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WO/2001/068659 |
The invention relates to a method for the production of perbenzylated 1-O glycosides of general formula (I), or the salts thereof, where Zucker?1¿ = a monosaccharide with a 1-OH functionality, R = benzyl, n = 2, 3 or 4, X = -O-, -S-, -C...
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WO/2001/066100 |
A pharmaceutical composition comprising floridoside for use in the therapeutic or prophylactic treatment of neoplastic disease and a range of viral infections, particularly viruses of the Herpes family.
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WO/2001/066554 |
A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited fo...
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WO/2001/064605 |
The present invention concerns a method for selectively establishing a dynamic combinatorial library of ligands for a target which binds at least two functionalities, which method comprises the following steps: selecting a plurality of f...
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WO/2001/062769 |
A process for preparing indolopyrrolocarbazole derivatives [I] by treating a compound [V] with a base in an inert solvent to prepare a compound [IV], reacting the compound [IV] with a compound [III] to prepare a compound [II], and debloc...
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WO/2001/060324 |
Skin preparations for external use containing a melanin formation inhibitor which is highly stable to heat and oxidation and thus suffers from no degradation/coloration in the preparations with the passage of time, as observed in the exi...
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WO/2001/060832 |
The invention relates to a compound of formula (I) wherein R¿1? is a sugar; R¿2? is -CH¿2?-O-(R¿7?)m, R¿7? representing a sugar, or R¿2? is -COOH; R¿3? is an epoxide-comprising group, C¿1?-C¿6?-alkyl or C¿2?-C¿6?-alkenyl, unsu...
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WO/2001/060835 |
The present invention relates to the compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, composites containing, and t...
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WO/2001/061353 |
An array having a target substance immobilized at 2 or more points in a pre-determined region on a solid phase per cm?2¿ of a solid phase base, wherein the target substance is immobilized at 2 or more points at different concentrations ...
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WO/2001/059067 |
Compounds containing a specific branched chain end terminal group, which is isopropyl, sec.-butyl, or tert.-butyl; a polar leading group; and long-chain aliphatic, non-cyclic, saturated or unsaturated, hydrocarbon group linking them; and...
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WO/2001/058932 |
The invention concerns cytostatic agents which are more tumor-specific as a result of modification with carbohydrates. Urea or dicarboxylic acid units as appropriate spacers ensure serum stability and simultaneous intracellular effect. T...
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WO/2001/056959 |
A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes m...
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WO/2001/057054 |
The invention concerns novel compounds of formula (I): R-T-O-[CH¿2?-CH(OH)-CH¿2?-O]¿n?-(G)¿x? wherein: R represents a linear or branched, saturated or unsaturated hydrocarbon radical comprising 6 to 30 carbon atoms; T represents one ...
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WO/2001/057053 |
The invention concerns a novel method for preparing by chemical process functionalised $g(b)-(1,3)-glucan derivatives, enabling to obtain free oligosaccharides or comprising specific groups such as, for instance, sulphate, phosphate, met...
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WO/2001/054691 |
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
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WO/2001/055157 |
The invention concerns novel compounds having a chemical structure of the type N-substituted 4-amino-4,6-didesoxy-$g(a)-D glucopyranosyl-(1$m(7)4)-$g(a)-D-glucopyranosyl-(1$m(7)4)-D-
glucopyranose or N-substituted 4-amino-4,6-didesoxy-$g...
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WO/2001/054702 |
The present invention relates to combinations of xylose compounds with other pharmaceutically active compounds, to pharmaceutical compositions comprising said combinations, as well as to use of these combinations for the manufacture of a...
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WO/2001/052746 |
Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allo...
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WO/2001/053292 |
The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are dis...
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WO/2001/051057 |
Serum levels of therapeutically useful glucocorticosteroids are substantially increased by oral administration of the corresponding glycoside or orthoester glycoside.
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WO/2001/051499 |
This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising $g(a)-D-Gal(1$m(7)3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the s...
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WO/2001/051003 |
The invention provides novel methods for treating disease based on the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiol...
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WO/2001/051498 |
A high yield, low cost process for the preparation of essentially calcium-free lactobionic acid from calcium lactobionate is disclosed. In a preferred embodiment, a series of ion-exchange resins are used to convert a solution of the rela...
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WO/2001/051060 |
This invention provides methods of preventing and treating endotoxemia and related complications associated with surgical procedures, such as cardiac surgical procedures, by administration of an antiendotoxin compound.
