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Matches 1 - 50 out of 4,190

Document Document Title
WO/2018/010170A1
Provided is a novel embodiment of a flavonoid with reduced hygroscopicity and improved storage stability. The flavonoid is applicable for preparing a food, health food, or pharmaceutical product or composition thereof to provide preventi...  
WO/2018/011067A2
Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.  
WO/2018/007035A1
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exch...  
WO/2018/005630A1
The invention provides a compound of the formula (I), and a capture support of the formula (9), wherein R1, R2, R3, R6, A, B, D, E, J, K, Q, W, and Z are as defined herein. The invention also provides a method of purifying an oligonucleo...  
WO/2017/222202A1
The present invention relates to a method for producing glucose from an agricultural byproduct, and to a microalgal culture medium for producing a biodiesel, said culture medium comprising an enzymatic hydrolysate obtained by treating a ...  
WO/2017/219509A1
Disclosed are a quinoid chalcone and flavonol conjugate having an anti-tumor activity and an anti-inflammatory activity and a preparation method therefor. Analyses on wave spectrum and mass spectrum data show that a compound (formula I) ...  
WO/2017/223258A1
The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the unreacted 5'-OH groups.  
WO/2017/219110A1
The present invention discloses a process for obtaining monosaccharides in acid aqueous solution from chitin or chitosan by means of chemical and/or enzymatic hydrolysis. By using low-cost and easily obtainable reagents, this process mak...  
WO/2017/217842A1
The invention is directed to a method for recovering lactose from an aqueous lactose solution comprising a concentration step, wherein water is removed from the aqueous lactose solution by freezing out water at a temperature below the eu...  
WO/2017/218454A1
The present invention is directed to a method of purifying oligonucleotides hydrophobic interaction chromatography.  
WO/2017/202351A1
The present invention relates to a new crystal form of a sodium-glucose co-transporter inhibitor medicine (Sotagliflozin) and a preparation method and use thereof. In addition, the present invention relates to a pharmaceutical compositio...  
WO/2017/194498A1
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefined oligonucleotides. Herein are disclosed solvent compositions...  
WO/2017/190568A1
Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl) methyl)-4-ethylb...  
WO/2017/190715A1
The invention relates to a preparation method of an amorphous form of sofosbuvir of formula I, (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2 H)-yl)-4- fluoro-3-hydroxy-4-memyltetrahydrofuran-2-yl)methoxy)-(ph...  
WO/2017/192902A1
Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating sa...  
WO/2017/185900A1
Provided are a series of crocins compounds and related pharmacological application thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasmi...  
WO/2017/185549A1
Provided is a method for preparing nicotinamide mononucleotide. Raw materials nicotinamide, ATP, and ribose react under the catalytic effects of nicotinamide phosphoribosyltransferase, phosphoribose pyrophosphokinase, and ribokinase so a...  
WO/2017/189631A3
Disclosed herein are methods of identifying target binding ligands from tagged combinatorial libraries. The methods generally involve contacting a combinatorial library with a target, washing the target to remove non-binding ligands, elu...  
WO/2017/182965A1
The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of pr...  
WO/2017/180592A1
The present disclosure provides, in some aspects, methods and compositions for producing nucleic acid nanostructures having little to no kinetic barriers to self-assembly.  
WO/2017/177896A1
Disclosed in the present invention are a compound represented by formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition o...  
WO/2017/178664A1
The present invention relates to the preparation of a synthetic tetrasaccharide, hexasaccharide and octasaccharide representing part of the repeating unit of the Streptococcus pneumoniae type 3 capsular polysaccharide as well as conjugat...  
WO/2017/176010A1
The present invention relates to a novel method for purifying 3,6-anhydro-L-galactose by using microorganisms and provides an effect of improving the production yield of 3,6-anhydro-L-galactose by using microorganisms during purification...  
WO/2017/167168A1
Compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids having more than three galloyl moieties, methods of preparing such, and uses the...  
WO/2017/161986A1
A natural extract high-intensity sweetener steviol glycoside, specifically related to a novel steviol C-glycoside crystal, a preparation method for same, and applications thereof. The novel crystal has the advantages of high crystallinit...  
WO/2017/161987A1
The present invention relates to the naturally extracted high intensity sweetener stevioside, and specifically relates to a novel crystal form of steviolbioside, and a manufacturing method and application therefor. The novel crystal form...  
WO/2017/162169A1
The present invention relates to a uridine phosphoramide prodrug, the preparation method therefor, and the medicinal uses thereof. The prodrug of the present invention is a chemical compound as shown in formula I, an optical isomer there...  
