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Matches 1 - 50 out of 1,098

Document Document Title
WO/2018/067730A1
The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a s...  
WO/2018/035050A1
Hypersulfated disaccharides with utility in asthma or asthma related disorders are disclosed. The heptasulfated disaccharides administered orally have comparable bioavailability to the intravenous administered dosage form.  
WO/2017/154938A1
[Problem] The purpose of the present invention is to provide a method for uniformly and efficiently producing a sugar having a sulfate group and/or phosphate group in the molecule or a compound containing the sugar. [Solution] The presen...  
WO/2017/071152A1
Provided are a phosphoryl mannose pentasaccharide as shown in formula (I) and derivatives of the phosphoryl mannose pentasaccharide as shown in formulas (II)-(XI), and a preparation method thereof. In the preparation method of this inven...  
WO/2017/024255A1
The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutica...  
WO/2017/002120A1
Compounds useful for selectively eliminating senescent cells, compositions comprising same and uses thereof in treating diseases and disorders in which selective elimination of senescent cells is beneficial are provided. The compounds ar...  
WO/2016/069826A1
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae vims infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (IV): The compounds, compositions, and methods pro...  
WO/2016/069825A1
Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections the compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola vir...  
WO/2016/069827A1
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (I), wherein the position of the nucleoside sugar...  
WO/2016/054745A1
Novel methods and uses for modulating immune responses are provided. The methods and uses involve the use of a TIFA activator such heptose-1,7- 5 bisphosphate or an analogue or derivative thereof. The methods may be used to activate, inh...  
WO/2016/037720A1
The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-...  
WO/2016/013938A1
The present invention relates to a family of carbohydrate monosulphate fatty acid esters, which contain less than 10 mole % of carbohydrate polysulphate fatty acid esters, and to a method of preparation thereof. The monosulphate carbohyd...  
WO/2016/004512A1
A synthetic charged glycolipid is described comprising a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone of an archaeal core lipid via a beta linkage. The synthetic charged glycolipids...  
WO/2015/081297A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2015/056011A1
A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the proc...  
WO/2015/040209A1
A molecule responding to formula (I)of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by P...  
WO/2015/021415A1
Methods and computer systems are described herein for identifying small molecules that bind to selected RNA structural features (e.g., to RNA secondary structures). Also described are compounds and compositions that modulate RNA function...  
WO/2014/013495A1
The present invention relates to amphiphilic aminoglycoside (AG) derivatives, especially derivatives of tobramycin, kanamycin A and paromomycin comprising hydrophobic side chains linked to the AG moiety by various linkers. These novel de...  
WO/2013/152279A1
The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).  
WO/2013/081028A1
The present invention relates to an amyloid β-binding material which contains sugar, or a sugar residue derived from the sugar. According to the amyloid β-binding material of the present invention, the sugar or the sugar residue specif...  
WO/2013/071409A1
A novel lipoteichoic acid (LTA) was isolated from C. difficile, the structure of which is illustrated below wherein n is an interger between 1 and 20, R3 and R4 are independently selected from C 14:0, C 16:0, C 16: l, C 18:0 or C18: l fa...  
WO/2013/006906A1
There is provided methods for the enrichment, isolation and/or modification of the dermatan sulphate (DS) derived from sources including hide processing waste streams. There is also provided uses of dermatan sulphate and/or low molecular...  
WO/2012/172104A1
The invention concerns a pentasaccharide compound of formula (I) and the salts thereof. The invention also concerns a pharmaceutical composition comprising the synthetic pentasaccharide compound of formula (I) and its salts. The inventio...  
WO/2012/160337A1
Compounds which interact with HlsTONES Compounds of Formula I : • 4"'-Sulfo-Fucose [alpha]1-3 (4"-sulfo)-Fucose [alpha]1-3 (4'-Sulfo-Fu- cose [alpha]1-4-Glucuronic acid [beta]1-0-Methyl or • 4" "-Sulfo-Fucose [alpha]1-3 (4"-sulfo)-Fu...  
WO/2012/146914A1
Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants.  
WO/2012/129651A1
The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the com...  
WO/2012/113404A1
The present invention relates to providing compounds of general formula (1) wherein A is glycosyl residue of a mono-, di- or oligosaccharide in protected form and R is selected from optionally substituted aryl or optionally substituted h...  
WO/2012/103990A1
The present invention relates novel phosphorainidates of monosaccharides of formula (I), wherein R1 is a monosaccharide group selected from A and B: R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and X are as defined h...  
