Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 651 - 700 out of 12,286

Document Document Title
WO/2014/090246A1
The invention provides an agent and method for modifying the 5' cap of RNA, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synth...  
WO/2014/093924A1
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.  
WO/2014/082935A1
A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection wherein R1, R2 and R3 are as defined herein.  
WO/2014/078436A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/078652A1
The present disclosure provides compositions and methods to sequence nucleic acid polymers for improving sequencing read length using electron microscopy, e.g., high-resolution scanning transmission electron microscopy (STEM). The presen...  
WO/2014/076490A1
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside wi...  
WO/2014/078427A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/077292A1
In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleosi...  
WO/2014/078295A1
The present invention provides compounds according to formula I and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, -C(=O) (CH2)2-aryl, and C(=O)...  
WO/2014/078463A1
The present invention relates to 2'-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to co...  
WO/2014/074883A1
Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.  
WO/2013/142124A8
The present application relates to solid state forms, for example, crystalline forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl) ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more soli...  
WO/2014/074725A1
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods...  
WO/2014/069645A1
Provided is an analysis technique for detecting 8-oxo-dG in DNA using a compound represented by formula (II). In formula (II): R3 is H, a protecting group of the 3'-hydroxyl group, oligodeoxynucleotide group 1 (ODN group 1) or -P(OR5)R6 ...  
WO/2014/070771A1
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengu...  
WO/2014/070948A1
Provided herein are methods of treating a disease or disorder associated with dysregulation of histone deacetylase, and more specifically sensitizing and treating chemoresistant cancer comprising administering a therapeutically effective...  
WO/2013/019945A3
The subject invention relates to determining the presence and level of hENT1 expression in tumor tissue that is appropriate for gemcitabine therapy, and more importantly, the level of hENT1 expression that signifies that treatment with a...  
WO/2014/066239A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/062596A1
The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositi...  
WO/2014/059740A1
Disclosed are a compound as shown in formula (I) and pharmaceutically acceptable salts thereof. R1, R2, R3, R4, R5, W, and n are defined as in the description of the present application.  
WO/2014/058801A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/059275A2
The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin pro...  
WO/2014/028739A4
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/053397A1
The present description refers to photocleavable compounds which can be used as a photocleavable linker in order to link two biomolecules, such as oligonucleotides and peptides. The present description further refers to a method for the ...  
WO/2012/009666A3
The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated int...  
WO/2014/053897A1
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step c...  
WO/2014/048969A1
The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, co...  
WO/2014/052638A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/048998A1
The present invention relates to 5-fluorouracil derivatives represented by formula (i), pharmaceutical compositions comprising said derivative and their use in the treatment of cancer as well as a process for preparing the 5-fluorouracil...  
WO/2014/052896A1
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprisi...  
WO/2014/022563A3
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences...  
WO/2014/047117A1
Processes for the production of nucleoside phosphoramidate compounds having the following Formula I are provided.  
WO/2014/047199A1
The present invention provides a compound having the structure: (Formula (I)) wherein X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbon α; ...  
WO/2014/046212A1
 This oligonucleotide or pharmaceutically acceptable salt thereof contains a compound represented by formula I or II or a salt thereof, and at least one nucleoside structure represented by formula I' or II'. Thus provided is a nucleic ...  
WO/2014/043046A1
Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5'-methylthioadenosine deaminase (MTADA).  
WO/2014/038561A1
Provided is a compound, a tautomer of said compound, a stereoisomer of said compound, or a salt of the compound, tautomer, or stereoisomer that is characterized by being represented by chemical formula (I). L is a single bond or a linker...  
WO/2014/033617A1
The present invention provides a compound of formula A or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of ...  
WO/2014/003950A3
Nutritional supplements are described comprising selenium containing nucleosides. Methods of making the nutritional supplements and using the nutritional supplements are also described.  
WO/2014/028081A2  
WO/2014/028739A1
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/027658A1
A compound represented by general formula [1D] (in the formula, R1A, R1B, R2A, R2B, R3A and R3B each denote a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucle...  
WO/2014/028079A1
Prostate cancer is treated by administration of N 6-benzyladenosine-5'- monophosphate or pharmaceutically acceptable salt thereof.  
WO/2014/025272A1
The subject of the invention is a new method of the synthesis of polyphosphate analogues, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, ...  
WO/2014/022563A2
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences...  
WO/2014/022577A1
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5'-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compou...  
WO/2014/022839A1
The present invention provides nucleosides comprising a sterically hindered silyl protecting group on the exocyclic nitrogen atom of the nucleobase, oligonucleotides comprising the same, and methods for producing the same. In particular,...  
WO/2014/017615A1
The purpose of the present invention is to provide: a monomer for the synthesis of RNA, which can be produced with high efficiency and consequently enables the remarkable reduction in the cost for the production of RNA; a method for prod...  
WO/2014/016361A1
The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:  
WO/2014/008344A1
The present invention relates to compounds and methods for treating retroviral infections, HIV, Hepatitis B, and/or HTLV viral infections. Some compounds of the invention are described by formula (I): or a pharmaceutically acceptable sal...  
WO/2014/008236A1
The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:  

Matches 651 - 700 out of 12,286