WO/2017/161985A1
The present invention relates to a naturally-extracted high-sweetener stevioside, and in particular to a new crystal form of a rebaudioside B, and a preparation process therefor and a use thereof. The new crystal form is fully characteri...  
WO/2017/160672A1
Modified Tryptamine, Tryptamine-2'-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nu...  
WO/2017/158624A1
The present disclosure provides novel crystalline sofosbuvir form- M3 and a process for the preparation of sofosbuvir form-M3. The crystalline sofosbuvir form-M3 disclosed herein may be useful in the formulation of pharmaceutical dosage ...  
WO/2017/160846A1
A method for making a highly soluble steviol glycoside composition is described. The resulting composition readily provides aqueous solutions with at least 0.3% concentration.  
WO/2017/153452A1
The present invention relates to a method for preparing 2'-O-fucosyllactose and to the protected fucosyl donor of the formula (I) used in this method. The method comprises reacting the fucose derivative of the formula (I) below with the ...  
WO/2017/152918A1
The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ...  
WO/2017/150766A1
Disclosed herein is a method of producing D-psicose. The method of producing D-psicose includes subjecting D-fructose to D-psicose epimerization to produce a D-psicose-containing solution, subjecting the D-psicose-containing solution to ...  
WO/2017/151742A1
The present invention provides a method of enriching a lipopeptide in a microbial cell culture, the method comprising mixing an amphiphilic sulfonate and/or an amphiphilic sulfate with the cell culture to induce the formation of aggregat...  
WO/2017/144318A1
The invention relates to derivatives of rhamnolipids of formula (I), formulations containing same, and the use thereof, in particular for scent retention on hair.  
WO/2017/144829A1
The field of this invention is that of recycling sugars from the by-products of the paper and cellulose industries and lignocellulosic biorefineries. The aim of the invention is to facilitate extraction and purification of sugars contain...  
WO/2017/145151A1
Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variet...  
WO/2017/144317A1
The invention relates to ester derivatives of rhamnolipids of formula (I) as nonionic surfactants, formulations containing same, and the use thereof.  
WO/2017/143956A1
The present invention relates to a naturally-extracted high potency sweetener rebaudioside, and particularly relates to a novel crystal form of a sodium salt of rebaudioside B and a preparation method thereof. The novel crystal form is c...  
WO/2017/144423A1
The present invention relates to a process for the synthesis of Sofosbuvir of formula (I) comprising the selective mono-deacetylation reaction of a compound of formula (V) to obtain a compound of formula (IV).  
WO/2017/133465A1
The present invention relates to a baicalin magnesium and further relates to a preparation method and extraction method of the baicalin magnesium. The preparation method comprises the steps of preparing a suspension of a baicalin, prepar...  
WO/2017/134176A1
The present invention relates to a process for producing 2'-O-fucosyllactose, to the intermediates obtainable by this process and to the use of these intermediates. Production comprises the reaction of a protected fucose of general formu...  
WO/2017/134606A1
The present invention relates to a crystalline Form B of {(1 R,2S,3S,4R,5S)-5-[4-chloro-3-(4-ethoxybenzylphenyl]- 2,3,4-trihydroxy- 6,8-dioxabicyclo [3.2. 1]oct-1-yl}methyl acetate of Formula (II) and a process for its preparation. The p...  
WO/2017/124222A1
Disclosed are a method and an intermediate for preparing a tulathromycin. The method comprises the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition s...  
WO/2017/124970A1
Provided are a dicaffeoyl-spermidine derivative glycoside, a preparation method therefor and a use. Biological activity tests show that the dicaffeoyl-spermidine derivative glycoside has antioxidant activity and antiviral activity, the a...  
WO/2017/124969A1
Provided are a dicaffeoyl-spermidine cyclic derivative and a use. Biological activity tests show that the dicaffeoyl-spermidine cyclic derivative has anti-senile dementia activity and antioxidant activity, the activity of the derivative ...  
WO/2017/120729A1
The present invention discloses a method and an intermediate for the preparation of an epirubicin hydrochloride. The method comprises the following step: in an organic solvent and under an action of an alkali, subjecting compound 4 and a...  
WO/2017/118355A1
Provided in the present application are a nucleotide derivative of a deuterated HCV (Hepatitis C Virus) NS5b inhibitor, or a pharmaceutically acceptable salt, stereoisomer, tauromer inhibitor thereof, and a use thereof in the preparation...  
WO/2017/118690A1
The present invention relates to an efficient route of synthesis of solithromycin and to a method of its purification which obviates the necessity of chromatographic purifications and improves the quality of the product by efficiently re...  

Matches 1 - 50 out of 4,190