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Matches 201 - 250 out of 1,001

Document Document Title
WO/1995/021184A1
This invention is directed to novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents -- agents that are capabl...  
WO/1995/021183A1
In one of its aspects, the present invention provides novel compounds of formula (I) wherein: X is a halide; Y is selected from the group consisting essentially of halide, sulfate, acetate, tosyl, mesyl, benzoate and phosphate; R1 is sel...  
WO/1995/021180A1
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In said formula eac...  
WO1995015971A3  
WO1995009848A3  
WO/1995/019167A1
A composition suitable for administration to a warm-blooded animal comprising an antisense oligonucleotide to the C-C chemokine family typified by MCP-1 and MIP-1-Alpha which may or may not be labeled with a radionuclide by means of a ch...  
WO/1995/018787A1
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wher...  
WO/1995/015971A2
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...  
WO/1995/015333A1
Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.  
WO/1995/014707A1
This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents -- agents that are capable of s...  
WO/1995/009848A2
This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula (V) (wherein each X which may be the same or differ...  
WO/1995/008644A1
This invention relates to an improved process for detecting and quantifying a desired nucleic acid sequence. This process involves synthesizing single stranded RNA, single stranded DNA, double-stranded DNA followed by detection using an ...  
WO/1995/006474A1
Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention...  
WO/1995/005202A1
Highly iodinated borane and carborane cage molecules, having from 60 % to 90 % w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functi...  
WO/1995/004065A1
Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic interm...  
WO1994028907A3  
WO/1995/001363A1
Compounds having the formula (I), in which the substituents R', Y, W and R have the meanings cited, have in vivo the activity of the active substance residue W with improved pharmacokinetics.  
WO/1994/029324A1
Described are siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents, particularly for use in plant protection, or in the manufacture of surface-active or surface-modifying agents.  
WO/1994/028907A2
The invention pertains to the use of compounds of formula (I), where R is CN, OH, CH3 or H2O, in topical treatment of skin diseases and hair-growth disorders, and to a pharmaceutical preparation which contains, besides common carriers an...  
WO/1994/029322A1
Described are cationic siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents or in the manufacture of surface-active or surface-modifying agents.  
WO/1994/029323A1
Described are anionic siloxanyl-modified compounds, their preparation and their use as surface-active and surface-modifying agents.  
WO/1994/006811A1
A class of oligodeoxyribonucleotide and oligoribonucleotide analogs containing one or more stable internucleotide siloxy linkages is presented here. The linkages, in which the phosphodiester group is replaced by a siloxy group, are neutr...  
WO/1994/005681A1
New acetals of ketophosphamide and alkylglycoside have the general formula (I), in which R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning given in the description. Also disclosed is a process for preparing the same and their use as hig...  
WO/1994/004614A1
Porphyrins substituted with, for example, vinyl and acetylene groups are provided, along with polymers containing the same. In preferred embodiments, the substituted porphyrins are prepared by coupling halogenated porphyrins with anionic...  
WO/1994/001444A1
Phosphite-borane compounds wherein the borane moiety covalently bonded to the phosphorous atom is a BH3 moiety, and/or wherein the phosphorous atom has covalently bonded thereto a natural or synthetic nucleoside. The phosphite-borane com...  
WO/1994/001413A1
A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds ...  
WO/1994/001440A1
A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are boronated by an aminoalkyl substituted p...  
WO/1994/000465A1
The invention relates to novel sucrose ligands, methods for their preparation and their use as ligands for complexation with metals or metal containing compounds, as bulking agents or to make novel crosslinking agents. Bis(platinum) comp...  
WO/1994/000477A1
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (I), R1 ...  
WO/1993/025566A1
The preparation of deuterated nucleoside and nucleotide units for RNA and DNA synthesis is described. Preparation of the deuterated sugar residue is also described. The deuterated units are used to synthesize strands of RNA and DNA where...  
WO/1993/023414A1
The present invention is directed toward a novel process of 2'-exocyclic vinylfluoride derivatives of cytidine analogues (I) for use as ribonucleotide reductase inhibitors, wherein V is oxy or methylene and Y is hydrogen, C¿1?-C¿4? alk...  
WO/1993/017717A1
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably compris...  
WO/1993/018051A1
A process for producing a nucleoside derivative (1) by reacting a substituted 2,3-dihydrofuran derivative (2) with an organohalogen compound (3) containing a group 16 element of the periodic table to give a substituted 2-halotetrahydrofu...  
WO/1993/007883A1
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitam...  
WO1992020650A3  
WO/1993/002094A1
Disclosed herein is a process for producing novel DMEP-beta-D-glucosides of formula (I), wherein R1 is lower alkanoyl group, haloacetyl group, or both R1, taken together, form an alkylidene, arylalkylidene or heteroarylalkylidene group; ...  
WO/1993/001204A1
A method and compositions are provided for synthesizing polynucleotides wherein the exocyclic amino groups of 5'-O-protected-2'-O-alkylsilyl-adenosine phosphoramidite and 5'-O-protected-2'-O-alkylsilyl-guanosine phosphoramidite monomers ...  
WO/1992/021689A1
Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing silyl substituted alcohols include hydrosilation of a vin...  
WO/1992/021690A1
There are provided purine-base modified guanosine analogues, for example 2'-deoxy, and then ribonucleosides for incorporating into triplex-forming oligonucleotides. Also provided are triplex-forming oligonucleotides for binding into stra...  
WO/1992/020650A2
Phosphite-borane compounds of formula (I) wherein each R1 is independently selected from: H; C1-C10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R4)4N+, in which the substituents R4 ...  
WO/1992/018522A1
Improved DNA structures are disclosed which contain target sequences which bind to control proteins (such as the CREB protein). The structures of the present invention are stable to degradation, and are effective as decoys for control pr...  
WO/1992/014841A1
Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually h...  
WO/1992/009615A1
Support system for the synthesis of oligonucleotides wherein the first nucleoside is bound to the support via a silylether linkage, especially of formula (I) wherein B is a nucleoside or deoxynucleoside base. R1 is a protecting group. R2...  
WO/1992/004364A1
A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides ...  
WO/1992/003577A1
Novel oligonucleotides formed from alpha-D-arabinofuranosyl nucleoside monomers, including oligonucleotides in which one or more of the monomer units is functionalized, are disclosed herein, as well as functionalized monomeric alpha-D-ar...  
WO/1992/003568A1
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are p...  
WO/1992/002528A1
Novel reagents useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable...  
WO/1992/001699A1
Platinum complexes are disclosed which contain at least one leaving group and at least one detectable group. These complexes can be used for diagnostic purpose and for the labelling of nucleic acids. Specific example is Pt(ethylenediamin...  
WO/1992/001700A1
The instant invention is drawn to 2'-fluoroarabinofuranosyl compounds and a process for preparing same.  
WO/1991/019730A1
The selected sequence-directed hydrolysis of RNA under physiologically relevant conditions is described using conjugates comprising metal complexes covalently linked to oligodeoxynucleotides as hydrolysis agents. The oligodeoxynucleotide...  

Matches 201 - 250 out of 1,001