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WO/1997/010233A1 |
The invention is in the field of biologically active compounds such as taxol-2'-adipate derivatives, derivatives of bergenin and erythromycin derivatives. Taxol-2'-adipate derivatives have anti-cancer activity analogous to taxol. Bergeni...
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WO/1997/008207A1 |
Sialyl-Lewis X derivatives wherein the 2-hydroxyl group of fucose has been substituted by a fluorine atom as represented by general formula (I-1) and intermediates for use in synthesizing the derivatives.
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WO/1996/040701A1 |
A continuous transesterification method for preparing polyol polyesters is disclosed. The transesterification reaction of alkyl fatty acid esters and polyols to make polyol polyesters can be coupled with a process to make a lower alkyl, ...
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WO/1996/040699A1 |
Disclosed is a process for manufacturing a sugar ester product of a sugar and a fatty acid. First, a fatty acid and methyl or ethyl alcohol is reacted in the presence of sulfuric acid catalyst to produce a fatty acid ester and water. The...
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WO/1996/039411A1 |
Novel substituted liposaccharides useful in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are method...
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WO/1996/039160A1 |
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypepti...
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WO/1996/035700A1 |
The present invention describes glycomimetic saccharopeptides of formula (I): W-(X)n-Y-[(X)n-W-(X)n-Y]m-(X)n-W, wherein W is independently selected from the group consisting of a) saccharides; b) aryl, aralkyl; c) alkyl of 1 to 8 carbon ...
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WO/1996/025935A1 |
A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat ad...
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WO/1996/025408A1 |
An oxygen-containing heterocyclic derivative represented by general formula (I), a salt thereof, a solvate thereof or a hydrate thereof: wherein R1 represents hydrogen, A, B, etc., (wherein R8 represents C1-20 alkyl, aryl, etc); R2, R4 a...
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WO/1996/022996A1 |
Dihydrophenazine derivatives represented by structural formulae (I, II), obtained from the strains of ray fungi of the genus Streptomyces deposited with an international depositary authority, and having an antioxidant effect and the effe...
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WO/1996/021665A1 |
Compounds of Formula (I), wherein R1, R2, R3 may be alkyl or a variety of functional groups and their use as radiation sensitizers.
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WO/1996/018632A1 |
The present invention relates to a method for the making pure homologous series of fatty acyl esters of sugars. The production mono- to tetrapalmitates of maltose is particularly exemplified. Specific compositions containing di-, tri-, a...
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WO/1996/018600A1 |
The vast number of theoretically conceivable compounds resulting from the combination of all claimed substituents in formula (I) precludes a comprehensive search. For economical reasons the search has been limited to the following compou...
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WO/1996/016973A1 |
A keratan sulfate oligosaccharide comprising a di- to penta-saccharide which has a sulfated N-acetylglucosamine at the reducing end and wherein at least two hydroxyl groups per molecule have been sulfated, preferably one containing a dis...
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WO/1996/013511A1 |
The present invention relates to polymerisable derivatives of carbohydrates comprising a carbohydrate radical and more than one radically polymerisable hydrocarbon group which is linked optionally via a spacer to the carbohydrate radical...
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WO/1996/013258A1 |
The present invention provides breast cancer chemopreventive arylamide analogues of retinoic acid, more particularly C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide and N-glycoside analogue of retinoyl 'beta'-glucuro...
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WO/1996/009309A1 |
A specific ligand for E- and P-selectin was isolated from in vivo[3H]-glucosamine labeled HL-60 cells by a combination of weat germ agglutinin agarose and E- or P-selectin rIg-agarose chromatography. The total O-linked oligosaccharides o...
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WO/1996/008503A1 |
A compound of formula (I) or salts thereof, where Ro is hydrogen or together with R7O denotes a C1-C15 hydrocarbylidenedioxy group, R1 is hydrogen, R1a or a group of formula (II), R1a is R1b or a protecting group Q, R1b is C1-C20 alkyl, ...
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WO/1996/006102A1 |
The present invention relates to oligosaccharide mixtures whose individual constituents have an identical core structure which is substituted by at least one sugar and in which all positional isomers are represented, and all isomers with...
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WO/1996/005211A1 |
A ganglioside GM3 analog having the sialic acid residue fluorinated at the 9-position, represented by general formula (I), and an intermediate therefor, wherein R represents lower aliphatic acyl; R1 represents hydrogen or lower alkyl; R2...
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WO/1996/004249A1 |
Novel agents useful for detecting hypoxic tumor cells are provided. The compounds have structural formula (I), wherein R1 and R2 are as defined herein. Methods of using the compounds to detect hypoxic tumor cells are also provided, as ar...
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WO/1996/003411A1 |
Esters associating phenylacetic, 3-phenylpropionic, 4-phenylbutyric and n-butyric acids with Su(OH)n monosaccharides or sugar alcohols, of general formula (I), in which the Su(OH)n precursor is a monosaccharide or sugar alcohol, selected...
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WO/1996/003357A1 |
A process for the preparation of a selectively fluorinated organic compound, which process includes reaction of a precursor of said organic compound, the precursor containing at least one Group VI element selected from sulfur, selenium a...
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WO/1996/001832A1 |
The invention relates to an improved process for the synthesis and application of sugar esters, that are useful as effective, environmentally-safe pesticides for the control of soft-bodied arthropod pests.
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WO/1996/001639A1 |
A class of molecules that alter cell adhesion. A cell adhesion affector according to the present invention essentially consists of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a co...
