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WO/2015/118498A1 |
The present invention relates to a stabilized kit for the preparation of a radiopharmaceutical. In particular, the present invention relates to the use of a non-aqueous solvent for the stabilisation of the ligand component of the kit.
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WO/2015/111627A1 |
The purpose of the present invention is to provide an amino acid precursor capable of improving the properties (especially water solubility, stability in water, bitterness, and the like) of an amino acid and being converted into an amino...
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WO/2015/112016A1 |
The present invention relates to a cycloaddition process comprising the step of reacting a halogenated aliphatic 1,3-dipole compound with a (hetero)cycloalkyne according to Formula (1): Preferably, the (hetero)cycloalkyne according to Fo...
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WO/2015/093929A1 |
The present invention relates to the synthesis of bioconjugate molecules, from among two or more of the following functional groups: sugars, prebiotics, oligosaccharides, polysaccharides, triglycerides, fatty acids, fatty acid esters, an...
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WO/2015/092374A1 |
There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate,
wherein said method comprises the following steps (i) to (v): (i) providing a first compone...
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WO/2015/092720A1 |
Provided herein are metabolites of N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)- 2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
(Sonidegib, LDE225) that modulate the activity of the Hedgehog signaling pathway and tha...
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WO/2015/070571A1 |
The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermedia...
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WO/2015/063500A1 |
A glycan having the structure galβ1-3GLc Nacβ1-3Galβ1-4(Fucα1-3)Glc NAc (LecLex) which is attached to a lipid or protein backbone, and isolated binding members capable of binding thereto.
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WO/2015/020073A1 |
Provided is a method for producing sucrose fatty acid ester having suppressed coloration and a negligible amount of residual organic solvent. A method for producing sucrose fatty acid ester that acquires sucrose fatty acid ester from a r...
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WO/2014/196887A1 |
Derived for the first time are individual (without the addition of penta- and hexa-acyl derivatives) di-, tri- and tetra-acyl S-LPS of endotoxic bacteria and combinations thereof, and the immunobiological, physicochemical and chemical...
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WO/2014/182966A1 |
Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbi...
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WO/2014/177771A1 |
The invention relates to a glycoprotein-toxic pay- load molecule conjugate, a toxic payload molecule- glycan conjugate, and a pharmaceutical composi- tion.The invention further relates to a method for preparing the glycoprotein-toxic pay...
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WO/2014/161960A1 |
Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries...
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WO/2014/147168A1 |
It was the object to perform surface functionalization with as low as possible a procedural effort and without deleterious side effects, wherein the functionalized surface is to have a permanent chemical activity and a high degree of sub...
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WO/2014/143620A1 |
The invention provides compounds, formulations and methods for improving plant emergence, growth and yield. More specifically, the present invention relates to compositions comprising the synthetic lipoamino acid glucosamine compounds of...
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WO/2014/138490A1 |
Compounds that are related to natural synthetic lipochitooligosaccharide analogs were chemically synthesized and found to be effective as plant performance enhancers. The compounds of general formula (I) are amine-oligosaccharides with a...
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WO/2014/132940A1 |
Provided is a method for producing α-halo-tetraacyl glucose, the efficiency of which is excellent and suited to industrial production. The present invention is a method for producing α-halo-tetraacyl glucose represented by general form...
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WO/2014/124214A1 |
Naturally-derived compounds having various structures elicit the perception of salty taste, enhance the perception of salty taste of a salt, or act at one or more sodium channels. Food products may include such naturally-derived compound...
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WO/2014/106856A1 |
The present invention relates to the mannose - receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the present invention can target DNA vaccines to antigen presenting cells (APCs) su...
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WO/2014/086373A1 |
The present invention relates to a method of obtaining a non-acidic human milk oligosaccharide (HMO) or a precursor in crystalline form from an aqueous medium, such as a fermentation broth, by drying the aqueous medium and then treating ...
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WO/2014/077960A1 |
The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate -based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a ...
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WO/2014/053603A1 |
The invention relates to compounds of formula (I); wherein A and L are as defined in the description. The invention also relates to immunogens obtained from said compounds, and to antibodies raised against said immunogens. The compounds ...
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WO/2014/032188A1 |
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and d...
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WO/2014/032187A1 |
The invention provides compounds of Formula (I) for inhibiting gh cosidases, prodrugs of the compounds, and pharmaceutical compositions comprising the compounds or prodrugs of the compounds. The invention also provides method of treating...
