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Matches 1 - 50 out of 4,343

Document Document Title
WO/2019/055331A1
Methods and compositions for extracting nucleic acids such as microRNAs (miRNAs) from biological samples are provided. Aspects of the methods include contacting a biological sample with proteinase K followed by contact with ferric oxide ...  
WO/2019/052359A1
The aim of the present invention is to provide a compound containing a diheterocyclic ribavirin analog, a stereoisomer, a prodrug, a pharmaceutically acceptable salt, a compound salt and/or a solvated compound with structural general for...  
WO/2019/053659A1
The present disclosure relates to compounds and compositions containing 5'-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.  
WO/2019/053476A1
The present invention relates to a process for the preparation of floxuridine, said process comprising reacting a compound of Formula la with a compound of Formula lla in the presence of an acid Al to provide a compound of Formula Ilia i...  
WO/2019/047848A1
The invention belongs to the field of quality analysis and control of traditional Chinese medicine, and provides a method for separating eighteen components in a traditional Chinese medicine composition, comprising: (1) preparing the tra...  
WO/2019/048881A1
The present invention relates to a process for preparing oligonucleotides or oligonucleotide analogues comprising triazole and (phosphor)amidate internucleoside linkages. The present invention also relates to the oligonucleotides and oli...  
WO/2019/043029A1
Disclosed is a method for purifying sialylated oligosaccharides from a fermentation broth, cell-lysate or biocatalytic reaction mixture for obtaining high amounts of desired sialylated oligosaccharides in high purity. The method is parti...  
WO/2019/043069A1
The present invention relates to a new class of sucrose esters and a method for their preparation.  
WO/2019/038366A1
The present invention relates to a method for preparing at least one oligosaccharide, comprising a step of ultrasound irradiation, at a frequency higher than 100 kHz, of an alcohol composition comprising at least one saccharide monomer a...  
WO/2019/036029A1
Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is...  
WO/2019/020767A1
The present application relates to compounds of formula (I), their process of preparation and the therapeutic uses thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.  
WO/2019/023439A1
The present invention relates to compositions comprising oligonucleotides, specifically SMAD7 antisense oligonucleotides, and methods for preparing the same.  
WO/2019/020759A1
The present invention relates to the compounds of formula (I), this process of preparation, and the therapeutic uses thereof. These macrolides of formula (I) are useful in the treatment of tuberculosis.  
WO/2019/020763A1
The present invention relates to compounds of formula (I), their process of preparation and the therapeutic use thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.  
WO/2019/019985A1
The present invention falls within the technical field of selenium-containing compounds. Disclosed are selenium-containing compounds - selenocarbohydrate, selenoglucoside - and preparation methods therefor. The method comprises the steps...  
WO/2019/011829A1
The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid- phase support bound process comprising the steps of deprotection of the 3'-amino group of the support-bound oli...  
WO/2019/012476A1
The present invention generally refers to novel intermediate polysaccharide units, useful for the preparation of polysaccharide antigen of GBS Ia, Ib and III; the invention also refers to a process for their preparation and their use as ...  
WO/2019/014286A3
Described are procedures and intermediates for the preparation of guadecitabine, and guadecitabine salts and solid state forms thereof.  
WO/2019/014286A2
Described are procedures and intermediates for the preparation of guadecitabine, and guadecitabine salts and solid state forms thereof.  
WO/2019/004554A1
The present invention relates to a method for producing a functional crystalline sweetener, and, more specifically, to a method for producing a crystalline sweetener for improving crystal yield and increasing particle size by controlling...  
WO/2019/003133A1
The invention relates to separation of disaccharides from tri- or higher oligosaccharides by nanofiltration.  
WO/2019/004693A1
The present invention relates to a method for preparing an N-glycoside compound from an alkoxyallene compound using a metal catalyst regioselectively and stereoselectively. According to the method for preparing an N-glycoside compound ac...  
