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Matches 101 - 150 out of 12,335

Document Document Title
WO/2019/060740A1
Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the...  
WO/2019/060692A1
The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5 -carboxamide. The morphic form can be a stable hemihydra...  
WO/2019/053696A1
Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat disea...  
WO/2019/052359A1
The aim of the present invention is to provide a compound containing a diheterocyclic ribavirin analog, a stereoisomer, a prodrug, a pharmaceutically acceptable salt, a compound salt and/or a solvated compound with structural general for...  
WO/2019/004970A3
The present invention relates to the use of novel drug molecules and,use of said novel drug molecules in the treatment of neurodegenerative diseases, such as Parkinson's disease.  
WO/2019/053609A1
The present invention describes W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of ΛΡ-modified cytidine nucleoside triphosphates and their applications as well as uses of the c...  
WO/2019/053659A1
The present disclosure relates to compounds and compositions containing 5'-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.  
WO/2019/053476A1
The present invention relates to a process for the preparation of floxuridine, said process comprising reacting a compound of Formula la with a compound of Formula lla in the presence of an acid Al to provide a compound of Formula Ilia i...  
WO/2019/042888A1
Disclosed is the use of perfluorinated nucleic acids and perfluorinated peptides as compounds with excellent properties. Surprisingly, it has been shown that compounds of nucleic acids and peptides with short-chain perfluorocarbons havin...  
WO/2019/043177A1
The present invention relates to 2'-spirothietane nucleosides, and the phosphates and the prodrugs thereof, and the pharmaceutically acceptable salts and solvates thereof, and the use of such compounds as a medicament, in particular in t...  
WO/2019/040418A1
Compounds and methods for treating viral infections and reducing viral multiplication, including flaviviruses. Provided is a derivative of a compound or a pharmaceutical salt thereof, wherein the compound comprises a 3',4-didehydroribose.  
WO/2019/036225A1
Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection metho...  
WO/2019/032859A1
The disclosure is directed to compounds of Formula (I). Pharmaceutical compositions comprising compounds of Formula (I), as well as methods of their use and preparation, are also described.  
WO/2019/032411A1
The invention provides potent anti-cancer methods and compositions that employ novel glycome compounds exemplified by glyco-benzaldehydes that disrupt anaerobic respiration and trigger apoptosis in cancer cells. Additionally, the inventi...  
WO/2018/229493A3
The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.  
WO/2019/025600A1
The present invention relates to a hydrate of sofosbuvir, more precisely to a monohydrate of sofosbuvir, and to a process for its preparation. Furthermore, the invention relates to a pharmaceutical composition comprising the sofosbuvir h...  
WO/2019/027920A1
Crystalline and amorphous forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihyd rofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate (GS-9131), the vanillate, phosphate and xinafoate salts as well as the phospha...  
WO/2019/023748A1
The present invention relates to a method of increasing fertility, or reducing rate of decline in fertility, or restoring fertility, of a female subject, comprising administering to the subject an effective amount of an agent which eleva...  
WO/2018/236814A3
The disclosure provides derivatives of both the oxidized form and the reduced form of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The NR and NAR derivatives have improved stability and bioavailability compared to NR and...  
WO/2019/023459A1
The present invention is directed to compounds of the formulae I, II and III as shown below (I) (II) (III) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the inven...  
WO/2019/022158A1
Provided are a compound represented by formula I that can be used in nucleic acid photoreaction techniques, and a photoreactive crosslinking agent comprising the compound.  
WO/2019/012080A1
The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications. The compounds have formula (I) wherein B is a nucleoside base; and Fl is a fluorophore attached through...  
WO/2019/012328A1
The present invention relates to combination therapies of a cytarabine conjugate and one or more anti-neoplastic agents for inhibiting cancer cell growth. In particular, the present invention relates to a conjugate of cytarabine and aspa...  
WO/2018/041942A9
Embodiments of the invention are directed to new polymer linked multimeric guanosine-3', 5'-cyclic monophosphate (cGMP) analogues that modulate the cGMP-signaling system, preferably having activating properties, and more preferably being...  
WO/2019/005898A1
Compositions and method are therefore disclosed for treating chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis (PF). In particular, disclosed a composition that contains one, two, or more cytidine diphosphate (CDP)-c...  