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WO/2001/051497 |
Glycosides and orthoester glycoside derivatives of bisphosphonate compounds useful for treating and/or preventing hypercalcaemia of malignancy, Paget's disease, osteoporosis, metastatic cancer in bone and soft tissue and periodontal dise...
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WO/2001/049698 |
A cytotoxic agent comprising one or more modified doxorubicins/daunorubicin linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more modified doxoru...
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WO/2001/047940 |
The invention concerns: (i) [4-(4-cyanobenzyl)phenyl]glycopyranosides of formula (I) wherein: the glycopyranosyl group R represents a $g(b)-D arabinopyranosyl, $g(b)-D-lyxopyranosyl, $g(b)-D-ribopyranosyl, $g(b)-D-mannopyranosyl, $g(b)-L...
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WO/2001/047941 |
The invention concerns (i) [4-(4-cyanobenzyl)phenyl]$g(a)-D-glycopyranosides of formula (I) wherein: the group $g(a)-D-glycopyranosyl R represents a $g(a)-D-glycopyranosyl, $g(a)-D-galactopyranosyl, $g(a)-D-mannopyranosyl, $g(a)-D-arabin...
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WO/2001/046385 |
The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC 8973P) was isolated from the soil. From the cu...
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WO/2001/044247 |
The present invention provides selective kinase inhibitors of formula (I).
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WO/2001/042179 |
Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation.
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WO/2001/042262 |
The present invention relates to compounds of the formula (I), wherein R is independently SO¿3??-¿ or CH¿3?; the spacer is a flexible spacer of a length of 13-25 atoms; the charge of the pentasaccharide residue is compensated by posit...
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WO/2001/042264 |
A method for the synthesis of aryl thioglycosides comprising a sialylated residue of $g(b)-D-galactose is disclosed. The method consists of preparing by a chemical synthesis a non-sialylated aryl thioglycoside, and enzymatically sialylat...
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WO/2001/039726 |
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection....
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WO/2001/040232 |
Novel C-13?2¿-COXR¿1?, C-17?2¿-COXR¿2? and C-13?2¿-COXR¿1?, C-17?2¿-COXR¿1? derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R¿1? and R¿2? , the same or different, may be an o...
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WO/2001/038337 |
One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another asp...
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WO/2001/037790 |
Disclosed is the use of alkyl- and/or alkenyloligoglycoside fatty acid esters for improving the sensory evaluation of emulsions.
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WO/2001/037843 |
The invention provides methods of preventing and treating pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin and related conditions in a patient by administering to the patient antiendotoxin compounds by inhalat...
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WO/2001/038339 |
Antimitotic terpenoid compounds including sarcodictyin A and diterpenes such as eleutherobin may be obtained from organisms of the order Gorgonacea. Methods of obtaining or preparing such compounds are provided, as are novel antimitotic ...
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WO/2001/036435 |
A $g(b)-D-glucofuranose compound which is 1,2,3,5,6-penta-O-propanoyl-$g(b)-D-glucofuranose, preferably in crystalline form, is prepared from D-glucose. The compound is prepared by reacting D-glucose with boric acid, or an equivalent the...
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WO/2001/036433 |
New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found...
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WO/2001/034176 |
A method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase. In one embodiment, a method of treating prostate cancer in a l...
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WO/2001/034617 |
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are pho...
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WO/2001/034207 |
jp007453riers comprising a hydrogen-binding polymer wherein a hydrogen-binding site is formed on a polymer chain having a conformation similar to nucleic acids (in particular, a polymer chain having a helix parameter similar to nucleic a...
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WO/2001/032667 |
Compounds represented by general formula (I), esters of the same, or pharmacologically acceptable salts thereof, [wherein R?1¿ is C¿1-20? alkanoyl optionally substituted with at least one member selected from the group A of substituent...
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WO/2001/030794 |
The invention concerns novel enzymatic substrates of general formula (I) wherein: X represents a nitrogen atom or a carbon atom substituted with a phenyl group, said phenyl group being optionally substituted in meta or para position; Y a...
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WO/2001/030793 |
This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein a, b, X, Y, Z, R?1¿, R?2¿, and R?3¿ are as defined herein. The compounds of formula (I) are antibacterial and an...
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WO/2001/030795 |
The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, produgs and solvates thereof, wherein X, Y, V, W?1¿, W?2¿, Z?1¿ and Z?2¿ are as defined herein. The invention also relates to pharmac...
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WO/2001/030776 |
The invention relates to novel limonoids, to a method for purifying them, to a method for producing them and to their use, particularly in the treatment of cancer or malaria.
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WO/2001/030796 |
Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing solution using a synthetic adsorbent to...
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