WO/2019/004579A1
The present invention relates to a method wherein a purified product obtained from high-purity isolation of a solution containing allulose as a functional sweetener is concentrated to lead to a reduction in the content of impurities, suc...  
WO/2019/004555A1
The present invention relates to a functional saccharide having specific crystallinity, a method for producing the same, and a functional sweetener comprising the crystalline saccharide.  
WO/2019/002594A1
The present invention discloses a method for separating chromatographically indistinguishable 1,2-diaxial from 1,2- diequatorial disaccharide 2-azido-1-nitrates, wherein the disaccharide is a 1→4 disaccharide, comprising the steps of -...  
WO/2019/002237A1
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefined oligonucleotides using said monomer. Herein are disclosed o...  
WO/2019/003136A1
This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, suc...  
WO/2019/003135A1
The invention relates to a method for separating sialylated oligosaccharides, preferably sialylated human milk oligosaccharides (HMOs), from disaccharides, preferably lactose, produced by a fermentation or enzymatic process.  
WO/2019/001292A1
A method for preparing a compound of formula T-3 according to route I is disclosed. The method comprises the following steps: a first step of reacting a compound of formula T-1 with a reagent comprising a PG group in the presence of an o...  
WO/2018/233092A1
A method for preparing Rubusoside, comprising the following steps: grinding raw materials, performing flash extraction, double centrifugation, macroporous resin purification, desorption, enzymolysis, organic membrane grading decolorizati...  
WO/2018/229493A3
The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.  
WO/2018/229493A2
The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.  
WO/2018/229495A1
The present invention generally relates to a novel process for the preparation of 3'-deoxyadenosine derivatives,and particularly NUC-7738 (3'-deoxyadenosine-5'-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyade...  
WO/2018/215391A1
The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt...  
WO/2018/215049A1
The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt...  
WO/2018/213290A1
Methods of preparing highly purified steviol glycosides, particularly rebaudiosides M, D, E and I are described. The methods include utilizing enzyme preparations and recombinant microorganisms for converting various staring compositions...  
WO/2018/212236A1
Provided is a novel oligonucleotide production method using a nucleoside or oligonucleotide that can be isolated easily and has high storage stability. An oligonucleotide production method including a coupling step of reacting a 5'-hydro...  
WO/2018/209255A1
Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.  
WO/2018/207111A1
The present invention relates to an industrially feasible and economically viable process for preparation of SGLT2 inhibitors of formula (X) in significantly high yield and purity.  
WO/2018/194330A1
The present invention relates to an SMB-based fucose separation method and an apparatus therefor and, more particularly, to a method and an apparatus for continuously separating fucose from a microalgae-derived monosaccharide mixture or ...  
WO/2018/192502A1
Provided in the present invention are an antiviral precursor drug nucleoside cyclophosphate compound based on liver-specific delivery (LSD) technology and the use thereof, and in particular, provided in the present invention are a compou...  
WO/2018/195179A1
Compositions comprising at least one steviol glycoside are provided for reducing increased blood sugar level (hyperglycemia) in Diabetes mellitus Type 1 and Type 2 patients.  
WO/2018/191598A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/189546A1
The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical link...  
WO/2018/185182A1
The present invention relates to a process for the selective isolation of highly purified, crystalline D-mannose from complex sugar mixtures, in particular from mixed wood sugars, more particularly from spent sulfite liquor (SSL).The pro...  
WO/2018/177825A1
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers comprising an amine containing chiral auxiliary group, and methods of orthogonally protecting the nit...  
WO/2018/177881A1
The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3' oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and depr...  
WO/2018/175800A1
The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.  
WO/2018/172129A1
The invention relates to sialic acid derivatives of formula (I) which contain a C-C triple bond, methods for the preparation thereof, conjugates produced therefrom and drugs containing same, wherein the symbols have the meanings defined ...  
WO/2018/166475A1
The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparat...  

Matches 1 - 50 out of 4,343