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Matches 1 - 50 out of 4,227

Document Document Title
WO/2018/069243A1
The present invention relates to processes for preparing glucopyranosyl-substituted benzylbenzene derivatives of general formula III, wherein R1, R2 and R' are defined according to claim 1; and the use of such processes in the synthesis ...  
WO/2018/058091A1
Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a γ-peptide nucleic acid (γPNA). Also provided ...  
WO/2018/058150A1
Disclosed herein is a method of maintaining corn protein yield during extraction and managing stickiness and viscosity comprising obtaining a corn material having a corn protein content and washing the corn material to remove non-protein...  
WO/2018/053706A1
A composition comprises a compound of formula (I) and at least one cosmetically acceptable carrier. It can be used for preventing or decreasing skin pigmentation and /or lightening skin tone.  
WO/2018/052849A1
This document provides methods and materials for producing and/or using mitochondrial preparations. For example, methods and materials for using xyloglucan (e.g., xyloglucan material obtained from potato) to produce improved mitochondria...  
WO/2018/053535A1
The present invention relates to purified and concentrated human milk oligosaccharide compositions and methods of making and using the same.  
WO/2018/050099A1
Provided is a panaxdiol-type ginsenoside derivative having a structure as shown in formula I or formula II. Also provided is the use thereof in the preparation of a drug for preventing and treating atherosclerosis. The panaxdiol-type gin...  
WO/2018/053135A1
The present disclosure provides a novel sweetener composition of improved taste of the sweetener (e.g., reduced bitterness and/or astringency, and improved overall sweet quality of the composition); food and beverage products containing ...  
WO/2018/045997A1
The present application falls within the field of drug synthesis, and relates to a method for preparing 2-fluoro-2-methyldeoxynucleoside as an intermediate of Sofosbuvir. In particular, the present application provides a method for prepa...  
WO/2018/039923A1
A preparation method of diosmin, comprising: A) mixing an amide solvent, hesperidin, an alkaline reagent, with iodine, and heating to react to obtain diosmin. Compared with the prior art, the amide solvent used as a reaction solvent has ...  
WO/2018/042464A1
The present disclosure provides a process for rapid hydrolysis of a substrate the process comprises the steps of obtaining a substrate slurry; contacting the 10 substrate slurry with at least one enzyme to obtain a soluble fraction and a...  
WO/2018/032272A1
A novel method for preparing an important bioactive substance, oligomeric mannuronic diacid. The method uses oligomeric mannuronic acid as the starting material and obtains the target substance by means of steps of acid degradation and a...  
WO/2018/033639A1
The present invention is directed to lactones of the following structural formula for use as precursors of NAD, and their use as nutritional supplements.  
WO/2018/033676A1
The invention relates to a frozen dessert with a reduced sugar content, more particularly ice cream with reduced sugar. The invention also relates to the use of maltooligosaccharides for replacing some of the sugar contained in a frozen ...  
WO/2018/035050A1
Hypersulfated disaccharides with utility in asthma or asthma related disorders are disclosed. The heptasulfated disaccharides administered orally have comparable bioavailability to the intravenous administered dosage form.  
WO/2018/033677A1
The invention relates to dairy compositions having a low sugar content and organoleptic and rheological properties similar to standard dairy compositions. The invention also relates to the use of maltooligosaccharides for replacing some ...  
WO/2018/030698A1
The present invention provides a method for electrochemically converting aldose into a ketone compound, comprising the steps of: performing a reduction reaction on aldose through an electrochemical catalytic reaction in the presence of a...  
WO/2018/029272A1
A method for purifying rebaudioside M, which method comprises: (a) providing a solution comprising rebaudioside M at a concentration of at least about 10g/L and at a purity of at least about 10% by weight on a dry basis; and (b) crystall...  
WO/2018/028494A1
A gemcitabine ProTide hypoxic-activated prodrug and a use thereof in the preparation of a medicament for treating tumors. The general structural formula thereof is formula (A), wherein: one of R1 and R2 is a hypoxic-activated group of -C...  
WO/2018/028050A1
Disclosed is an asymmetric aryl-alkyl persulfate compound as represented by formula (3) and a synthesis method therefor, in which an arylboronic acid of formula (1) and R2SSCOR3 of formula (2) serve as reaction raw materials and, under t...  
WO/2018/029274A1
A method for purifying rebaudioside A, which method comprises: (a) providing a solution comprising rebaudioside A; (b) concentrating the said solution; and (c) crystallizing from the solution a high purity composition comprising rebaudio...  
WO/2018/023205A1
A purification method for nicotinamide mononucleotide, relating to a method for purifying an NMN crude product obtained via a biocatalysis method. The purpose of the present method is to solve the problems in existing NMN purification me...  