WO/2016/075701A3
Disclosed herein is a method for extraction of DNA using naked magnetic nanoparticles. More particularly, the invention discloses a method for DNA extraction from various biological systems using naked magnetic nanoparticles with high ef...  
WO/2019/006455A1
Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar ...  
WO/2019/005901A1
Compositions and method are therefore disclosed for treating asthma. In particular, disclosed a composition that contains one, two, or more cytidine diphosphate (CDP)-conjugated phospholipid precursors selected from the group consisting ...  
WO/2019/002237A1
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefined oligonucleotides using said monomer. Herein are disclosed o...  
WO/2019/001292A1
A method for preparing a compound of formula T-3 according to route I is disclosed. The method comprises the following steps: a first step of reacting a compound of formula T-1 with a reagent comprising a PG group in the presence of an o...  
WO/2019/005977A1
Disclosed herein, inter alia, are trioxolane compounds and methods of using the same for treatment and detection of diseases.  
WO/2018/236814A2
The disclosure provides derivatives of both the oxidized form and the reduced form of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The NR and NAR derivatives have improved stability and bioavailability compared to NR and...  
WO/2018/229493A2
The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.  
WO/2018/229495A1
The present invention generally relates to a novel process for the preparation of 3'-deoxyadenosine derivatives,and particularly NUC-7738 (3'-deoxyadenosine-5'-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyade...  
WO/2018/229261A1
The invention relates to a prodrug compound consisting of a drug moiety comprising an amine or hydroxyl moiety and a protecting group moiety covalently linked to the amine or hydroxyl moiety. The drug moiety is effective in the treatment...  
WO/2018/224822A1
The invention relates to tunicamycin analogues which are compounds according to Formula (I), or pharmaceutically acceptable salts thereof, (I) Wherein [Base] and R1 to R9 are as defined herein. The tunicamycin analogues are useful in the...  
WO/2018/227168A1
Provided herein are nicotinamide adenine dinucleotide analogues, compositions comprising such compounds, and methods of using such analogues and compositions.  
WO/2018/226930A1
A method performs expansion fluorescent in situ sequencing (ExSEQ) against a specific one or more target nucleic acids of interest. The method takes advantage of the isotropic expansion of swellable polymer matrices. Such swelling can be...  
WO/2018/222774A1
Described herein are methods for treating and/or ameliorating a paramyxovirus infection, such as RSV, that include using compound (A), or a pharmaceutically acceptable salt thereof.  
WO/2018/220376A1
The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one son...  
WO/2018/213420A1
Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside ...  
WO/2018/212236A1
Provided is a novel oligonucleotide production method using a nucleoside or oligonucleotide that can be isolated easily and has high storage stability. An oligonucleotide production method including a coupling step of reacting a 5'-hydro...  
WO/2018/208667A1
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as induc...  
WO/2018/207950A1
Provided are a novel class A GPCR antagonist, a production method for same, and a novel compound which interacts with the binding site of a class A GPCR Na+- water molecule cluster. A compound, or a salt thereof, having a structure in wh...  
WO/2018/208727A1
Nucleoside and nucleotide compounds and analogues, and pharmaceutically acceptable compositions thereof, as inhibitors of CD73 for the treatment of diseases or disorders associated with CD73 activities, especially cancers, and methods of...  
WO/2018/204784A1
Methods of minimizing hook effect interference in an immunoassay are disclosed. Also disclosed are reagents, kits, and immunoassay devices that may be utilized in accordance with the method.  
WO/2018/203099A1
The present invention relates to a method for synthesizing diversely substituted purines starting from a pyrimidine. Formula (I). The method comprises the formation of an amidine group on the pyrimidine by implementing a Vilsmeier type r...  
WO/2018/200357A1
Provided herein are methods and compositions related to treating and/or preventing infertility, improving fertility and/or increasing lactation in a subject by administering to the subject (e.g., orally administering to the subject) a co...  
WO/2018/200356A1
Provided herein are methods and compositions related to treating and/or preventing kidney related diseases and disorders, treating and/or preventing acute kidney injury, and for improving kidney health in a subject by administering to th...  
WO/2018/200859A1
Multitargeted pyrimidlne nucleoside carbamates, substituted with fluorine at both the base and the sugar moieties, are disclosed (see Formula I) where R =linear or branched alkyl (C1-7); R' = H, hydroxy protecting group; R" = H, phosphat...  

Matches 101 - 150 out of 12,335