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WO/2012/032513 |
The present invention provides pharmaceutical compositions and methods for treatment and management of osteoarthritis using certain dinucleotide boranophosphate derivatives or nucleoside boranophosphate derivatives. The invention further...
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WO/2012/030745 |
Conjugates comprising vitamin B12 (Fig. 1) and oligonucleotides are useful in inhibiting expression of other oligonucelotides in a cell.
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WO/2011/115817 |
Provided herein are methods for preparing 2'-O-substituted purine nucleosides without protecting exocyclic amino groups on the base during alkylation. The methods are particularly useful in that the products are crystalline enabling puri...
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WO/2011/055374 |
The present invention related to novel processes for the preparation of iron (III) carboxymaltose complex. Thus, for example, heating a mixture of one or more maltodextrins, ferric hydroxide and water, oxidizing the iron maltodextrin com...
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WO/2010/114683 |
A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removin...
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WO/2010/113937 |
A process for producing an NC-type purine nucleoside readily has been demanded. Thus, disclosed is a process for producing a purine nucleoside represented by formula (I') or a salt thereof, which comprises reacting a pyrimidine nucleosid...
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WO/2010/094130 |
An antimalarial conjugate according to a non-limiting embodiment of the present invention may include a metallocene, a carbohydrate, and an antimalarial agent. The metallocene may include two cyclopentadienyl rings bound to a central met...
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WO/2010/090541 |
A purine nucleoside derivative comprising a boron cluster or its complex with a metal (metallocarborane) conjugated to at least one of: a nucleic base, sugar residue or sugar residue analogue.
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WO/2010/086667 |
A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M' is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosacchari...
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WO/2010/076433 |
The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates...
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WO/2009/154276 |
Disclosed is a process for producing a spiroketal derivative through a compound represented by formula (VI) [wherein the variable groups and the variable numbers are as defined in the description] which can be produced from a dihalobenzy...
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WO/2009/146711 |
The present invention relates to a method for purification and/or concentration of natural cobalamins by adsorption on insoluble materials containing carboxylic groups. Especially the method comprises providing a first solution comprisin...
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WO/2009/146711 |
The present invention relates to a method for purification and/or concentration of natural cobalamins by adsorption on insoluble materials containing carboxylic groups. Especially the method comprises providing a first solution comprisin...
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WO/2009/137966 |
The present invention discloses a new inhibitor for depressing the absorption of sucrose, wherein the inhibitor is arabinose complexes of trace element which frequently occurs in the body. The effect of the complexes is same whenever alo...
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WO/2009/078037 |
The present invention provides a novel reproducible method for the preparation of Iron sucrose complex using ferric acetate that is prepared freshly from ferric hydroxide. This method affords iron sucrose complex in a powder form and an ...
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WO/2009/078037 |
The present invention provides a novel reproducible method for the preparation of Iron sucrose complex using ferric acetate that is prepared freshly from ferric hydroxide. This method affords iron sucrose complex in a powder form and an ...
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WO/2009/065181 |
Nanostructures capable of carrying a pharmaceutical agent are described. The nanostructures comprise a core which includes a pharmaceutical agent and a cover which includes a polymer. Methods for the preparation of the nanostructures inv...
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WO/2009/047870 |
A functional material in which DNA is coupled with an inorganic compound for providing a functional material which retains a function of DNA (an organic compound) and has a strength of an inorganic compound. The functional material is ob...
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WO/2009/041002 |
Disclosed is a method for detoxifying a toxic compound, which is useful for efficiently detoxifying a toxic compound containing arsenic or the like. Specifically disclosed is a method for detoxifying a toxic compound, which is characteri...
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WO/2008/136850 |
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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WO/2008/136850 |
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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WO/2008/113686 |
The present invention is related to photoreactive Ru (II) complexes anchored on a G- containing oligonucleotide, e.g. compound 1, the method for obtaining them and their use, especially for targeting specific nucleotide sequences that be...
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WO/2008/113686 |
The present invention is related to photoreactive Ru (II) complexes anchored on a G- containing oligonucleotide, e.g. compound 1, the method for obtaining them and their use, especially for targeting specific nucleotide sequences that be...
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WO/2008/115805 |
The present invention is directed to methods and compositions including a taxane covalently bonded to the cobalt atom of a cobalamin. The composition can be delivered by any effective route, but is particularly useful as an oral anti-can...
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WO/2008/104486 |
The present invention refers to diagnostically or radiotherapeutically useful compounds which are able to selectively bind to lectins, having formula (I) wherein R, R', R1, R2 and R3 are as defined in the specification; the process for t...
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WO/2008/087135 |
The invention relates to an iron-hydrocarbon complex compound which is characterized by an iron (II) content. The invention also relates to methods for producing said iron-hydrocarbon complex compound as well as the use thereof for the t...
