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WO/2019/145713A9 |
The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and d...
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WO/2020/155519A1 |
Disclosed is a synthesis of a Helicobacter pylori O2 serotype O-antigen oligosaccharide compound, which belongs to the field of organic synthesis. The invention obtains, through chemical synthesis, Helicobacter pylori O2 serotype O-antig...
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WO/2020/160443A1 |
Methods for preparing a polyene macrolide antifungal with improved aqueous solubility. The method involves providing a polyene macrolide antifungal having a carboxylic acid group; activating the carboxylic acid group; introducing a prima...
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WO/2020/155494A1 |
A preparation method of a sweetener composition comprises the following steps: acquiring minced leaves of Rubus suavissimus; using water as a solvent to perform extraction; removing phenolic hydroxyl group-containing components; performi...
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WO/2020/154217A1 |
This specification relates to a process for preparing fucose from a human milk oligosaccharide ("HMO") comprising a fucose moiety, as well as L-fucose compositions prepared by such a process.
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WO/2020/151623A1 |
The present invention pertains to the medical field and relates to a compound of formula (III), a stereoisomer or pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the compound, a ster...
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WO/2020/150915A1 |
A nucleic acid-drug conjugate based on a phosphorothioate-modified nucleic acid, a drug delivery system, and preparation methods therefor. The nucleic acid-drug conjugate is formed by reacting and binding a phosphorothioate group in a ph...
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WO/2020/143740A1 |
Disclosed are a cyclic dinucleotide prodrug molecule, a preparation method therefor and an application thereof relating to the field of pharmaceuticals. The cyclic dinucleotide prodrug molecule has a structure shown in formula I, II, or ...
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WO/2020/143653A1 |
Provided are a preparation method for a glucopyranosyl derivative compound used as an inhibitor of a sodium-dependent glucose transporter (SGLT) and an important intermediate of the glucopyranosyl derivative compound. The preparation met...
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WO/2020/140559A1 |
Provided is a 5-deoxy-D-ribose derivative (III), when the derivative (III) is used for preparing capecitabine, the stereoselectivity is good and the yield is high. Further provided is a preparation method of the derivative, wherein the p...
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WO/2020/141032A1 |
The invention relates to the field of nutritional ingredients, in particular to economically attractive methods for producing hypoallergenic galactooligosaccharides (HA-GOS) and the use thereof in food and feed items. Provided is a metho...
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WO/2020/132027A2 |
Provided herein, in some embodiments, are cell-free systems, methods, kits, and compositions (e.g., cells and cell lysates) for converting a polysaccharide to allulose via the use of enzymes, such as thermostable enzymes.
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WO/2020/124168A1 |
Provided herein is a method of separating a polyol from a liquids fraction obtained from treating a lignocellulosic material with an agent comprising the polyol, which includes contacting the liquids fraction with a first separation unit...
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WO/2020/125307A1 |
Disclosed is a method for constructing a Pseudomonas aeruginosa O11 serotype O antigen oligosaccharide using a D-glucose block, a L-fucosamine block and a D-fucosamine block, wherein the D-glucose block or the L-fucosamine block is conne...
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WO/2020/128945A1 |
The invention relates to a method for the separation of two hydrophilic neutral oligosaccharides from each other with a chromatography on a bromine functionalized polystyrene cross-linked with divinylbenzene (BPS-DVB) stationary medium.
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WO/2020/127156A1 |
The present invention relates to an improved process to produce a specific and very efficient epoxidation-catalyst (1,2:4,5-Di-O-isopropylidene-β-D-erythro-2,3-hexodiulo-2,6-
pyranose).
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WO/2020/129901A1 |
[Problem] To provide a novel method for preparing a ketone compound. [Solution] Provided is a method for preparing compound (I) represented by formula (I), the method comprising a step for obtaining compound (I) by reacting compound (II)...
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WO/2020/127140A1 |
The present invention relates to a method for separating biomass from a solution comprising biomass and at least one oligosaccharide.comprising providing the solution comprising biomass and oligosaccharides.lowering the pH value of the s...
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WO/2020/128469A1 |
The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chl...
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WO/2020/126918A1 |
The present invention relates to a processing method at acidic or neutral pH in a reactor (4) for processing lignocellulosic biomass (P), said method including a continuous cleaning phase of the reactor which comprises introducing a basi...
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WO/2020/127391A1 |
The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microa...
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WO/2020/122072A1 |
A method for preparing a glycan from a glycoprotein. The method includes (I) a step in which a glycoprotein is brought into contact with a glycan isolation solution to isolate a glycan from the glycoprotein and obtain a glycan-containing...
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WO/2020/113926A1 |
The present invention relates to the field of modification and extraction of natural compounds. Disclosed is a method for realizing a high value for a stevioside mother liquor sugar. According to the present invention, lactase is used to...
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WO/2020/114418A1 |
The present invention relates to an anticoagulant compound having an anionic form represented by formula (A), a preparation method thereof, and a use of the same in preparing a drug for preventing and/or treating a disease related to coa...
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WO/2020/117739A1 |
The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.
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WO/2020/114850A1 |
The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer (10), wherein crystallization by evaporation and/or crystallizat...
