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Matches 1 - 50 out of 13,013

Document Document Title
WO/2019/036566A1
Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof.  
WO/2019/018940A1
Natural sweetener compositions are disclosed, which generally include steviol glycosides extracted from a Stevia rebaudiana plant and an amino acid component consisting of free glycine. The natural sweetener compositions may optionally f...  
WO/2019/019985A1
The present invention falls within the technical field of selenium-containing compounds. Disclosed are selenium-containing compounds - selenocarbohydrate, selenoglucoside - and preparation methods therefor. The method comprises the steps...  
WO/2019/012476A1
The present invention generally refers to novel intermediate polysaccharide units, useful for the preparation of polysaccharide antigen of GBS Ia, Ib and III; the invention also refers to a process for their preparation and their use as ...  
WO/2019/011914A1
The present invention relates to the novel use of saponins comprising acetyl residues on one of their sugar residues. These saponins are able to enhance the transfection efficiency to a surprisingly much higher extent than already known ...  
WO/2019/010563A1
The invention relates to the use of a compound having the structure of Formula (I) or a pharmaceutically acceptable salt or solvate thereof, for treating or preventing nephrolithiasis in patients. The invention further relates to an assa...  
WO/2019/008441A1
Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active age...  
WO/2019/007999A1
The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype la, lb, 2a,...  
WO/2019/006244A1
The present disclosure provides a method of producing enhanced amounts of rebaudioside M (Reb M) from various steviol glycosides utilizing the hydrolytic activity of beta-glucosidase. More specifically, the present disclosure provides an...  
WO/2018/233092A1
A method for preparing Rubusoside, comprising the following steps: grinding raw materials, performing flash extraction, double centrifugation, macroporous resin purification, desorption, enzymolysis, organic membrane grading decolorizati...  
WO/2018/237327A1
Disclosed herein are methods and compounds for treating glioblastoma with iniparib. Also disclosed herein is a method of selecting subjects having a glioblastoma for treatment based on a biomarker panel.  
WO/2018/237136A1
Disclosed are anti-cancer compounds and imaging agents. More specifically, the disclosed agents target carbonic anhydrase IX and XII and their use in the treatment of cancer, in particular breast cancer. Specific compounds are those that...  
WO/2018/229663A1
The invention provides fluorescence-quenched substrates of exo-glycosidase enzymes. The invention also provides methods for imaging exo-glycosidase enzymes activity within cells.  
WO/2018/231091A1
Field of use: the invention relates to combinatorial chemistry, pharmaceutics and cosmetology, and allows the synthesis of novel combinatorial libraries of antibiotic derivatives for use in pharmaceutics and cosmetology. Essence of the i...  
WO/2018/231089A1
Field of use: The invention relates to organic and bio-organic combinatorial chemistry, specifically to new combinatorial libraries of polysaccharide derivatives and to supramolecular structures based thereon, which have high biological ...  
WO/2018/232334A1
The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, na...  
WO/2018/225065A1
Novel aminoglycosides, represented by Formulae (e.g., a compound of Formula A, B, I, I*, III or III*, including compounds represented by Formula Ia, I**, I*a, I*b, IIIa, III**, III*a and, III*b), as defined in the instant specification, ...  
WO/2018/217808A1
The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavabl...  
WO/2018/216013A1
The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as wel...  
WO/2018/217769A1
The present invention is generally directed to processes for producing lactitol granulates. The present invention is also directed to lactitol granulates exhibiting one or more desirable and improved properties as compared to prior lacti...  
WO/2018/217700A1
The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula (I), where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods ...  
WO/2018/217699A1
The invention relates to thiocarbamate prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I) wherein R1, R2, R3, R4 and n are as defined. The invention also relates to pharmaceutical compositions comprising...  
WO/2018/213279A1
Methods of preparing highly purified steviol glycosides, particularly rebaudiosides M, D, E and / are described. The methods include utilizing enzyme preparations and recombinant microorganisms for converting various staring compositions...  
WO/2018/205286A1
Provided is a conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the present invention comprises one fluorescent chromophore an...  
WO/2018/207113A1
The present invention relates to an industrially feasible and economically viable process for preparation of Bexagliflozin of formula V in significantly high yield and purity.  
WO/2018/209255A1
Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.  
WO/2018/205039A1
A sugar substitute composition comprises a digestion resistant soluble fiber and a stevia leaf extract. The sugar substitute composition may include a natural masking flavor. The digestion resistant soluble fiber may be an isomalto-oligo...  
WO/2018/204358A1
The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention ...  
WO/2018/201076A2
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. Th...  
WO/2018/200663A1
Compositions and consumables comprising certain sweeteners and at least one dihydrochalcone of Formula I are provided herein, wherein the at least one sweetener is selected from certain steviol glycoside and/or mogroside sweeteners in sw...  
WO/2018/200645A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/200656A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/201087A1
Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted ...  
WO/2018/195179A1
Compositions comprising at least one steviol glycoside are provided for reducing increased blood sugar level (hyperglycemia) in Diabetes mellitus Type 1 and Type 2 patients.  
WO/2018/191598A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/190378A1
The purpose of the present invention is to provide a protein, said protein having an activity of synthesizing rhamnose from glucose, and a polynucleotide encoding the same. Provided are a rhamnose synthase derived from stevia and a metho...  
WO/2018/190452A1
The present invention relates to a novel amphipathic molecule based on tandem malonate, a method for producing same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the amph...  
WO/2018/185495A1
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...  
WO/2018/187738A1
The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6', C2' and/or C5''. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasi...  
WO/2018/185494A1
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...  
WO/2018/181515A1
The purpose of the present invention is to: determine the structure of a novel steviol glycoside which is detected from species containing a large amount of Reb. C (also referred to as dulcoside B), and a trace amount of which is capable...  
WO/2018/177381A1
The invention relates to the field of pharmaceutical chemistry, and particularly relates to a compound represented by formula (I), a preparation method thereof, and a medical use thereof. In the compound represented by formula (I), a lac...  
WO/2018/175994A1
The present invention provides improved processes for the preparation of drug-linkers with a β-glucuronide cleavable unit, as well as intermediates thereof.  
WO/2018/174725A1
The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neur...  
WO/2018/175622A1
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides anthracycline compounds that are chemically modified to have one or more moieties that include hydrophobic portions....  
WO/2018/173068A1
The present invention relates to novel synthetic Neisseria meningitidis Serogroup A (hereinafter MenA) capsular polysaccharide repeating unit oligomer and a process for synthesizing said synthetic MenA capsular polysaccharide repeating u...  
WO/2018/172129A1
The invention relates to sialic acid derivatives of formula (I) which contain a C-C triple bond, methods for the preparation thereof, conjugates produced therefrom and drugs containing same, wherein the symbols have the meanings defined ...  
WO/2018/169853A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists ar...  
WO/2018/166475A1
The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparat...  
WO/2018/167259A1
The invention relates to a method of transglycosylation for producing glycoconjugates and multivalent carbohydrates structures, comprising the transfer via a 4-α-glucanotransferase (EC 2.4.1.25) of at least one terminal non-reducing end...  

Matches 1 - 50 out of 13,013