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WO/2008/082440 |
Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or analog thereof, and a modified sugar moiety ...
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WO/2008/044443 |
A novel gadolinium compound which (1) has a high T1 relaxation ability and can form an image with high sensitivity even when administered in a small amount, (2) is highly effective in imaging systemic blood vessels and the liver, (3) is ...
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WO/2008/025886 |
The invention relates to novel chelating agents and metal chelates containing 1,2,3-triazolyl subunits, and their conjugates with biomolecules or particles. The invention concerns also a process for the preparation of the novel chelating...
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WO/2008/012945 |
Disclosed is a compound which has excellent anti-tumor activity and excellent oral absorbability and is useful as an anti-tumor agent. Specifically disclosed is a 3'-ethynylcytidine derivative represented by the general formula (1) [wher...
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WO/2007/149098 |
A stable pharmaceutical aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and yields a bi...
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WO/2007/132005 |
The invention relates to novel hybrid compounds comprising at least one polyol entity (Po) - for example oligomer or polymer - in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a...
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WO/2007/132005 |
The invention relates to novel hybrid compounds comprising at least one polyol entity (Po) - for example oligomer or polymer - in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a...
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WO/2007/104834 |
This invention concerns novel terminating substrates for DNA polymerases. The substrates are nucleoside triphosphates labeled with lanthanide chelates.
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WO/2007/097404 |
[PROBLEMS] To provide a method for production of a composite material, such as a nanoglass, which contains a luminescent substance or a particulate substance having a functional sugar chain carried on its surface by a simple process, and...
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WO/2007/092916 |
Methods and materials are disclosed for rapid and simple extraction and isolation of RNA from a biological sample involving the use of an acidic solution and a solid phase binding material that has the ability to liberate nucleic acids f...
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WO/2007/092916 |
Methods and materials are disclosed for rapid and simple extraction and isolation of RNA from a biological sample involving the use of an acidic solution and a solid phase binding material that has the ability to liberate nucleic acids f...
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WO/2007/072208 |
An oil product comprises a metal complex polymer solution for its esterification and fermentation reactions. The metal complex polymer is composed of oil, water, R-COOHs soluble saccharide (including sugar-metal) molecules, polymer with ...
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WO/2007/072208 |
An oil product comprises a metal complex polymer solution for its esterification and fermentation reactions. The metal complex polymer is composed of oil, water, R-COOHs soluble saccharide (including sugar-metal) molecules, polymer with ...
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WO/2007/049736 |
This invention provides a process for producing a natural product having stable quality with high recovery. There is also provided a method for concentration-crystallizing a natural product, characterized by comprising continuously measu...
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WO/2007/012494 |
The invention relates to stable nicotinamide adenine dinucleotide (NAD/NADH) derivatives or nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of said derivatives, and the use thereof in...
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WO/2006/135447 |
Chimeric nucleic acids are presented in which a portion of the polymerase gene or one picornavirus is replaced with the corresponding portion of another picornavirus. Remarkably, such constructs can produce positive and negative strand R...
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WO/2006/128048 |
The invention provides methods for reducing blood homocysteine levels in mammals, and treating or preventing diseases associated with elevated blood homocysteine levels, such as cardiovascular diseases and cognitive disorders. The invent...
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WO/2006/100059 |
The present invention relates to a new process for the production of methylcobalamin that comprises the methylation of cyanocobalamin or hydroxocobalamin with dimethyl carbonate in the presence of a reducing agent.
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WO/2006/086799 |
Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents or antibodies to the reagents for detection, diagnosis, purification, therapy and prophylaxis for prions ...
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WO/2006/061685 |
The present invention relates to a cost-effective process for manufacture of iron sucrose complex.
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WO/2006/020291 |
The present invention provides improved vitamin B12 compositions containing a mixture of vitamin B12 analogues that are better absorbed into the bloodstream of a patient with vitamin B12 deficiency, preferably via their mucosal membranes...
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WO/2005/116040 |
A process for preparing an iron saccharose complex has the following steps: (a) an iron salt in an aqueous solution is mixed at low temperature with sucrose and an inorganic base, either simultaneously or in any given order, so that the ...
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WO/2005/116046 |
The invention relates to a method for producing an iron sucrose complex by (a) mixing, in an aqueous solution and at low temperature, an iron salt with sucrose and an inorganic base, simultaneously or in a random order, so that the react...
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WO/2005/080490 |
The present invention relates to a solution of metal-polymer chelate(s) and applications thereof, the solution contains one kind or more kinds of metal-polymer chelate(s) , the metal-polymer chelate(s) is/are prepared as follows: a polym...
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