WO/2018/019748A1
The invention relates to a compound of formula (I) wherein R2 and R4 are joined and together form a group, such a -CH2O-. The compound of formula (I) can be used in the manufacture of 5'S-LNA oligonucleotides as antisense drugs.  
WO/2018/019799A3
The invention relates to a process for the manufacture of an oligonucleotide comprising at least one non-chiral phosphorothioate intemucleoside linkage of formula (I) wherein R1 is as defined in the description and in the claims.  
WO/2018/019188A1
Provided are a crystal form A of a nucleoside phosphoramidate prodrug as shown in formula I and a preparation method therefor. The crystal form A at least has an X-ray powder diffraction (XRPD) pattern with peaks at the 2θ angles of 6.9...  
WO/2018/014866A1
Disclosed are a crystal form of a dapagliflozin intermediate and a preparation method therefor, and specifically disclosed are a crystal form of the dapagliflozin intermediate (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2-eth ...  
WO/2018/011067A3
Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a ...  
WO/2018/010170A1
Provided is a novel embodiment of a flavonoid with reduced hygroscopicity and improved storage stability. The flavonoid is applicable for preparing a food, health food, or pharmaceutical product or composition thereof to provide preventi...  
WO/2018/011067A2
Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.  
WO/2018/013466A3
The present invention is based on the identification of novel biomarkers predictive of endocrine resistance in breast cancer.  
WO/2018/007035A1
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exch...  
WO/2018/005630A1
The invention provides a compound of the formula (I), and a capture support of the formula (9), wherein R1, R2, R3, R6, A, B, D, E, J, K, Q, W, and Z are as defined herein. The invention also provides a method of purifying an oligonucleo...  
WO/2017/222202A1
The present invention relates to a method for producing glucose from an agricultural byproduct, and to a microalgal culture medium for producing a biodiesel, said culture medium comprising an enzymatic hydrolysate obtained by treating a ...  
WO/2017/219509A1
Disclosed are a quinoid chalcone and flavonol conjugate having an anti-tumor activity and an anti-inflammatory activity and a preparation method therefor. Analyses on wave spectrum and mass spectrum data show that a compound (formula I) ...  
WO/2017/223258A1
The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the unreacted 5'-OH groups.  
WO/2017/219110A1
The present invention discloses a process for obtaining monosaccharides in acid aqueous solution from chitin or chitosan by means of chemical and/or enzymatic hydrolysis. By using low-cost and easily obtainable reagents, this process mak...  
WO/2017/217842A1
The invention is directed to a method for recovering lactose from an aqueous lactose solution comprising a concentration step, wherein water is removed from the aqueous lactose solution by freezing out water at a temperature below the eu...  
WO/2017/218454A1
The present invention is directed to a method of purifying oligonucleotides hydrophobic interaction chromatography.  
WO/2017/202351A1
The present invention relates to a new crystal form of a sodium-glucose co-transporter inhibitor medicine (Sotagliflozin) and a preparation method and use thereof. In addition, the present invention relates to a pharmaceutical compositio...  
WO/2017/194498A1
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefined oligonucleotides. Herein are disclosed solvent compositions...  
WO/2017/190568A1
Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl) methyl)-4-ethylb...  
WO/2017/190715A1
The invention relates to a preparation method of an amorphous form of sofosbuvir of formula I, (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2 H)-yl)-4- fluoro-3-hydroxy-4-memyltetrahydrofuran-2-yl)methoxy)-(ph...  
WO/2017/192902A1
Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating sa...  
WO/2017/185900A1
Provided are a series of crocins compounds and related pharmacological application thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasmi...  
WO/2017/185549A1
Provided is a method for preparing nicotinamide mononucleotide. Raw materials nicotinamide, ATP, and ribose react under the catalytic effects of nicotinamide phosphoribosyltransferase, phosphoribose pyrophosphokinase, and ribokinase so a...  
WO/2017/189631A3
Disclosed herein are methods of identifying target binding ligands from tagged combinatorial libraries. The methods generally involve contacting a combinatorial library with a target, washing the target to remove non-binding ligands, elu...  
WO/2017/182965A1
The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of pr...  
WO/2017/180592A1
The present disclosure provides, in some aspects, methods and compositions for producing nucleic acid nanostructures having little to no kinetic barriers to self-assembly.  
WO/2017/177896A1
Disclosed in the present invention are a compound represented by formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition o...  
WO/2017/178664A1
The present invention relates to the preparation of a synthetic tetrasaccharide, hexasaccharide and octasaccharide representing part of the repeating unit of the Streptococcus pneumoniae type 3 capsular polysaccharide as well as conjugat...  

Matches 1 - 50 out of 4,227