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Matches 1 - 50 out of 6,484

Document Document Title
WO/2019/178119A1
Disclosed are aminocoumarin compounds, pharmaceutical compositions containing aminocoumarin compounds, and methods of their use, e.g., in the treatment of a Gram- negative bacterial infection.  
WO/2019/141209A1
A pyranoglucose-substituted pyrazole compound, used as a pharmaceutical intermediate, having the structural formula represented by formula (9c). The present invention further relates to an intermediate compound represented by formula (10...  
WO/2019/135010A1
The invention relates to a compound according to formula (1), wherein R1 to R4 and X are independently from each other a small functional group and R5 is -OH, or a moiety consisting of specific combinations of -L-, -Ra-, -Rb-, -Rd- and R...  
WO/2019/119628A1
Disclosed in the present invention is a method for preparing tulathromycin.  
WO/2019/120830A1
The invention relates to ascorbic 3-xyloside derivative compounds of formula (I) and also the salts thereof, the solvates thereof and the optical isomers thereof, the geometric isomers thereof, the tautomers thereof, and/or the racemic m...  
WO/2019/069297A3
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes de...  
WO/2019/112567A1
This invention provides protease activity screening matrices that contain a solid support conjugated to a substrate moiety that can be specifically cleaved by a specific protease. The invention also provides methods for utilizing the pro...  
WO/2018/067663A3
The present invention relates to ketolide compounds of Formula I. The compounds have good anti-microbial activities, reduced inhibition of cytochrome P4503 A4 (CYP3 A4), and acceptable safety of co-administration of other drugs. The pres...  
WO/2019/091287A1
The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among c...  
WO/2019/069297A2
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes de...  
WO/2019/047848A1
The invention belongs to the field of quality analysis and control of traditional Chinese medicine, and provides a method for separating eighteen components in a traditional Chinese medicine composition, comprising: (1) preparing the tra...  
WO/2019/044941A1
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structu...  
WO/2019/036537A1
In one aspect, the present disclosure provides trioxacarcin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein ...  
WO/2018/201076A3
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. Th...  
WO/2019/030367A1
The present invention relates to a method for the synthesis of compounds useful in the preparation of antibody drug conjugates (ADC), namely, monoprotected dimeric bifunctional prodrugs based on duocarmycin analogs. In a further aspect, ...  
WO/2019/028185A1
In some aspects, the disclosure relates to methods for screening clinical samples for the presence of L-form bacteria associated with endometriosis and/or ovarian fibroid tumors. The disclosure is based, in part, on screening methods use...  
WO/2019/020767A1
The present application relates to compounds of formula (I), their process of preparation and the therapeutic uses thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.  
WO/2019/020759A1
The present invention relates to the compounds of formula (I), this process of preparation, and the therapeutic uses thereof. These macrolides of formula (I) are useful in the treatment of tuberculosis.  
WO/2019/021510A1
This method for producing a flavonoid clathrate includes a detachment step in which a poorly-soluble flavonoid having a rhamnoside structure is treated with an enzyme having rhamnosidase activity in the presence of cyclodextrin, to detac...  
WO/2019/020763A1
The present invention relates to compounds of formula (I), their process of preparation and the therapeutic use thereof. These sequanamycin macrolides are useful in the treatment of tuberculosis.  
WO/2019/018286A1
This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, includin...  
WO/2019/004693A1
The present invention relates to a method for preparing an N-glycoside compound from an alkoxyallene compound using a metal catalyst regioselectively and stereoselectively. According to the method for preparing an N-glycoside compound ac...  
WO/2018/193476A3
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly in cancer stem cells. Particularly, the invention relates to compounds of Formula III to XIV for the treatment of cancer, such as br...  
WO/2018/223227A1
There are provided compositions and methods for prevention or treatment of atherosclerosis and related disorders. More specifically, there are provided desmocollin 1 inhibitor compounds and pharmaceutical compositions thereof for use in ...  
WO/2018/213690A1
The present invention relates to the discovery that mutant KCNJ5 is associated with adrenal diseases and disorders. The invention includes compositions and methods for the diagnosis and treatment of adrenal diseases and disorders, based ...  
WO/2018/201076A2
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. Th...  
WO/2018/193124A1
This invention relates to compounds that can be used to treat bacterial infections. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to method...  
WO/2018/193111A1
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...  
WO/2018/193126A1
The invention relates to compounds that can be used to treat bacterial infections. The compounds comprise azithromycin derivatives having a phosphonium ion tethered to the azithromycin macrocycle. The invention also relates to methods of...  
WO/2018/193476A2
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly in cancer stem cells. Particularly, the invention relates to compounds of Formula III to XIV for the treatment of cancer, such as br...  
WO/2018/193116A1
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...  
WO/2018/193117A1
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...  
WO/2018/193125A1
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using ...  
WO/2018/191682A1
The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.  
WO/2018/185684A1
The present technology is directed to compounds (e.g., Avermectin derivatives), compositions, and methods related to modulation of FXR. In particular the present compounds and compositions may be used to treat FXR-mediated disorders and ...  
WO/2018/183512A1
A single-dose oral formulation of spinosad and lufenuron and methods for its use in the extended control of a flea infestation on a domestic animal such as a dog without emesis.  
WO/2018/177381A1
The invention relates to the field of pharmaceutical chemistry, and particularly relates to a compound represented by formula (I), a preparation method thereof, and a medical use thereof. In the compound represented by formula (I), a lac...  
WO/2018/167675A1
A process for preparing ketolide compounds is disclosed. (Formula I) (I)  
WO/2018/165250A1
The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising...  
WO/2018/161039A1
Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer a...  
WO/2018/153954A1
The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating viral diseases and cancer.  
WO/2018/153957A1
The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating intracellular bacterial, fungal, and protozoal infections.  
WO/2018/153960A1
The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in the claims. The macrolides have utility in treating viral diseases and cancer.  
WO/2018/153966A1
The present invention relates to novel compounds useful for visualizing cell sen es c en ce in vitro and in vivo, the preparation of said compounds and their use. In particular, the present invention pertains to novel hexose and particul...  
WO/2018/153959A1
The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in claim 1. The macrolides have utility in treating intracellular bacterial, fungal, and protozoal infections.  
WO/2018/080072A3
The present invention relates to a novel macrolide-based compound, a method for producing the same, and a pharmaceutical composition, which is for preventing or treating malaria and contains the novel macrolide-based compound as an activ...  
WO/2018/028511A9
Provided are a myricetin derivative, a preparing method and pharmaceutical composition thereof, an application of same in treating colitis, preventing and treating colitis tumorigenesis, and treating colorectal cancer, and a use of same ...  
WO/2018/140594A1
Described herein are prodrugs of cysteamine and pharmaceutically acceptable salts, solvates, and esters thereof. Also described herein are pharmaceutical compositions comprising prodrugs of cysteamine, or pharmaceutically acceptable salt...  
WO/2018/133600A1
Disclosed is a method for preparing high-activity sugarcane anthocyanin. The method comprises: 1) airing and crushing bagasse obtained after juice extraction, and adding distilled water to the bagasse; mixing cellulase, hemicellulase and...  
WO/2018/134412A1
The present invention generally relates to a class of antimicrobial compounds, to compositions containing said compounds and to the use of said compounds for medical and non-medical purposes. More specifically, the present invention rela...  

Matches 1 - 50 out of 6,484