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Matches 751 - 800 out of 12,551

Document Document Title
WO/2014/152723A1
The present invention relates to an ophthalmic formulation which comprises a fine particle of Compound A in an aqueous suspension and a manufacturing process thereof. More specifically, the present invention relates to a topically applie...  
WO/2014/145207A1
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods...  
WO/2014/143051A1
Fluorinated pyrimidine analog compounds, compositions that include the fluorinated pyrimidine analog compounds, methods for making the fluorinated pyrimidine analog compounds, and methods for inhibiting DNA methyltransferase, treating so...  
WO/2014/139596A1
Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3'-hydroxy protecting groups. Said 3'-hydroxy protecting groups form a structure -O-C(R)2N3 covalently attached to the 3'-carbon atom whe...  
WO/2014/140348A1
The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present invention further provides oligomeric compounds prepared therefrom. Incorporatio...  
WO/2014/137930A1
Provided herein are compounds, compositions, and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, the compounds are according to Formula 2001; where PD, Base, RA and RB are as provid...  
WO/2014/137926A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/135107A1
Provided are a novel nucleoside phosphoramidate compound, stereoisomer, salt, hydrate, solvate or crystal thereof for treating flaviviridae virus, in particular a hepatitis C virus infection. Also provided are a pharmaceutical compositio...  
WO/2014/134251A1
Described herein are compositions that can include Compound 1 or Form J of Compound 1, or a pharmaceutically acceptable salt of the aforementioned compounds. Also, described herein is a method of treating a HCV infection in a subject tha...  
WO/2014/131892A1
The present invention relates to modified oligonucleotides of 5-50 nucleotide residues, wherein at least 25% of the nucleotides are independently modified at the 2' position to comprise the structure of formula (I), wherein base is a pur...  
WO/2014/126229A1
The present invention provides a novel nucleoside or nucleotide usable as a material for the synthesis of a nucleic acid medicine, particularly, a compound represented by formula (I) or a salt thereof [wherein: Y1 is CR6 or N; Y2 is CR7 ...  
WO/2014/116755A1
The present invention provides pharmaceutical compositions comprising a dihydro base described herein (e.g., compound DHdC). The dihydro base may show multiple tautomerism and may increase mutation of an RNA and/or DNA of a virus or canc...  
WO/2014/112463A1
The invention provides compounds shown by the formula (in the formula Y1-Y2 is S(=O)2-NR6, NR6-S(=O)2, or the like; R6 is a hydrogen atom, substituted or unsubstituted alkyl group, or the like; Bx is a nucleic acid base moiety; Z1 and Z2...  
WO/2014/113609A1
Stable indole-3-propionic acid salts of S-adenosyl-L-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical compositions comprising the indole-3-propionic acid salts, methods of using the indo...  
WO/2014/109256A1
Provided is a means for improving the chemical stability and lipid solubility of an artificial cyclic nucleoside linked body, which is an analogue of a naturally-occurring-type cyclic dinucleotide, while keeping the structural similarity...  
WO/2014/109384A1
The present invention provides a method for producing an amide cross-linked nucleic acid derivative, which is useful as a molecule for use as an antisense, with high efficiency. An intermediate that is important for the synthesis of an a...  
WO/2014/068589A3
The present invention relates to a novel process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl} pyrazole-4-yl)-N-methylcarboxamide.  
WO/2014/060941A3
Disclosed are compounds of formula I, their pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of...  
WO/2014/103704A1
A method for producing P1,P4-di(uridine 5'-)tetraphosphate (UP4U) is developed, which does not require the use of free UTP and does not undergo the decrease in synthesis efficiency. A method for producing UP4U, characterized by reacting ...  
WO/2014/100498A1
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.  
WO/2014/094544A1
Provided are a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, pharmaceutical composition containing same, and uses thereof in the preparation of drugs for treati...  
WO/2014/099941A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/100158A1
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I). The invention also provides pharmaceutically acceptable compositions containing the compounds and...  
WO/2014/100505A1
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.  
WO/2014/094312A1
Disclosed is a method for synthesizing nucleoside amino acid derivatives through enzyme catalysis, which comprises the step of: under the catalysis of protease or lipase, nucleoside compounds and L-amino acid ester reacting to obtain nuc...  
WO/2014/090246A1
The invention provides an agent and method for modifying the 5' cap of RNA, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synth...  
WO/2014/093924A1
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.  
WO/2014/082935A1
A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection wherein R1, R2 and R3 are as defined herein.  
WO/2014/078436A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/078652A1
The present disclosure provides compositions and methods to sequence nucleic acid polymers for improving sequencing read length using electron microscopy, e.g., high-resolution scanning transmission electron microscopy (STEM). The presen...  
WO/2014/076490A1
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside wi...  
WO/2014/078427A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/077292A1
In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleosi...  
WO/2014/078295A1
The present invention provides compounds according to formula I and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, -C(=O) (CH2)2-aryl, and C(=O)...  
WO/2014/078463A1
The present invention relates to 2'-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to co...  
WO/2014/074883A1
Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.  
WO/2013/142124A8
The present application relates to solid state forms, for example, crystalline forms of 2'-C-methyluridine-5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl) ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more soli...  
WO/2014/074725A1
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods...  
WO/2014/069645A1
Provided is an analysis technique for detecting 8-oxo-dG in DNA using a compound represented by formula (II). In formula (II): R3 is H, a protecting group of the 3'-hydroxyl group, oligodeoxynucleotide group 1 (ODN group 1) or -P(OR5)R6 ...  
WO/2014/070771A1
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengu...  
WO/2014/070948A1
Provided herein are methods of treating a disease or disorder associated with dysregulation of histone deacetylase, and more specifically sensitizing and treating chemoresistant cancer comprising administering a therapeutically effective...  
WO/2013/019945A3
The subject invention relates to determining the presence and level of hENT1 expression in tumor tissue that is appropriate for gemcitabine therapy, and more importantly, the level of hENT1 expression that signifies that treatment with a...  
WO/2014/066239A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/062596A1
The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositi...  
WO/2014/059740A1
Disclosed are a compound as shown in formula (I) and pharmaceutically acceptable salts thereof. R1, R2, R3, R4, R5, W, and n are defined as in the description of the present application.  
WO/2014/058801A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/059275A2
The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin pro...  
WO/2014/028739A4
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/053397A1
The present description refers to photocleavable compounds which can be used as a photocleavable linker in order to link two biomolecules, such as oligonucleotides and peptides. The present description further refers to a method for the ...  
WO/2012/009666A3
The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated int...  

Matches 751 - 800 out of 12,551