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WO/1996/001807A1 |
New pseudoceramides have the formula (I), in which R1CO stands for a branched, saturated and/or unsaturated acyl residue with 8 to 50 carbon atoms, R2 stands for hydrogen or an optionally hydroxy-substituted alkyl residue with 1 to 30 ca...
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WO/1995/035112A2 |
The present invention relates to compositions and methods for preventing pneumococcal infection. In particular, the invention relates to identification of the major reception for Streptococcus pneumoniae on activated human cells, and dia...
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WO/1995/035111A2 |
A method of treating Candida albicans infection is disclosed. In one embodiment, for treatment of oral or vaginal infection, the treatment is by topical application of a composition of conjugates that are each composed of a carrier struc...
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WO/1995/033467A2 |
The present invention relates to compositions and methods for preventing pneumococcal infection. In particular, this invention relates to the identification of the minimum receptor targets of pneumococcal adherence to pulmonary and vascu...
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WO/1995/032955A1 |
2, 7-Deoxy-7-fluoro-2, 3-didehydrosialic acid of general formula (IV) and intermediates therefor of general formulae (II) and (III); in formula (II), R represents aliphatic acyl; R1 represents lower alkyl; R2s represent each independentl...
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WO/1995/029183A1 |
The proposal is for novel sugar tensides obtained by reacting alkyl and/or alkenyl oliglucosides a) with quaternary chlorine compounds or quaternary epoxides or b) with firstly halogen compounds and then amines. The cationic sugar tensid...
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WO/1995/027719A1 |
A process for preparing polyol fatty acid polyesters having levels of triglyceride below 0.5 % is described. Methyl esters having a level of monoglycerides below 500 ppm, a nondetectable level of di- and triglyceride and a glycerine leve...
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WO/1995/025524A1 |
The use of ginsenoside Ro or a plant extract containing same to prepare a cosmetic or pharmaceutical composition, particularly a skin care composition, for promoting collagen synthesis, particularly collagen I and/or collagen III synthes...
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WO/1995/024412A1 |
Novel anthracycline derivatives represented by general formulae (I) and (II) and having a higher antitumor activity than that of the antibiotics practically used as carcinostatics, such as daunomycin and adriamycin, and a low toxicity. I...
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WO/1995/024701A1 |
A stereodirected process for synthesizing 'alpha'-N-acetylgalactosaminides from N-acetylgalactosamine which, in a preferred embodiment, comprises: reacting N-acetylgalactosamine with a dialkyl acetal of an aldehyde or ketone to form a 4,...
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WO/1995/023605A1 |
A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of the following formula (I): (NeuAc-'alpha'(2-3)-pGal-'beta'(1)-(-X-)m-(-Y-)n-)p-Z ...
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WO/1995/023807A1 |
Novel pseudoceramides of formulae (Ia) and (Ib) are proposed, (Ia) (Ib) in which R1 stands for a linear or branched alkyl and/or alkenyl residue having 6 to 30 carbon atoms, Y stands for oxygen or an NR5 group, R2 stands for hydrogen or ...
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WO/1995/023157A1 |
Novel azide groups containing sialosides and a process for their preparation is provided. The methods and resulting compounds may be of pharmaceutical interest for the inhibition of the influenza virus neuraminidase.
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WO/1995/023156A1 |
A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3...
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WO/1995/021851A1 |
New pseudoceramides have the formula (I), in which R1 stands for a residue of a hydroxydicarboxylic acid diester with 3 to 10 carbon atoms in the dicarboxylic acid component and 1 to 30 carbon atoms in the alcohol components, R2 stands f...
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WO/1995/021182A1 |
Proposed are new pseudoceramides of formula (I), where R1 is a branched alkyl and/or alkenyl radical with 12 to 50 carbon atoms, R2 is hydrogen or an optionally hydroxy- substituted alkyl radical with 1 to 30 carbon atoms, R3 is a hydrox...
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WO/1995/021181A1 |
The proposal is for novel pseudo-ceramides of the formula (I) in which R1 is a linear alkyl and/or alkenyl radical with 6 to 30 carbon atoms, R2 is hydrogen or a possibly hydroxy-substituted alkyl radical with 1 to 30 carbon atoms, R3 is...
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WO/1995/019974A2 |
Calixarene-based compounds are described which have biological activity, particularly anti-bacterial, anti-fungal, anti-cancer and anti-viral activity. Some compounds have been found to have anti-HIV activity. The compounds are calixaren...
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WO/1995/018971A1 |
An efficient and versatile method of forming N-linked glycoconjugates is described wherein a glycosyl acceptor, typically comprising an activated carboxyl group, is reacted with a glycosylating agent, typically a glycosylamine, in the pr...
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WO/1995/018186A1 |
The design and synthesis of novel aminimide-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
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WO/1995/017903A1 |
The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
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WO/1995/015978A1 |
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin, as well as related compounds, are described. Clea...
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WO/1995/015309A1 |
Compounds selected from those of general formula [A-B (Groups I and II)] and (group III), (1, 2 and 3) where B is (4) and A is selected from specified aminoacyl compounds are inhibitors of DP-IV mediated processes.
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WO/1995/014493A1 |
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.
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WO/1995/014026A1 |
The invention relates to 'beta'(1}6) glucosamine disaccharides having general formula (I) to a method for preparing these disaccharides, comprising the steps of: i) providing a starting material comprising lipid A moiety of lipopolysacch...
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