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WO/2008/099368A1 |
The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or ...
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WO/2008/091554A1 |
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms a...
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WO/2008/089669A1 |
The present invention relates to novel pharmaceutical compositions comprising Epimedium wushanense Ying extracts, their methods of preparation, and their use in inhibiting thrombosis and lipid deposition. Also provided by the present inv...
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WO/2008/091518A1 |
The present invention is related to pharmaceutical compositions of one or more tiacumicins that exhibit improved stability, and methods of treatment using such formulations. The formulations contain one or more tiacumicins, such as difim...
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WO/2008/088047A1 |
Disclosed is a method for producing a glycoside of a flavonoid, which comprises the step of reacting the flavonoid and a sugar donor with an enzymatic agent having a glycosylation activity and derived from a bacterium belonging to the ge...
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WO/2008/084498A1 |
A process is described in which decolorization of solutions or reaction mixtures containing trichlorogalactosucrose or 6-acetyl trichlorogalactosucrose is achieved described by bubbling ozone. The method can be used at various stages in ...
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WO/2008/083200A2 |
Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using...
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WO/2008/072034A1 |
The present invention relates to macrolide derivatives of formula (I) in which R1 and R2 have the meanings given in the description; which are endowed with antiinflammatory activity and are substantially free of antibiotic properties, to...
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WO/2008/068593A2 |
Polymorphs of a motilide having a structure represented by formula (Ia).
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WO/2008/061480A1 |
The present invention provides a mangiferin calcium having the following formula and its preparation and use. The said mangiferin calcium can lower plasma insulin, glucose, lipid, and also can improve the solubility, oral bioavailability...
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WO/2008/060767A2 |
Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and ...
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WO/2008/057520A1 |
Spinetoram is selectively produced in excellent yields by hydrogenating a mixture of 3'-O-ethyl spinosyn J and 3'-O-ethyl spinosyn L in a water miscible organic solvent using hydrogen gas and a heterogeneous catalyst.
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WO/2008/056608A1 |
The invention aims at providing novel 4'-substituted avermectin monoglycoside derivatives which have excellent miticidal, insecticidal or antiparasitic activity and exert excellent control activity against mites or excellent effects agai...
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WO/2008/043962A1 |
The present invention relates to novel morphine-6-glucuronide derivatives, to pharmaceutical compositions containing them and to uses thereof. Said derivatives have the following structures, where the group Pcntite (A), except substituen...
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WO/2008/037922A1 |
The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or prevent...
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WO/2008/034575A1 |
The iminosugar conjugates having the structural formula (I) with integer n≥0; R1, R2, being chosen from H, OH, NHAc, OGlycosyl, O(CH2)mCH3, or O(CF2)mCF3; R3, R4, R5, and R6 being chosen from H, OH, OGlycosyl, O(CH2)mCH3, or O(CF2)mCF3...
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WO/2008/032105A2 |
A compound having: a bicyclic ring structure that comprises two fused six-membered carbon rings, wherein one of the rings is aromatic, and wherein one carbon in the bicyclic ring structure may optionally be replaced with a nitrogen, sulf...
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WO/2008/028050A2 |
The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot rea...
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WO/2008/026310A1 |
The object of the invention is to provide a protective agent for oral mucosa for protecting the mucosa in the oral cavity from dry irritation. The object can be basically achieved by a protective agent for oral mucosa containing an effec...
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WO/2008/023383A1 |
The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts wherein, (R) is a.
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WO/2008/020490A1 |
Disclosed is a substance having an ability of inhibiting a testosteron-5α-reductase activity, an ability of inhibiting or reducing the proliferation of a cancer cell, an ability of inhibiting a cyclooxygenase, an ability of inhibiting a...
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WO/2008/019784A2 |
Disclosed are novel avermectin derivatives of formula (I), wherein -C22R1-A-C23R2, R3, R4, and R5 have the meanings indicated in the description, methods for producing said substances, the use thereof for controlling animal pests, novel ...
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WO/2008/019240A2 |
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof, which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions com...
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WO/2008/017696A1 |
Macrolide compounds of formula I: with PDF4 inhibiting activity are described, wherein R1 is a residue -Y-X-Q; Y is S, SO or SO2; X is a bond or a linear group consisting of hydrogen atoms and with up to 9 atoms selected from C, N, O and...
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WO/2008/016105A1 |
Disclosed are: a highly safe pharmaceutical composition for the prevention and/or treatment of a bone disease; and a pharmaceutical preparation, a health food or a functional food comprising the composition. An arylheptanoid compound rep...
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WO/2008/016132A1 |
Disclosed is a benzyl phenyl glucopyranoside derivative having excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. Specifically disclosed is a compound represented by the general formula (I) or a pharmacologically acceptabl...
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WO/2008/014722A1 |
Prenyl flavonoids, their preparation and use. The prenyl flavonoids are shown by formula I,in which ring A is five or six carbon ring glucide, or disaccharide; R is substitute of hydroxy on ring A selected from H,COCmH2m+1(m is natural n...
