Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 989

Document Document Title
WO/2018/007035A1
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exch...  
WO/2018/005630A1
The invention provides a compound of the formula (I), and a capture support of the formula (9), wherein R1, R2, R3, R6, A, B, D, E, J, K, Q, W, and Z are as defined herein. The invention also provides a method of purifying an oligonucleo...  
WO/2017/144099A1
The present invention relates to a compound of formula (I) wherein the substituents are as defined in the claims. Said compound may be used as a ligand in order to purify glycosylated bio molecules. The present invention further relates ...  
WO/2017/133465A1
The present invention relates to a baicalin magnesium and further relates to a preparation method and extraction method of the baicalin magnesium. The preparation method comprises the steps of preparing a suspension of a baicalin, prepar...  
WO/2017/134176A1
The present invention relates to a process for producing 2'-O-fucosyllactose, to the intermediates obtainable by this process and to the use of these intermediates. Production comprises the reaction of a protected fucose of general formu...  
WO/2017/112787A1
Anti-proliferative iron prochelator compounds conjugated with a carbohydrate moiety or a derivative thereof. The glycoconjugate molecules may feature thiosemicarbazone iron prochelators. The glycoconjugates are prochelators that are acti...  
WO/2016/199165A3
This invention comprises a method of transmucosal delivery of process of Vitamin B 12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B 12 and at least one bifunctional macromolecule...  
WO/2016/194000A1
The present invention relates to aqueous solutions of iron sucrose and a process for its preparation. The molecular weight of said complexes is in the range 45000 to 60000 Dalton. The compositions are used in the treatment of anaemia.  
WO/2016/173425A1
This present invention relates to a glucopyranosyl derivative as sodium dependent glucose cotransporters (SGLTs) inhibitor, preparation processes thereof, and pharmaceutical uses thereof, pharmaceutical compositions containing the compou...  
WO/2016/119004A1
The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment of vitamin B12 deficiency.  
WO/2015/191303A2
The present disclosure provides a unique methodology and protecting groups that enable synthesis of oligonucleotides having Z nucleotide in an easy, clean and site-specific fashion with high yield. In particular, the method causes little...  
WO/2015/128622A1
A method of detecting peroxynitrite in a sample is described comprising the steps of: (a) providing a complex of a saccharide with an aryl boronate compound of formula (I): Fp - L1 - Z - L2 - Ar - B(OH)2 (I) wherein: Fp comprises a fluor...  
WO/2015/101916A1
An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are also disclosed, wherein R1 and R2 are independently hydrogen or hydroxyl protec...  
WO/2014/142640A1
The invention relates to a novel method for the production and purification of hydroxocobalamin and the pharmaceutically acceptable salts of same, wherein the method consists in converting cyanocobalamin into hydroxocobalamin by reductio...  
WO/2014/144907A1
Compounds have been identified and tested in a zebrafish model of dystroglycanopathy and found to be efficacious based on an increase in the survival rate of dystroglycan deficient fish. Several of the compounds affect the GABA and acety...  
WO/2014/027203A1
An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or...  
WO/2014/010250A1
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (-NO2), a halogen atom, a cyano group (-CN), a group of ...  
WO/2013/191129A1
A compound represented by general formula (III), which is an intermediate for an oligonucleotide analogue that is stable and has an excellent antisense antigene activity or an excellent activity for acting as a detecting agent (a probe) ...  
WO/2013/191549A1
The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, c...  
WO/2013/036868A1
Synthesis and uses of conformationally restricted nucleomonomers (CRN) to prepare nucleic acid compounds. Methods for preparing nucleomonomers for nucleic acid compounds in high yields and in multi-gram scale for therapeutic modalities u...  
WO/2012/175046A1
Disclosed in the present invention is the use of a water soluble platinum coordination complex in preparing drugs for the prevention and treatment of tumours, said coordination complex being shown as formula (I). Experiments have demonst...  
WO/2012/175044A1
Disclosed are a water-soluble platinum coordination complex for tumour treatment and a preparation method therefor, said coordination complex being shown as formula (I): The present platinum coordination complex shows a long-term antineo...  
WO/2012/175045A1
Disclosed are a water-soluble fluorine-containing platinum coordination complex for tumour treatment and a preparation method therefor, said coordination complex being shown as formula (I): The present platinum coordination complex shows...  
WO/2012/165934A1
The present invention discloses a process for the synthesis and purification of methylcobalamin by using dimethyl sulphate as alkylating agent, either alone or in a Vilsmeier complex, with non-alkylated, mono-alkylated and dialkylated am...  
WO/2012/155124A2
It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a "ligand moiety") through linkage of such molecules to a metal bin...  