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WO/2020/114287A1 |
The present invention relates to a ruthenium-nickel/activated carbon co-supported catalyst, a preparation method therefor and a use thereof in the preparation of sugar alcohols by means of sugar catalysis and hydrogenation. According to ...
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WO/2020/113450A1 |
A preparation method for pseudo-ginseng total saponins by means of extraction and purification, specifically comprising using pseudo-ginseng medicinal materials as raw materials, extracting with ethanol, performing concentration and dryi...
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WO/2020/111851A1 |
The present application relates to a method for preparing a D-psicose crystal comprising 98%(w/w) or more of D-psicose and 0.05%(w/w) or less of ethanol on the basis of 100%(w/w) of the entire crystal, the method comprising: a first step...
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WO/2020/108343A1 |
(I) An oral pharmaceutical composition containing a 4'-thionucleoside compound of formula (I), a capsule and a product containing same, and a preparation method therefor and the use thereof. The oral pharmaceutical composition has a good...
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WO/2020/108149A1 |
Disclosed is a preparation method for cyclic purification of mother liquor sugar and extraction of renaudiside (RA) and stevioside (ST), comprising heating and stirring a mother liquor sugar comprising more than 70% of total glycosides w...
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WO/2020/112957A1 |
Methods of preparing highly purified steviol glycosides, particularly steviolmonoside, steviolmonoside A, steviolbioside, steviolbioside D, rubusoside, steviolbioside A, steviolbioside B, rebaudioside B, stevioside, rebaudioside G, stevi...
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WO/2020/103916A1 |
Provided is a separation and purification method for uridine triphosphate. The separation and purification method comprises the following steps: 1) loading: filtering crude uridine triphosphate and then loading same into a chromatography...
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WO/2020/104492A1 |
The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling act...
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WO/2020/106636A1 |
Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions ...
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WO/2020/102980A1 |
Proposed is a preparation method for a nucleotide for sequencing, i.e. a preparation method for a compound represented by formula (I), comprising (1) performing a first nucleophilic substitution reaction on a compound represented by form...
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WO/2020/099599A1 |
The invention relates to apparatus and a method for the extraction of one or more components from a biomass material, said apparatus including means to allow the biomass material to be pre-processed, which may include extraction and/or c...
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WO/2020/098659A1 |
The present invention relates to a method for removing impurities in a xylose mother liquor. A xylose mother liquor produced during xylose production is used as a raw material, and the xylose mother liquor is pretreated by using a lytic ...
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WO/2020/090948A1 |
A freeze-dried product of cyclic-di-AMP requires special production facilities and, therefore, is not suitable for large-scale production. A free acid crystal of cyclic-di-AMP is unstable under severe conditions at 105°C. Under these ci...
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WO/2020/092543A1 |
Provided are methods for non-enzymatically synthesizing nucleic acids. The methods include submerging a first portion of the outer surface of a cylinder in a non-enzymatic nucleic acid synthesis reaction mixture. The reaction mixture has...
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WO/2020/091423A1 |
The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide ...
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WO/2020/086366A1 |
The present disclosure provides methods for separating nucleic acids in a sample based on the length of the nucleic acids using a capillary electrophoresis device with formamide as a denaturing agent and a non-aqueous separation matrix c...
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WO/2020/083898A1 |
The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5'hydroxy protecting group at the 5'- O- oligonucleotide terminus of the oligonucleotide by way of tangential ...
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WO/2020/086559A1 |
Methods of isolating dihydrochalcone compounds of Formula (I) from Balanophora harlandii are provided herein. Compositions and consumables comprising at least one sweetener and at least one dihydrochalcone compound described herein are a...
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WO/2020/083871A1 |
The present invention relates to novel oligogalacturonans having a degree of methylation of 0 and a degree of polymerisation of 1 to 10, and to the use thereof for stimulating defence responses of plants against pathogenic microorganisms.
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WO/2020/079114A1 |
The present invention relates to a method for obtaining crystalline 2'-fucosyllactose from a 2'-FL raw material, which contains 2'-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at l...
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WO/2020/079146A1 |
Crystalline form II of 2'-O-fucosyl lactose having an X-ray powder diffraction pattern comprising three reflections at 2θ angles (13.65 ± 0.20)°, (16.98 ± 0.20)° and (18.32 ± 0.20)°, determined at a temperature of 25 °C with Cu-K...
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WO/2020/077970A1 |
Provided in the present invention is a highly efficient stevioside mixture preparation method, the preparation method comprising the following steps: (1) placing crude stevioside into a sealed pressure-resistant system or apparatus, and ...
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WO/2020/078000A1 |
1,3-disubstituted-2H-imidazolyl-2-carbene is a common type of azacyclocarbene, which may be used in a plurality of fields, comprising catalyzing organic reactions, acting as a transition metal ligand, and acting as a supporting ligand in...
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WO/2020/063894A1 |
An industrialization method for comprehensive utilization of stevia rebaudiana. The major improvement is in that the stevia rebaudiana is extracted by using a high-concentration alcohol solution, then the extracted solution is purified b...
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