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JP6981639B2 |
To provide methods for synthesizing a sugar chain stereoselectively, without using the intramolecular stereocontrol group, such as neighboring-group participation.A production method of a stereoselective sugar chain is characterized by r...
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JPWO2020090211A1 |
(1) The step of introducing a modification into the skeleton of double-stranded RNA, (2) the double-stranded RNA obtained by step (1), and 2,6-diamino-2,6-dideoxy-β- (1). 4) -Provides a method for regulating the stability of double-stra...
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JP6917607B2 |
To provide new radioactive halogen labeled substances with a D-allose skeleton, a production method thereof, and the like.A radioactive halogen labeled deoxyhalogeno-D-allose derivative is a compound represented by the general formula (1...
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JP2021116271A |
To provide a method for conveniently obtaining chitosan oligosaccharides with a number of saccharides controlled in a predetermined range.A chitosan oligosaccharide fractionating method comprises the steps of adding acid to aqueous solut...
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JP6898323B2 |
The invention relates to a method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy-D-mannose. This method comprises the chemical reaction of compound of formula X: Wherein: R 1 can be a C 1 to C 6 alkyl including methyl, ethyl, i...
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JP6869600B2 |
To provide fucose-binding lectin which can be immobilized to a support with high efficiency and site-specificity, methods for producing the lectin, and adsorbents for fucose-containing sugar chains and/or glycoconjugates obtainable by im...
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JP6871587B2 |
To provide: sialic acid derivatives to which resistance can hardly be developed and which have strong inhibitory activity; and sialidase inhibitors, antimicrobials and antivirals containing the same as active ingredients.The invention pr...
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JP2021508737A |
The present invention relates to secondary functional moieties including transition metal based linkers and primary functional moieties attached thereto. The secondary functional moiety according to the present invention comprises a tran...
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JP2021508732A |
Provided are compounds of formula (A) used in the prevention or treatment of joint and bone disorders in mammals, such as arthritis and osteoporosis, as well as pharmaceutically acceptable salts and esters thereof, and pharmaceutical com...
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JP6827709B2 |
To provide a technique for producingF-FDG stably in high yield, even if using a large scale of [F] fluoride ion in order to enhance the production amount ofF-FDG.A production method ofF-FDG comprises (a) separating [F] fluoride ion fromO...
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JP2020534361A |
The compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed herein. [Chemical 1] The variables in formula (I) are described herein. Methods for synthesizing such compounds, as well as for treating diseases an...
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JP2020531457A |
The present disclosure is useful as a drug in the treatment of diseases and conditions, including cancer, in formulas (I) (in formula, A).2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X and Y have any of...
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JP6770207B2 |
A 99mTc-labeled isonitrile-containing glucose derivative having the general formula [99mTc-(CNDG)6]+, preparation method and use thereof is disclosed herein. The derivative is centered on 99mTc+, and the carbon atom of the isonitrile in ...
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JP6762027B2 |
The present invention provides a method of producing a sialooligosaccharide, which comprises: (1) hydrolyzing a sialoglycoprotein by heating at a temperature from 70 to 90° C. in an alkaline aqueous solution; and (2) purifying the hydro...
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JP6745510B2 |
To provide a method for producing a chitin oligomer, N-acetylglucosamine, and 1-O-alkyl-N-acetylglucosamine by hydrolysis reaction of a chitin-containing biomass with an acid catalyst.According to the present invention, there is provided...
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JP2020114811A |
To provide a process for the 1,3-dipolar cycloaddition of (hetero) aryl 1,3-dipole compounds and (hetero) cycloalkynes.The invention relates to a process for the 1,3-dipolar cycloaddition, in which a (hetero) aryl 1,3-dipole compound is ...
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JP6726665B2 |
The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]-labelled compound on a single cassette. The invention allows one synthesiz...
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JP2020090675A |
To provide methods for the treatment of an inflammation caused by polymicrobial infections, and sepsis and severe sepsis, SIRS and septic shock.The present invention provides a composition containing chitin and chitosan derivatives as an...
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JP2020055749A |
To provide: a novel aminoglycoside antibiotic which has an antibacterial activity against both of gram-positive bacteria and gram-negative bacteria and is useful especially against multiple drug-resistant gram-positive and gram-negative ...
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JP6667856B2 |
Provided is a method for liberating sugar chains from a glycoprotein, including: a step of brining a reaction solution which contains hydroxylamines (a) and a basic reagent (b) into contact with the glycoprotein to obtain a mixed solutio...
