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Matches 1,151 - 1,200 out of 12,336

Document Document Title
WO/2009/125042A1
Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacterial strains. The invention also relate...  
WO/2003/083074A9  
WO/2009/124254A1
The invention provides for novel nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.  
WO/2009/094190A3
The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV...  
WO/2009/120878A2
One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides. Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method...  
WO/2009/094191A3
The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective to treat HIV and/or HBV ...  
WO/2009/119785A1
Disclosed is a method for purifying 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is characterized in that a crystal of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof is deposited by brin...  
WO/2009/067035A3
The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti- aging composition. As 4-furfurylcytosine and/or its deri...  
WO/2009/115927A2
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3' position. The ...  
WO/2009/115694A1
The invention relates to a method for preparing nucleotides or monomer nucleotide analogues, which comprises the following steps: (1) bonding a soluble polyethyleneglycol substrate including at least one diacid or ether-acid bonding arm ...  
WO/2009/116044A2
The present invention relates to a novel class of guanine nucleotide analogs of formula (I) which inhibit Re1A and Relseq synthetic activity and which possess anti -bacterial activity. The present invention also relates to pharmaceutical...  
WO/2009/116067A2
A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein 'a' - is selected from the group consisting of substituted or unsubstituted heterocycloalky...  
WO/2009/113303A1
Disclosed is a method for detecting methylcytosine in DNA rapidly, conveniently, and with high sensitivity. The method for detecting methylcytosine uses a methylcytosine photoligating agent (a photoresponsive probe) comprising a nucleic ...  
WO/2009/107692A1
A manufacturing method for a 2'-protected nucleoside derivative in which a ribonucleoside and an acylating agent are caused to react in the presence of a metal complex comprising a copper compound and an optically active ligand. A 2'-hyd...  
WO/2007/123740A3
The present invention relates to pharmaceutical compositions and methods for promoting wound healing. The invention also relates to methods of making pharmaceutical compositions disclosed herein. Pharmaceutical compositions are disclosed...  
WO/2009/105077A2
A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nu...  
WO/2009/101810A1
The present invention provides a manufacturing method that can easily manufacture a compound known as a photoresponsive (photocoupling) nucleic acid at high yield in a shorter period of time than that of the conventional technology. The ...  
WO/2009/053654A3
The present invention relates to gemcitabine phosphoester prodrugs with antitumour activity, of formula (I) in which n, Y, Z and Ri are as defined in claim 1, and also the pharmaceutical compositions comprising such a compound, in combin...  
WO/2009/098404A2
The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially ...  
WO/2009/094847A1
A capecitabine hydroxyl-derivative as the following structure, its preparation processes and intermediates in the processes, and the use of the said capecitabine derivative in the preparation of capecitabine by hydrolization. The capecit...  
WO/2009/096572A1
Disclosed is an industrially advantageous process for producing a nucleic acid derivative (e.g., an L-thymidine) and an intermediate compound of the nucleic acid derivative. Also disclosed is a novel intermediate compound which is useful...  
WO/2009/092295A1
A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the man...  
WO/2009/089702A1
A stable 6-methoxy-2', 3'-dideoxyguanosine comprises 6-30% water content. It is prepared by absorbing water in 6-methoxy-2', 3'-dideoxyguanosine with less than 6% water content at low temperature and certain humidity, or drying 6-methoxy...  
WO/2009/089804A1
The invention provides compounds of formula (I), wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.  
WO/2008/059130A9
The invention relates to a pharmaceutical composition containing as an active ingredient at least one compound selected from the compounds of the formula (II), in which the S atom is bonded to the nucleoside carbon at T or to the nucleos...  
WO/2009/086687A1
The invention discloses a simple synthesis method of decitabine, which uses 2-deoxy-D-ribose as the raw material to prepare intermediate 1-methoxy-2-deoxy-3,5-di-O-acyl-D-ribofuranose (3), the above intermediate is directly reacted with ...  
WO/2009/086192A1
Disclosed herein are nucleotide analogs of formula (I) with one or more protecting groups, methods of synthesizing nucleotide analogs with one or. more protecting groups and methods of treating diseases and/or conditions such as viral in...  
