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WO/2000/050621A2 |
A process for producing aldehydes, and/or carboxylic acids is described, in which a primary alcohol, especially a carbohydrate, is oxidised using a catalytic amount of a nitrosonium compound obtained by oxidising a nitroxyl compound in t...
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WO/2000/050388A1 |
A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidised using an oxidising agent in the presence of a complex of a transition metal such as Mn, Fe, Cu, and a complexing agent such as ...
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WO/2000/047595A1 |
Compounds represented by general formula (I), which have excellent macrophage inhibiting effects and are thus useful in the prevention or treatment of inflammation, autoimmune diseases or sepsis: wherein R?1¿ and R?3¿ are each C¿1?-CÂ...
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WO/2000/039751A2 |
A system and method for providing improved $i(de novo) structure-based drug design that includes a method for more accurately predicting binding free energy. The system and method use a coarse-graing model with corresponding knowledge-ba...
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WO/2000/039140A1 |
Compounds represented by formulae (I), (V) and (X), which are novel siastatin B derivatives having potent glycosidase inhibitory activities, are synthesized by a novel process. The compounds of the formulae (I), (V) and (X) have potent i...
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WO/2000/038697A1 |
Methods for preventing or treating a viral infection in a subject are described that include administering N-glycolylneuraminic acid or a derivative thereof to the subject.
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WO/2000/039139A1 |
Conjugates of saccharide and an acetamidino- or guanidino- compounds of formula (I), wherein A is CH¿3? or NH¿2?; X is a linear or branched C¿1?-C¿8? alkyl chain optionally containing hydroxy, amino and/or oxo groups; n is an integer...
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WO/2000/036419A1 |
The present invention provides a method for immobilising a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (-C(=O)-COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (...
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WO2000018777A9 |
The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.
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WO/2000/029419A1 |
The present invention discloses chemiluminescent 1,2-dioxetane substrates capable of reacting with a neuraminidase to release optically detectable energy. These 1,2-dioxetanes have general formula (I), wherein Z is formula (II) and the v...
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WO/1999/067265A1 |
There are provided according to the invention, novel compounds of formula (I) wherein R?1¿, R?2¿ and R?3¿ are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the...
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WO/1999/064410A1 |
The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and Z have the cited descr...
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WO/1999/064409A2 |
The invention relates to benzothiepine-1,1-dioxide derivatives and their acid addition salts, i.e. compounds of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and Z have the meanings given in the description and their physiologica...
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WO/1999/058540A2 |
Disclosed are novel 1-galactose derivatives of formula (I) having a carbon- or nitrogen-containing aglycon linkage. The disclosed compounds inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors e...
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WO/1999/057158A1 |
Primary alcohols, especially in carbohydrates, can be selectively oxidised to aldehydes and carboxylic acids in a low-halogen process by using a peracid in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl (TEMPO) and a ...
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WO/1999/043689A1 |
KDN derivatives represented by general formula (1) or salts thereof and antiviral agents containing the same as the active ingredient wherein R?1¿ represents lower alkyl, lower alkenyl or aralkyl; R?2¿ and R?3¿ may be the same or diff...
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WO/1999/042617A1 |
An antiretroviral composition for inhibiting the action of reverse transcriptase includes a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiret...
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WO/1999/034676A1 |
The present invention discloses a method for the synthesis of derivatives of aloesin, alkylated at the C-7 hydroxyl group. The present invention includes the modified aloesins produced by the method of this invention and the use of these...
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WO1999000399A9 |
C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments ...
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WO/1999/012944A2 |
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte bin...
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WO/1999/008511A1 |
The present invention provides methods for producing sialyloligosaccharides $i(in situ) in dairy sources and cheese processing waste streams, prior to, during, or after processing of the dairy source during the cheese manufacturing proce...
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WO/1999/003853A1 |
According to the inventive method, 2-keto-L-gulonic acid is converted to 2-keto-L-gulonic acid ester in a two-stage esterification process, before being further processed to ascorbate. The two-stage esterification enables efficient remov...
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WO/1999/000436A2 |
The present invention relates to new polymerisates of unsaturated saccharide acids (aldonic, uronic or arsenial acids) as well as to the salts or derivatives thereof, wherein said polymerisates contain a double bond in the ring or in the...
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WO/1998/058941A1 |
The invention relates to a method for the production of aldobionic or aldonic acid amides by reacting the aldobionic acid and/or aldonic acid and/or the lactones or solutions thereof with fatty amines. According to the invention, aldobio...
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WO/1998/053813A1 |
A saccharide compound and a library of saccharide compounds are disclosed with a scaffold design that incorporates a carboxylic acid moiety, a free or protected hydroxy group and an amino or protected amino group.
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WO/1998/031696A2 |
A method for synthesizing C-glycosides of ulosonic acids such as Neu5Ac, by which diastereocontrolled synthesis of $g(a)-C-glycosides of ulosonic acids is attained, is disclosed. In the method of the present invention, an ulosonic acid s...
