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WO/2023/283434A9 |
The present disclosure relates generally to monomers and methods for conjugating one or more ligands to oligonucleotides.
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WO/2024/050809A1 |
Provided is a method for the glycosylation modification of proteins and/or polypeptides, belonging to the technical field of medicinal chemistry. Using glycosyl sulfinate as a raw material, a method for the glycosylation modification of ...
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WO/2023/222732A1 |
The present invention relates to a novel and efficient method for the production of glycosyl fluorides by the fluorination of a protected saccharide with a fluorinating agent, such as poly(hydrogen fluoride), triethylamine trihydrofluori...
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WO/2023/216992A1 |
Provided are a cyanine-trehalose compound, a method for preparing same, and use thereof. Specifically, the compound is represented by formula I. The cyanine-trehalose compound can be used for detecting Mycobacterium tuberculosis, and fea...
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WO/2023/213035A1 |
Disclosed is a method for preparing an aryl carbon glycoside compound including a gliflozin drug, belonging to the technical field of pharmaceutical chemistry. According to the present invention, a sulfinate glycosyl donor represented by...
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WO/2023/213034A1 |
Disclosed are a sulfinate glycosyl donor, a method for preparing same, and use thereof, belonging to the technical field of pharmaceutical chemistry. The present invention particularly provides a sulfinate glycosyl donor represented by f...
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WO/2023/175130A1 |
It is disclosed a new crystalline form of lacto-N-triose II, a method to obtain the same and nutritional or pharmaceutical compositions comprising the same.
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WO/2023/141513A2 |
New derivatives of human milk oligosaccharides and methods for preparing them are disclosed. Also described herein are hST6GALNAC V and hGCNT2-B variants, along with polynucleotides encoding the variants and host cells comprising the pol...
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WO/2023/096715A9 |
Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds...
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WO/2023/131355A1 |
The present invention relates to the technical field of antibacterial. Disclosed are a water-soluble chlorhexidine antibacterial, a preparation method therefor and an application thereof. In the present invention, the preparation method ...
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WO/2023/117673A1 |
The invention relates to a method for selective crystallization of LNnT from an aqueous solution comprising LNnT and one or more other fucosylated carbohydrates by adding methanol to the solution.
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WO/2023/070223A1 |
The invention provides for a vaccine against S. suis serotype 2. The vaccine comprises chemically synthesized fragments and thus may be made widely commercially available. The vaccine is used in the livestock production and may be adapte...
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WO/2023/045995A1 |
Multivalent ligand clusters, having a diamine scaffold, for targeted delivery of pharmaceutical agents conjugated thereto are described. A multivalent ligand cluster may comprise one or more N-acetylgalactosamine (GalNAc) targeting ligan...
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WO/2023/039292A2 |
Provided herein are novel sugar derivatives which are intermediates for preparing senolytic agents that selectively kill senescent cells associated with numerous pathologies and diseases, including age-related pathologies and diseases.
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WO/2023/032788A1 |
Provided are a protective agent, a surfactant composition, a composition for blood sugar level control, an autophagy inducing agent, a stain for mycobacteria, or a protein extraction agent characterized by containing a compound represent...
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WO/2023/024676A1 |
Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vacc...
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WO/2023/010323A1 |
Provided is a method for preparing sucralose. The method comprises the steps of: feeding a chlorination reaction solution for preparing sucralose-6 ester, a first liquid alkali and first reuse water into a neutralization reaction rectify...
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WO/2023/002452A1 |
The present application provides synthetic processes for preparing N-acetyl-galactosamines (NAG) based compounds for targeted drug delivery. Also disclosed are Poly-NAG compounds, intermediates and targeting ligands, which are used and/o...
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WO/2023/001004A1 |
The present invention relates to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine, and in particular to a mannose derivative and an application thereof. The mannose derivative is an isonitrile-containin...
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WO/2023/279276A1 |
The present application provides a method for purifying sucralose-6-ester. The method comprises: adding an oxidizing agent to a mother solution to be purified, carrying out an oxidation reaction under a first preset condition, then addin...
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WO/2023/279278A1 |
The present application provides a method for purifying sucralose-6-ester, comprising: a concentration step: concentrating a mother liquor to be purified so as to remove an organic solvent, and adding water after concentration is complet...
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WO/2023/280227A2 |
The present invention provides Polar units, Linker intermediates, Linkers, Drug-Linkers and Conjugates thereof
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WO/2022/269652A1 |
The present disclosure provides compounds of the general formula (I), or salts thereof, a method of preparation, and their use for treating diabetes mellitus: Formula (I) wherein R1 is selected from a group containing alkyl, cycloalkyl, ...
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WO/2022/243848A1 |
The present technology is direct to methods of producing 6,6'-diamino-6,6'-deoxy-trehalose ("DATH") or a salt thereof. The methods include optionally protecting one or more hydroxyl groups of D-trehalose and converting the primary hydrox...
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WO/2022/191312A1 |
[Abstract] [Problem] To provide a method for producing a dealkoxyphenylation product with high yield from a substrate, e.g., a sugar, which is bonded to an alkoxyphenyl group through an oxygen atom. [Solution] A substrate that is bonded ...
