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Matches 851 - 900 out of 12,306

Document Document Title
WO/2012/065912A1
The invention relates to derivatizing agents for biogenic amines in order to produce aminated haptenes which provide antibodies after coupling to a support, said antibodies being capable of binding the aminated haptene with a higher affi...  
WO/2011/123668A3
Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing th...  
WO/2012/062870A1
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate useful in the treatment of patients infected with the hepatitis C virus (HCV).  
WO/2012/062869A1
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate of formula (I) which inhibits the hepatitis C virus (HCV).  
WO/2010/061402A3
The present invention direct to an improved process for the preparation of the compound 5-deoxy-2, 3-O-isopyridene-N-[(pentyloxy) carbonyl]-5-fluorocystidine of the formula (I).  
WO/2012/060482A1
The present invention relates to a CDK-inhibiting pyrrolopyrimidinone carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treati...  
WO/2012/056976A1
Provided is a novel compound capable of inhibiting cardiac adenylate cyclase. The compound is a compound represented by formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof. (In the formula, R1, R2 and R3 independe...  
WO/2011/115513A9
This invention provides a cytosine analogue, a method of preparation of a cytosine analogue, a DNA rhethyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated w...  
WO/2012/053917A1
The object of the invention are nucleotide analogues, antiviral pro-nucleotides, a use of nucleotide analogues and pharmaceutical composition, a phosphorylating agent for synthesis of nucleotide analogue, and a method of synthesis of nuc...  
WO/2012/024625A3
Disclosed are compounds of nucleoside 5 '-triphosphates of formula (I), or derivatives thereof, or pharmaceutically acceptable salts of said nucleoside 5 '-triphosphates or said derivatives, wherein the Base of formula (I) is Adenine (A)...  
WO/2012/050264A1
Provided is novel selenyl-methyluracil compounds, and more particularly, a pharmaceutical composition for enhancing the effect of radiation treatment, which comprises at least one compound selected from the group consisting of the seleny...  
WO/2012/049464A1
The invention relates to reagents for use in investigating the presence and activation state of G-proteins. There is provided a compound for use in the identification of the activity of G- proteins. The compound comprises a G-protein bin...  
WO/2012/048063A2
Cyanine compounds having the general formula I, conjugates, complexes, and compositions comprising the cyanine compounds are provided. Fluorescence resonance energy transfer (FRET) dye pairs and viability dyes are also provided.  
WO/2011/159471A3
The disclosure provides linked purine pterin compounds and analogues thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general Formula I: (I). ...  
WO/2012/048202A2
The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the proc...  
WO/2012/045999A1
Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR'R" where R' is H and R" is CR5R6CO2R7, where R6 is H, R5 is the side chain, including...  
WO/2012/048013A2
This invention is directed to novel compounds of formula (I) having the structure that are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses. Methods of tr...  
WO/2012/040124A1
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are meth...  
WO/2012/039448A1
An asymmetric auxiliary group which is useful for the efficient production of a nucleic acid derivative modified with a phosphorus atom and having high stereoregularity; and a compound represented by general formula (I) or general formul...  
WO/2012/038097A1
The present invention relates to the use of a compound of the formula (A), its use in medicine and for the prophylaxis and/or treatment of infectious diseases. Also disclosed are pharmaceutical formulations containing at least one of the...  
WO/2012/040126A1
Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the...  
WO/2012/017434A3
The present invention generally relates to Rel proteins as a novel therapeutic target for treating bacterial threats. More specifically, the present invention relates to a novel class of compounds of formula (I) which inhibit RelA and/or...  
WO/2012/040127A1
Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the...  
WO/2012/035436A1
Compounds of Formula (I) and (I') are disclosed, as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation a...  
WO/2012/032513A1
The present invention provides pharmaceutical compositions and methods for treatment and management of osteoarthritis using certain dinucleotide boranophosphate derivatives or nucleoside boranophosphate derivatives. The invention further...  
WO/2011/070152A3
The present invention relates to novel antiviral compounds, which are aryl 3-deazauridine analogues at the C3 position, to a method for synthesizing said compounds, as well as to the antiviral uses thereof. The compounds are of the gener...  
