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Matches 551 - 600 out of 12,285

Document Document Title
WO/2015/081133A2
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside der...  
WO/2015/077966A1
Provided are crystalline forms of the compound of formula (I), which is a nucleoside inhibitor of HCV, processes for the preparation thereof, and pharmaceutical compositions comprising these crystalline forms.  
WO/2015/077292A1
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further provided are methods of making and using the same, and compositions and uses of the ...  
WO/2015/077368A1
The present invention regards nucleoside 5'-monophosphate compounds of Formula I, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.  
WO/2014/078295A8
The present invention provides compounds according to formula I and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, -C(=O) (CH2)2-aryl, and C(=O)...  
WO/2015/073706A1
The present invention relates to DOT1L inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, su...  
WO/2015/065661A1
Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5...  
WO/2015/066370A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2015/066382A1
Compositions containing nicotinamide riboside (NR) are provided. NR containing compositions are used in the care or treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosm...  
WO/2015/066162A1
The present invention relates to methods and intermediates for synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine compounds.  
WO/2015/065956A1
The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof.  
WO/2015/064718A1
 Provided is a means for preventing inactivation of a photoresponsive nucleic acid probe by suppressing formation of photocrosslinking between a photoresponsive base having a photocrosslinkable vinyl structure and a photocrosslinkable ...  
WO/2015/066001A1
Methods and compositions are provided for identifying novel ligands for a protein target.  
WO/2015/026845A3
Provided herein is technology relating to the manipulation and detection of nucleic acids, including but not limited to compositions, methods, and kits related to nucleotides comprising a chemically reactive linking moiety.  
WO/2015/064223A1
This nucleotide derivative or a salt thereof is represented by one of formulae (I-1) to (I-6). (In formulae (I-1) to (I-6), R1-R5, A1-A3, B, X, Y and k represent the meanings set forth in claim 1.)  
WO/2015/061507A1
This invention is related to nucleic acid chemistry and describes novel 1,2- dithiolane functionalized nucleoside phosphoramidites (1, Chart 1) and corresponding solid supports (2, Chart 1). In addition to these derivatives, 1,2- dithiol...  
WO/2015/061683A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2015/056213A1
The invention provides compounds of the formula (I) wherein B is a nucleobase selected from the groups (a) to (d): and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C viru...  
WO/2014/052896A9
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprisi...  
WO/2015/054465A1
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, ...  
WO/2015/050467A1
The subject matter of the invention is novel 2',3'-dideoxy-5-fluorouridine derivatives of general formula 1. wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In the second aspect, t...  
WO/2015/051169A2
The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.  
WO/2015/050468A1
The subject matter of the invention is novel 2,3'-anhydro-2'-deoxy-5-fluorouridine derivatives of general formula (1) where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-d...  
WO/2015/051239A1
Described are methods of treating a subject after acute trauma to the head, viral encephalitis, or other causes of acute neurodegeneration, and/or after acute vascular insults, including ischemic and hemorrhagic strokes, the method compr...  
WO/2014/178082A9
The present invention provides novel chiral serinyl functionalized tethered oligonucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a...  
WO/2015/044365A1
The invention provides a compound of the formula (1): or a salt or tautomer thereof, wherein either (i) R1 is hydroxy and R2 is hydrogen; or (ii) R1 and R2 are both fluorine; and R3 is hydroxy or a group that is convertible under physiol...  
WO/2015/048558A1
This invention relates to antisense oligonucleotides comprising at least one N3'→P5' phosphorodiamidate linkage (NPN) in the backbone as well as methods for using the same. The antisense oligonucleotides can effectively prevent or decr...  
WO/2015/041550A1
The subject matter of the invention is novel 2',5'-dideoxy-5-fluorouridine derivatives of general formula 1. (1) wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8and C-9 atoms. In a second aspect, t...  
WO/2015/042073A1
Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) ...  
WO/2015/013352A3
The invention provides phosphoramidate prodrugs of chemotherapeutlc and/or antiviral agents for targeting and treating liver disease, including liver cancer, hepatocellular carcinoma, and hepatitis. The prodrugs are suitable for oral adm...  
WO/2015/042447A1
Provided herein are compounds comprising one or more therapeutic nucleosides and one or more targeting groups. In certain embodiments, the compounds further comprise one or more oligonucleotides. In certain embodiments, a targeting group...  
WO/2015/038596A1
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or t...  
WO/2015/034420A1
The invention provides compounds of the formula:(I) wherein B is a nucleobase selected from the groups (a) to (d) and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus...  
WO/2015/034038A1
[Problem] The purpose of the present invention is to develop a pharmaceutical composition that is for malignant tumor treatment and/or prevention and that by using a compound that is normally present in vivo and affects a cellular signal...  
WO/2015/026845A2
Provided herein is technology relating to the manipulation and detection of nucleic acids, including but not limited to compositions, methods, and kits related to nucleotides comprising a chemically reactive linking moiety.  
WO/2015/027137A1
Provided herein are compounds of Formula I, Formula II, and Formula X, which are useful for the treatment of infectious diseases. Also provided herein are processes for preparing 1-[5-0-[4,6-Dideoxy-6-oxo-6-[[[(3S)-hexahydro-2-oxo-1H-aze...  
WO/2015/021432A1
Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. ...  
WO/2015/015517A1
The present invention provide water soluble polyfluorenes functionalized with glucuronic acid useful in sensing bilirubin in aqueous medium and process for preparation thereof. The invention further deals with detecting bilirubin in huma...  
WO/2015/014722A1
The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is sel...  
WO/2015/017713A1
Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives ...  
WO/2014/169206A3
Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition r...  
WO/2015/007291A1
The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such bioactive Ribes alkaloid fractions and t...  
WO/2015/003131A1
The present invention relates to substituted purine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation play...  
WO/2014/209983A1
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are meth...  
WO/2014/202493A1
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula (I) wherein Ar is a heteroaryl group, containing one, two or three heteroatoms, selected from N, S or O; R1 is hydrogen, lower alkyl, halogen, amino, di...  
WO/2014/204861A1
The present invention provides a compound having the adenosylmethionine structure, wherein the sulfur atom of the methionine moiety is modified with alkene or succinimide groups, wherein R1, R2 and R3 are independently H, alkyl, aryl, C(...  
WO/2014/169280A3
Deuterated nucleoside analogs of Formula (I) and the pharmaceutically acceptable salts thereof are provided by this disclosure Formula (I) The variables, e.g., B1, Y, R1, R2, R3, R3', R4, R5, R6, R7, R8, and R9 carry definitions set fort...  
WO/2014/194826A1
The present invention provides a three-circle fused-heterocycle nucleoside phosphoramidate compound, a preparation method therefor, a composition containing the fused-heterocycle nucleoside phosphoramidate compound, and an application of...  
WO/2014/197578A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/159669A3
Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided.  

Matches 551 - 600 out of 12,285