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JP6666243B2 |
The present application discloses a process for the purification of 2'-fucosyllactose produced by fermentation, enzymatic synthesis or chemical synthesis or combinations thereof. The process uses simulated moving bed (SMB) chromatography...
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JP2020025535A |
To provide fucose binding proteins in which binding affinity to fucose-containing sugar chains such as sugar chains comprising a structure consisting of Fucα1-2Galβ1-3GlcNAc and/or Fucα1-2Galβ1-3GalNAc is improved.Provided is a metho...
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JP6613112B2 |
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JP6608918B2 |
wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have anti-inflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein ...
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JP6605034B2 |
The present disclosure relates to a method for preparing a radiopharmaceutical and, specifically, to a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, to a method for purifying the prepared or...
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JP6605201B2 |
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JP6601220B2 |
wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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JP6596421B2 |
Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of tr...
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JP6594853B2 |
There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agen...
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JP2019142870A |
To provide conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates.The invention provides hydrazinyl-pyrrolo compound structures, and a method of producing a conjugate comprising a polypeptide. Th...
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JP2019520342A |
The present invention describes a novel conjugate of a drug and part of formula (I) that can bind to a glucose-sensing protein that allows the reversible release of the drug depending on the glucose concentration.
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JP2019518083A |
The present invention discloses a method for obtaining monosaccharides from chitin or chitosan by chemical and / or enzymatic hydrolysis in an acid solution. By using reagents that are readily available at low cost, this method makes it ...
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JP2019515876A |
The present disclosure relates to novel modular methods for making a variety of high mannose, hybrid and complex N-glycans. The present disclosure also relates to an exemplary array of synthetic N-glycans spotted on slides coated with al...
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JP2019085363A |
To provide a method for producing 2-deoxy-2-fluoro-glucose efficiently in an industrial scale.The present invention makes it possible to produce 1,3,4,6-tetra-O-acyl-2-deoxy-2-fluoro-glucose by reacting 1,3,4,6-tetra-O-acyl-2-O-(trifluor...
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JP2019514962A |
It is characterized by administering at least one active agent (including one or more of a thioredoxin reductase inhibitor and a glutathione depleting agent), followed by a pentaaza macrocyclic ring complex corresponding to formula (I) b...
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JP6518214B2 |
Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-²-D-arabinofuranosyl)cytosine A compound represented by the formula [1F]: wherein R 1 represents a hydrogen atom or a hydroxyl protecting group; R 2 represents a hydrogen atom or a hy...
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JP2019052112A |
To provide a novel substance useful as a functional substance having a biomass-derived structure and a composite function.A glucosamine derivative is represented by formula (I) (Ris H, a protective group of a hydroxy group or an organic ...
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JP2019504091A |
The present invention relates to a method for producing 2'-O-fucosyllactose, to intermediates available by this method, and to the use of those intermediates. Manufacture is to try (C) the protected fucose of general formula (I)1~ C6Reac...
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JP6466637B2 |
A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a car...
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JP6455857B2 |
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JP2018537517A |
The present invention relates to compounds effective in the treatment of hepatotoxicity and fatty liver disease and their use.
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JP2018537402A |
The present invention describes novel compounds useful for image-guided surgery and photodynamic therapy. In particular, after the compound is delivered to the affected tissue, such as cancer, using a ligand that targets the receptor exp...
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JP6441821B2 |
The present invention relates to synthetic fucosylated oligosaccharide for use in the treatment or prophylaxis of an infection with a Norwalk-like Virus or Rotavirus of a mammal, wherein the synthetic fucosylated oligosaccharide comprise...
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JP6416001B2 |
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JP6401380B2 |
This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b...
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JP2018099081A |
To improve the recovery rate of a carbohydrate chain from a glycosylation substance.A method for producing a carbohydrate chain has a decomposition step and a liberation step. In the decomposition step a sample containing glycoprotein is...
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JP6336695B2 |
Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting ...
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JP6327565B2 |
The present invention aims at providing: a sugar derivative capable of producing a blue fluorescent col-or, which can be used for the imaging of a cell or an intracellular molecule; and a method for imaging a cell using the derivative. T...
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JP2018510878A |
The present invention provides desosamine and mycaminose analogs and nitrosaccharides, and methods for their preparation. The present invention also provides a method for cyclizing a compound of formula (A') with glyoxal to obtain a nitr...
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JP2018053067A |
To provide a large scale manufacturing method of amorphous chitin which is a raw material of functional foods, cosmetics, medical materials, oligosaccharide or N acetylglucosamine which is a hydrolysate.There is provided a manufacturing ...
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