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Matches 1 - 50 out of 12,980

Document Document Title
WO/2018/225065A1
Novel aminoglycosides, represented by Formulae (e.g., a compound of Formula A, B, I, I*, III or III*, including compounds represented by Formula Ia, I**, I*a, I*b, IIIa, III**, III*a and, III*b), as defined in the instant specification, ...  
WO/2018/217808A1
The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavabl...  
WO/2018/216013A1
The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as wel...  
WO/2018/217769A1
The present invention is generally directed to processes for producing lactitol granulates. The present invention is also directed to lactitol granulates exhibiting one or more desirable and improved properties as compared to prior lacti...  
WO/2018/217700A1
The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula (I), where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods ...  
WO/2018/217699A1
The invention relates to thiocarbamate prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I) wherein R1, R2, R3, R4 and n are as defined. The invention also relates to pharmaceutical compositions comprising...  
WO/2018/213279A1
Methods of preparing highly purified steviol glycosides, particularly rebaudiosides M, D, E and / are described. The methods include utilizing enzyme preparations and recombinant microorganisms for converting various staring compositions...  
WO/2018/205286A1
Provided is a conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the present invention comprises one fluorescent chromophore an...  
WO/2018/207113A1
The present invention relates to an industrially feasible and economically viable process for preparation of Bexagliflozin of formula V in significantly high yield and purity.  
WO/2018/209255A1
Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.  
WO/2018/205039A1
A sugar substitute composition comprises a digestion resistant soluble fiber and a stevia leaf extract. The sugar substitute composition may include a natural masking flavor. The digestion resistant soluble fiber may be an isomalto-oligo...  
WO/2018/204358A1
The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention ...  
WO/2018/201076A2
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. Th...  
WO/2018/200663A1
Compositions and consumables comprising certain sweeteners and at least one dihydrochalcone of Formula I are provided herein, wherein the at least one sweetener is selected from certain steviol glycoside and/or mogroside sweeteners in sw...  
WO/2018/200645A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/200656A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/201087A1
Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted ...  
WO/2018/195179A1
Compositions comprising at least one steviol glycoside are provided for reducing increased blood sugar level (hyperglycemia) in Diabetes mellitus Type 1 and Type 2 patients.  
WO/2018/191598A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2018/190378A1
The purpose of the present invention is to provide a protein, said protein having an activity of synthesizing rhamnose from glucose, and a polynucleotide encoding the same. Provided are a rhamnose synthase derived from stevia and a metho...  
WO/2018/190452A1
The present invention relates to a novel amphipathic molecule based on tandem malonate, a method for producing same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the amph...  
WO/2018/185495A1
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...  
WO/2018/187738A1
The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6', C2' and/or C5''. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasi...  
WO/2018/185494A1
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, pro...  
WO/2018/181515A1
The purpose of the present invention is to: determine the structure of a novel steviol glycoside which is detected from species containing a large amount of Reb. C (also referred to as dulcoside B), and a trace amount of which is capable...  
WO/2018/177381A1
The invention relates to the field of pharmaceutical chemistry, and particularly relates to a compound represented by formula (I), a preparation method thereof, and a medical use thereof. In the compound represented by formula (I), a lac...  
WO/2018/175994A1
The present invention provides improved processes for the preparation of drug-linkers with a β-glucuronide cleavable unit, as well as intermediates thereof.  
WO/2018/174725A1
The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neur...  
WO/2018/175622A1
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides anthracycline compounds that are chemically modified to have one or more moieties that include hydrophobic portions....  
WO/2018/173068A1
The present invention relates to novel synthetic Neisseria meningitidis Serogroup A (hereinafter MenA) capsular polysaccharide repeating unit oligomer and a process for synthesizing said synthetic MenA capsular polysaccharide repeating u...  
WO/2018/172129A1
The invention relates to sialic acid derivatives of formula (I) which contain a C-C triple bond, methods for the preparation thereof, conjugates produced therefrom and drugs containing same, wherein the symbols have the meanings defined ...  
WO/2018/169853A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists ar...  
WO/2018/166475A1
The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparat...  
WO/2018/167259A1
The invention relates to a method of transglycosylation for producing glycoconjugates and multivalent carbohydrates structures, comprising the transfer via a 4-α-glucanotransferase (EC 2.4.1.25) of at least one terminal non-reducing end...  
WO/2018/167794A1
Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of...  
WO/2018/167230A1
The invention relates to polymers comprising carbohydrate ligands and moieties, respectively, that bind to carbohydrate-binding proteins (CBPs), as well as to these carbohydrate ligands, and to their use in diagnosis and therapy of disea...  
WO/2018/170420A1
Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use th...  
WO/2018/165330A1
Stevia varieties with a high content of RebM, are disclosed Further provided are methods for producing Stevia plants having a high RebM content by negatively regulating certain genes selecting the resulting plants, and breeding with such...  
WO/2018/161979A1
The present invention provides lincosamides of general formula I, (I) wherein R1 is selected from C2-C8 alkyl or C2-C8 alkenyl; R3 is selected from OH, 0(C1-C4 alkyl), SH, S(C1-C4 alkyl) or halogen; R4 is H or C1-C3 alkyl; each of R21, R...  
WO/2018/163194A1
The present invention relates to a process for the preparation of D-glucitol, 1,5- anhydro-1-C-[4-chloro-3-[[ 4-[[(3S)-tetrahydro-3-furanyl)oxy )phenyl] methyl]phenyl]-, (IS) formula-1.  
WO/2018/162806A1
The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing ...  
WO/2018/165250A1
The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising...  
WO/2018/159393A1
The purpose of the present invention is to provide a component that promotes the growth of leguminous plants. Provided are: a promoter for leguminous plant growth, which contains a glycoside of Soyasapogenol B as an effective component; ...  
WO/2018/155970A1
The present invention relates to a novel glucose derivative, and said novel compound is useful as an SGLT-2 inhibitor. In addition, the novel glucose derivative according to the present invention has a relatively higher melting point, lo...  
WO/2018/153966A1
The present invention relates to novel compounds useful for visualizing cell sen es c en ce in vitro and in vivo, the preparation of said compounds and their use. In particular, the present invention pertains to novel hexose and particul...  
WO/2018/156950A1
A pharmaceutical composition for shifting a Th2 immune response to a Th1 response by natural killer T cells (NKT cells) including a therapeutically effective amount of a glycolipid of one or more of Formulas II- V or a pharmaceutically a...  
WO/2018/151872A1
2-pyrrolino- 13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino- 13-deoxyanthracycline and a 13-deoxyanthracycline can be administered to a patient simultaneously or sequentially in amou...  
WO/2018/152470A1
The present invention is directed to the method for selecting an RNA molecule that binds to a target molecule and a kit for carrying out the method. This method includes: providing a pool of oligonucleotide complexes that each comprise a...  
WO/2018/149945A1
The present invention relates to a compound bearing at least two fucose moieties for its use as a drug in the prevention or treatment of infections caused by Aspergillus spp, said compound having a molecular weight comprised from 0.6 to ...  
WO/2018/147306A1
The present invention addresses the problem of providing a method for glycosylating a hydroxylated stilbene compound. The means for solving the problem is a method for glycosylating a hydroxylated stilbene compound by the conventional Ko...  

Matches 1 - 50 out of 12,980