WO/2009/082846A1
A capecitabine hydroxyl-derivative as the following structure, its preparation processes and intermediates in the processes, and the use of hydrolyzing the said capecitabine hydroxyl-derivative to get capecitabine. The capecitabine hydro...  
WO/2009/082844A1
A capecitabine hydroxyl-derivative as the following structure, its preparation processes and intermediates in the processes, and the use of hydrolyzing the said capecitabine hydroxyl-derivative to get capecitabine. The capecitabine hydro...  
WO/2009/085909A1
The present invention provides novel crystal forms of 2-[2-(4- chlorophenyl)ethoxy]adenosine of the formula processes for the production of such crystal forms, and methods for the manufacture of pharmaceutical compositions for the treatm...  
WO/2009/082720A2
The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-pur in-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containg the same that are selective agonis...  
WO/2008/104893A3
Described herein are compounds and methods that prevent the viral infection of cells. The compounds and methods described herein minimize viral resistance and maximize the number of targeted viruses. Additionally, the compounds and metho...  
WO/2009/081833A1
A dried microorganism cell or microorganism extract which contains (SS)-S-adenosyl-L-methionine ((SS)-SAM) and in which the chemical decomposition of SAM and the progress of the epimerization of (SS)-SAM are significantly reduced can be ...  
WO/2009/074253A2
The subject of the present invention are specific phospholipidesters of clofarabine and the use of such lipidesters in the treatment of tumors.  
WO/2001/061028A3
A method for genetic analysis in which two or more nucleic acid samples are derived from two or more heterogeneous biological samples, with expression and assessment of the corresponding peptides. The assessment of the peptides focuses o...  
WO/2009/073506A2
This application provides compositions or compounds as disclosed herein that are suitable for treating hepatic viral diseases, such as hepatitis C (HCV).  
WO/2009/071726A1
The invention relates to a method for obtaining the compound capecitabine and the pharmaceutically acceptable derivatives thereof. In addition, the invention relates to novel intermediates used in the preparation of the compound capecita...  
WO/2002/099058A3
Human KCNMA genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that mod...  
WO/2001/055301A3
The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided a...  
WO/2009/069095A2
Compounds having the formula (I) or (II) wherein R1, R2, B, and V are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replic...  
WO/2009/069291A1
Disclosed is a prophylactic and/or therapeutic composition for chronic obstructive pulmonary disease (COPD) which is a disease caused by the inhalation of tobacco smoke. A composition is prepared, which comprises, as an active ingredient...  
WO/2009/066298A1
The invention provides non-hydrolyzable nucleoside polyphosphate derivatives, e.g., 2MeS-adenosine- β,γ-CH2-5'-O-(1-boranotriphosphate), 2MeS-adenosine- β,γ-CC12-5'-O-(1-boranotriphosphate), 2-MeS-adenosine-5'-dichloro methylene-diph...  
WO/2009/067035A2
The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti- aging composition. As 4-furfurylcytosine and/or its deri...  
WO/2008/043426A3
The invention relates to nucleotide analogues containing a sterically-hindered macromolecular ligand and a marker. Said nucleotide analogues can be used for enzymatic synthesis and sequencing of nucleic acids.  
WO/2009/066447A1
Disclosed is a photoreactive crosslinking agent which enables the cross-linking of sequences that cannot be photo-crosslinked with psoralen, and which enables the photo-crosslinking of sequences with a light having a longer wavelength th...  
WO/2009/067409A1
Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention aur 2 ', 4 ' -substituted nucleoside compounds us...  
WO/2009/060063A1
Compositions for controlling parasites, comprising a combination of ivermectin, abamectin, albendazole sulphoxide and trichlorfon and the use of such compositions in the preparation of a medicament for controlling endoparasites.  
WO/2006/012624A3
The present invention provides novel mechanism-based crosslinkers useful in covalently linking a kinase and an interactor.  
WO/2008/088779A3
The present invention provides novel crystalline forms of 5-deazacytidine, and pharmaceutical compositions comprising these novel forms. The invention also provides methods for the preparation of the novel forms and compositions.  
WO/2009/061941A2
Baseless nucleotide analogs are provided. Said analogs are used in the detection of target nucleic acids. The analogs have formula (I) wherein X is a backbone spacer; S is a solubility moiety; t is 0 or 1; V is a redox active moiety; L1 ...  

Matches 1,151 - 1,200 out of 12,336