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WO/1998/031695A1 |
A free acid form of a polysaccharide is produced from its alkali-metal salt. In one example, free-form hyaluronic acid is produced by preparing a solution of an alkali-metal salt of hyaluronic acid, dispersing into the solution a strong ...
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WO/1998/031697A1 |
An aryl C-glycoside of formula (I), wherein R?1� is a natural or artificial monosaccharide having an $g(a) or $g(b) bond or a disaccharide, trisaccharide or tetrasaccharide of the monosaccharide; m is 1 to 4; Ar is an aromatic or heter...
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WO/1998/030573A1 |
Analogues of formula (I) of the so-called sulfatides (3-O-sulphated galactosyl ceramides) are disclosed in which the natural ceramide is substituted by a simple dialkylated unit. This aglycone may be O-, S- or C-glycosidically linked. Th...
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WO/1998/028319A1 |
There are provided according to the invention novel compounds of formula (I) wherein R?1�, R?2� and R?3� are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for...
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WO/1998/023625A1 |
A class of molecules and methods that alter cell adhesion, inhibit cancer metastasis, and induce apoptosis. A method according to the present invention comprises bringing cells into contact with compounds that essentially consist of an a...
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WO/1998/023626A1 |
The invention relates to benzoic acid derivatives, in which $g(a)-C-fucosides or $g(a)-C-mannosides and alkyl chains or rings, which have at least one acid function, are attached in positions 3 and 5 of the aromatic ring, via ether linka...
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WO/1998/016186A2 |
Novel monocyclic L-nucleoside compounds have general formula (I). Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases....
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WO/1998/013328A1 |
A process for preparing 4,5-dihydroxy-2-cyclopenten-1-one represented by formula (1), characterized by heat-treating at least one member selected among: (a) uronic acids or uronic acid derivatives; (b) sugar compounds containing uronic a...
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WO/1998/013372A1 |
Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of general formula (I) are provided wherein R�1? and R�2? are alkyl groups containing 1 to 4 carbon atoms and R�3? is a chromogenic or fluorogenic group. T...
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WO/1998/011104A1 |
The present invention pertains to compounds of general formula (I), where R�1? to R�7? have the notations given in the application, as well as preparation thereof. Compounds can be used as substrates for RNA and DNA polymerases and c...
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WO/1998/011119A1 |
The present invention relates to novel pyranoside derivatives having general formula (I), process for the manufacture thereof and their use as medicaments.
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WO/1998/008854A2 |
Sialyl Lewis X mimetics which mimic the inhibition of selectin-mediated cellular adhesion by sialyl X having a core of formula (I).
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WO/1998/003554A1 |
A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly...
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WO/1997/045107A1 |
The use of compounds represented by the following general formula (I): CH2=CH-CH2-S(O)n-R, (wherein R represents hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkylthio, alkenylthio, optionally substituted pheny...
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WO/1997/043298A1 |
The present invention provides fluorescent nucleosides carrying polycyclic aromatic hydrocarbons such as anthracene, phenanthrene, pyrene, stilbene, tetracene or pentacene. The subject nucleosides may be synthesized using a C-glycosidic ...
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WO/1997/033593A1 |
A product of heat treatment of at least one member selected from among (a) uronic acid or uronic acid derivatives, (b) a saccharide containing uronic acid or uronic acid derivatives, and (c) a substance comprising a saccharide containing...
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WO/1997/028807A1 |
An anticancer agent capable of suppressing metastasis of cancer cells even when employed alone, exhibiting little side effects and an extremely low toxicity even in the case of prolonged administration. The agent comprises sialic acid, i...
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WO/1997/027205A1 |
This invention pertains to nucleoside analogs which have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to ...
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WO/1997/027204A1 |
This invention pertains to nucleoside analogs which have antiviral activity and improved metabolic stability. More specifically, this invention pertains to modified sugar benzimidazole nucleosides, as exemplified by compounds such as ben...
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WO/1997/023637A1 |
The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Gal'alpha'1-3Gal), GlcNAc'beta'1-3Gal, 'alpha'- or 'beta'-glycoside...
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WO/1997/021416A2 |
They are comprised of a series of derivatives of carbohydrates of a family of biologically active opiated agents, which present in their structure at least one residue of cabohydrate per opiate molecule, linked directly to a hydroxyl gro...
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WO/1997/020860A1 |
The invention relates to a process for the alcaline oxidative degradation of an ose, an ulose, polymers or mixtures thereof in aqueous solution and in the presence of a redox couple comprised of a mixture of monosulfonic anthraquinone-2-...
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WO/1997/020000A2 |
The present invention comprises colorant stabilizers and a colorant composition which includes a colorant and a colorant stabilizer. The colorant stabilizer imparts light-stability to the colorant so that the colorant does not fade when ...
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WO/1997/006810A1 |
A peritoneal dialysis solution comprising an effective amount of an acetylate or deacetylated amino sugar and/or combinations thereof.
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