WO/2012/077828A1
The purpose of the present invention is to provide a prophylactic or therapeutic agent for inflammatory diseases, which can inhibit the function of an inflammatory cytokine and therefore can exhibit an anti-inflammatory effect. The prese...  
WO/2012/073214A3
Compounds having the general formula (I) pharmaceutical compositions containing them for use in inhibiting bacterial heptose biosynthesis and thereby lowering or suppressing bacterial virulence.  
WO/2012/073214A4
Compounds having the general formula (I) pharmaceutical compositions containing them for use in inhibiting bacterial heptose biosynthesis and thereby lowering or suppressing bacterial virulence.  
WO/2012/073214A2
Compounds having the general formula (I) and their biological applications.  
WO/2012/025744A1
A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting on average in the range of 9 to 64 terminal carboxylic acid groups, and b) conjungated to said core in the range of 2 to 8 amino sugars or a sulph...  
WO/2012/025745A1
Aglycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting 16 terminal carboxylic acid groups, and b) conjungated to said core 2, 3, 4 or 5 glucosaminemolecules, wherein each glucosamineis linked directly t...  
WO/2011/069921A1
The present invention relates to an sucrose octasulfate of zinc of general formula (I), to the method for the preparation of same and to the use thereof in the pharmaceutical and/or cosmetic field, where: 0 ≤n ≤ 4, n is an integer, a...  
WO/2011/069921A9
The present invention relates to an sucrose octasulfate of zinc of general formula (I), to the method for the preparation of same and to the use thereof in the pharmaceutical and/or cosmetic field, where: 0 ≤n ≤ 4, n is an integer, a...  
WO/2011/039634A9
Described herein are methods and genetically engineered cells useful for uncapping a mannose- 6 -phosphate residue on an oligosaccharide by using a mannosidase capable of hydrolyzing mannose- 1 -phospho- 6 -mannose linkage to phospho - 6...  
WO/2011/039634A3
Described herein are methods and genetically engineered cells useful for uncapping a mannose- 6 -phosphate residue on an oligosaccharide by using a mannosidase capable of hydrolyzing mannose- 1 -phospho- 6 -mannose linkage to phospho - 6...  
WO/2011/033392A3
The invention relates to a nitration method having the following principles: a phosgene species is converted with two equivalent silver nitrates into a double-mixed anhydride of carbonic acid and nitric acid, known here as carbonic acid ...  
WO/2011/025286A2
The present invention relates to lipoteichoic acid-derived glycolipids, and to pharmaceutical, food or cosmetic compositions and vaccine adjuvants comprising same. The lipoteichoic acid-derived glycolipids according to the present invent...  
WO/2011/025286A3
The present invention relates to lipoteichoic acid-derived glycolipids, and to pharmaceutical, food or cosmetic compositions and vaccine adjuvants comprising same. The lipoteichoic acid-derived glycolipids according to the present invent...  
WO/2010/131712A1
Disclosed are a therapeutic pharmaceutical agent for diseases associated with the decrease in the function of GNE protein, a food composition, and a food additive. The therapeutic pharmaceutical agent is characterized by comprising a com...  
WO/2010/072977A1
The invention relates to a bacterial strain that produces enzymes having a fucanolytic activity, to a bacterial mixture containing said strain, to the use of said strain or bacterial mixture containing same for producing enzymes having a...  
WO/2010/058130A1
The invention relates to the methyl pentasaccharide O-2,3,4-tri-O-methyl-α-D-glucopyranosyl-(1 →4)-O-2,3-di-O-methyl-β-D-glucopyranosyluronic acid-(1 →4)-O-α-D-glucopyranosyl-(1 →4)-O-2,3-di-O-méthyl-α-L-idopyranosyluronic aci...  
WO/2010/051961A1
The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the ...  
WO/2010/040880A1
Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl ...  
WO/2010/006982A1
The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C-C bond, and wherein the sulfation degree expressed as perc...  
WO/2010/000013A1
The present invention relates to a sulfated polysaccharide compound and the preparation and use thereof, and in particular to a narrow distribution low molecular weight, highly sulfated pentosan (in this instance a xylan) referred to as ...  
WO/2009/143545A2
Method for sulphating pentose saccharides with diorgano-tin oxide and a sulphating agent in an organic solvent and sulphated pentose saccharides.  
WO/2009/143545A3
Method for sulphating pentose saccharides with diorgano-tin oxide and a sulphating agent in an organic solvent and sulphated pentose saccharides.  

Matches 1 - 50 out of 1,098