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Matches 801 - 850 out of 12,557

Document Document Title
WO/2014/058801A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/059275A2
The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin pro...  
WO/2014/028739A4
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/053397A1
The present description refers to photocleavable compounds which can be used as a photocleavable linker in order to link two biomolecules, such as oligonucleotides and peptides. The present description further refers to a method for the ...  
WO/2012/009666A3
The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated int...  
WO/2014/053897A1
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step c...  
WO/2014/048969A1
The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, co...  
WO/2014/052638A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2014/048998A1
The present invention relates to 5-fluorouracil derivatives represented by formula (i), pharmaceutical compositions comprising said derivative and their use in the treatment of cancer as well as a process for preparing the 5-fluorouracil...  
WO/2014/052896A1
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprisi...  
WO/2014/022563A3
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences...  
WO/2014/047117A1
Processes for the production of nucleoside phosphoramidate compounds having the following Formula I are provided.  
WO/2014/047199A1
The present invention provides a compound having the structure: (Formula (I)) wherein X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbon α; ...  
WO/2014/046212A1
 This oligonucleotide or pharmaceutically acceptable salt thereof contains a compound represented by formula I or II or a salt thereof, and at least one nucleoside structure represented by formula I' or II'. Thus provided is a nucleic ...  
WO/2014/043046A1
Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5'-methylthioadenosine deaminase (MTADA).  
WO/2014/038561A1
Provided is a compound, a tautomer of said compound, a stereoisomer of said compound, or a salt of the compound, tautomer, or stereoisomer that is characterized by being represented by chemical formula (I). L is a single bond or a linker...  
WO/2014/033617A1
The present invention provides a compound of formula A or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of ...  
WO/2014/003950A3
Nutritional supplements are described comprising selenium containing nucleosides. Methods of making the nutritional supplements and using the nutritional supplements are also described.  
WO/2014/028081A2  
WO/2014/028739A1
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or...  
WO/2014/027658A1
A compound represented by general formula [1D] (in the formula, R1A, R1B, R2A, R2B, R3A and R3B each denote a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucle...  
WO/2014/028079A1
Prostate cancer is treated by administration of N 6-benzyladenosine-5'- monophosphate or pharmaceutically acceptable salt thereof.  
WO/2014/025272A1
The subject of the invention is a new method of the synthesis of polyphosphate analogues, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, ...  
WO/2014/022563A2
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences...  
WO/2014/022577A1
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5'-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compou...  
WO/2014/022839A1
The present invention provides nucleosides comprising a sterically hindered silyl protecting group on the exocyclic nitrogen atom of the nucleobase, oligonucleotides comprising the same, and methods for producing the same. In particular,...  
WO/2014/017615A1
The purpose of the present invention is to provide: a monomer for the synthesis of RNA, which can be produced with high efficiency and consequently enables the remarkable reduction in the cost for the production of RNA; a method for prod...  
WO/2014/016361A1
The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:  
WO/2014/008344A1
The present invention relates to compounds and methods for treating retroviral infections, HIV, Hepatitis B, and/or HTLV viral infections. Some compounds of the invention are described by formula (I): or a pharmaceutically acceptable sal...  
WO/2014/008236A1
The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:  
WO/2014/007323A1
The present invention addresses the problem of providing a useful production intermediate for producing 1-[2'-deoxy-4'-thio-1'-β-D-ribofuranosyl]-5-fluorouracil and a production method using said intermediate. As a means for solving the...  
WO/2014/003950A2
Nutritional supplements are described comprising selenium containing nucleosides. Methods of making the nutritional supplements and using the nutritional supplements are also described.  
WO/2013/178571A1
An improved process for the preparation of (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivatives of formula I, (I), wherein R1 is selected from C1-4-alkyl is described. The (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivatives of formu...  
WO/2013/176844A1
An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R3 is a first oligonucleotide; R1 is selected from the group consisting of alkyl, cycloalky...  
WO/2013/177188A1
Provided herein are compounds of formula (I) compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, whi...  
WO/2013/174962A1
The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof. The present invention also ...  
WO/2013/177219A1
Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives a...  
WO/2013/177195A1
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be admi...  
WO/2013/173759A2
The present invention provides nucleoside phosphoramidate compounds of Formula I, where R1, R2a, R2b, R3, R4, R5a, R5b, R6, R7, R8a, R8b, M and W are as defined herein. The invention further includes pharmaceutical compositions comprisin...  
WO/2013/168627A1
The problem is to provide novel crystals of 5'-glucosyl adenosine the crystal structure of which has been elucidated, a 5'-glucosyl adenosine crystal-containing powder containing these crystals, the use of the same as a medical drug, and...  
WO/2013/165266A1
The invention relates to a method of simultaneously protecting two functions which are the same or different, namely hydroxyl, amine, or thiol groups, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic ...  
WO/2013/166121A1
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; an...  
WO/2013/166155A1
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4)...  
WO/2013/154799A1
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. More particularly, the tricyclic nucleosides provided herein comprise a tricyclic ribosyl sugar moiety having a bridge between the 4' and ...  
WO/2013/154798A1
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms furt...  
WO/2007/083173A3
The present invention relates to thiolated pyrimidine-mononucleotides and pyrimidine- mononucleosides and their use as therapeutic agents. More closely, the present invention relates to therapeutic applications of 4-thio-uridine, its ana...  
WO/2013/068850A8
The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.  
WO/2013/151033A1
A compound or pharmaceutically acceptable salt thereof represented by general formula (I) providing a compound or pharmaceutically acceptable salt thereof having a novel structure, low adverse effects, and excellent human SGLT1 and/or SG...  
WO/2013/150902A1
Provided is a terminal-phosphorylated oligodeoxynucleotide which is produced by introducing a deoxynucleotide containing a non-naturally-occurring nucleotide into a DNA strand and then cleaving the DNA strand through a chemical reaction ...  
WO/2013/146833A1
The problem of the present invention is to provide a superior anti-tumor agent. A salt of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine is useful as the active ingredient of a medicine because it has at least one of character...  

Matches 801 - 850 out of 12,557