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WO/2014/032185A1 |
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and d...
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WO/2014/027203A1 |
An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or...
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WO/2014/019855A1 |
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group...
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WO/2014/013495A1 |
The present invention relates to amphiphilic aminoglycoside (AG) derivatives, especially derivatives of tobramycin, kanamycin A and paromomycin comprising hydrophobic side chains linked to the AG moiety by various linkers. These novel de...
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WO/2013/172436A1 |
The invention pertains to glycosylated crocin compounds obtained by condensing glucose or glucose oligomer to one or more hydroxyl groups of crocin represented by formula (1) as novel glycosylated compounds of crocin, or a mixture thereo...
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WO/2013/157267A1 |
[Problem] To provide a novel method for producing an acyl glucuronide which is an ester compound of a compound containing a carboxy group and a glucuronic acid. [Solution] An acyl glucuronide is obtained, for example, by reacting 1-chlor...
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WO/2013/151697A1 |
The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using co...
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WO/2013/133271A1 |
The present invention relates to a trehalose fatty acid ester composition that contains trehalose fatty acid esters, wherein a fatty acid residue having 8 to 22 carbon atoms makes up more than 50 mass% of the total amount of all of fatty...
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WO/2013/115817A1 |
The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermed...
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WO/2013/100105A1 |
Provided are: a Maillard reaction inhibitor which can inhibit the progress of a Maillard reaction in a living body effectively, does not cause any adverse side effect, can be applied safely, and can be produced without requiring any comp...
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WO/2013/089792A1 |
Compositions resulting from the dehydration and esterification of a sugar alcohol (i.e., an alditol). In some particular embodiments, the composition comprises mono-acylated sorbitan and/or mono-acylated isosorbide.
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WO/2013/011098A9 |
The present disclosure relates to iminosugar derivatives and processes for the preparation thereof. The disclosed compounds have glycosidase inhibiting properties, and are useful in the treatment of various diseases, such as type 2 diabe...
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WO/2013/071409A1 |
A novel lipoteichoic acid (LTA) was isolated from C. difficile, the structure of which is illustrated below wherein n is an interger between 1 and 20, R3 and R4 are independently selected from C 14:0, C 16:0, C 16: l, C 18:0 or C18: l fa...
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WO/2013/059927A1 |
The present application relates to the compounds of formula I (I) as well as their use for inhibiting at least one of AKT-1, FAK and PKCα and in the treatment and/or prevention of metastatic diseases.
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WO/2013/050377A1 |
The present invention relates to the use of a compound of formula (1): wherein - R represents a linear or branched alkyl group comprising from 3 to 27 carbon atoms, said alkyl group being replaced by at least two hydroxyl groups, and opt...
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WO/2013/046180A1 |
A method that can be used to make a precursor of L-fiicose from D-glucose, that comprises the steps of: a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), Formula...
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WO/2013/022985A2 |
The present invention relates to compounds involved in nematode signaling.
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WO/2013/017254A1 |
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1→3 ) -β-D-Glcp- ( 1→4 ) - [a-L-R...
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WO/2013/004669A1 |
Helicobacter pylori infects over half of the world's population and thought to be a leading cause of chronic gastritis, peptic ulcer, and gastric cancer. Campylobacterjejuni is another enteric and gastric bacteria which is the most commo...
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WO/2012/160337A1 |
Compounds which interact with HlsTONES Compounds of Formula I : • 4"'-Sulfo-Fucose [alpha]1-3 (4"-sulfo)-Fucose [alpha]1-3 (4'-Sulfo-Fu- cose [alpha]1-4-Glucuronic acid [beta]1-0-Methyl or • 4" "-Sulfo-Fucose [alpha]1-3 (4"-sulfo)-Fu...
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WO/2012/153128A1 |
A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes the steps of: A) forming an extraction medium comprising an acid-extracting tin species and an extraction solvent that is immiscible with th...
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WO/2012/140596A1 |
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a ph...
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WO/2012/137604A1 |
Provided is a method for producing a diester of a polyhydric alcohol and a fatty acid, the method being provided with a step of obtaining a diester of a polyhydric alcohol and a fatty acid by reacting a monoester of a polyhydric alcohol ...
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WO/2012/129651A1 |
The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the com...
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WO/2012/126091A1 |
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating di...
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WO/2012/103990A1 |
The present invention relates novel phosphorainidates of monosaccharides of formula (I), wherein R1 is a monosaccharide group selected from A and B: R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and X are as defined h...
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