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Matches 1 - 50 out of 13,186

Document Document Title
WO/2019/196920A1
The present application falls within the field of medical technology, and relates to crystals of glycyrrhizic acid derivatives, crystalline compositions, pharmaceutical compositions and uses thereof, in particular relates to type A cryst...  
WO/2019/194858A1
The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.  
WO/2019/178116A8
The present disclosure relates to the production of steviol glycosides rebaudioside J and rebaudioside N through the use of rebaudioside A as a substrate and a biosynthetic pathway involving various 1,2 RhaT-rhamnosyltransferases.  
WO/2019/189422A1
A method for separating steviol glycoside(s), said method involving separation step 55 for performing continuous liquid chromatography wherein a liquid to be separated, which contains multiple kinds of steviol glycosides, is passed throu...  
WO/2019/190986A1
Disclosed is a compound of the formula (I) or (II): wherein a f are as described herein. The compounds are useful in the activation of Type II NKT cells and in treating cancer.  
WO/2019/178699A1
The present description relates to glycoconjugates, glycoconjugate immunogens and glycoconjugate vaccines comprising carbohydrate antigens coupled to immunogenic carrier proteins, or materials used for detection and screening of resultin...  
WO/2019/178980A1
A method for preparing gynostemma pentaphylla makino saponin LVI, XLVI, L, LI, Damulin A or Damulin B. In said method, Gynostemma cardiospermum Cogn.ex Oliv is used as a raw material to prepare a high content of target product by means o...  
WO/2019/183159A1
Provided are variants of saponins that are found in Quillaja saponaria (QS) Molina tree bark that are chemically modified to distinguish them from naturally occurring parent saponins. The modified saponins have increased adjunctive activ...  
WO/2019/177634A1
Methods of preparing highly purified steviol glycosides, particularly steviolmonoside, steviolmonoside A, steviolbioside, steviolbioside A, steviolbioside B, rubusoside, stevioside, stevioside A (rebaudioside KA), stevioside B, steviosid...  
WO/2019/178541A1
Methods of using highly purified rebaudioside AM are described. The methods include utilizing enzyme preparations and recombinant microorganisms for converting various staring compositions to target steviol. glycosides. The highly purifi...  
WO/2019/178116A1
The present disclosure relates to the production of steviol glycosides rebaudioside J and rebaudioside N through the use of rebaudioside A as a substrate and a biosynthetic pathway involving various 1,2 RhaT-rhamnosyltransferases.  
WO/2019/178471A1
Methods of preparing highly purified steviol glycosides, particularly steviolmonoside, steviolmonoside A, steviolbioside, steviolbioside D, rubusoside, steviolbioside A, steviolbioside B, rebaudioside B, stevioside, rebaudioside G, stevi...  
WO/2019/172210A1
[Problem] To provide a novel compound having great potential as a prodrug-type anticancer agent. [Solution] A compound represented by general formula (I) or a salt thereof  
WO/2019/170731A1
The present disclosure relates to novel nucleotide precursors and nucleotide analogs that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs. Oligonucleotides containing these analogs hav...  
WO/2019/168082A1
The purpose of the present invention is to provide a crystal of rebaudioside D that exhibits high solubility in water. In one embodiment, the present invention provides a rebaudioside D crystal having a crystalline form α that shows pea...  
WO/2019/162509A1
The various aspects presented herein relate to processes for preparing food ingredients, flavors and sweeteners from extracts of plants that contain terpene glycosides such as Stevia rebaudiana Bertoni, Rubus suavissimus or Siraitia gros...  
WO/2019/160922A1
This specification relates to a process for preparing a dried fucosyllactose (FL) from an FL solution by spray drying. This specification also relates to an FL in powder form having high bulk density, such as is obtained by the process d...  
WO/2019/154195A1
The present invention relates to a novel therapeutic drug for a neurodegenerative disease and an application thereof. Provided is a novel compound of formula (I). The compound can effectively facilitate the proliferation of neural stem c...  
WO/2019/156907A1
Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6 dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3'-fluoro-[1,1'-biphe nyl]-2-yl)ethyl)-acetamide and L proline or D- proline, their pharmaceutical compositions,...  
WO/2019/154859A1
The present invention relates to a compound, a liposome comprising said compound, a virus-like particle comprising said compound, a pharmaceutical composition comprising or consisting of said compound, said liposome or said virus-like pa...  
WO/2019/053700A3
Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degr...  
WO/2019/147617A1
Novel diterpene glycosides isolated from Stevia extract as well as diterpene glycosides that are synthetically prepared are provided herein. Compositions and consumables comprising the novel diterpene glycosides are also provided herein....  
WO/2019/143918A1
The disclosure relates generally to sweetener compositions. The disclosure relates more particularly to aqueous sweetener compositions of high intensity sweeteners, such as specific combinations of rebaudioside A, rebaudioside D, and reb...  