WO/2012/136793A1
A method for selective detection of cyanide in a sample comprises determining a color change of a corrinoid compound caused upon contact with the sample. A high detection sensitivity and selectivity are achieved by having the corrinoid c...  
WO/2012/075140A1
Disclosed herein are 2'-spiro-nucleosides of formula I and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus. Formula (I), where z is a four-or five-membered ring selected from among radicals...  
WO/2012/075005A1
The present invention provides for compounds of Formula (I): wherein X-N and R1-R4 have any of the values disclosed in the specification. The compounds of Formula I are useful as reagents to introduce N-alkyl nucleosides into DNA oligonu...  
WO/2012/032513A1
The present invention provides pharmaceutical compositions and methods for treatment and management of osteoarthritis using certain dinucleotide boranophosphate derivatives or nucleoside boranophosphate derivatives. The invention further...  
WO/2012/030745A1
Conjugates comprising vitamin B12 (Fig. 1) and oligonucleotides are useful in inhibiting expression of other oligonucelotides in a cell.  
WO/2011/115817A1
Provided herein are methods for preparing 2'-O-substituted purine nucleosides without protecting exocyclic amino groups on the base during alkylation. The methods are particularly useful in that the products are crystalline enabling puri...  
WO/2011/055374A3
The present invention related to novel processes for the preparation of iron (III) carboxymaltose complex. Thus, for example, heating a mixture of one or more maltodextrins, ferric hydroxide and water, oxidizing the iron maltodextrin com...  
WO/2011/055374A2
The present invention related to novel processes for the preparation of iron (III) carboxymaltose complex. Thus, for example, heating a mixture of one or more maltodextrins, ferric hydroxide and water, oxidizing the iron maltodextrin com...  
WO/2010/113937A1
A process for producing an NC-type purine nucleoside readily has been demanded. Thus, disclosed is a process for producing a purine nucleoside represented by formula (I') or a salt thereof, which comprises reacting a pyrimidine nucleosid...  
WO/2010/114683A1
A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removin...  
WO/2010/094130A1
An antimalarial conjugate according to a non-limiting embodiment of the present invention may include a metallocene, a carbohydrate, and an antimalarial agent. The metallocene may include two cyclopentadienyl rings bound to a central met...  
WO/2010/090541A1
A purine nucleoside derivative comprising a boron cluster or its complex with a metal (metallocarborane) conjugated to at least one of: a nucleic base, sugar residue or sugar residue analogue.  
WO/2010/086667A3
A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M' is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosacchari...  
WO/2010/076433A1
The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates...  
WO/2009/154276A1
Disclosed is a process for producing a spiroketal derivative through a compound represented by formula (VI) [wherein the variable groups and the variable numbers are as defined in the description] which can be produced from a dihalobenzy...  
WO/2009/146711A2
The present invention relates to a method for purification and/or concentration of natural cobalamins by adsorption on insoluble materials containing carboxylic groups. Especially the method comprises providing a first solution comprisin...  
WO/2009/146711A3
The present invention relates to a method for purification and/or concentration of natural cobalamins by adsorption on insoluble materials containing carboxylic groups. Especially the method comprises providing a first solution comprisin...  
WO/2009/137966A1
The present invention discloses a new inhibitor for depressing the absorption of sucrose, wherein the inhibitor is arabinose complexes of trace element which frequently occurs in the body. The effect of the complexes is same whenever alo...  
WO/2009/078037A2
The present invention provides a novel reproducible method for the preparation of Iron sucrose complex using ferric acetate that is prepared freshly from ferric hydroxide. This method affords iron sucrose complex in a powder form and an ...  
WO/2009/078037A3
The present invention provides a novel reproducible method for the preparation of Iron sucrose complex using ferric acetate that is prepared freshly from ferric hydroxide. This method affords iron sucrose complex in a powder form and an ...  
WO/2009/065181A1
Nanostructures capable of carrying a pharmaceutical agent are described. The nanostructures comprise a core which includes a pharmaceutical agent and a cover which includes a polymer. Methods for the preparation of the nanostructures inv...  
WO/2009/047870A1
A functional material in which DNA is coupled with an inorganic compound for providing a functional material which retains a function of DNA (an organic compound) and has a strength of an inorganic compound. The functional material is ob...  
WO/2009/041002A1
Disclosed is a method for detoxifying a toxic compound, which is useful for efficiently detoxifying a toxic compound containing arsenic or the like. Specifically disclosed is a method for detoxifying a toxic compound, which is characteri...  
WO/2008/136850A2
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.  
WO/2008/136850A3
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.  

Matches 1 - 50 out of 989