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WO/2022/183254A1 |
The invention relates inter alia to methods of producing sulfated oligosaccharide derivatives and intermediates thereof. The sulfated oligosaccharide derivatives may be represented by the following formula (I) wherein: X and Y are any D-...
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WO/2022/174520A1 |
Disclosed is a preparation method for vegetarian D-glucosamine hydrochloride. In the present method, citric acid residual waste obtained after producing citric acid using a fermentation method is used as a raw material, expansion is perf...
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WO/2022/169855A1 |
The present invention includes compositions and methods for preventing or treating a patient for kidney injury comprising administering an effective amount of a compound of Formula I: where n = 0-5; X = NH, O, S, or CH2; Y = phenyl, or a...
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WO/2022/163846A1 |
The purpose of the present invention is to provide: a novel stereoselective method for producing a cyclic dinucleotide derivative that can be used for an antibody-immunostimulator conjugate; and a production intermediate thereof. Another...
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WO/2022/150726A1 |
The present disclosure provides hypoimmunogenic biotherapeutic compositions that suppress the development of an immune response to themselves in an individual. The present disclosure also provides pharmaceutical compositions that include...
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WO/2022/141227A1 |
The present application provides a preparation method for sucralose and a crude product solution thereof. The preparation method comprises: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solutio...
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WO/2022/141229A1 |
A sucralose preparation method, a crude product solution, and sucralose, the method comprising: dissolving sucralose-6-ethyl ester in ethanol to form a sucralose-6-ethyl ester reaction solution; distilling the sucralose-6-ethyl ester rea...
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WO/2022/141228A1 |
A preparation method for sucralose, a crude product solution, and sucralose, the method comprising: dissolving a sucralose-6-acetate into methanol, adding calcium oxide into the reaction solution of the sucralose-6-acetate for a deacylat...
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WO/2022/110017A1 |
A method for purifying sucralose-6-ethyl ester, comprising: a preparation step: obtaining an ethyl acetate saturated solution of crude sucralose-6-ethyl ester heated to a predetermined temperature; a gradient crystallization step: perfor...
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WO/2022/099606A1 |
A method for purifying sucralose, comprising: removing a solvent from a sucralose reaction liquid to obtain a concentrated solution of a sucralose crude product; under stirring, adding ethyl acetate to the concentrated solution of the su...
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WO/2022/083106A1 |
The present invention relates to the field of pharmaceutical chemicals, and relates to a method for preparing a glucosamine sulfate composite salt. The method comprises: adding N-acetylglucosamine and a solvent into a reaction vessel, th...
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WO/2022/067621A1 |
A sucralose purification method, sequentially comprising: putting sucralose in ultrapure water, heating for dissolving and then filtering, and extracting with an extraction solvent to remove non-polar impurities; evaporating an extracted...
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WO/2022/038198A1 |
Monosaccharide compounds, in particular deoxy-pentose compounds and preferably 5-azido-5-deoxy-D-arabinofuranose, for use in for use in labelling and/or concentrating and/or targeting and/or diagnosis of cell secretions from eukaryotic c...
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WO/2022/011554A1 |
The invention relates to a compound represented by general formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable hydrate thereof or pha...
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WO/2021/261444A1 |
The present invention relates to a compound that is useful as a vaccine adjuvant, a method for producing the same, a pharmaceutical composition that contains the compound, and use of the compound as a vaccine adjuvant.
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WO/2021/248697A1 |
Provided are a glucosamine salt produced by means of an enzymatic method, and a purification method therefor. According to the enzymatic method, N-acetylglucosamine is taken as a raw material and is subjected to deacetylase hydrolysis to...
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WO/2021/248696A1 |
A separation and purification method for N-acetylglucosamine of the present invention relates to the technical field of bioengineering. In the present invention, a raw material liquid containing N-acetylglucosamine is obtained by means o...
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WO/2021/247722A1 |
The present invention relates to seleno-NSAID compounds, compositions comprising such compounds, and methods of use. In particular, provided herein are compounds, pharmaceutical compositions, and methods of using of the same for treating...
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WO/2021/231397A1 |
Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.
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WO/2021/231751A1 |
The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection ...
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WO/2021/227441A1 |
A compound inhibiting a sodium-glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer thereof. The compound is used in a pharmaceutical composition. Also disclosed are methods for preparing and using the pharm...
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WO/2021/227439A1 |
Provided in the present invention are a compound for inhibiting sodium glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer of the compound. The compound is used for a pharmaceutical composition, and further...
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WO/2021/222727A1 |
Described herein are methods of treating a Nontuberculosis Mycobacteria (NTM) infection in a subject in need thereof, the methods comprising administering an effective amount of a polyglucosamine derivative or a composition comprising a ...
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WO/2021/187559A1 |
The purpose of the present invention is to provide an efficient method for producing 2-deoxy-2-[18F]-fluorosorbitol. The present invention can provide, by bringing an alumina-supported reducing agent into contact with 2-deoxy-2-[18F]-flu...
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WO/2021/170620A1 |
The present invention relates to a method for producing a glycosyl fluoride of interest, the method comprising providing an internalized exogenous precursor and a genetically modified cell, wherein one or more glycosylation reactions can...
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