WO/2019/136517A1
The invention provides a viscoelastic fluid comprising non-ionic surfactant, wherein the non-ionic surfactant comprises surfactant molecules having the formula: X–L–R, wherein: each X group is independently a head group comprising a ...  
WO/2019/136287A1
Disclosed in certain embodiments is a compound of Formula I: X-Z (I) wherein X is a monosugar or disugar moiety and Z is a C8-20 straight chain alkyl, alkenyl or alkynyl having 1-5 substituents (Y) on the first 6 carbons proximal to the ...  
WO/2019/133878A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For examp...  
WO/2019/127004A1
The present invention falls within the field of biomedical technology, and in particular relates to modified oligonucleotides and a compound that can be used for synthesizing same, and a method for modifying oligonucleotides. The present...  
WO/2019/128611A1
Disclosed are a compound for forming a conjugate with an active agent such as an oligonucleotide having a structure represented by Formula (321), and a corresponding conjugate. The conjugate can specifically target hepatocytes, thereby e...  
WO/2019/121734A1
The invention is in the field of medical sciences. It provides new pharmaceutical methods and preparations. In particular, the invention relates to a method for increasing the oral bioavailability of drugs. The invention also provides ne...  
WO/2019/119117A1
There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis...  
WO/2019/083309A3
The present application relates to a method for preparing transfructosylated stevioside by using arthrobacter-derived microorganisms, a culture thereof, a cutlure supernatant, a culture extract and a fragmented material of a strain.  
WO/2019/115702A1
The present invention relates to the field of pharmaceutical products, specifically the glycosidic derivatives of treprostinil. The glycosidic treprostinil derivatives can be used to treat any conditions responsive to treatment with trep...  
WO/2019/117667A1
The present application relates to a method for producing transfructosylated steviol glycoside by using a crude enzyme extract of a Lactobacillus mali strain.  
WO/2019/115903A1
Composition based on a polyol of formula HO-CH2 -(CHOH)m -CH2 -OH and on alkyl polyrhamnosides of formula HO-CH2 -(CHOH)m -CH2-O-(Rham)x -H; process for preparing same, and cosmetic or pharmaceutical composition comprising same.  
WO/2019/115904A1
Composition based on a polyol of formula HO-CH2-CHOH-CH2-OH and on alkyl polyrhamnosides of formula HO-CH2-CHOH-CH2-O-(Rham)x-H; process for preparing same, and cosmetic or pharmaceutical composition comprising same.  
WO/2019/069297A3
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes de...  
WO/2019/106201A1
The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide ...  
WO/2019/106192A1
Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.  
WO/2019/106200A1
The present invention relates to a synthetic oligosaccharide of general formula (I): T*―[(―Ux+4―Ux+3―Ux+2―Ux+1―Ux)m―(Vx+2―Vx+1― Vx)1-m―T―O―L―E that is related to Klebsiella pneumoniae serotype O3, O3b and/or O5 ...  
WO/2019/104253A1
Novel cultivars of Stevia rebaudiana plant, with a novel genetic trait of self-compatibility, and the advantageous use of this genetic trait in Stevia rebaudiana crossing breeding for increasing steviol glycosides production, including f...  
WO/2019/103050A1
Provided is a compound that, after administration into an organism, rapidly binds to blood albumin, persistently circulates systemically, and efficiently accumulates in tumor tissue and then releases an active drug. The compound exhibits...  
WO/2019/100676A1
A preparation method for enzyme-modified stevioside is provided in the invention and comprises: adding beta-fructofuranosidase into a solution having a stevioside raw material and sucrose dissolved therein so as to obtain a reaction liqu...  
WO/2019/092504A1
The compounds of the present invention are useful for stabilizing biological molecules, particularly in the presence of pH and thermal stress. Formula (I) wherein X is an hexosyl uronic acid or uronic acid amide group.  
WO/2019/092572A1
The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase ...  
WO/2018/225065A9
Novel aminoglycosides, represented by Formulae (e.g., a compound of Formula A, B, I, I*, III or III*, including compounds represented by Formula Ia, I**, I*a, I*b, IIIa, III**, III*a and, III*b), as defined in the instant specification, ...  
WO/2019/088374A1
The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystalizing a membrane protein using same. By using a compound according to...  
WO/2019/079160A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2019/079706A1
Provided herein are aminoglycosides for the treatment of infections, and pharmaceutical compositions, methods, kits, and uses thereof. Also provided are a methods of making aminoglycosides that enables late-stage derivatization of the C6...  
WO/2019/079613A1
The present disclosure relates to novel methods for preparing antibacterial sisomicin-type aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.  
WO/2019/074171A1
The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using...  

Matches 1 - 50 out of 13,186