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Matches 701 - 750 out of 12,317

Document Document Title
WO/2014/028081A2  
WO/2014/028739A1
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/027658A1
A compound represented by general formula [1D] (in the formula, R1A, R1B, R2A, R2B, R3A and R3B each denote a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucle...  
WO/2014/028079A1
Prostate cancer is treated by administration of N 6-benzyladenosine-5'- monophosphate or pharmaceutically acceptable salt thereof.  
WO/2014/025272A1
The subject of the invention is a new method of the synthesis of polyphosphate analogues, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, ...  
WO/2014/022563A2
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences...  
WO/2014/022577A1
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5'-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compou...  
WO/2014/022839A1
The present invention provides nucleosides comprising a sterically hindered silyl protecting group on the exocyclic nitrogen atom of the nucleobase, oligonucleotides comprising the same, and methods for producing the same. In particular,...  
WO/2014/017615A1
The purpose of the present invention is to provide: a monomer for the synthesis of RNA, which can be produced with high efficiency and consequently enables the remarkable reduction in the cost for the production of RNA; a method for prod...  
WO/2014/016361A1
The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:  
WO/2014/008344A1
The present invention relates to compounds and methods for treating retroviral infections, HIV, Hepatitis B, and/or HTLV viral infections. Some compounds of the invention are described by formula (I): or a pharmaceutically acceptable sal...  
WO/2014/008236A1
The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:  
WO/2014/007323A1
The present invention addresses the problem of providing a useful production intermediate for producing 1-[2'-deoxy-4'-thio-1'-β-D-ribofuranosyl]-5-fluorouracil and a production method using said intermediate. As a means for solving the...  
WO/2014/003950A2
Nutritional supplements are described comprising selenium containing nucleosides. Methods of making the nutritional supplements and using the nutritional supplements are also described.  
WO/2013/178571A1
An improved process for the preparation of (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivatives of formula I, (I), wherein R1 is selected from C1-4-alkyl is described. The (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivatives of formu...  
WO/2013/176844A1
An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R3 is a first oligonucleotide; R1 is selected from the group consisting of alkyl, cycloalky...  
WO/2013/177188A1
Provided herein are compounds of formula (I) compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, whi...  
WO/2013/174962A1
The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof. The present invention also ...  
WO/2013/177219A1
Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives a...  
WO/2013/177195A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2013/173759A2
The present invention provides nucleoside phosphoramidate compounds of Formula I, where R1, R2a, R2b, R3, R4, R5a, R5b, R6, R7, R8a, R8b, M and W are as defined herein. The invention further includes pharmaceutical compositions comprisin...  
WO/2013/168627A1
The problem is to provide novel crystals of 5'-glucosyl adenosine the crystal structure of which has been elucidated, a 5'-glucosyl adenosine crystal-containing powder containing these crystals, the use of the same as a medical drug, and...  
WO/2013/165266A1
The invention relates to a method of simultaneously protecting two functions which are the same or different, namely hydroxyl, amine, or thiol groups, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic ...  
WO/2013/166121A1
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; an...  
WO/2013/166155A1
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4)...  
WO/2013/154799A1
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. More particularly, the tricyclic nucleosides provided herein comprise a tricyclic ribosyl sugar moiety having a bridge between the 4' and ...  
WO/2013/154798A1
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms furt...  
WO/2007/083173A3
The present invention relates to thiolated pyrimidine-mononucleotides and pyrimidine- mononucleosides and their use as therapeutic agents. More closely, the present invention relates to therapeutic applications of 4-thio-uridine, its ana...  
WO/2013/068850A8
The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.  
WO/2013/151033A1
A compound or pharmaceutically acceptable salt thereof represented by general formula (I) providing a compound or pharmaceutically acceptable salt thereof having a novel structure, low adverse effects, and excellent human SGLT1 and/or SG...  
WO/2013/150902A1
Provided is a terminal-phosphorylated oligodeoxynucleotide which is produced by introducing a deoxynucleotide containing a non-naturally-occurring nucleotide into a DNA strand and then cleaving the DNA strand through a chemical reaction ...  
WO/2013/146833A1
The problem of the present invention is to provide a superior anti-tumor agent. A salt of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine is useful as the active ingredient of a medicine because it has at least one of character...  
WO/2013/144894A1
The invention relates to a compound of formula (1). The invention includes all isomeric forms and tautomeric forms of the compound of formula (1) and pharmaceutically acceptable salts and derivatives such as esters and ethers. The presen...  
WO/2013/142125A1
Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.  
WO/2009/152353A3
The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides ...  
WO/2013/141350A1
The purpose of the present invention is to provide an oligosaccharide with high versatility that can produce a protected sulfate oligosaccharide that can become a manufacturing intermediate of polysulfated hyaluronic acid, and to provide...  
WO/2013/142124A1
The present application relates to solid state forms, for example, crystalline forms of 2'- C-methyluridine-5 '-(O-phenyl-N-(S)- 1 -(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more s...  
WO/2013/137427A1
Provided is a pyrimidine nucleoside compound represented by general formula (1) [wherein A1 and A2 may be the same as or different from each other and independently represent a hydrogen atom, an alkyloxycarbonyl group which may have a su...  
WO/2013/061105A8
The invention relates to compounds of formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof and processes for preparing them. In formula (I) X is -CH= or -N= or -N(R") -; Y is -N= or -N(R") -; R is an alk...  
WO/2013/135900A1
The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties o...  
WO/2013/138236A1
Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and m...  
WO/2013/132489A1
The invention provides particular mono- and dinucleoside 5'-phosphorothioate analogues, more particularly mono- or di- adenosine or uridine 5'-di- or tri- phosphorothioate analogues in which at least one of the bridging oxygen atoms of t...  
WO/2013/128393A1
Disclosed herein is a process for preparing highly pure Citicoline (CDP-Choline) or sodium salt of Citicoline with the aid of dicarboxylic acid or its salts. The process of the present invention results in Citicoline with a purity of mor...  
WO/2013/129667A1
A high-purity acid-form SL containing composition which is characterized by being substantially free from acetic acid. This high-purity acid-form SL containing composition can be prepared, for example, by a process which comprises: (i) a...  
WO/2013/123745A1
The present invention provides an azidothymidine quinoline conjugated compound N-((l-(2-(hydroxymethyl)-5-(5-methyl-2, 4-dioxo-3, 4-dihydro-pyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl)-1H-1, 2, 3-triazol-4-yl) methyl)-6-(4b, 8, 8-trimethyl-...  
WO/2013/068850A3
The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.  
WO/2013/122236A1
Provided is a protected nucleotide for elongation that makes it possible to realize a method for producing oligonucleotides by the phosphoramidite process that allows purification to be conducted by liquid-liquid extraction efficiently a...  
WO/2013/121607A1
The present invention addresses the problem of providing a copper catalyst which has higher catalytic activity than conventional copper catalysts, is able to be easily recovered, and can be reused repeatedly. The present invention relate...  
WO/2013/122112A1
Provided is a prodrug of a therapeutically active organic compound having: an amino group, a cyclic amino group or a hydroxyl group in the molecule; and a 2-nitro-1-imidazole propionic acid. In particular, provided is a prodrug in which ...  
WO/2013/112850A1
The present invention provides novel anhydrous polymorph forms of 2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihy droxytetrahydrofuran-2-yl)methyl nitrate (Compound A). The present invention also provides processes for prepa...  

Matches 701 - 750 out of 12,317