WO/2012/031539A1
The present invention relates to the field of pharmachemistry. Disclosed are fluorinated and azide-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These com...  
WO/2011/133871A3
The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with th...  
WO/2009/047314A3
Method of producing a free nucleoside compound, the compound 2'- deoxy-5-azacytidine (Decitabine) being excluded, by reacting a glycoside donor preferably a 1-halogen derivative, or 1-0-acyl, 1-0-alkyl, or an imidate preferably a trichlo...  
WO/2009/047313A3
Method of producing 2'-deoxy-5-azacytidine (Decitabine) by providing a compound of formula (I), wherein R is a removable substituent known per se; and R1 is a removable substituent; further providing a silylated base of formula (II), whe...  
WO/2012/024776A1
The invention relates to the chemical synthesis of oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) : processes for making these compounds, and the use thereof in the chemical synthesis of oligo...  
WO/2011/115513A3
This invention provides a cytosine analogue, a method of preparation of a cytosine analogue, a DNA rhethyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated w...  
WO/2012/024625A2
Disclosed are compounds of nucleoside 5 '-triphosphates of formula (I), or derivatives thereof, or pharmaceutically acceptable salts of said nucleoside 5 '-triphosphates or said derivatives, wherein the Base of formula (I) is Adenine (A)...  
WO/2012/023572A1
The purpose of the present invention is to provide a 5-formyl nucleic acid production process whereby a 5-formyl group can be introduced into a nucleoside located at any position. This 5-formyl nucleic acid production process involves a ...  
WO/2011/160216A3
Provided in the following specification are precursors or synthons that are useful for the synthesis of various arabinose-based chemical and radiochemical derivatives of nitroimidazole-containing azomycin arabinosides, such as radioiodin...  
WO/2012/019284A1
The present invention relates to a pharmaceutical composition for treating a neoplasm, a preneoplasm, a proliferative disorder and/or a precancerous lesion, the use of such compositions for the treatment of the listed conditions, and met...  
WO/2011/134444A9
The invention relates to substitution derivatives of N6-benzyladenosine-5'- monophosphate of the general formula (I), wherein (R)n represents 1 to 4 substituents (n is in the range 1 - 4), which can be the same or different, and R is sel...  
WO/2011/109113A9  
WO/2012/017400A1
The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthes...  
WO/2012/018697A1
The present invention provides methods that more accurately predict melting temperatures for duplex oligomers. The invented methods predict the Tm of chimeric duplexes containing various amounts of locked nucleic acid modifications in ol...  
WO/2012/017434A2
The present invention generally relates to Rel proteins as a novel therapeutic target for treating bacterial threats. More specifically, the present invention relates to a novel class of compounds of formula (I) which inhibit RelA and/or...  
WO/2012/012902A1
Provided herein are compositions and methods to enhance the absorption of S- adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non- parenteral SAMe formulations with enhanced-absorption and improved bi...  
WO/2012/012465A1
Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas (la) and (lb): The compounds of Formula la and lb are useful for the treatment Hepatitis C infections.  
WO/2012/012776A1
Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (I): wherein the 1 ' position of the nucleoside sugar is substituted. The compounds, comp...  
WO/2012/011114A2
The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the ma...  
WO/2012/008228A1
Disclosed is a method for oxidizing alcohols, wherein it is possible to efficiently oxidize primary alcohols and secondary alcohols and to achieve high reaction efficiency even when air is used as the bulk oxidant. Specifically disclosed...  
WO/2012/009666A2
The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated int...  
WO/2011/133868A3
This invention relates to conformationally locked dinucleotide motifs for exo- and phosphate stabilization. For instance, oligonucleotides can be prepared having one or more of the following formulas (IV-IX).  
WO/2011/111501A9
Disclosed is RNA that includes a translated region having a 5' cap structure as well as a 5' side start codon and 3' side stop codon on the ends. A nucleoside compound in which a group represented by formula (I) is bonded to position 8 o...  
WO/2011/103468A3
The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3' end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5'-> 3' dir...  

Matches 851 - 900 out of 12,306