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WO/2008/014221A2 |
The present invention discloses compounds of formulae (I) and (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical composi...
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WO/2008/012343A2 |
This invention relates to a method for making macrolides, and, in particular, to a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl- tylonolide and derivatives thereof, as well as uses of macrolides to make me...
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WO/2008/007388A1 |
The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts; wherein R is formula (A).
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WO/2008/007027A1 |
The invention relates to new 5-thioxylose compounds, preferably 5-thioxylopyranose type derivatives, and the method of preparation thereof and their use as active ingredient for drugs, in particular intended for treatment or prevention o...
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WO/2008/007684A1 |
In the process of investigating a mechanism by which a tree growing in a cold climate maintains cellular water in a liquid state at a low temperature, the inventor conducted an investigation to identify a causative substance of that. As ...
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WO/2007/148697A1 |
Disclosed is an inhibitor of the expression of a nuclear transcription factor AP-1, which is excellent in safety and inhibitory activity on the expression of the nuclear transcription factor AP-1. The inhibitor is characterized by compri...
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WO/2007/144200A1 |
The present invention relates to a process for the coupling of two molecules by means of a Diels-Alder reaction with an inverse electron requirement, which comprises the following steps: reaction of (a) a triazine or tetrazine having one...
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WO/2007/141513A1 |
The invention provides coumarin compounds, in particular glycosidic coumarin compounds, useful in the treatment of dermatophyte fungal infections.
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WO/2007/143507A2 |
The present disclosure is directed to novel macrolide antibiotics of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof; and the chemical syntheses and medical uses of these novel macrolide antibiotics for the treatme...
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WO/2007/132937A1 |
Seven kinds of novel antibiotics could be produced by culturing a strain named Microbispora sp. A34030 strain (deposited under the accession number of FERM BP-10505 under Budapest Treaty) which had been isolated from a soil sample. The s...
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WO/2007/129646A1 |
Compounds represented by the formula (I): (I) and the formula (VI): (VI) have an action of inhibiting the production of MMP-9, and hence they are useful as a preventive agent and a therapeutic agent for oncogenic angiogenesis, chronic rh...
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WO/2007/129668A1 |
Disclosed is a novel pyrazolyl 5-thio-β-D-glucopyranoside compound which can inhibit the SGLT1 activity selectively and can prevent the absorption of glucose through the digestive tract, thereby controlling the IGT (impaired glucose tol...
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WO/2007/125562A2 |
The present invention concerns a method for the preparation and the use of an extract enriched of cyanidin-3-O-β-glucopyranoside and of its derivatives obtained from fruits or vegetables containing the aforementioned anthocyanin, and fo...
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WO/2007/119754A1 |
[PROBLEMS] To provide a novel agent for the prevention or treatment of leukemia. [MEANS FOR SOLVING PROBLEMS] Disclosed is an agent for the prevention or treatment of leukemia, which comprises at least a composition derived from an olive...
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WO/2007/116015A1 |
The present invention relates to novel lactose-derived compounds of general formula (I) and to their use as agents for stimulating the immune system of the skin and/or as immunoregulators, and for preparing a composition containing a cos...
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WO2006100413A9 |
The invention relates to novel compounds derived from 5-thioxylose, preferably 5-thioxylopyranose-type derivatives, and to the preparation method thereof and the use of same as an active principle in medicaments which are intended, for e...
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WO/2007/112473A1 |
A process for purifying a crude α- or a crude β-anomer of a 2,2'-difluoronucleoside, or a derivative thereof, which process includes: providing: an organic or inorganic acid; an amount of crude α- or β-anomer of a 2,2'-difluoronucleo...
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WO/2007/114304A1 |
Disclosed is a benzene production inhibitor which can inhibit the production of harmful benzene from a benzoic acid-containing product and is innoxious to a human body. The inhibitor comprises flavonol and/or a glycoside thereof or a com...
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WO/2007/109804A2 |
The present invention relates to extracts of cinnamon species plant material prepared by supercritical CO2 extractions methods.
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WO/2007/109600A2 |
The present invention relates to extracts of elder species plant material prepared by supercritical CO2 extractions methods, methods of treating viruses in a subject and methods of inhibiting viral infections in cells thereof.
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WO/2007/105547A1 |
The invention provides methods for improving the absorbability and antioxidant ability of myricetin in the body. Either of the methods can be achieved by binding one or a plurality of glucosyl groups to the oxygen atom at the 3 or 3' pos...
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WO/2007/104242A1 |
The invention has disclosed 1,2,3-trihydroxy benzene and its derivatives or pharmaceutically acceptable salts of formula I for zinc ion metal-protease inhibition. These compounds are used for selective depressants of zinc ion metal-prote...
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WO/2007/102438A1 |
[PROBLEMS] To provide: a fractionation method for extracting an ingredient, particularly a pharmacologically active ingredient such as an iridoid compound, from an Eucommia ulmoides oliver leaf with good efficiency; a fractionation produ...
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