched alkyl having from 2 to 22 carbon atoms, R being CH-CH(OH)-CO2R2 or -CH(OH)-CH-CO2R2, of which the carbon carrying the hydroxyl group is attached to the endocycli...
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WO/1992/021359A1 |
The invention relates to active principles having an antineoplastic action, extracted from plants of the family Pittosporacee, and to pharmaceutical preparations based on at least one of the substances or compositions to be found in said...
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WO/1992/020761A1 |
The invention concerns a fuel mixture containing at least one vegetable and/or animal oil, at least one aliphatic alcohol with 1-5 C-atoms and petrol, and which can be produced by mixing these components together. This fuel mixture is su...
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WO/1992/020694A1 |
The use of magnesium oxide of specified, low, reactivity in a process for the production of overbased magnesium sulphonates, together with the introduction of water and an alcohol, into the reaction mixture during carbonation, makes it p...
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WO/1992/016216A1 |
The peat-derived bioactive product contains not more than 70 %, preferably not more than 60 % by weight of inorganic salts, especially of sodium chloride, based on dry solids. It is obtainable by a process wherein a highly concentrated a...
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WO/1992/013865A1 |
The invention is concerned with the discovery, isolation and purification of an agent or factor named herein the CR3 modulator or CMF-1 that is synthesized by polymorphonuclear leukocytes (PMN) in response to agonists which enhance CD18 ...
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WO/1992/012720A1 |
A compound for the treatment of calcium oxalate kidney stone disease which can be extracted and purified from leaves of the plant Eriobotrya japonica is disclosed. The compound has the following characteristics: inhibits calcium oxalate ...
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WO/1992/009295A1 |
An extract is produced from tropical plants, of which the individual parts, such as roots, stems, seeds, flowers and leaves, are administered to the person under treatment according to his or her age, origin and stage of disease. The use...
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WO/1992/008470A1 |
A biologically active component of emu oil is disclosed which is useful in pharmaceutical compositions for the treatment of inflammation of environmental and systemic origins. Pharmaceutical compositions including emu oil and dermal tran...
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WO/1992/007052A1 |
Additives for improving the low temperature flow properties and oxidative stability of hydrocarbon oils are disclosed, which comprise the alkylation of a phenol in the presence of a dipolar aprotic cosolvent to produce an essentially lin...
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WO/1992/006698A1 |
Unlike prior art methods for producing spagyric essences from plants, the present process provides standardised products in relation to the dry residue of the plants used with a defined alcohol content. The components of a spagyric essen...
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WO/1992/004457A1 |
The present invention is directed to a new antibiotic denominated antibiotic GE1655 complex, its factors antibiotic GE1655 factor A, antibiotic GE1655 factor B, and antibiotic GE1655 factor C, the pharmaceutical acceptable salts thereof,...
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WO/1992/000367A1 |
Reaction products of sulfur, olefins and sodium sulfide hydrates are improved extreme-pressure/antiwear additives for lubricants and liquid hydrocarbyl fuels. These products contain no or substantially no dithiolethiones.
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WO/1991/019718A1 |
A novel antibiotic reveromycin A of structural formula (I), which is useful because it has antitumor and fungicidal activities. The production process comprises culturing a streptomyces which produces an antibiotic reveromycin A, i.e., S...
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